Medicine and Health Sciences Commons^™

Michigancovid19miscdatacollection, Michigan Department Of Health & Human Services

Michigan COVID-19 MIS-C Data

This is a zipped file of all the pdfs uploaded to this collection, spanning from 2020-12-14 through 2023-04-20.

It also includes a comma separated file that lists the metadata for each file, including the file name within the Michigan COVID-19 MIS-C Data ScholarWorks Collection (ScholarWorksFileTitle), the archived URL (InternetArchiveLink), the description of the file within the Michigan COVID-19 MIS-C Data ScholarWorks Collection (ScholarWorksAbstract), and any additional comments about the file within the Michigan COVID-19 MIS-C Data ScholarWorks Collection (ScholarWorksComments).

Arthroscopic Treatment Of Shoulder Stiffness With Rotator Cuff Repair Yields Similar Outcomes To Isolated Rotator Cuff Repair, Parker L. Brush, Adrian Santana, Ruchir Nanavati, Gregory R. Toci, Tariq Z. Issa, Daniel J. Fletcher, Joshua Hornstein

Rothman Institute Papers

Purpose To compare patient-reported and surgical outcome measures in patients with and without secondary shoulder stiffness (SSS) undergoing rotator cuff repair (RCR).

Methods Patients undergoing rotator cuff repair from 2014 to 2020 with complete patient-reported outcome measures (PROMs) by the short-form 12 survey (SF-12) were retrospectively reviewed to identify if operative intervention for SSS was performed alongside the RCR. Those patients with operative intervention for SSS were propensity matched to a group without prior intervention for stiffness by age, sex, laterality, body mass index, diabetes mellitus status, and the presence of a thyroid disorder. The groups were compared by rotator …

Gene Signature Reveals Decreased Sox10-Dependent Transcripts In Malignant Cells From Immune Checkpoint Inhibitor-Resistant Cutaneous Melanomas, Timothy J. Purwin, Signe Caksa, Ahmet Sacan, Claudia Capparelli, Andrew E. Aplin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Evidence is mounting for cross-resistance between immune checkpoint and targeted kinase inhibitor therapies in cutaneous melanoma patients. Since the loss of the transcription factor, SOX10, causes tolerance to MAPK pathway inhibitors, we used bioinformatic techniques to determine if reduced SOX10 expression/activity is associated with immune checkpoint inhibitor resistance. We integrated SOX10 ChIP-seq, knockout RNA-seq, and knockdown ATAC-seq data from melanoma cell models to develop a robust SOX10 gene signature. We used computational methods to validate this signature as a measure of SOX10-dependent activity in independent single-cell and bulk RNA-seq SOX10 knockdown, cell line panel, and MAPK inhibitor drug-resistant datasets. Evaluation …

Increased Sirt3 Combined With Parp Inhibition Rescues Motor Function Of Sbma Mice, David R. Garcia Castro, Joseph R. Mazuk, Erin M. Heine, Daniel Simpson, R. Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V. Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E. Merry, Qiang Tong, Maria Pennuto, Heather L. Montie

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD+-dependent deacetylase, SIRT3, reduced oxidative stress and death of cells modeling SBMA. However, increasing diminished SIRT3 in AR100Q mice failed to reduce acetylation of the SIRT3 target/antioxidant, SOD2, and had no effect on increased total acetylated peptides in quadriceps. Yet, overexpressing SIRT3 resulted in a trend of motor recovery, and corrected TCA cycle activity by decreasing acetylation of SIRT3 target proteins. We sought to boost blunted SIRT3 activity …

Michigancovid19testingcollection, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

This is a zipped file of all the pdfs uploaded to this collection, spanning from 2020-04-09 through 2021-05-28.

It also includes a comma separated file that lists the metadata for each file, including the file name within the Michigan COVID-19 Testing Turnaround Data ScholarWorks Collection (ScholarWorksFileTitle), the archived URL (InternetArchiveLink), the description of the file within the Michigan COVID-19 Testing Turnaround Data ScholarWorks Collection (ScholarWorksAbstract), and any additional comments about the file within the Michigan COVID-19 Testing Turnaround Data ScholarWorks Collection (ScholarWorksComments).

Michigancovid19outbreakreportcollection, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

This is a zipped file of all the pdfs uploaded to this collection, spanning from 2020-08-20 through 2023-04-27 for the overall outbreak reports, 2020-09-14 through 2022-06-13 for school outbreak reports, and 2022-06-21 through 2023-04-25 for ISD K-12 outbreak reports.

The zip file also includes a comma separated file that lists the metadata for each file, including the file name within the Michigan COVID-19 Outbreak Reports ScholarWorks Collection (ScholarWorksFileTitle), the archived URL (InternetArchiveLink), the description of the file within the Michigan COVID-19 Outbreak Reports ScholarWorks Collection (ScholarWorksAbstract), and any additional comments about the file within the Michigan COVID-19 Outbreak Reports ScholarWorks …

Michigancovid19vaccinecollection, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

This is a zipped file of all the pdfs uploaded to this collection, spanning from 2020-12-16 through 2023-04-26. It also includes a few additional pdfs: 2020-10-16_Michigan_COVIDVaccination_Plan.pdf; 2020-12-13_Michigan_COVIDVaccination_PrioritizationGuidance.pdf; 2020-12-13_Michigan_COVIDVaccine_FAQ.pdf; 2020-12-13_Michigan_COVIDVaccine_Infograph.pdf; 2021-01-21_Michigan_COVIDVaccine_Locations.pdf.

The zip file also includes a comma separated file that lists the metadata for each file, including the file name within the Michigan COVID-19 Vaccine Data ScholarWorks Collection (ScholarWorksFileTitle), the archived URL (InternetArchiveLink), the description of the file within the Michigan COVID-19 Vaccine Data ScholarWorks Collection (ScholarWorksAbstract), and any additional comments about the file within the Michigan COVID-19 Vaccine Data ScholarWorks Collection (ScholarWorksComments).

Healthy Eating Interventions Delivered In Early Childhood Education And Care Settings For Improving The Diet Of Children Aged Six Months To Six Years, Sze Lin Yoong, Melanie Lum, Luke Wolfenden, Jacklyn Jackson, Courtney Barnes, Alix E. Hall, Sam Mccrabb, Nicole Pearson, Cassandra Lane, Jannah Z. Jones, Lauren Dinour, Therese Mcdonnell, Debbie Booth, Alice Grady

Department of Nutrition and Food Studies Scholarship and Creative Works

Background

Dietary intake during early childhood can have implications on child health and developmental trajectories. Early childhood education and care (ECEC) services are recommended settings to deliver healthy eating interventions as they provide access to many children during this important period. Healthy eating interventions delivered in ECEC settings can include strategies targeting the curriculum (e.g. nutrition education), ethos and environment (e.g. menu modification) and partnerships (e.g. workshops for families). Despite guidelines supporting the delivery of healthy eating interventions in this setting, little is known about their impact on child health.

Objectives

To assess the effectiveness of healthy eating interventions delivered …

The Impact Of Covid-19 On Hospitalization Outcomes Of Patients With Acute Myocardial Infarction In The Usa, F.E. Markson, E. Akuna, C.Y. Lim, L. Khemani, A, Amanullah

Einstein Health Papers

Background/study objective: The effect of the COVID-19 pandemic affected health care delivery, as it led to variable outcomes in different disease states including cardiovascular diseases. In this study, we evaluated the impact of coexisting COVID-19 on Acute Myocardial Infarction (AMI). Design/setting: We analyzed discharge records of AMI patients from the National Inpatient Sample (NIS) in the year 2020.

Main outcome measures: Using propensity score matching, we assessed the impact of COVID-19 infection on the in-hospital outcomes of patients presenting with AMI.

Results: There were 1154 patients with concomitant COVID-19 infection and AMI who were matched with 109,990 patients with AMI …

Impact Of Social Media And Multimedia Platforms: View From The Jacc: Case Reports Some Editors, Estefania Oliveros, Yevgeniy Brailovsky, Alessandro Beneduce, Hooman Bakshi, Edoardo Zancanaro, Indah Sukmawati, Mrinali Shetty, Gina Lundberg

Division of Cardiology Faculty Papers

No abstract provided.

Physical And Stressful Psychological Impacts Of Prolonged Personal Protective Equipment Use During The Covid-19 Pandemic: A Cross-Sectional Survey Study, Giuseppe Candido, Costanza Tortù, Chiara Seghieri, Riccardo Tartaglia, Chiara Baglioni, Paolo Citti, Ida Marina Raciti, Micaela La Regina, Silvia Simonini, Moira Urbani, Chiara Parretti, Paul Barach

College of Population Health Faculty Papers

BACKGROUND: Healthcare workers (HCWs) caring for COVID-19 infected patients are exposed to stressful and traumatic events with potential for severe and sustained adverse mental and physical health consequences. Our aim was to assess the magnitude of physical and mental health outcomes of HCWs due to the prolonged use of personal protective equipment (PPE) treating COVID-19 patients.

METHODS: This cross-sectional study assessed the symptoms of stress, anxiety, insomnia, and psychological resilience using the Stress and Anxiety to Viral Epidemics (SAVE) scale, Insomnia Severity Index (ISI), and Resilience Scale (RS), respectively, in Italy between 1st February and 31st March 2022. The physical …

Assessing Boil Water Notices As Health-Risk Communication: Risk Perceptions, Efficacy, And Compliance During Winter Storm Uri, Ashleigh M. Day, Sydney O'Shay, Khairul Islam, Matthew W. Seeger, Shawn P. Mcelmurry

Open Data at Wayne State

Winter Storm Uri was an extreme disaster that impacted much of the United States during February of 2021. Texas and Oklahoma were generally not prepared for such an event and experienced massive power grid failures. This led to cascading risks including water system disruptions and many boil water notices (BWNs). The breakdown of some communication channels and the inability to enact protective actions due to power outages, as well as travel limitations on public roads, complicated both dissemination and implementation. Under these conditions, a non-representative, cross-sectional, survey was collected to assess individuals experience BWNs and how perceived efficacy impacts compliance. …

Michigancovid19longtermcaredatacollection, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

This is a zipped file of all the pdfs uploaded to this collection, spanning from 2020-04-24 through 2023-04-25.

It also includes a comma separated file that lists the metadata for each file, including the date it was captured (CheckedEST), the archived URL (InternetArchiveLink), the date that the website was updated (WebsiteUpdate), information included on the website (Website Notes), the file name within the Michigan COVID-19 Long Term Care Data ScholarWorks Collection (ScholarWorksFileTitle), the description of the file within the Michigan COVID-19 Long Term Care Data ScholarWorks Collection (ScholarWorksAbstract), and any additional comments about the file within the Michigan COVID-19 Long …

Differential Response Of C9orf72 Transcripts Following Neuronal Depolarization, Layla T. Ghaffari, Davide Trotti, Aaron R. Haeusler

Farber Institute for Neuroscience Faculty Papers

The (G4C2)n nucleotide repeat expansion (NRE) mutation in C9orf72 is the most common genetic cause of ALS and FTD. The biological functions of C9orf72 are becoming understood, but it is unclear if this gene is regulated in a neural-specific manner. Neuronal activity is a crucial modifier of biological processes in health and neurodegenerative disease contexts. Here, we show that prolonged membrane depolarization in healthy human iPSC-cortical neurons leads to a significant downregulation of a transcript variant 3 (V3) of C9orf72, with a concomitant increase in variant 2 (V2), which leads to total C9orf72 RNA transcript levels remaining unchanged. However, the …

Michigancovid19hospitalcollection, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

This is a zipped file of all the pdfs uploaded to this collection, spanning from 2020-04-02 through 2023-04-28.

It also includes a comma separated file that lists the metadata for each file, including the file name within the Michigan COVID-19 Hospital Data ScholarWorks Collection (ScholarWorksFileTitle), the archived URL (InternetArchiveLink), the description of the file within the Michigan COVID-19 Hospital Data ScholarWorks Collection (ScholarWorksAbstract), and any additional comments about the file within the Michigan COVID-19 Hospital Data ScholarWorks Collection (ScholarWorksComments).

Acute Diplopia After Glabellar Hyaluronic Acid Filler Injection, Caroline W. Chung, Eric J. Shiuey, César A. Briceño, Vivian Lee

SKMC Student Presentations and Publications

Purpose: Blindness is a well-known complication of filler injection in the glabellar region. Acute diplopia from filler injection without vision loss is a rare complication that typically results in clinical ophthalmoplegia which can have permanent sequelae. Here, we describe a patient who presented with acute diplopia with grossly intact full extraocular motility after glabella hyaluronic acid filler injection that resolved after 1 month.

Observations: A previously healthy 43-year-old woman underwent her first hyaluronic acid injection in the glabella and developed immediate binocular double vision with severe pain and skin mottling above her right eyebrow and central forehead. Hyaluronidase injections, nitroglycerin …

Modeling Honeymoon And Divorce Effects In Wolbachia Control Trials Of Dengue, Casey P. O'Brien

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dailymichigancovid19collection, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

This is a zipped file of all the pngs uploaded to this collection, spanning from 2020-03-04 through 2023-04-25.

Automated Subfield Volumetric Analysis Of Amygdala, Hippocampus, And Thalamic Nuclei In Mesial Temporal Lobe Epilepsy, Arichena Manmatharayan, Michael Kogan, Caio Matias, Mashaal Syed, India Shelley, Amar Chinni, Kichang Kang, Kiran Talekar, Scott H. Faro, Feroze B. Mohamed, Ashwini Sharan, Chengyuan Wu, Mahdi Alizadeh

Department of Neurosurgery Faculty Papers

Purpose: Identifying relationships between clinical features and quantitative characteristics of the amygdala-hippocampal and thalamic subregions in mesial temporal lobe epilepsy (mTLE) may offer insights into pathophysiology and the basis for imaging prognostic markers of treatment outcome. Our aim was to ascertain different patterns of atrophy or hypertrophy in mesial temporal sclerosis (MTS) patients and their associations with postsurgical seizure outcomes. To assess this aim, this study is designed in 2 folds: (1) hemispheric changes within MTS group and (2) association with postsurgical seizure outcomes.

Methods and materials: 27 mTLE subjects with mesial temporal sclerosis (MTS) were scanned for conventional 3D …

Impact Of The Covid-19 Pandemic On The Management Of Risk Factors In Patients With Stable Atherosclerotic Vascular Disease, Dean Karalis, Patrick Moeller, Albert Crawford, Maria Janelli, Scott Hessen

Division of Cardiology Faculty Papers

Background

Effective control of risk factors in patients with ASCVD is important to reduce recurrent cardiovascular events. However, many ASCVD patients do not have their risk factors controlled, and this may have worsened during the COVID-19 pandemic.

Methods

We retrospectively evaluated risk factor control among 24,760 ASCVD patients who had at least 1 outpatient encounter both pre-pandemic and during the first year of the pandemic. Risk factors were uncontrolled if the blood pressure (BP) ≥ 130/80 mm Hg, LDL-C ≥ 70 mg/dL, HgbA1c ≥ 7 for diabetic patients, and patients were current smokers.

Results

During the pandemic, many patients had …

Multiple Sequence Alignment Guided By Clam, Emily Light

Senior Honors Projects

For my honors project, I am continuing my research with my academic advisor, Dr. Daniels on creating an approach to the Multiple Sequence Alignment problem in the Rust programming language. This approach will be attached to Dr. Daniels’ CLAM (Clustered Learning for Approximate Manifolds) to enable it to globally and locally align DNA sequences. This research was divided into three separate parts: building the algorithms, implementing them into CLAM’s metric, and measuring and improving the performance of the algorithms. This project includes two separate but related algorithms; Needleman-Wunsch algorithm and the Smith-Waterman algorithm.

The Needleman-Wunsch algorithm takes in two DNA …

Hearing Aid Fitting Software Manipulations, Fadi Najem

Pacific Open Texts

This learning module is suitable for Doctor of Audiology students at the intermediate level of their learning about amplification. The module provides a comprehensive and interactive guideline for hearing aid finetuning and troubleshooting patients’ complaints regarding hearing aids. The module also provides a quick guide on how to set the hearing aids in test mode for test box measurements and how to locate data sheets for selected manufacturers.

Publication Rates Of Abstracts Presented Across 6 Major Spine Specialty Conferences, Tariq Z. Issa, Yunsoo Lee, Mark J. Lambrechts, Christopher Reynolds, Ryan Cha, James Kim, Jose A. Canseco, Alex R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder, Alan S. Hilibrand

Rothman Institute Papers

Background: Although scientific researchers aim to present their projects at academic conferences as a step toward publication, not all projects mature to become a peer-reviewed manuscript. The publication rate of meetings can be utilized to assess the quality of presented research. Our objective was to evaluate the contemporary publication rate of abstracts presented at spine conferences.

Methods: We reviewed annual meeting programs of North American Spine Society (NASS), Scoliosis Research Society (SRS), International Meeting on Advanced Spine Techniques (IMAST), Spine Global Spine Congress (GSC), Lumbar Spine Research Society (LSRS), and Cervical Spine Research Society (CSRS) from 2017 to 2019. Abstracts …

Incidence And Risk Factors For Retinal Detachment And Retinal Tear After Cataract Surgery: Iris® Registry (Intelligent Research In Sight) Analysis, Michael J. Morano, M. Ali Khan, Qiang Zhang, Colleen P. Halfpenny, Douglas M. Wisner, James Sharpe, Alexander Li, Maurizio Tomaiuolo, Julia A A. Haller, Leslie Hyman, Allen C. Ho

Wills Eye Hospital Papers

Objective To report the incidence of and evaluate demographic, ocular comorbidities, and intraoperative factors for rhegmatogenous retinal detachment (RRD) and retinal tear (RT) after cataract surgery in the American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight).

Design Retrospective cohort study.

Participants Patients aged ≥ 40 years who underwent cataract surgery between 2014 and 2017.

Methods Multivariable logistic regression was used to evaluate demographic, comorbidity, and intraoperative factors associated with RRD and RT after cataract surgery.

Main Outcome Measures Incidence and risk factors for RRD or RT within 1 year of cataract surgery.

Results Of the 3 177 195 …

Effects Of Pregnancy And Progesterone On Atrial Fibrillation, Heloisa M. Rutigliano

Browse all Datasets

Atrial Fibrillation (AF) is the most common cardiac arrythmia in adults with likely sex-specific risk factors. Female sex hormones may be important in modulating risk for atrial fibrillation. We hypothesize that pregnancy and progesterone (P4), a hormone found in high levels during pregnancy with abrupt withdrawal immediately after parturition, modulates AF susceptibility in female goats. Cardiac specific TGF-?1 transgenic female goats and age-matched wild-type (WT) female goats were utilized. Pacemakers were implanted in all animals for continuous arrhythmia monitoring and AF inducibility. AF inducibility was evaluated using 5 separate 10 s bursts of atrial pacing (160 - 200 ms). In …

The Influence Of Mass Media On The Covid-19 Vaccination Decision-Making Process: A Prospective Survey-Based Study, Cameron Quon

Biomedical Sciences Publications

No abstract provided.

Dynamic Fecal Microbiota Transfer From Mice With Western Diet-Induced Severe Colitis And Colon Tumorigenesis Did Not Exacerbate Colitis Symptoms Or Colon Tumorigenesis In Recipient Mice Fed Either The Ain93g Diet Or The Total Western Diet, Abby D. Benninghoff

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Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter the fecal microbiome composition in mice as com-pared to mice fed a healthy diet, AIN93G (AIN). However, it is unclear whether the gut micro-biome contributes directly to colitis-associated CRC in this model. The objective of this study was to determine whether dynamic fecal microbiota transfer (FMT) from host mice fed either AIN or TWD basal diets would alter colitis symptoms or colitis-associated CRC in recipient mice, which were fed either AIN or TWD directly using a 2x2 factorial experiment …

Bazedoxifene, Parth M. Raina, Mayur Parmar

HPD Articles

No abstract provided.

Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo

HPD Articles

No abstract provided.

Abaloparatide, Miis Akel, Mayur Parmar

HPD Articles

No abstract provided.