Medicine and Health Sciences Commons^™

Can The Cross-Education Of Strength Attenuate The Impact Of Detraining After A Period Of Strength Training? A Quasi-Randomized Trial, Grant S. Rowe, Anthony J. Blazevich, Janet L. Taylor, Timothy Pulverenti, G. Gregory Haff

Research outputs 2022 to 2026

Purpose: Unilateral strength training may attenuate the decline in muscle strength and size in homologous, contralateral muscles. This study aimed to determine whether the cross-education of strength could specifically attenuate the effects of detraining immediately after a short (prehabilitation-type) period of strength training. Methods: Twenty-six strength-trained participants were assigned to either four weeks of unilateral strength training of the stronger arm (UNI) or detraining (Detrain). Motor evoked potential (MEP) and cortical silent period (cSP) responses, muscle cross-sectional area (CSAFlexor; peripheral quantitative computed tomography) and maximal strength, rate of force development (RFD) and muscle activation (EMG) were examined in both elbow …

Optimizing Resistance Training For Sprint And Endurance Athletes: Balancing Positive And Negative Adaptations, Bas Van Hooren, Per Aagaard, Anthony J. Blazevich

Research outputs 2022 to 2026

Resistance training (RT) triggers diverse morphological and physiological adaptations that are broadly considered beneficial for performance enhancement as well as injury risk reduction. Some athletes and coaches therefore engage in, or prescribe, substantial amounts of RT under the assumption that continued increments in maximal strength capacity and/or muscle mass will lead to improved sports performance. In contrast, others employ minimal or no RT under the assumption that RT may impair endurance or sprint performances. However, the morphological and physiological adaptations by which RT might impair physical performance, the likelihood of these being evoked, and the training program specifications that might …

Confronting Cte: A Blog Dedicated To Increasing Awareness In Chronic Traumatic Encephalopathy, Caden Shea

Honors Program Theses

The variation on a creative thesis that I formed was a website and blog that utilized research about Chronic Traumatic Encephalopathy and how it affects athletes of all kinds, specifically athletes in the National Football League. The reason that I chose this topic is because the field that I hope to go into is that of sports journalism. One of the biggest problems facing sports leagues all over the world is the issue of safety. One of the biggest safety concerns in sports is that of head injuries, and one of the most prominent head injuries is CTE. I chose …

The Role Of Age As A Risk Factor For Pickleball-Related Injuries, Ches Jones, Bart Hammig

Health, Human Performance and Recreation Faculty Publications and Presentations

Pickleball is a popular sport that includes players from many different demographics. The popularity has resulted in not only increases in participation but also in activity related injuries. The purpose of this study was to identify risk factors along with potential mechanisms for injuries related to pickleball and identify effective countermeasures. Methods included the identification of pickleball related injuries from a US National Emergency Room database (NEISS). A narrative section of the database was used to identify and categorize potential mechanisms of injury. Results indicated that the types and mechanisms of injury relate to three specific age groups: younger, middle …

Bone Stress Injuries, Risk Of Low Energy Availability, Disordered Eating, Menstrual Dysfunction, Training Volume, And Exercise Dependence In Female Trail Runners, Saleen Zarate, Kelly Pritchett, Robert Pritchett, Namrita Kumar Brooke

All Master's Theses

ABSTRACT

BONE STRESS INJURIES, RISK OF LOW ENERGY AVAILABILITY, DISORDERED EATING, MENSTRUAL DYSFUNCTION, TRAINING VOLUME, AND EXERCISE DEPENDENCE IN FEMALE TRAIL RUNNERS

by

Saleen Zarate

June 2024

Problematic LEA can lead to REDs, which results in negative health outcomes such as impaired bone health. Trail runners may engage in a higher volume of training and may be at risk for LEA, MD, DE, and EXD, which may further increase the risk for bone stress injuries. This study aimed to explore and compare the prevalence of self-reported SFs between competitive and recreational female trail runners. Specifically, we aimed to examine risk …

Effects Of Eccentric Exercise Of The Extensors On Eccentric Exercise-Induced Muscle Damage Of The Flexors In Limbs, Trevor C. Chen, Wei Chin Tseng, Hsing Yu Kang, Chuan Wei Chan, Hsin Lian Chen, Kazunori Nosaka

Research outputs 2022 to 2026

Introduction:

We tested the hypothesis that muscle damage protection effect would be induced by its antagonist muscle eccentric exercise.

Methods:

Sedentary young (20-28y) men were randomly assigned into six groups; three groups each for arm or leg exercise group (n=12/group). One group performed two bouts of 30 maximal eccentric contractions (30MaxEC) of the elbow flexors (EF) or 60 maximal eccentric contractions (60MaxEC) of the knee flexors (KF) using a different arm (contra-EF-EF) or leg (contra-KF-KF) between bouts. The other two groups performed 30MaxEC of the elbow extensors (EE) or 60MaxEC of the knee extensors (KE) first followed by the 30MaxEC …

An Athlete's Perspective: Comparing Talent Development Environments For Boys And Girls In Western Australia Youth Soccer, Mikayla J. Lyons, Jenny A. Conlon, Sophia Nimphius, Brad S. Keller, Christopher Joyce

Research outputs 2022 to 2026

This study aimed to compare the perceptions of boys and girls regarding their gender-specific talent development environments (TDEs) in state-level youth soccer. Seventy-one players (girls, n = 35; boys, n = 36) aged 11–18 years completed the Talent Development Environment Questionnaire (TDEQ-5), Sports Motivation Scale (SMS-6), Coach-Athlete Relationship Questionnaire (CART-Q), and Self-Efficacy and Outcome Expectancies (SEOE) of strength training questionnaire. Mann–Whitney U tests and Hedges’s g effect sizes were used to identify group differences. Boys scored higher for TDEQ-5 subdimensions: long-term development focus, alignment of expectations, and holistic quality preparation. For the CART-Q, boys perceived greater coach commitment, whilst girls …

Barriers To Exercise In Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Patient Survey, Kedar Deshpande, John Olynyk, Oyekoya Ayonrinde, Kazunori Nosaka

Research outputs 2022 to 2026

Background: Although adequate physical activity is an essential component of treatment for metabolic dysfunction-associated stea-totic liver disease (MASLD), the majority of people with MASLD do not engage in regular exercise and lead sedentary lifestyles. We aimed to identify perceived barriers to exercise and to examine awareness about the role of exercise in the treatment of MASLD. Methods: Individuals aged 18 years and above were recruited from a hepatology outpatient clinic. MASLD severity was assessed using controlled attenuation parameter (CAP) and transient elastography (TE) determined liver stiffness measurement (LSM) for the severity of hepatic steatosis and fibrosis, respectively. An online questionnaire …

Effect Of Sampling Frequency On A Unilateral Isometric Hamstring Strength Assessment Using Force Plates, Nicholas J. Ripley, J. J. Mcmahon, Paul Comfort

Research outputs 2022 to 2026

The purpose of this study was to determine the effect of sampling frequency on the 90–90° (90-degrees hip and knee flexion) isometric hamstring assessment. Thirty-three elite female soccer players (age: 18.7 ± 3.7 years; height: 158.3 ± 5.9 cm; body mass: 62.8 ± 5.5 kg) performed three unilateral trials on a single occasion of the 90–90° isometric hamstring assessment. Force-time data were collected using force plates at 1000 Hz and down sampled to 500-, 250-, and 100 Hz. Peak force (N), force (N) at 100- and 200 ms and average rate of force development (aRFD) (N/s) over a 100- and …

Injury In Starting And Replacement Players From Five Professional Men’S Rugby Unions, Simon P. Roberts, Keith A. Stokes, Sean Williams, Stephen W. West, Simon Kemp, Matt Cross, Isabel S. Moore, Charlotte L. Bitchell, Prabhat Mathema, Ken Quarrie, Warren Mcdonald, Lauren Fortington, Eduardo R. Rubio Del Castillo, Clint Readhead, Nicola Sewry, Éanna Falvey, Ross Tucker

Research outputs 2022 to 2026

Objectives: The aim of this study was to compare the incidence, severity, and burden of injury in starting and replacement players from professional men’s teams of five rugby unions. Methods: Match injuries of greater than 24 h time-loss (including data on the severity, match quarter, event, body region) and player minutes of match exposure data were collated for all starting and replacement players in the men’s English Premiership, Welsh Pro14 (both 2016/17–2018/19 seasons), and Australian, New Zealand, and South African Super Rugby (all 2016–2018 seasons) teams. Injury incidences and mean injury burden (incidence × days missed) were calculated, and rate …

Powerlifting Participation And Engagement Across All Ages: A Retrospective, Longitudinal, Population Analysis With Comparison To Community Strength Norms, Daniel J. Van Den Hoek, Alistair Mallard, Joel M. Garrett, Patrick L. Beaumont, Robert J. Howells, Jemima G. Spathis, Joshua Pearson, Christopher Latella

Research outputs 2022 to 2026

Background: In Australia, one-third of people ≥ 15 years perform regular resistance training and 90% of those do not meet current health guidelines. All age groups should engage in regular resistance exercise, to maintain strength and function. Objectives: To identify trends in powerlifting competition participation in Australia by sex and age group from 1968 to 2022, and to compare the strength of powerlifting competitors to population age- and sex-based normative values. Method: The number of unique participants and total competition entries for each year were analysed using Australian powerlifting competition data. Subdomains of age and sex were investigated, and mean …

Resistance Training Effects On Pubertal Children With A Risk Of Developing Pediatric Dynapenia, Cassio V. Victora Ruas, Sébastien Ratel, Kazunori Nosaka, Gabriela Castellano, Ronei S. Pinto

Research outputs 2022 to 2026

Purpose: Many modern-day children are at risk of pediatric dynapenia (muscle weakness). We examined the effects of a 12-week resistance training (RT) program on neuromuscular function and body composition parameters in pubertal children with a risk of dynapenia. Methods: Twelve children (13.4 ± 0.9 y) with dynapenia performed a progressive RT program consisting of knee extension and flexion, bench press, abdominal crunch, back extension, lateral pull-down, elbow flexion, and upright row (1–2 sets of 10–15 repetitions/exercise) twice/week for 12 weeks. Outcome measures included one-repetition maximum (1-RM) strength, maximal voluntary isometric contraction (MVIC) torque, rate of torque development (RTD), electromyographic (EMG) …

Variations In Strength-Speed-Power Performance Across The Season: Do True Changes Occur In Elite Rugby Players?, Irineu Loturco, Chris Bishop, Santiago Zabaloy, Túlio B. M. A. Moura, Maurício S. Ramos, Lucas A. Pereira, Michael R. Mcguigan

Research outputs 2022 to 2026

This study aimed to determine, through the use of a highly sensitive statistical tool, whether real changes in performance were present; and compare the rates of meaningful variations in strength, speed, and power parameters at different time-points during the competitive season in national team rugby players. Thirty-two players were assessed 5 times across the season using the following tests: squat jump and countermovement jump tests; 30-m sprint velocity; and one-repetition maximum (1RM) in the half-squat and bench-press exercises. A repeated-measures analysis of variance was conducted to test for differences between successive time-points. Individual coefficients of variation values were used to …

Athlete Monitoring Perspectives Of Sports Coaches And Support Staff: A Scoping Review, Wouter P. Timmerman, Chris R. Abbiss, Nathan G. Lawler, Mandy Stanley, Annette J. Raynor

Research outputs 2022 to 2026

Objectives: To map and summarise the sports coaches’ and support staff's perspectives on athlete monitoring to explore the breadth of literature, identify knowledge gaps and inform future research. Design: Scoping review based on the Joanna Briggs Institute (JBI) methodology. Methods: SPORTDiscus, MEDLINE, APA PsycInfo, and Embase databases were searched in English until 6 September 2022. The inclusion criteria were (1) coach(es) and/or support staff were explicitly questioned about their knowledge, perceptions, understanding, opinions, and/or applied practice of athlete monitoring; (2) results could be directly attributed to coach(es) and/or support staff; (3) primary research projects that are available as full-text. Exclusion …

Recovery From Sport-Induced Muscle Damage In Relation To Match-Intervals In Major Events, Kazunori Nosaka, Trevor C. Chen

Research outputs 2022 to 2026

Muscle damage could affect the next match performance in sports when the time to recover from a previous match is shorter. We examined the interval between matches in nine team sports (e.g., soccer, rugby, field hockey, basketball, volleyball, baseball) and two racket sports (badminton, tennis) in World Cups held in 2022-2023, 2020 Tokyo Olympic Games and Gland Slam in 2023. We then performed narrative review using three electronic databases (PubMed, Scopus, Google Scholar) to get information about muscle damage and recovery in the 11 sports, and discussed whether the intervals in the events would be enough for athletes. We found …

Error In Jump Height Estimation Using The Flight Time Method: Simulation Of The Effect Of Ankle Position Between Takeoff And Landing, Carlos Gonçalves, Roberto Baptista, James Tufano, Anthony J. Blazevich, Amilton Vieira

Research outputs 2022 to 2026

During vertical jump evaluations in which jump height is estimated from flight time (FT), the jumper must maintain the same body posture between vertical takeoff and landing. As maintaining identical posture is rare during takeoff and landing between different jump attempts and in different individuals, we simulated the effect of changes in ankle position from takeoff to landing in vertical jumping to determine the range of errors that might occur in real-life scenarios. Our simulations account for changes in center of mass position during takeoff and landing, changes in ankle position, different subject statures (1.44–1.98 m), and poor to above-average …

Prevalence Of Disordered Eating And Its Relationship With Rapid Weight Loss Amongst Male And Female Combat Sport Competitors: A Prospective Study, Colin S. Doherty, Lauren V. Fortington, Oliver R. Barley

Research outputs 2022 to 2026

Objectives:

To compare prevalence and change scores of disordered eating (DE) in combat sport athletes by sex and explore the potential relationship between rapid weight loss (RWL) and DE scores.

Design:

Prospective study based on 24 events (September 2022–2023).

Methods:

A body mass (BM) questionnaire was completed at ~ 1 day post-competition providing pre-competition BM data for − 7 days, − 24 h, and weigh-in. The Athletic Disordered Eating (ADE) online questionnaire was completed at ~ 7 and ~ 28 days post-competition, providing overall DE and four subscale scores (food and energy control, bingeing, body control, and body discontent).

Results: …

A Systematic Review And Network Meta-Analysis On The Effectiveness Of Exercise-Based Interventions For Reducing The Injury Incidence In Youth Team-Sport Players. Part 1: An Analysis By Classical Training Components, Francisco Javier Robles-Palazón, Desirée Blázquez-Rincón, Alejandro López-Valenciano, Paul Comfort, José Antonio López-López, Francisco Ayala

Research outputs 2022 to 2026

Objectives: The primary purposes were (a) to estimate the pooled effects of injury prevention programs (IPPs) on reducing overall and some specific body regions (lower extremity, thigh, knee, and ankle) injury incidence rates (IIRs) and (b) to compare the effects of single- and multi-component IPPs on mitigating injury risk in youth team sport athletes. A secondary objective was to explore the individual effects of different components on these IIRs. Materials and methods: Searches were performed up to 15 January 2024 in PubMed, Web of Science, SPORTDiscus, and Cochrane Library. Eligible criteria were: exercise-based interventions evaluated against a control group, overall …

Reliability Of Time-Motion Analysis In Striking Combat Sports, L. Rohner, C. R. Abbiss, W. Poon, O. R. Barley

Research outputs 2022 to 2026

Introduction: Time-motion analysis (TMA) is a noninvasive performance analysis technique used in various sports to provide broad insights into the technical, tactical, and physiological demands of competitions by quantifying the mode, frequency, and duration of discrete activities. Objectives: This study aimed to assess the intra- and inter-observer reliability of activities in full-contact kickboxing athletes determined using TMA. Equipment and methods: A total of 29 bouts from the World Association of Kickboxing Organizations World Championships 2019, involving 58 male athletes, were analyzed by two expert analysts in a randomised order to determine the number of actions performed (i.e., punches, kicks, significant …

Effects Of Resveratrol Supplementation On Delayed Onset Muscle Soreness And Muscle Recovery: A Systematic Review, Nurdiana Zainol Abidin, Cheong Hwa Ooi, Kazunori Nosaka, Vishanth Rathakrishnan, Siok Yee Chan, Noor Khairiah A. Karim

Research outputs 2022 to 2026

Delayed onset muscle soreness (DOMS) and impaired muscle recovery significantly affect athletes and recreational exercisers, influencing their performance and training consistency. Resveratrol, a natural polyphenol known for its anti-inflammatory and antioxidant properties, is thought to mitigate these effects, yet its effectiveness remains to be fully verified. This systematic review evaluates the impact of RES supplementation on muscle recovery in adults by examining its influence on DOMS, oxidative stress, and inflammation, along with its interactions with other supplements. Three electronic databases and one registry were searched in October 2023. A total of 10 studies met the inclusion criteria, encompassing a combined …

Introduction Of The ‘Blue Card’ Concussion Policy To Semi-Elite Australian Football: Medical Staff Experiences And Perceptions, Jacob Raymond Msando, Gill Cowen, Sarah A. Harris, Troy Kirkham, Myles C. Murphy

Research outputs 2022 to 2026

Background The Western Australian Football League (WAFL) introduced a new umpire driven ‘blue-card rule’ for concussion, but its benefit to the sports medicine team is unknown. Purpose To determine the experiences and perceptions of medical staff within the 2022-2023 Men’s and Women’s WAFL competitions following the introduction of the ‘blue-card rule’. Study Design Cross-sectional study. Method An online survey was delivered through Qualtrics to all WAFL medical staff (doctors, physiotherapists, head trainers). The survey contained four sections (demographics, concussion knowledge, concussion exposure and blue-card perceptions) with closed and multiple-answer questions. Standard methods for reporting descriptive data were applied, including mean …

Best Practice Recommendations For Coaching Gymnasts To Avoid Burnout And Reframe Performance Anxiety, Clare A. Mccall

Theses: Doctorates and Masters

Gymnastics is deemed a psychologically demanding sport, with associated risk factors of burnout and performance anxiety. To date, relatively little research has explored the specific goal and perfectionistic processes of gymnasts, despite these risks. This body of work identified the specific goal-related constructs and perfectionistic orientation of young athletes and examined how these associated with burnout and performance anxiety. It comprised of two studies with a mixed methods design. The first study aimed to systematically review literature investigating how goal-related constructs and perfectionism associate with burnout and performance anxiety in young athletes. This review focused on summer and winter Olympic …

The Physiological And Performance Consequences Of The Australian Special Forces Selection Course, Angela Uphill

Theses: Doctorates and Masters

Special Forces (SF) soldiers are the most elite element of military forces, who have undergone rigorous training in order to prepare them for a wide array of specialised missions. In Australia, entry into the SF is determined through the highly competitive SF Selection Course (SF-SC), which is a gruelling program involving extreme physical demands, psychological stress, and restricted access to sleep and nutrition. The stressors involved in arduous military training events such as the SF-SC can result in significant losses of fat mass and lean mass, disruption to hormonal homeostasis, and significant decreases in neuromuscular capacity, which can potentially increase …

The Stability Of The Deadlift Three Repetition Maximum, Stuart N. Guppy, Tsuyoshi Nagatani, Wayne C. K. Poon, Kristina L. Kendall, Jason P. Lake, G. Gregory Haff

Research outputs 2022 to 2026

This study investigated the stability of three repetition maximum (3RM) strength during the deadlift. Eleven participants performed four testing sessions comprising a one repetition maximum test and 3RM tests separated by 48 h. Preparedness was assessed before each testing session using countermovement jumps and by measuring barbell velocity during each set of deadlifts. Trivial statistically significant differences were determined for the 3RM between T1 and both T2 (p = 0.012; ES [95% CI] = −0.1 [−0.58, 0.41]) and T3 (p = 0.027; ES [95% CI] = −0.09 [−0.57, −0.43]). No significant differences were noted between T2 and T3 …

Changes In Deadlift Six Repetition Maximum, Countermovement Jump Performance, Barbell Velocity, And Perceived Exertion Over The Duration Of A Microcycle, Stuart N. Guppy, Tsuyoshi Nagatani, Wayne C. K. Poon, Kristina L. Kendall, Jason P. Lake, G. Gregory Haff

Research outputs 2022 to 2026

The primary aim of this study was to investigate the stability of the six-repetition maximum (6RM) deadlift over the length of a five-day microcycle and whether the fatigue induced by maximal effort testing detrimentally impacted preparedness. Twelve participants performed four testing sessions, comprising a one-repetition maximum test and three 6RM tests separated by 48 hours. Countermovement jumps were performed before each testing session, and barbell velocity was measured during each warm-up set to assess changes in preparedness. The 6RM deadlift was not statistically different between any of the testing sessions (p  =  .056; η_p²  =  0.251). Similarly, …

Neuromuscular Adaptations To Different Set Configurations During A Periodized Power Training Block In Elite Junior Judokas, Dale M. Harris, Dustin J. Oranchuk, Christopher Latella

Research outputs 2022 to 2026

Although the impacts of traditional sets (TS) versus cluster (CL) sets resistance training have been broadly explored among recreationally trained populations, no studies have previously compared these set configurations among elite Judokas. Twenty-two elite male and female Judokas (age = 17.5 ± 1.2 years) performed identical periodized 4-week hypertrophy and strength blocks (8 weeks in total). Following this, for the final 4-week power training block, the cohort was separated into either TS (n = 11) or CL (n = 11) set structures. CL were prescribed by including 45-second intra-set rest every two repetitions. One-repetition maximum (1RM) and peak barbell velocities …

In Vivo Human Medial Gastrocnemius Fascicle Behaviour And Belly Gear During Submaximal Eccentric Contractions Are Not Affected By Concentric Fatiguing Exercise, Matheus Daros Pinto, Kazunori Nosaka, Anthony J. Blazevich

Research outputs 2022 to 2026

Changes in muscle geometry and belly gearing during eccentric contractions influence fibre strain and susceptibility to muscle damage. They are modulated by the interaction between connective tissues and intracellular-intrafascicular fluid pressures and external pressures from neighbouring structures. Fatiguing exercise triggers fluid shifts (muscle swelling) and muscle activation changes that may influence these modulators. Our purpose was to measure medial gastrocnemius (MG) geometric changes in vivo during eccentric contractions before and after maximal concentric muscle work to test the hypothesis that fatigue would reduce fascicle rotation and muscle gear and provoke greater fascicle strain. Submaximal eccentric plantar flexor contractions at 40% …

The Association Between Lateral Hip Muscle Size/Intramuscular Fat Infiltration And Hip Strength In Active Young Adults With Long Standing Hip/Groin Pain, Zuzana Perraton, Andrea B. Mosler, Peter R. Lawrenson, Kenneth Weber Ii, James M. Elliott, Evert O. Wesselink, Kay M. Crossley, Joanne L. Kemp, Christopher Stewart, Michael Girdwood, Matthew G. King, Joshua J. Heerey, Mark J. Scholes, Benjamin F. Mentiplay, Adam I. Semciw

Research outputs 2022 to 2026

Objectives: To investigate associations between lateral hip muscle size/intramuscular fat infiltration (MFI) and hip strength in active young adults with longstanding hip/groin pain.

Design: Cross-sectional study. Setting: University/Clinical.

Participants: Sub-elite soccer and Australian Football players (n = 180; 37 female) with long standing hip/groin pain.

Main outcome measures: Muscle size (volume) and MFI of gluteus maximus, medius, and minimis, and tensor fascia latae (TFL) were assessed using magnetic resonance imaging. Isometric hip strength was measured with handheld dynamometry. Associations between muscle size/MFI were assessed using linear regression models, adjusted for body mass index and age, with sex-specific interactions.

Results: Positive …

Different Methods Of Winning, Losing, And Training In Combat Sports And Their Relationship With Overall Competitive Winningness, Oliver R. Barley, Craig A. Harms

Research outputs 2022 to 2026

This study aimed to investigate how overall competitive winningness in combat sports depended on patterns of victory and loss, as well as training habits. Competitors (N = 280) from several combat sports participated in the study. The online survey included questions on self-reported patterns of victory (and loss), training habits, general demographics (e.g., age), and sport-specific information (e.g., stage of career and competitive style). Overall, it was found across four models that reflected diversity of winningness in combat sports that the most important predictors of competitive winningness were loss by points (negative), loss by submission (negative), loss (negative) or victory …

A 16-Week Progressive Exercise Training Intervention In Treatment-Naïve Chronic Lymphocytic Leukaemia: A Randomised-Controlled Pilot Study, Frankie F. Brown, Rebecca Oliver, Rachel Eddy, Adam J. Causer, Annabelle Emery, Harrison D. Collier-Bain, David Dutton, Josephine Crowe, Daniel Augustine, John Graby, Daniel Rees, Daniela Rothschild-Rodriguez, Oliver J. Peacock, Sally Moore, James Murray, James E. Turner, John P. Campbell

Research outputs 2022 to 2026

Background: Chronic lymphocytic leukaemia (CLL) typically presents with asymptomatic, early-stage disease that is monitored until disease progression (‘treatment-naïve’ CLL). The objective of this pilot study was to assess the feasibility and preliminary safety of an exercise program in treatment-naïve CLL. We also sought to preliminarily assess the impact of the exercise program on disease activity, as it has been proposed that exercise training may reduce disease outgrowth in treatment-naïve CLL. Methods: A total of 40 treatment-naïve CLL patients were recruited into this randomised-controlled pilot study, and after screening, n = 28 were randomised into a 16-week, home-based, partially supervised, personalised, …