Medicine and Health Sciences Commons^™

Accuracy And Precision Of Occlusal Contacts Of Stereolithographic Casts Mounted By Digital Interocclusal Registrations, Jason T. Krahenbuhl, Seok-Hwan Cho, Jon Patrick Irelan, Naveen K. Bansal

Mathematics, Statistics and Computer Science Faculty Research and Publications

Statement of problem

Little peer-reviewed information is available regarding the accuracy and precision of the occlusal contact reproduction of digitally mounted stereolithographic casts.

Purpose

The purpose of this in vitro study was to evaluate the accuracy and precision of occlusal contacts among stereolithographic casts mounted by digital occlusal registrations.

Material and methods

Four complete anatomic dentoforms were arbitrarily mounted on a semi-adjustable articulator in maximal intercuspal position and served as the 4 different simulated patients (SP). A total of 60 digital impressions and digital interocclusal registrations were made with a digital intraoral scanner to fabricate 15 sets of mounted stereolithographic …

The Precarious Health Of Young Mexican American Men In South Texas, Cameron County Hispanic Cohort, 2004–2015, Gordon P. Watt, Kristina Vatcheva, Derek M. Griffith, Belinda M. Reininger, Laura Beretta, Michael Fallon, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Mathematical & Statistical Sciences Faculty Publications

Introduction

Hispanic men have higher rates of illness and death from various chronic conditions than do non-Hispanic men. We aimed to characterize the health of Mexican American men living on the US–Mexico border in South Texas and elucidate indications of chronic disease in young men.

Methods

We sampled all male participants from the Cameron County Hispanic Cohort, an ongoing population-based cohort of Mexican Americans in Brownsville, Texas. We calculated descriptive statistics and stratified the sample into 3 age groups to estimate the prevalence of sociodemographic, behavioral, and clinical factors by age group and evaluated differences between age groups.

Results

Obesity …

Evaluating The Risk To Ostomy Patients Working With Uranium Using The Icrp Biokinetic Model For The Gastrointestinal Tract, Sara Taylor

UNLV Theses, Dissertations, Professional Papers, and Capstones

The ICRP has published two biokinetic models providing a basis for radiation dose assessment due toradionuclides incorporated inside the gastrointestinal tract. These models are a sufficient tool to assess the committed dose equivalent for occupational exposures to workers assuming normal anatomy. The colostomy is becoming a more prevalent procedure. A colostomy permanently or temporarily bypasses a portion of colon to allow rest and healing. There are four different colostomies; ascending, transverse, descending and sigmoid and an ileostomy. As a patient’s strength returns, they can return to normal daily activities, including returning to work. Therefore, as an ostomy patient returns to …

Preterm Birth And Air Pollution: Critical Windows Of Exposure For Women With Asthma, Pauline Mendola, Maeve Wallace, Beom Seuk Hwang, Danping Liu, Candace Robledo, Tuija Männistö

School of Medicine Publications

Background: Ambient air pollutants may increase preterm birth (PTB) risk, but critical exposure windows are uncertain. The interaction of asthma and pollutant exposure is rarely studied.

Objective: We sought to assess the interaction of maternal asthma and air pollutant exposures in relation to PTB risk.

Methods: Electronic medical records for 223,502 US deliveries were linked with modified Community Multiscale Air Quality model outputs. Logistic regression with generalized estimating equations estimated the odds ratio and 95% CIs for PTB on the basis of the interaction of maternal asthma and particulate matter with aerodynamic diameter of less than 2.5 microns and particulate …

Fuzzy Logic In Health Care Settings: Moral Math For Value-Laden Choices, Sarah Voss

Journal of Humanistic Mathematics

This essay is intended as an example of “moral math”, i.e., ideas culled from mathematics which can positively impact social behavior. Specifically, it combines fuzzy logic with the ethical decisions which hospital staff and others are sometimes forced to make about health care (e.g., euthanasia issues following Hurricane Katrina). The assumption is that such decisions involve value-laden choices which lend themselves to “fuzzy” or “smart” protocols. The article discusses the history of fuzzy logic – what it is, how it is used, and how it might be even better-used as a support basis for making difficult choices …

Apoe Ε4 Allele Modifies The Association Of Lead Exposure With Age-Related Cognitive Decline In Older Individuals, Diddier Prada, Elena Colicino, Melinda C. Power, Marc G Weisskopf, Jia Zhong, Lifang Hou, Avron Spiro, Pantel Vokonas, Plus 4 Others...

Epidemiology Faculty Publications

BACKGROUND: Continuing chronic and sporadic high-level of lead exposure in some regions in the U.S. has directed public attention to the effects of lead on human health. Long-term lead exposure has been associated with faster cognitive decline in older individuals; however, genetic susceptibility to lead-related cognitive decline during aging has been poorly studied.

METHODS: We determined the interaction of APOE-epsilon variants and environmental lead exposure in relation to age-related cognitive decline. We measured tibia bone lead by K-shell-x-ray fluorescence, APOE-epsilon variants by multiplex PCR and global cognitive z-scores in 489 men from the VA-Normative Aging Study. To determine global cognitive …

Artificial Intelligence And Amikacin Exposures Predictive Of Outcomes In Multidrug-Resistant Tuberculosis Patients, Chawangwa Modongo, Jotam G. Pasipanodya, Shashikant Srivastava, Nicola Zetola, Scott Williams, Giorgio Sirugo, Tawanda Gumbo

Dartmouth Scholarship

Aminoglycosides such as amikacin continue to be part of the backbone of treatment of multidrug-resistant tuberculosis (MDR- TB). We measured amikacin concentrations in 28 MDR-TB patients in Botswana receiving amikacin therapy together with oral levofloxacin, ethionamide, cycloserine, and pyrazinamide and calculated areas under the concentration-time curves from 0 to 24 h (AUC0 –24). The patients were followed monthly for sputum culture conversion based on liquid cultures. The median duration of amikacin therapy was 184 (range, 28 to 866) days, at a median dose of 17.30 (range 11.11 to 19.23) mg/kg. Only 11 (39%) pa- tients had sputum culture conversion during …

Update On Schizophrenia And Bipolar Disorder: Focus On Cariprazine, Rona Jeannie Roberts, Lillian Jan Findlay, Peggy El-Mallakh, Rif S. El-Mallakh

Nursing Faculty Publications

Schizophrenia and bipolar disorder are severe psychiatric disorders that are frequently associated with persistent symptoms and significant dysfunction. While there are a multitude of psychopharmacologic agents are available for treatment of these illnesses, suboptimal response and significant adverse consequences limit their utility. Cariprazine is a new, novel antipsychotic medication with dopamine D2 and D3 partial agonist effects. Its safety and efficacy have been investigated in acute psychosis of schizophrenia, bipolar mania, bipolar depression, and unipolar depression. Efficacy has been demonstrated in schizophrenia and mania. It is unclear if cariprazine is effective in depression associated with unipolar or bipolar illness. Adverse …

Ciliate Codon Translator Program Manual, Quentin D. Altemose

Mathematics Summer Fellows

Understanding the evolutionary history of organisms allows us to better comprehend selective pressures and their effects on larger populations. In our study, we focused on analyzing the DNA of ciliate groups, which are single celled protozoans characterized by the presence of cilia on their outer membrane. We utilized the DNA of the organisms to analyze the changes in population genotype over time. We tested existing evolutionary models (designed to represent natural genetic variation over time in populations) against our data to identify the model with the best fit and likelihood. From the DNA and the evolutionary model with the highest …

Retention Of Mothers And Infants In The Prevention Of Mother-To-Child Transmission Of Hiv Programme Is Associated With Individual And Facility-Level Factors In Rwanda., Godfrey B Woelk, Dieudonne Ndatimana, Sally Behan, Martha Mukaminega, Epiphanie Nyirabahizi, Heather J. Hoffman, Placidie Mugwaneza, Muhayimpundu Ribakare, Anouk Amzel, B Ryan Phelps

Epidemiology Faculty Publications

OBJECTIVES: Investigate levels of retention at specified time periods along the prevention of mother-to-child transmission (PMTCT) cascade among mother-infant pairs as well as individual- and facility-level factors associated with retention.

METHODS: A retrospective cohort of HIV-positive pregnant women and their infants attending five health centres from November 2010 to February 2012 in the Option B programme in Rwanda was established. Data were collected from several health registers and patient follow-up files. Additionally, informant interviews were conducted to ascertain health facility characteristics. Generalized estimating equation methods and modelling were utilized to estimate the number of mothers attending each antenatal care visit …

Optimal Control Analysis Of Ebola Disease With Control Strategies Of Quarantine And Vaccination, Muhammad Dure Ahmad, Muhammad Usman, Adnan Khan, Mudassar Imran

Mathematics Faculty Publications

The 2014 Ebola epidemic is the largest in history, affecting multiple countries in West Africa. Some isolated cases were also observed in other regions of the world.

How To Impress: Coordinating A Large Video Data Set For A Collaborative Project, Noah-Kee Marks, Rita Dawod

DePaul Discoveries

Though many different research methods involve mass quantities of video/audio data, there is little discussion of best practices for organization, especially when the research is collaborative. The guidelines we provide here were created while conducting educational research on the IMPRESS project, an integrated metacognitive program for at risk STEM majors at Rochester Institute of Technology (RIT). Our hope is to encourage large-scale, collaborative research of qualitative video data by using our project as an example and providing enough information for readers to make a judgment on the efficacy of this process for their own projects.

Assessment Of A Mycorrhizal Fungi Application To Treat Stormwater In An Urban Bioswale, Alaina Diane Melville

Dissertations and Theses

This study assessed the effect of an application of mycorrhizal fungi to stormwater filter media on urban bioswale soil and stormwater in an infiltration-based bioswale aged 20 years with established vegetation. The study tested the use of commercially available general purpose biotic soil blend PermaMatrix^® BSP Foundation as a treatment to enhance Earthlite^™ stormwater filter media amelioration of zinc, copper, and phosphorus in an ecologically engineered structure designed to collect and infiltrate urban stormwater runoff before it entered the nearby Willamette River.

These results show that the application of PermaMatrix^® BSP Foundation biotic soil amendment to Earthlite …

Santa Clara Magazine, Volume 57 Number 3, Summer 2016, Santa Clara University

Santa Clara Magazine

26 - CAN’T THREAD A MOVING NEEDLE To tackle sexual assault on college campuses, a playwriting project comes to the screen. By Danae Stahlnecker ’15.

28 - MISSION CRITICAL When three students fell ill from meningitis-causing bacteria—which can be fatal—it meant the clock was ticking. And to get through this, it would take everybody’s help. By Harold Gutmann.

36 - “WHERE ARE THEY TAKING US?” A journal from the front lines of the Syrian refugee crisis in Greece. By Colleen Sinsky ’10.

40 - NO STRANGERS HERE Refugees, home, and work by Ameera Naguib ’16 from Jordan to Silicon Valley. …

The Derivation Of Sea Surface Velocities From Satellite Imagery Using Maximum Cross Correlation (Mcc), Philip Lawrence

The Plymouth Student Scientist

An investigation into the use of cross-correlation statistics to resolve surface velocities from satellite imagery was conducted for the region characterised by the Benguela current at approximately 24oS - 28oS and 9oE - 17oE for July 14th and 15th 2011. Colour images depicting concentrations for chlorophyll_a taken by the MODIS sensor and provided by NASA’s Ocean Color Browser, were used to conduct the statistical analysis using distinguishable surface colour features as tracers. Three runs using different parameter values for the cross correlation were carried out and the output vector fields examined. The first run produced 126 vectors with mean u …

Improved Estimation Of Optimal Cut-Off Point Associated With Youden Index Using Ranked Set Sampling, Jingjing Yin, Hani M. Samawi, Daniel Linder

Biostatistics: Faculty Publications

A diagnostic cut-off point of a biomarker measurement is needed for classifying a random subject to be either diseased or healthy. However, the cut-off point is usually unknown and needs to be estimated by some optimization criteria. One important criterion is the Youden index, which has been widely adopted in practice. The Youden index, which is defined as the maximum of (sensitivity + specificity −1), directly measures the largest total diagnostic accuracy a biomarker can achieve. Therefore, it is desirable to estimate the optimal cut-off point associated with the Youden index. Sometimes, taking the actual measurements of a biomarker is …

"It's Such A Battle": A Phenomenological Account Of Raising A Child On The Autistic Spectrum - A Battle With Bureaucracy And Behaviour, Tara Vassallo

The Plymouth Student Scientist

A sharp rise in the prevalence of Autism Spectrum Disorder (ASD), has led to it becoming one of the most widely researched neurodevelopmental conditions. Although the predominant focus in autism research is child centred, research on parent outcomes has highlighted considerable impact, in terms of parent’s mental health and wellbeing. Previous studies have shown that parents of children with autism suffer extremes of distress, in excess of that of parents of children with other disabilities. However, why this is so is less understood. Interpretative phenomenological analysis was used to analyse data, gathered from semi-structured interviews of seven parents raising children …

From Offline To Online: How Health Insurance Policies Drive The Demand For Online Healthcare Service?, Yue Yu, Qiu-Yan Mei, Qiu-Hong Wang

Research Collection School Of Computing and Information Systems

Online healthcare service has gradually become a significant part of healthcare services, especially in emerging economy with shortage in medical resources and wide coverage in the Internet usage. This paper studies how health insurance policies affect the demand for online healthcare consultation by using longitudinal online healthcare and offline medical services datasets of a major city in China. The two policies we study are the integration of health insurance systems in urban and rural regions and the integration of health insurance systems between pairwise-cities. The empirical results show that both policies significantly affected the demand for online consultation. Our study …

Oversampling Methods For Imbalanced Dataset Classification And Their Application To Gynecological Disorder Diagnosis, Iman Nekooeimehr

USF Tampa Graduate Theses and Dissertations

In many applications, the dataset for classification may be highly imbalanced where most of the instances in the training set may belong to some of the classes (majority classes), while only a few instances are from the other classes (minority classes). Conventional classifiers will strongly favor the majority class and ignore the minority instances. The imbalance problem can occur in both binary data classification and also in ordinal regression. Ordinal regression is a supervised approach for learning the ordinal relationship between classes. Extensive research has been performed for addressing imbalanced datasets for binary classification; however, current methods do not address …

Environmental And Community Health In South San Diego County: A Behavior Analysis Of Recreational Ocean Users Along Imperial Beach, California, Trista Brophy

USF Tampa Graduate Theses and Dissertations

Garbage & sewage runoff into the Pacific Ocean at the shoreline along the U.S./Mexico Border region poses serious health and environmental threats. The purpose of this study was to analyze the current beach users’ behavioral factors that may be linked to illness prevalence from Coronado Island to the U.S./Mexico border at Imperial Beach in San Diego County. It is a continuation of a study completed by Wildcoast and Imperial Beach Clinic in 2011. The study tried to answer the following two major questions: How have the number of illnesses reported by users along South San Diego County beaches changed in …

Burden Of Disease Resulting From Lead Exposure At Toxic Waste Sites In Argentina, Mexico And Uruguay, Jack Caravanos, Jonathan Carrelli, Russell Dowling, Brian Pavilonis, Bret Ericson, Richard Fuller

Publications and Research

Background: Though lead contaminated waste sites have been widely researched in many high-income countries, their prevalence and associated health outcomes have not been well documented in low- and middle-income countries.

Methods: Using the well-established health metric disability-adjusted life year (DALY) and an exposure assessment method developed by Chatham-Stephens et al., we estimated the burden of disease resulting from exposure to lead at toxic waste sites in three Latin American countries in 2012: Argentina, Mexico and Uruguay. Toxic waste sites identified through Pure Earth’s Toxic Sites Identification Program (TSIP) were screened for lead in both biological and environmental sample media. Estimates …

Predictors Of Neonatal Abstinence Syndrome In Buprenorphine Exposed Newborn: Can Cord Blood Buprenorphine Metabolite Levels Help?, Darshan Shah, Stacy Brown, Nick Hagemeier, Shimin Zheng, Amy Kyle, Jason Pryor, Nilesh Dankhara, Piyuesh Singh

ETSU Faculty Works

Background

Buprenorphine is a semi-synthetic opioid used for the treatment of opioid dependence. Opioid use, including buprenorphine, has been increasing in recent years, in the general population and in pregnant women. Consequently, there has been a rise in frequency of neonatal abstinence syndrome (NAS), associated with buprenorphine use during pregnancy. The purpose of this study was to investigate correlations between buprenorphine and buprenorphine-metabolite concentrations in cord blood and onset of NAS in buprenorphine exposed newborns.

Methods

Nineteen (19) newborns who met inclusion criteria were followed after birth until discharge in a double-blind non-intervention study, after maternal consent. Cord blood and …

A Randomized, Double-Blind, Placebo-Controlled Phase Ii Trial Investigating The Safety And Immunogenicity Of Modified Vaccinia Ankara Smallpox Vaccine (Mva-Bn®) In 56-80-Year-Old Subjects, Richard N. Greenberg, Christine M. Hay, Jack T. Stapleton, Thomas C. Marbury, Eva Wagner, Eva Kreitmeir, Siegfried Röesch, Alfred Von Krempelhuber, Philip Young, Richard Nichols, Thomas P. Meyer, Darja Schmidt, Josef Weigl, Garth Virgin, Nathaly Arndtz-Wiedemann, Paul Chaplin

Internal Medicine Faculty Publications

Background Modified Vaccinia Ankara MVA-BN^® is a live, highly attenuated, viral vaccine under advanced development as a non-replicating smallpox vaccine. In this Phase II trial, the safety and immunogenicity of Modified Vaccinia Ankara MVA-BN^® (MVA) was assessed in a 56–80 years old population.

Methods MVA with a virus titer of 1 x 10⁸ TCID₅₀/dose was administered via subcutaneous injection to 56–80 year old vaccinia-experienced subjects (N = 120). Subjects received either two injections of MVA (MM group) or one injection of Placebo and one injection of MVA (PM group) four weeks apart. Safety was evaluated …

Using Wastewater-Based Epidemiology To Estimate Drug Consumption—Statistical Analyses And Data Presentation, Caleb J. Banta-Green, Alex J. Brewer, Christoph Ort, Dennis R. Helsel, Jason R. Williams, Jennifer A. Field

All Faculty Scholarship for the College of the Sciences

Aim

Analysis of wastewater samples can be used to assess population drug use, but reporting and statistical issues have limited the utility of the approach for epidemiology due to analytical results that are below the limit of quantification or detection. Unobserved or non-quantifiable—censored—data are common and likely to persist as the methodology is applied to more municipalities and a broader array of substances. We demonstrate the use of censored data techniques and account for measurement errors to explore distributions and annual estimates of the daily mean level of drugs excreted per capita.

Measurements

Daily 24-hour composite wastewater samples for 56 …

Development And Validation Of A Remote Sensing Model To Identify Anthropogenic Boreholes That Provide Dry Season, Refuge Habitat For Anopheles Vector Mosquitoes In Sub-Saharan Africa, James Pkemoi Kukat

USF Tampa Graduate Theses and Dissertations

A lack of surveillance systems is an impediment to public health intervention for perennial vector-borne disease transmission in northern tropical savanna region of Kenya. The population in this area are mostly poor nomadic pastoralists with little acquired functional immunity to Plasmodium falciparum, due to infrequent challenges with the parasite. A common characteristic in tropical savanna climatic zone is the availability of riverbeds that have anthropogenic boreholes that provide malaria vector mosquitoes, such as Anopheles gambiae s.l and Anopheles funestus, with aquatic refuge habitats for proliferation and endemic transmission to proximity human households during the dry-season. Unfortunately, currently there …

Total Versus Partial Splenectomy In Pediatric Hereditary Spherocytosis: A Systematic Review And Meta-Analysis, Leonardo Guizzetti

Epidemiology and Biostatistics Publications

To compare the clinical effectiveness of total (TS) or partial (PS) splenectomy in pediatric hereditary spherocytosis, a systematic review and meta-analysis was performed (PROSPERO registration CRD42015030056). There were 14 observational studies comparing pre- and post- operative hematologic parameters. Secondary outcomes include in-hospital infections, surgical complications, symptomatic recurrence and biliary disease. TS is more effective than PS to increase hemoglobin (3.6 g/dL vs 2.2 g/dL) and reduce reticulocytes (12.5% vs 6.5%) after one year; outcomes following PS are stable for at least 6 years. There were no cases of overwhelming post-splenectomy sepsis. A population-based patient registry is needed for long-term follow-up.

Identification Of Ecdysone Hormone Receptor Agonists As A Therapeutic Approach For Treating Filarial Infections, Amruta S Mhashilkar, Sai L Vankayala, Canhui Liu, Fiona Kearns, Priyanka Mehrotra, George Tzertzinis, Subba R Palli, H. Lee Woodcock Iii, Thomas R Unnasch

Chemistry Faculty Publications

BACKGROUND: A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic targets.

METHODOLOGY/ PRINCIPAL FINDINGS: Administration of 20-hydroxyecdysone to gerbils infected with B. malayi infective larvae disrupted their development to adult stage parasites. A stable mammalian cell line was created incorporating the B. malayi ecdysone receptor ligand-binding domain, its heterodimer partner and a secreted luciferase reporter in HEK293 cells. This was employed to screen a series of ecdysone agonist, identifying seven agonists active at sub-micromolar concentrations. …

Research On Problem Gambling Websites, Chang Boon Patrick Lee

International Conference on Gambling & Risk Taking

This is a continuation of a series of studies on problem gambling websites. It has been noted in prior studies that one avenue problem gamblers might look for help was to go online to perform a web search. Online help is practical as help can be located immediately and this can help to ease the gamblers’ concerns that they are left alone to handle their own problems. While there are some anecdotal evidences regarding the success of problem gambling websites, there have been few empirical studies that relate directly to the perceptions and usefulness of the websites for the problem …

An Empirical Evaluation Of The Clubsnsw (Australia) Multi-Venue Self-Exclusion Program, Dylan A. Pickering, Alexander Blaszczynski, Sally Gainsbury, Rowan Cameron

International Conference on Gambling & Risk Taking

Few empirical studies have evaluated the effectiveness of self-exclusion programs. Research is required to identify factors contributing to decisions to enter and/or breach self-exclusion orders, or to self-excluded gamblers to seek additional treatment. Clinical characteristics of self-excluders remain relatively unknown in addition to factors that differentiate gamblers who do or do not breach. Limitations of current programs are that gamblers can self-exclude from only one or a limited number of venues. The Multi-venue Self-exclusion program, developed and implemented by ClubsNSW (Australia), is a centralised web-based system designed to help problem gamblers self exclude from up to 35 venues at a …

Mandatory Pre-Commitment Loss Limits: Six Years’ Experience Shows It Works, Bjorn H. Hoffmann

International Conference on Gambling & Risk Taking

The Norwegian state owned company Norsk Tipping is a pioneer in the gambling indusrty with its secure player identification and mandatory registered play across all channels. Knowing who your player is and having a strong link between the player and his consumption of games across all channels (land based, EGM, web and mobile) is an important premise for having a credible responsible gaming platform.

Norsk Tipping introduced in 2009 EGM’s with both pre commitment tools and maximum loss limits. In 2014 we introduced our Internet casino with probably the best responsible gambling platform in the world, including mandatory loss limits. …