Medicine and Health Sciences Commons^™

Geospatial And Negative Binomial Regression Analysis Of Culex Nigripalpus, Culex Erraticus, Coquillettidia Perturbans, And Aedes Vexans Counts And Precipitation And Land Use Land Cover Covariates In Polk County, Florida, Joshua P. Wright

USF Tampa Graduate Theses and Dissertations

Although mosquito monitoring systems in the form of dry-ice bated CDC light traps and sentinel chickens are used by mosquito control personnel in Polk County, Florida, the placement of these are random and do not necessarily reflect prevalent areas of vector mosquito populations. This can result in significant health, economic, and social impacts during disease outbreaks. Of these vector mosquitoes Culex nigripalpus, Culex erraticus, Coquillettidia perturbans, and Aedes vexans are present in Polk County and known to transmit multiple diseases, posing a public health concern. This study seeks to evaluate the effect of Land use Land cover …

Cohort Profile: Seek, Test, Treat And Retain United States Criminal Justice Cohort., Redonna Chandler, Michael S Gordon, Bridget Kruszka, Lauren N Strand, Frederick L Altice, Irene Kuo, +Several Additional Authors

Epidemiology Faculty Publications

BACKGROUND: The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement.

METHODS: The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved …

Regioselective Baeyer–Villiger Oxidation Of Lignin Model Compounds With Tin Beta Zeolite Catalyst And Hydrogen Peroxide, John Adam Jennings, Sean R. Parkin, Eric Munson, Sean Delaney, Julie L. Calahan, Mark Isaacs, Kunlun Hong, Mark Crocker

Chemistry Faculty Publications

Lignin depolymerization represents a promising approach to the sustainable production of aromatic molecules. One potential approach to the stepwise depolymerization of lignin involves oxidation of the benzylic alcohol group in β-O-4 and β-1 linkages, followed by Baeyer–Villiger oxidation (BVO) of the resulting ketones and subsequent ester hydrolysis. Towards this goal, BVO reactions were performed on 2-adamantanone, a series of acetophenone derivatives, and lignin model compounds using a tin beta zeolite/hydrogen peroxide biphasic system. XRD, ¹¹⁹Sn MAS NMR spectroscopy, DRUVS and XPS were used to determine tin speciation in the catalyst, the presence of both framework Sn and extra framework …

2016 "Meeting Of The Minds" Research Symposium Abstracts

OSRI Journal of Student Research and Innovation

No abstract provided.

Artificial Islands In The South China Sea, Aaron Holmes

OSRI Journal of Student Research and Innovation

The purpose of this study was to understand the value and implications of artificial islands constructed by the People's Republic of China (PRC) in the South China Sea. Qualitative analysis was used with the available literature, sources, and treaties of the topics concerned. The paper concludes that the PRC gains many benefits primarily within the realm of energy security and explores what effects they may

The Face That Launched A Thousand Ships: Helen Of Troy In The Poetry Of Atwood And Tufts, Alea Walstrom

OSRI Journal of Student Research and Innovation

This paper considers the transformation of Greek myth over time, how character’s attributes change over time, and ultimately how contemporary poets employ these myths. The myth of focus in the paper is that of Helen of Troy and the depiction of her character throughout the many years and variations of the myth. Her character is then considered in the contemporary feminist poetry of Carol Tufts and Margaret Atwood.

Safety And Immunogenicity Of An Inactivated Whole Cell Tuberculosis Vaccine Booster In Adults Primed With Bcg: A Randomized, Controlled Trial Of Dar-901, C. Fordham Von Reyn, Timothy Lahey, Robert D. Arbeit, Bernard Landry, Leway Kailani, Lisa Adams, Brenda Haynes, Todd Mackenzie, Wendy Wieland-Alter, Ruth Connor, Sue Tvaroha, David Hokey, Ann Ginsberg, Richard Waddell

Dartmouth Scholarship

Development of a tuberculosis vaccine to boost BCG is a major international health priority. SRL172, an inactivated whole cell booster derived from a non-tuberculous mycobacterium, is the only new vaccine against tuberculosis to have demonstrated efficacy in a Phase 3 trial. In the present study we sought to determine if a three-dose series of DAR-901 manufactured from the SRL172 master cell bank by a new, scalable method was safe and immunogenic.

One-Pot Syntheses And Characterizations Of “Click-Able” Polyester Polymers For Potential Biomedical Applications, James F. Beach Ii

Electronic Theses & Dissertations

In this study, a synthetic polyester polymer was designed using polyethylene glycol, sorbitol, glutaric acid and 4-pentynoic acid as monomers. The synthesis was carried out using standard melt polymerization technique and catalyzed by Novozyme-435, an enzyme suitable for polyesterification of biocompatible compounds. The progress of the reaction was monitored with respect to time and vacuum exposure, with samples being subjected to standard characterization protocols. Polymers with high molecular weight and water solubility were chosen for further modification into folate-functionalized polymeric nanoparticles for targeted drug delivery to cancer cells. This was achieved by employing a solvent diffusion method, wherein the polymer …

Discovery Of A Diaminopyrimidine Flt3 Inhibitor Active Against Acute Myeloid Leukemia, Jamie A. Jarusiewicz, Jae Yoon Jeon, Michele C. Connelly, Yizhe Chen, Lei Yang, Sharyn D. Baker, R. Kiplin Guy

Pharmaceutical Sciences Faculty Publications

Profiling of the kinase-binding capabilities of an aminopyrimidine analogue detected in a cellular screen of the St. Jude small-molecule collection led to the identification of a novel series of FMS-like tyrosine kinase 3 (FLT3) inhibitors. Structure–activity relationship studies led to the development of compounds exhibiting good potency against MV4-11 and MOLM13 acute myelogenous leukemia cells driven by FLT3, regardless of their FLT3 mutation status. In vitro pharmacological profiling demonstrated that compound 5e shows characteristics suitable for further preclinical development.

The Academic Research Library And Science Education: A Roadmap For The Journey, Sue Ann Gardner

University of Nebraska-Lincoln Libraries: Presentations

Science libraries are integral to the process of science inquiry.

Science education is facilitated within science libraries.

The future of science libraries is predicated on librarians maintaining a meaningful relationship with those engaging in scholarship.

Science libraries need to combine traditional and emerging service models, provide access to a wide array of materials, incorporate appropriate technology, and offer ergonomic work spaces to promote effective learning.

The science commons includes varied work spaces which encourage innovation and creativity, facilitate situated and active learning, and promote communities of practice.

The National Science Education Standards definition of science inquiry includes the diverse ways …

Environmental Health, Tessa Oliaro

Student Scholar Symposium Abstracts and Posters

There is a very important intersection between the environment, public health, and socioeconomic factors (Braveman, 2014). These include waste disposal, water use and quality, road safety, ecosystem services, and many more. Environmental health stresses, “the health impacts of physical, chemical, and biological agents in the environment and workplace, and learns to develop strategies to measure and control major environmental health problems both locally…and in settings around the globe” (UC Berkeley School of Public Health, 2017). This overarching umbrella can have emphases in environmental epidemiology, exposure science, climate change, ergonomics, home and industrial hygiene, and molecular epidemiology. Exploring each of these …

Unreplicable: The Unscientific Nature Of Science Journals, Ernest M. Oleksy

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Academia shapes the way our species looks at veracity and defines what is deemed as well-founded science. The platform for researchers to make their work known is academic journals. The prerogative of these journals is to disseminate technically sound work so that the public may be informed of up-to-date advances in scientific fields. However, these journals are products on the market whose ultimate purpose is to garner a following that will make the producers money. This results in research that does not have statistically significant findings, or replications of past experiments which are integral to supporting the findings of the …

We Are Alfred: Empathy Learned Through A Medical Education Virtual Reality Project, Barbara Swartzlander, Elizabeth Dyer, Marilyn R. Gugliucci

Library Services Faculty Posters

Poster describing project collaboration among University of New England (UNE) librarians and College of Osteopathic Medicine (COM) faculty, whose goal was to adopt technology which will teach UNECOM students to be empathic with older adults and familiarize medical students with information resources from the NIH/NLM related to older adult health. Technology tested was the Alfred Lab developed by Embodied Labs. First year medical students were required to complete the ‘We Are Alfred’ virtual reality module and a pre and post assessment. Descriptive statistics were applied to finite questions on pre and post assessments, and content analysis on open ended answers. …

Cancer-Specific Mortality, Cure Fraction, And Noncancer Causes Of Death Among Diffuse Large B-Cell Lymphoma Patients In The Immunochemotherapy Era., Nadia Howlader, Angela B Mariotto, Caroline Besson, Gita Suneja, Kim Robien, Naji Younes, Eric A Engels

Epidemiology Faculty Publications

BACKGROUND

Survival after the diagnosis of diffuse large B-cell lymphoma (DLBCL) has been increasing since 2002 because of improved therapies; however, long-term outcomes for these patients in the modern treatment era are still unknown.

METHODS

Using Surveillance, Epidemiology, and End Results data, this study first assessed factors associated with DLBCL-specific mortality during 2002-2012. An epidemiologic risk profile, based on clinical and demographic characteristics, was used to stratify DLBCL cases into low-, medium-, and high-risk groups. The proportions of DLBCL cases that might be considered cured in these 3 risk groups was estimated. Risks of death due to various noncancer causes …

Place Events 2016-2017, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for 2016-2017.

Native Science In Practice: Cases For Broadening Understanding And Engagement Of Science In Education As A Plea For Future Generations, G. Sue Kasun, Dave López

Journal of Multicultural Affairs

We make a departure from the U.S.’s traditional “science education” in recognition of several stark realities—from the genocidal practices that have eliminated so many indigenous populations in the U.S. to the problems our planet faces, such dire environmental degradation. We are faced daily with a dissonance of knowing our planet needs our respect and care while at the same time bearing witness to “modern” lifestyles based in property rights and individualism. We engage Native science—which encapsulates all of Western science and expands upon it by including the spiritual and emotional realms as well as the physical and mental dimensions of …

Effects Of Ankle Weights On Metabolic Response And Muscle Activity On A Lower Body Positive Pressure Treadmill 2017, Saige Hupman

Master's Theses

Lower body positive pressure (LBPP) treadmills are growing in popularity for rehabilitative use, as the benefits of exercising at partially supported body weight may induce faster recovery. It is unknown if there are certain practices that increase exercise intensity while maintaining positive effects of LBPP. Adding ankle weights when walking or running could increase intensity of rehabilitation programs while maintaining the comfort of supported body weight. PURPOSE: To measure metabolic response (VO2, RER, HR, Caloric expenditure), RPE, and lower limb electromyography (EMG) amplitudes of LBPP treadmill walking and running with and without ankle weights. METHODS: Sixteen participants (Age: 21.94 ± …

Dispositions Of First Year Teachers Who Teach Mathematics For Social Justice, Kyndall A. Brown

Journal of Multicultural Affairs

For over 10 years, mathematics educators have sought to use mathematics tasks with social justice contexts to engage students. While student teachers in the UCLA Teacher Education Program (TEP) engage in social justice tasks in their secondary mathematics method classes, very few teachers use these types of tasks with students in the classrooms. The master’s inquiry projects of three TEP students who engaged their students in social justice tasks are analyzed to determine how their backgrounds and positionality influenced their instructional decision making. Results show that personal experiences in the teachers’ lives, as well as a desire to increase motivation …

Umass Memorial Healthcare Information System Job Ladder, Matthew Simoncini, Vamsi Kavuru, Antariksh Nanda, Tahaseen Mahaboob Basha, Vikram Patil

School of Professional Studies

The capstone project report emphasizes the importance of a job ladder and the need of an hour to implement it at UMASS Memorial health care. The scope of this project is to create a well-established job ladder at UMASS with pre-defined standards on job levels related to Information Technology department that would facilitate in hiring, developing and promoting employees at various stages.

A Learning Framework For The Ywca Central Massachusetts, Dayna Ankermann, Manjushree Burdekar, Priyanka Joshi, Ying Song, Yumeng Chen, Xing Xie

School of Professional Studies

After meeting with the Director of Wellness and Health Equity at the YWCA Central Massachusetts (which will be referred to as the YWCA from here on out), we learned that as a non-profit gym and health center, it is heavily underfunded. The main focus of the project was to determine how to upkeep the facility while bringing in new customers with limited resources and budget. Due to the needs of the YWCA, our group focused on six aspects: revenue stream, donor retention, increasing membership, customer experience, social media marketing, and membership fee structure. After completing extensive research, we were able …

Human Services Management (Hsm) Certificate Program Expansion To Western Massachusetts Feasibility Study, Paul Campbell, Patrick Deschenes, Maria Pacheco, Bradley Paul, Elizabeth Vittum, Jing Zhang

School of Professional Studies

One of the most popular cost-savings programs that the Providers’ Council currently offers its members is a Certificate in Nonprofit Human Service Management (HSM) provided in partnership with Clark University and Suffolk University. As human services providers are struggling to hire and retain qualified staff, the need to provide professional development opportunities to help grow and expand a skilled health and human services workforce is a critical issue facing nonprofit organizations and communities in Massachusetts. This feasibility study examines the viability of Providers’ Council and Clark University expanding its HSM Certificate Program to organizations and staff located in western Massachusetts. …

Somali National University, Sharmarke Abdulla, Nikala Pieroni, Jenna Caskie, Sergii Odnodvorets, Tanyue Gong, Lahari Dasari

School of Professional Studies

The executive summary presents an overview of the principal conclusions and recommendations for Somali National University Faculty of Education (FoEd) regarding the following concerns: Difficulty with recruiting high quality prospects to the FoEd; Ineffective and counterintuitive use of social media as a tool to improve brand equity, as well as as a tool to attract and communicate with prospective and current students; Unbalanced gender ratio of current student body; Absence of student services and student supports; Low student retention rate; Limited resources for academic advising; This document is the result of a Clark University School of Professional Studies Capstone Project.

Mri Analysis Of White Matter Myelin Water Content In Multiple Sclerosis: A Novel Approach Applied To Finding Correlates Of Cortical Thinning, Michael Dayan, Sandra M. Hurtado Rua, Elizabeth Monohan, Kyoko Fujimoto, Sneha Pandya, Eve M. Locastro, Tim Vartanian, Thanh D. Nguyen, Ashish Raj, Susan A. Gauthier

Mathematics and Statistics Faculty Publications

A novel lesion-mask free method based on a gamma mixture model was applied to myelin water fraction (MWF) maps to estimate the association between cortical thickness and myelin content, and how it differs between relapsing-remitting (RRMS) and secondary-progressive multiple sclerosis (SPMS) groups (135 and 23 patients, respectively). It was compared to an approach based on lesion masks. The gamma mixture distribution of whole brain, white matter (WM) MWF was characterized with three variables: the mode (most frequent value) m1 of the gamma component shown to relate to lesion, the mode m2 of the component shown to be associated with normal …

Becoming Women Engineers: Dismantled Notions And Distorted Perspectives, Lisa Zagumny, Holly Garrett Anthony, Sally J. Pardue

Journal of Multicultural Affairs

In an investigation of (non-international) undergraduate students’ experiences with their engineering major, we interviewed 10 young women asking questions about their interactions with instructors, academic successes/struggles, and any challenges they felt they had faced as women/girls in engineering. Initial findings echoed those in previous research serving to affirm held notions of interventions that would improve women/girls’ experiences in engineering. In reflecting on the research methods and troubling its design, we realized that we had approached the data with limited perspectives. A new approach to analysis opened up concepts and yielded findings that offer a different course of action for abating …

“Cultures As Toolboxes”: An Introduction To The Special Issue Focused On Stem, Anita L. Bright

Journal of Multicultural Affairs

The Journal of Multicultural Affairs welcomes Dr. Anita Bright as a guest editor to lead a special issue on Science, Engineering, Technology, and Mathematics (STEM). Dr. Bright centers this special issue around one particularly simple, yet complex question, Is the teaching of science, technology, engineering, and mathematics multicultural?

When Teachers Get It Right: Voices Of Black Girls’ Informal Stem Learning Experiences, Natalie S. King

Journal of Multicultural Affairs

This paper is a part of a larger research study exploring the STEM learning experiences of Black girls who participated in an informal STEM program – I AM STEM. Through the process of reflection and co-construction of counterstories, Black girls reclaimed authorship of their lives. They identified three major attributes of teachers who promoted their academic success and engagement in STEM learning as ones who (a) responded to their needs and built a community of learners, (b) interacted with their parents in a professional manner, and (c) encouraged them to think critically and creatively during the lessons. Excerpts of their …

Tuberculosis And Risk Of Acute Myocardial Infarction: A Propensity Score-Matched Analysis, Moises A. Huaman, Richard J. Kryscio, Carl J. Fichtenbaum, David Henson, Elizabeth G. Salt, Timothy R. Sterling, Beth A. Garvy

Biostatistics Faculty Publications

Several pathogens have been associated with increased cardiovascular disease (CVD) risk. Whether this occurs with Mycobacterium tuberculosis infection is unclear. We assessed if tuberculosis disease increased the risk of acute myocardial infarction (AMI). We identified patients with tuberculosis index claims from a large de-identified database of ~15 million adults enrolled in a U.S. commercial insurance policy between 2008 and 2010. Tuberculosis patients were 1:1 matched to patients without tuberculosis claims using propensity scores. We compared the occurrence of index AMI claims between the tuberculosis and non-tuberculosis cohorts using Kaplan–Meier curves and Cox Proportional Hazard models. Data on 2026 patients with …

Thermal And Developmental Ecology Of Pupfish, Cyprinodon, Alexander Jones

UNLV Theses, Dissertations, Professional Papers, and Capstones

Pupfish from the genus Cyprinodon are among the most endangered groups of fishes on the planet, with nearly 40% of species being threatened with extinction. These pupfishes are often assumed to be the most temperature tolerant of all fish, coping with temperatures as low as 0 °C and as high as 44 °C. However, conflicting data exist and certain measures of thermal tolerance are not markedly higher in pupfish compared to common game fish. Pupfish egg production and growth has been known to be hampered at temperatures well below what they apparently experience in nature. I addressed why eggs fail …

Evaluation Of A Fluorescence Method For Quantifying Bioaerosol Concentrations On Air Quality Filter Samples, Rachel Kolberg

UNLV Theses, Dissertations, Professional Papers, and Capstones

Airborne particulate matter (PM) in outdoor environments contains many components that cause adverse human health effects. The size of the particulates determine in what manner the particles would bypass the body’s defense mechanisms to enter the respiratory system and is directly related to their health impacts. Currently the United States Environmental Protection Agency is enforcing the National Ambient Air Quality Standards (NAAQS) to regulate the annual and 24-hour average concentrations of PM2.5 and PM10 in the air. PM2.5 are fine particles with aerodynamic diameter <2.5μm, small enough to reach the deepest parts of the bronchi and lungs. PM10 include PM2.5 and larger particles with aerodynamic diameter of 2.5-10μm. Both PM2.5 and PM10 contain multiple components from multiple sources. Bioaerosols are an important component of PM, but there is limited knowledge about how bioaerosols contribute to PM2.5 and PM10 concentrations. There is also a lack of research about the incidence and prevalence of disease caused by bioaerosols and about the limits of exposure to bioaerosol particulates. The main barrier to assess bioaerosol concentrations and health-related effects is the absence of quick and inexpensive methodology for quantifying bioaerosols. This study explored the feasibility of using fluorescence microscopy to quickly quantify bioaerosols in PM2.5 and PM10 collected on polycarbonate filters. Bioaerosols were stained with a DNA marker directly on a filter, followed by fixation, microscopic imaging, and automatic counting. The method was first validated using reference samples prepared by depositing different known concentrations of E. coli onto blank polycarbonate filters. The results indicated a linear response over two orders of magnitude (R2 = 0.9) and an accuracy within ±25%. E. coli were also deposited onto selected ambient PM10 and PM2.5 filter samples to determine if pre-loaded particles would interfere with bioaerosol imaging and counting. It was found that despite an increase in uncertainty (variability), the calibration slope remained within ±10% of unity for both PM2.5 and PM10 samples. Bioaerosol concentrations in ambient samples, as quantified by this method, were on average 14% higher for PM10 than for PM2.5 acquired concurrently in a desert environment of Las Vegas, Nevada. The application of this method to other types of compliance filters, such as Teflon filters and tapes of a Beta Attenuation Monitor (BAM) were also explored in this study. By means of a high-yield approach this method is expected to facilitate bioaerosol research, support exposure and health assessments, and help refine NAAQS for PM2.5 and PM10.

A Rural And Urban Study Of The Food Environment In Select Nevada Geographies, Joseph Nickelson

UNLV Theses, Dissertations, Professional Papers, and Capstones

National and county level examination of urban and rural food environments has taken place, but primary validation of venue existence and in-venue data are lacking. The literature show disparities in access to healthy foods through low density of large grocers/supermarkets, low variety and quality of produce and higher prices for a healthy diet in rural versus urban geographies. Rural areas are of unique concern due to poor health indicators such as higher obesity rates, higher diabetes rates, lower incomes and lower educations than urban residents. The goal of this study was to explore differences in the community and consumer level …