Medicine and Health Sciences Commons^™

Anticoagulant Half-Life Of Heparin In Human Subjects With Normal And Impaired Renal Function., Paul James Perry

University of the Pacific Theses and Dissertations

Numerous investigators have noted that individuals vary widely in their response to the anticoagulant, heparin. Animal model3 have suggested that patients with depressed renal function would be expected to clear heparin from the blood at a slower rate than patients with normal renal function.

Utilizing the Activated Coagulation Time clotting test, a method was developed to determine the anticoagulant half-life of heparin. The study calculated the half-life of heparin in a group of individuals with normal renal function and a population of patients in chronic renal failure. Intravenous heparin doses of 0,3 units/ml and 0.6 units/ml of blood were administered …

Technologies For Tissue Culture Electrophysiologic Recording, Lorne Bonkowski

University of the Pacific Theses and Dissertations

The development of tissue culture electrophysiology has been hindered by these numerous technological problems. The function of this thesis was to identify and propose solutions to these technological problems and concurrently develop a system for prolonged intracellular GME monitoring (30 to 40 hours) of membrane parameters from cells grown in tissue culture.

The technological problems identified in the present study and for which solutions have been proposed are: (1) Maintenance of a sterile environment for an open tissue culture vessel in which GME measurements can be made for periods exceeding 30 to 40 hours.; (2) Elimination of environmental electrical interference …

Pacific Information Service On Street-Drugs December 1972, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Pacific Information Service On Street-Drugs November 1972, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Pacific Information Service On Street-Drugs July 1972, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Pacific Information Service On Street-Drugs May 1972, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Pacific Information Service On Street-Drugs May 1972, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Pacific Information Service On Street-Drugs March 1972, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

1972 Apothecary, Southwestern Oklahoma State University

Apothecary

Thoughts of finals, summer fun, moving, leaving old friends and making new ones, and working come along with the close of another academic year and the arrival of the 1972 APOTHECARY. It is our hope that this year's graduate will continue to carry his idealistic dreams and use his energies to further enhance the profession of pharmacy. The 1972 APOTHECARY would like to take this opportunity to wish all Seniors the best of luck and congratulate them on their achievements.

Pacific Information Service On Street-Drugs January 1972, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Pacific Information Service On Street-Drugs November 1971, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

1971 Apothecary, Southwestern Oklahoma State University

Apothecary

The 1970 - 1971 academic year has come to a close bringing with it a new APOTHECARY. Many will be leaving these halls of learning to explore new fields. The 1971 APOTHECARY would like to congratulate these seniors on their achievements and wish them success in all future endeavors.

The Development Of An Oral Inhalation Dosage Form Antinauseant, Kit Michael Mills

University of the Pacific Theses and Dissertations

It would seem appropriate that studies be conducted on the development of an oral inhalation dosage form antinauseant. The present project will consist of developing and testing a series of aerosol formulations to determine their feasibility in antinauseant therapy. In vitro pressure, valve release, spray pattern, particle size, and aging studies will be performed. The present work will also include an in vivo evaluation of promising formulations.

In Vitro Resorption Characteristics Of Selected Diuretic Compounds By Thedesaga Resomat, Donald Gene Floriddia

University of the Pacific Theses and Dissertations

An in vitro method was tested whereby the processes of dissolution and distribution of active ingredient into a lipoid solvent were combined in one model and evaluated.

The objectives of this research project were: (1) to evaluate the efficacy of the in vitro model known as the Desaga Resomat, in the testing of gastrointestinal absorption; (2) to apply the procedure and instrument to a group of therapeutically important products in determining their absorption characteristics; (3) to graphically illustrate the absorption profile of a specific drug as per cent absorbed vs. time, simulating in vivo absorption; (4) to compare the profile …

A Retrospective Study Of Drug Interactions And Their Clinical Significance In 100 Hospitalized Patients, Michael Ray Alexander

University of the Pacific Theses and Dissertations

Within the past several years, a great deal of attention has been focused on the phenomena of drug-drug interactions and their importance in the therapeutic regimen of patients for whom multiple therapeutic agents might be indicated. The rather sudden concern for this aspect of medical and pharmaceutical practice is evidenced by the proliferation of literature devoted to the topic for both professions. While iatrogenic disease has long been recognized as one of the hazards inherent in prescribing practices, only isolated reports of specific interactions were found until recently. Although it cannot be said with certainty when the first interaction of …

Observations Related To The Mechanisms Of Tetracycline-Induced Lipid Accumulation In A Strain Of Mouse Fibroblasts Cultivated In Vitro, Dale William James

University of the Pacific Theses and Dissertations

Intravenous administration of tetracycline has been known to result in fatty degeneration of the liver. This study was undertaken in order to elucidate some of the actions of tetracycline on mammalian cells in culture and to attempt to relate these findings to the clinical condition of fatty degeneration of the liver mentioned above.

It is suggested that lipid accumulation occurring after tetracycline administration is possible the result of a decrease in B-lipoprotein synthesis and enzyme inhibition. These factors could result from the high blood levels of tetracycline seen after large and rapid intravenous injections of the drugs into normal patients …

A Pharmacologic Investigation Of The Antiinflammatory Activity Of Cryogenine, Donald Saadia Kosersky

University of the Pacific Theses and Dissertations

This study was conducted in an attempt to define the anti inflammatory efficacy of cryogenine, the major alkaloid of Heimia salicifolia Link and Otto. The anti inflammatory effects produced by cryogenine, phenylbutazone, indomethacin, mefenamic acid, paramethasone, hydrocortisone and 6-mercaptopurine were compared considering the sequential changes in various motameters during the course of adjuvant-induced polyarthritis in rats. Polyarthritis was induced by the subplantar injection of a suspension of heat-killed Mycobacterium butyricus in mineral oil into the right hind paw of Sprague-Dawley rats. The manifestations of the diseases were monitored in terms of hind paw swelling, subjective appearance of secondary lesions, impairment …

Antibradykinin Evaluation Of Cryogenine And Selected Other Agents, Ralph William Trottier Jr.

University of the Pacific Theses and Dissertations

One intent of this study was to detect and to define any antibradykinin capacity that cryogenine may have using both in vivo and in vitro pharmacological models. The activity of cryogenine in these tests was compared to a variety of clinically-proven anti-inflammatory compounds as well as to other agents known to possess anti-inflammatory activity in certain experimentally-induced inflammations. Cryogenine is an unusual anti-inflammatory agent since it is an alkaloid - all of the commonly used anti-inflammatories (aspirin, phenylbutazone, indomethacin, etc.) are organic acids.

The Effects Of Indomethacin On A Strain Of Fibroblasts Cultivated In Vitro, John Thomas Mccloskey

University of the Pacific Theses and Dissertations

Man has always searched for greater understanding of himself and his environment. As a result, much scientific investigation has been directed towards the understanding of the life process. In recent years, such scientific inquiry has become increasingly focused on the fundamental biochemical events taking place at the cellular, subcellular, and molecular levels. In the course of investigation into the nature of living things, research has often necessitated the development of new techniques and investigational tools to serve as experimental systems. Very often such new methods have made possible the discovery of previously unknown processes. One very interesting and useful investigational …

The Dialysis Of Caffeine Through Selected Semi-Permeable Membranes, Paul James Perry

University of the Pacific Theses and Dissertations

Until the past few years, cellulose derivatives, (e.g., cellophane, collodion, and parchment) and animal membranes (e.g., goldbeater’s skin) have been the only dialysis membranes employed commercially. Cellophane has been used as the dialysis membrane in the artificial kidney since the machine’s inception in 1914. It continues to serve in this capacity, even though, in the last few years, attempts have been made to develop better films.

An appreciation of both the “solution theory” and the “pore theory” is in order for this discussion. By incorporating the dynamics of these theories in the techniques of membram formulation, improved membrane performance can …

The Attempted Synthesis Of 4,4-Dimethyl-3-Dimethylamino-2,6-Cyclohexanedione Carboxamide, Roger Leith Cockerline

University of the Pacific Theses and Dissertations

The use of boron-containing amines for the amino alkylation of amides has been investigated in our laboratories with the aim of preparing compounds which could be used in neutron capture therapy. The purpose of this procedure is to achieve selective irradiation of a neoplactic growth by inducing radioactivity throughout that tissue. Although the results obtained in destroying tumors have not always been encouraging, they have been such - especially in cases not amenable to treatment by surgery or chemotherapy - that further research is warranted in order to develop drugs that can be used effectively in neutron capture therapy (Farr, …

The Pharmacology Of Rodenticides, S. A. Peoples

Vertebrate Pest Conference Proceedings: 4th (1970)

The compounds used as rodenticides are tremendously varied in their chemical structure and mechanism of action. With a few exceptions, these agents are generally poisonous to all animals, including man, and a great deal of study has been directed to their toxicity in animals other than rodents. However, the development of new compounds as Norbormide and certain antifertility drugs which are highly selective in their action may justify the hope that the ideal rodenticide free of secondary toxic hazards will soon be available. Until this happy announcement is made, a review of the pharmacology of the older compounds is in …

1970 Apothecary, Southwestern Oklahoma State University

Apothecary

The end of the academic year heralds the arrival of the 1970 APOTHECARY. It has been a fast-paced, hectic time for all. For some, this ends the formal pharmacy curriculum and thus many new situations lie ahead. The 1970 APOTHECARY would like to take this opportunity to wish all the Seniors the best of luck in the future and hearty congratulations on their achievements.

We are very proud of this edition of the APOTHECARY and we want to thank everyone involved in its completion. Certainly, the most "credit" goes to Dr. Ulrich, faculty sponsor. He made most of the …

Differential Spectrophotometric Analysis Of Intravenous Admixtures Containing Metaraminol With Selected Corticosteroids, Frederick Erin Turner

University of the Pacific Theses and Dissertations

Intravenous admixtures consisting of one or more drug formulations, diluted in a large volume of intravenous solution, are used extensively in current medical practice. Development of reliable methods to predict the compatibility of the admixture components is essential as a guide for their selection.

Because the majority of the reports published, to date, have used a visible change as the criterion for judging compatibility, it was the purpose of this study to demonstrate the use of spectrophotometric analysis to detect the occurrence of chemical interactions between two components of an intravenous admixture.

Interactions Of Sodium Ethacrynate In Intravenous Admixture With Selected Cardiovascular And Psychotherapeutic Agents, Patrick N. Catania

University of the Pacific Theses and Dissertations

The possibility of drug incompatibilities is a matter of serious concern when administering two or more therapeutic agents. This is especially true in the case of parenteral administration when one must be aware not only of therapeutic interactions but also chemical and physical reactions that might occur.

In order to avoid incompatibilities, drug manufacturers have suggested that parenteral solutions be used immediately after reconstitution and that admixtures of parenteral products not be administered wherever possible (1,2). Physicians have also stressed the importance in avoiding multiple drug therapy (3,4). In spite of these suggestions, the practice of multiple drug therapy is …

The Southwestern Pharmacist Vol. 1, No. 4, Southwestern Oklahoma State University

The Southwestern Pharmacist

Summer has not stopped the Pharmacy Wives organization. Two summer get-togethers have been held inviting all student pharmacy wives and faculty wo­ men and wives.

The Chemistry Of Pesticides, Walter R. Benson

United States Food and Drug Administration: Publications

Introduction

This review is limited to the structures and a few reactions of the pesticides mainly insecticides-that affect mammalian systems and that are the subject of papers by other authors in this monograph. There is no attempt to give a complete review of the chemistry of pesticides. It is intended only to show the breadth and depth of pesticide chemistry through the use of examples. With proper use of the references, and of the papers by Crosby, Freed and Montgomery, and Owens in this monograph, the reader will be able to find information for other chemicals.

Nomenclature

Pesticides or economic …

The Southwestern Pharmacist Vol. 1, No. 3, Southwestern Oklahoma State University

The Southwestern Pharmacist

If you have ever needed help in any way, then you have pro­bably met Mrs. Leroy Thomas (more affectionately known as Johnnie Faye). She is the guard­ian angel of the pharmacy faculty and student body; nothing would be organized without her.

1969 Apothecary, Southwestern Oklahoma State University

Apothecary

As we come to the close of another academic year, so ends this edition of THE APOTHECARY. For many of us, this is our last year of formal education at dear ole Southwestern. As well as rejoicing, we can look at this as a sad moment for in the future lies the inevitable visit with Uncle Sam (for the males) and facing the hard cruel world; also, we will be separated from our friends and acquaintances whom we've known for five years. We wish to congratulate all the Seniors and wish them the best of luck for a great and …

Syntheses And Antimicrobial Activities Of Some 4-Aza-Sitostane Derivatives, Hassan Y. Aboul-Enein

Electronic Theses and Dissertations

Research into the chemical and pharmacological properties of aza­steroids has become of interest because of their potential value as pharmacodynamic and chemotherapeutic agents. A nitrogen atom, for example, would be able to interact, unlike carbon, with a variety of sites in enzymes by means of ionic-ionic, ionic-dipole, dipole-dipole and hydrogen.bonds. Azasteroids having a nitrogen, atom might be adsorbed more strongly or in a different orientation to a given enzyme, and also may produce.a different biologic effect with a new spectrum of biological activities. The pharmacological.activities of a number of synthetic azasteroids, have been reported.

This investigation is concerned with the …