Medicine and Health Sciences Commons^™

Pharmacologic Investigation In Mice Of The Effects Of Narcotic Antagonists On Dopamine Agonist Reversal Of Oxotremorine Or Reserpine, Mike Minoru Namba

University of the Pacific Theses and Dissertations

In the present study, two different drugs were used to induce a Parkinson-like condition. The first drug was the centrally acting cholinergic agonist oxotremorine (OXTM) which readily induces tremor and rigidity in mice (54). This tremor has been reported to be antagonized by dopamine agonists such as L-dopa and apomorphine (50,54,55) as well as by anticholinergic drugs such as scopolamine (46) . The other drug used was reserpine which interferes with the neuronal storage of dopamine and results in its depletion in the brain (56). Reserpine induces tremor, rigidity, blepharoptosis (a drooping of the eyelids), and catalepsy (48,57-59). The catalepsy …

Special Edition 1979, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Special Edition 1979

Winter 1979, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Winter 1979

[Beta]-(2-Hydroxyphenyl)Ethanolamine Hydrochloride [2-Amino-1-(2-Hydroxyphenyl)Ethanol Hydrochloride], Alexandros Makriyannis, James B. Anderson, Joseph T. Dipiro, Edward Kostiner, Gilbert Hite

Publications from the Office of the Dean

CsH~2NO2+.C1 -, m.p. 441-449 K (from ethyl acetate), P212~2 l, a = 7.363 (2), b = 21.824 (6), c = 5.790 (2)/~, Z = 4, D x = 1.354, D m = 1.356 Mg m -3 (flotation: CC14-C6H6). The structure was solved by MULTAN. Full-matrix least-squares refinement converged to R = 0.057 for the R configuration and to R = 0.056 for the S configuration (P < 0.05). This is consistent with spontaneous resolution of the title compound, single crystals of which provided optically active aqueous solutions. A partially occupied oxygen site O(1)' is attributed to the oxidation of the alkyl hydroxyl group to a ketone during the data collection. The CI- is hydrogen bonded to H2(N)554, H3(N)555, and 1-t(O2)655 (2.37, 2-19, and 2.10 A). Both O(1) and 0(2) are internally hydrogen bonded [HI(N)...O(1), 2.41 and H(O1)...O(2) = 2.24 A]. Intramolecular hydrogen bonding may account for the unusual pharmacological properties of this compound in which only the N-C(1)-C(2)-O(1) and the O(1)-C(2)- C(3)-C(4) and O(1)-C(2)-C(3)-C(8) torsion angles (-41, -60, +122 ° ) differ significantly from those of other phenylethanolamines.

Behavioral Pharmacy, C. Anderson Johnson, Albert I. Wertheimer

CGU Faculty Publications and Research

In the text that follows, the development of a coherent and recognizable teaching and research field devoted to the development of the behavioral and social sciences in pharmacy is proposed. It is important for teachers and researchers in this field to establish a common and recognizable identity; to share basic definitions, purposes and criteria; and to develop forums (such as scientific meetings ·and perhaps a journal) for the exchange and nourishment of the behavioral science knowledge that they generate. It is suggested that this field be called behavioral pharmacy. This title is suggested primarily because Of recent· participant agreement and …

1979 Apothecary, Southwestern Oklahoma State University

Apothecary

THE APOTHECARY wishes to offer congratulations to the graduating seniors of the School of Pharmacy. During the last five years, you have learned the lessons which have qualified you to become members of an important profession. Also, enduring bonds of friendship have been tied between teachers and classmates. We all realize these have been tremendous and exciting years.

The Changing Role Of Pharmacists As Evidenced By The Strong Vocational Interest Blank, C. Anderson Johnson, Timothy R. Church, Albert I. Wertheimer, Clayton R. Rowland

CGU Faculty Publications and Research

The Strong Vocational Interest Blank/Strong Campbell Interest Inventory-Merged Form, or simply Strong Vocational Interest Blank (SVIB), is widely used to determine the suitability of a student's interests to a particular field. In the process of norming the instrument, data concerning the satisfaction of practitioners of a field and their responses on the instrument are gathered. Such data lend themselves to analysis of trends in the characteristics of those practitioners both over time and over the satisfaction spectrum. Hence changes in the field and characteristics lending themselves to satisfaction can be ascertained.

Biofeedback Treatment Of A Drug Induced Tremor, Ralph Nitta

University of the Pacific Theses and Dissertations

Two subjects exhibiting drug-induced hand tremor received EMG feedback from electrode sites above the forearm extensor muscles . EMG feedback resulted in reductions in muscle potentials for both subjects. However, self-report measures of tremor severity showed only general improvement in Subject l and little or no improvement in Subject 2. Behavioral measures of hand steadiness taken immediately after each treatment session showed slight changes across treatment conditions for both subjects. As indicated by a rapid increase in EMG measures during reversal, treatment effects appear transitory.

Investigation Of Lanolin Alcohol As A Film-Forming Delivery System: In Vitro Kinetics Of Triamcinolone Acetonide Release And Skin Penetration., Balasubramanian Venkataraman Iyer

University of the Pacific Theses and Dissertations

The nonpolymeric high molecular weight substances such as lanolin alcohol, stearyl alcohol, and cetyl alcohol have been investigated for their film-forming potential. Furthermore, the application of this potential in the design of topical drug-delivery systems has also been explored. The utilization of such film-forming systems may offer certain unique advantages not associated with the polymeric systems.

Stearyl alcohol and cetyl alcohol do not form films of acceptable integrity. Lanolin alcohol forms thin films capable of being isolated. Inclusion of appropriate amounts of ethyl cellulose and propylene glycol or hexadecyl alcohol in lanolin alcohol was found to improve the integrity, hardness …

Pacific Information Service On Street-Drugs October 1978, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Radiodiagnostic Agent, George A. Digenis, Manvendra B. Shambhu, Michael C. Theodorakis

Pharmaceutical Sciences Faculty Patents

A radiodiagnostic agent comprising a solid, insoluble nontoxic synthetic resin, such as polystyrene, bearing a detectable amount of technetium 99m thereon. This agent is useful for analyzing the gastrointestinal tract, for example, for gastric emptying time, by means of a gamma camera.

Summer 1978, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Summer 1978

Is "Natural" Better?, Russell W. Maatman

Pro Rege

No abstract provided.

Pacific Information Service On Street-Drugs February 1978, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Attitudes Of Doctor Of Pharmacy Students Toward The Application Of Social And Administrative Pharmacy In Clinical Practice, C. Anderson Johnson, J. Lyle Bootman

CGU Faculty Publications and Research

Over the past decade, dramatic changes have occurred in the education of pharmacists. A significant factor in this change has been the introduction of clinical pharmacy. The emerging role of the clinical pharmacist has forced educators to take a second look at the relevance of the pharmacy curriculum. In fact, many of the pharmacy disciplines have re-oriented their specific knowledge objectives to meet the needs of today's clinical practitioners.

1978 Apothecary, Southwestern Oklahoma State University

Apothecary

The staff of THE APOTHECARY '78 has worked hard to put together what we consider to be a very good publication, but our efforts would not have been possible without the advise and support of many people. Our sincerest thanks go to our financial boosters, advertisers, and of course to Dean Dickison for his gracious support. We would also like to thank Mrs. Thomas and the entire office staff for providing us with the alumni listings. Mr. Jack Shelton and the Public Relations Department were also invaluable in the completion of the book.

Pacific Information Service On Street-Drugs January 1978, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

Brunfelsia Hopeana - Pharmacologic Screening: Isolation And Characterization Of Hopeanine, Radhakrishnan Parameswaran Iyer

University of the Pacific Theses and Dissertations

The genus Brunfelsia (Fam. Solannceae) comprises some 40 species of shrubs native to South Africa and West Indies. Brunfelsia hopeana (common name: Manaca root) and related species are recognized in folk medicine in South America as being useful as diuretic, antirheumatic, antisyphilitic agents and as narcotic hallucinogens. In view of the interesting folkloric uses and a paucity of chemical and pharmacological investigation of B. hopeana, a systematic phytochemical and pharmacological investigation on B. hopeana was undertaken in our laboratory.

Hippocratic screening of the whole root powder and extracts of B. hopeana administered intrapcritonially to rats, indicated that the whole root …

A Method Of Detecting Viral Contamination In Parenteral Solutions., Joseph Alexander Woelfel

University of the Pacific Theses and Dissertations

The presence of contaminants in parenteral solutions is a constant nemesis against which pharmaceutical manufacturers, as well as medical, pharmacy , and nursing practitioners mus t vigilantly struggle to provide quality health care. At each level in the parenteral drug delivery system, contamination is possible before the patient actually receives the infusion. The implementation of better practices and procedures continues in the quest of contaminant-free parenterals, nevertheless, the literature is replete with articles documenting contamination of parenteral medication.

Foreign body particulate matter has been found sequestered in the lungs of patients who have received intravenous therapy. The entrapment of foreign …

Effects Of The Medication Reminder Record With Counseling And The Daily Medication Package On Drug Compliance By Ambulatory Psychiatric Patients, Albert T. Gazzar

University of the Pacific Theses and Dissertations

Drug default is the failure of a patient to comply fully with medication regimens and is major unsolved problem confronting health care providers oday. Drug default is also known as medication noncompliance.

Very few studies have been reported comparing the effects of counseling and the unit dose packaging upon compliance. Further, no studies have been reported on the effects of counseling and unit dose packaging upon compliance in ambulatory psychiatric patients. The present investigation was undertaken to (i) evaluate the effectiveness of the Medication Reminder Record, a type of patient calender sheet, with counseling as a means of improving compliance …

Pacific Information Service On Street-Drugs May 1977, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

1977 Apothecary, Southwestern Oklahoma State University

Apothecary

THE APOTHECARY would like to congratulate the Seniors on the completion of five years of hard work. Along with the work, there were fun times also. We have learned much about our profession as well as the high ethical standards we are to meet. I think we would all agree that our efforts will be well rewarded.

Interactions Of Ethanol And Methadone, Vijay Aggarwal

Theses and Dissertations

The effects of ethanol administration on the antinociceptive activity, lethal properties and brain concentration of methadone, were investigated. The effect of ethanol on the antinociceptive activity of methadone was assessed by the hot-plate and tail-flick tests. Concentrations of methadone in the brain were determined by the use of 3H-methadone as well as by gas liquid chromatographic analysis. The study showed that moderate doses of ethanol did not alter tail-flick or hot-plate response by themselves. However, when combined with methadone, ethanol produced a significant increase in the antinociceptive effectiveness of methadone as measured by both a decrease in the ED50 of …

The Biochemistry Of Vascular Smooth Muscle In The Spontaneously Hypertensive Rat, John Edward Taylor

University of the Pacific Theses and Dissertations

Cyclic adenosine 3’,5’-monophosphate (cAMP) was first described as the mediator of the glycogenolytic effect of epinephrine and glucagon in the liver almost two decades ago. It has since been found that cAMP may mediate the effects of a number of hormones and neurohormones, and this observation has led to the development of the second messenger hypothesis of hormone action. According to the second messenger theory, the hormone or first messenger brings information to the cell, whereas, the second messenger (cAMP) transfers this information into intracellular events. More recent evidence has described the existence of an additional second messenger, cyclic guanosine …

June 1976, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - June 1976

Pacific Information Service On Street-Drugs May 1976, School Of Pharmacy

Pacific Information Service on Street-Drugs

No abstract provided.

January 1976, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - January 1976

1976 Apothecary, Southwestern Oklahoma State University

Apothecary

1976, the year marking our country's 200th year of freedom. It also marks the beginning of a new career for the graduating Seniors of SOSU. Since this year is such a special one for many reasons, our theme is a mixture of the history of our country, and our profession, as well as the various happenings of the school year.

Prostaglandin Synthesis In The Feline Adrenal Cortex, Suzanne Gale Laychock

Theses and Dissertations

Studies were carried out on the feline adrenal gland to ascertain the role of prostaglandins in the mechanism of action of ACTH. Using tritiated arachidonic acid as a prostaglandin (PG) precursor , it was demonstrated by column and thin layer chromatography techniques that isolated trypsinized adrenocortical cells possess an active PG synthetase capable of synthesizing radiolabeled PGE, PGF, and PGA/B-like substances. Concentrations of ACTH (125 - 250 _μU) which stimulate steroidogenesis enhanced the conversion of radiolabeled arachidonic acid to PGE, PGF and the PGA/B products extracted from cortical cells and incubation media.

PG biosynthesis by isolated cortical cells was …

The Clinical Pharmacy Program In A Community Hospital Setting : An Integral Part Of The Educational Process, Franklin D. Kamian

University of the Pacific Theses and Dissertations

The intent of this work is to emphasize that the concept of clinical pharmacy is no longer an innovation or an educational experiment, but rather is a reality which requires national recognition, professional as well as legislative support, and clearly planned educational preparation.