Medicine and Health Sciences Commons^™

Design, Synthesis, And Evaluation Of Dasatinib-Amino Acid And Dasatinib-Fatty Acid Conjugates As Protein Tyrosine Kinase Inhibitors, Rakesh Tiwari, Alex Brown, Neda Sadeghiani, Amir Nasrolahi Shirazi, Jared Bolton, Amanda Tse, Gennady M. Verkhivker, Keykavous Parang, Gongqin Sun

Pharmacy Faculty Articles and Research

Derivatives of dasatinib were synthesized via esterification with 25 carboxylic acids including amino acids and fatty acids by extending the inhibitor to interact with more diverse sites and to improve specificity. Dasatinib-L-arginine derivative (Das-R, 7) was the most potent of the inhibitors tested with IC50 values of 4.4 nM, <0.25 nM, and <0.45 nM against Csk, Src, and Abl kinases, respectively. The highest selectivity ratio obtained in our study, 91.4 Csk/Src belonged to compound 18 (Das-C10) with an IC50 of 3.2 μM for Csk compared to 35 nM for Src. Furthermore, many compounds displayed increased selectivity toward Src, as compared with Abl. Compounds 15 (Das-E) and 13 (Das-C) demonstrated the largest gains (10.2 and 10.3 Abl/Src IC50 ratios). Das-R (IC50 = 2.06 μM) was significantly more potent than Das (IC50 = 26.3 μM) against Panc-1 cells while they both showed an IC50 < 51.2 pM against BV-173 and K562 cells. Molecular modeling and binding free energy simulations revealed a good agreement with the experimental results and rationalized differences in selectivity of the studied compounds. Integration of experimental and computational approaches in the design and biochemical screening of dasatinib derivatives facilitated rational engineering and diversification of dasatinib scaffold, providing useful insights into mechanisms of kinase selectivity.

Decreasing Cost Associated Medication Nonadherence, Shawn E. Raymond

Doctor of Nursing Practice Scholarly Project

An Abstract of the Scholarly Project by

Shawn E. Raymond

Medication cost is a major contributor for patient medication nonadherence. Take in the fact that a large population lives in poverty, many cannot afford to pay the retail prices associated with purchasing their medications. By incorporating wholesale medications into a charitable health clinic, the reduced cost of medications for treatment of both acute and chronic illnesses could be passed on to those in need thereby decreasing cost associated medication nonadherence. Nurse Practitioners in the state of Kansas are not afforded the privilege to purchase, repackage and distribute or resell wholesale …

Moseying Along At The Fda, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.

Causal Inference For Biomedical Research Php/Sta 592, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Proteasome Inhibitors, Kyung Bo Kim, Venod Kasam, Wooin Lee, Dong-Eun Kim, Zachary Miller, Chang-Guo Zhan, Do-Min Lee

Pharmaceutical Sciences Faculty Patents

To see this patent's abstract, please download it.

Prevalence Of Prescription Opioid Abuse In Patients With Pain, Samuel Godana, Ankoor Biswas, Nebiyu Biru, Abraham Getenet, Biana Leybishkis

Journal of Patient-Centered Research and Reviews

Background: Studies showed that 20% to 30% of opioid analgesic drugs prescribed for chronic pain in the United States are misused, while the rate of opioid addiction is approximately 10%. The study describes methods to identify high-risk behavior and forward recommendations to decrease opioid abuse.

Purpose: To assess prevalence and correlate multiple variables with opioid abuse and to forward appropriate recommendation to decrease the prevalence of opioid abuse in the primary care setting.

Methods: A prospective study was conducted at a primary health care clinic, Aurora Sinai Medical Center (Milwaukee, WI). Over 6 months, a total of 49 consecutive patients …

An Interdisciplinary Process Change: Conversion Of Picc Line Capping Solution From Heparin To Normal Saline, Angela Colella, Brandon Bodager, Frank Spexarth, Natalie Mcdonough, Deb Kastenholz, Paul Grebe

Journal of Patient-Centered Research and Reviews

Background: Heparin-induced thrombocytopenia (HIT) and HIT with thrombosis syndrome (HITTS) are serious conditions. Patients are at increased risk for developing HIT/HITTS with any exposure to heparin, even intravenous line flushes. Patients may be exposed to heparin multiple times each day when they have a peripherally inserted central catheter (PICC) that is flushed and capped with heparin. At Aurora Health Care, heparin is the standard capping solution for PICCs, but with a recent switch to positive pressurized caps, normal saline may be a capping option that reduces patient exposure to heparin.

Purpose: To reduce heparin exposure at a single hospital by …

Method And System For Producing Triterpenes, Joe Chappell, Thomas D. Niehaus, Shigeru Okada, Timothy P. Devarenne, David Watt

Pharmaceutical Sciences Faculty Patents

A method and system are provided for the production of triterpene including methylated triterpenes. The method and system include isolated nucleic acid sequences encoding triterpene methyltransferases such as triterpene methyltransferases 1, 2, 3. Advantageously, the method and system includes transgenic plant cells via an expression vector for triterpene methyltransferase and optionally various triterpene synthase and prenyltransferase all with tags directing these enzymes to the chloroplast of the transgenic plant cells for using the chloroplast methyl erythritol phosphate (MEP) pathway in the triterpene biogenesis.

Effects Of Antibiotic Mixtures Across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations, Jaclyn Rebecca Teixeira

Dissertations and Theses

Approximately 48% of Americans use prescription drugs within each 30-day period, and there are signs this trend is increasing. Although many studies track pharmaceuticals’ fates in contaminating waterways, only fairly recent efforts have examined the potential impacts of these drugs on non-target organisms. The antibiotics sulfamethoxazole and trimethoprim, often prescribed together to treat bacterial infections, have been detected worldwide in marine and estuarine environments at concentrations up to 700-800 ng/L each. Toxic effects of these drugs have been identified in freshwater organisms, with synergistic effects observed in short-term studies of mixtures of the two; however, little research has examined possible …

Treatment Of A Chemoresistant Neuroblastoma Cell Line With The Antimalarial Ozonide Oz513., Don W. Coulter, Timothy R. Mcguire, J. Graham Sharp, Erin M. Mcintyre, Yuxiang Dong, Xiaofang Wang, Shawn Gray, Gracey R. Alexander, Nagendra K. Chatuverdi, Shantaram Joshi, Xiaoyu Chen, Jonathan L. Vennerstrom

Journal Articles: Pharmacy Practice

BACKGROUND: Evaluate the anti-tumor activity of ozonide antimalarials using a chemoresistant neuroblastoma cell line, BE (2)-c.

METHODS: The activity of 12 ozonides, artemisinin, and two semisynthetic artemisinins were tested for activity against two neuroblastoma cell-lines (BE (2)-c and IMR-32) and the Ewing's Sarcoma cell line A673 in an MTT viability assay. Time course data indicated that peak effect was seen 18 h after the start of treatment thus 18 h pre-treatment was used for all subsequent experiments. The most active ozonide (OZ513) was assessed in a propidium iodide cell cycle flow cytometry analysis which measured cell cycle transit and apoptosis. …

Legislative Solutions To Narcotic And Drug Addiction, Joseph R. Corso

The Catholic Lawyer

No abstract provided.

The Pharmacology Of Addicting Drugs, Vincent De Paul Lynch

The Catholic Lawyer

No abstract provided.

November 2016, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Positive Allosteric Modulator Of Gabab Receptor Alters Behavioral Effects But Not Afterdischarge Progression Induced By Partial Hippocampal Kindling., L Stan Leung, Miao Jin, Liangwei Chu, Jingyi Ma

Physiology and Pharmacology Publications

Hippocampal seizures decreased the function of GABAB receptors, which may further increase seizure susceptibility and contribute to development of schizophrenia-like behaviors. Recent literature indicates that GABAB receptor agonist may normalize schizophrenia-like behaviors and prevent drug-induced behavioral sensitization. We hypothesized that positive modulation of GABAB receptor function during seizure induction will reduce seizure-induced schizophrenia-like behaviors. Using a partial hippocampal kindling model, afterdischarges were induced after injection of saline or dimethyl sulfoxide (vehicle-kindled rats), or a GABAB receptor positive allosteric modulator CGP7930, at 1 mg/kg i.p. (CGP1-kindled) or 5 mg/kg i.p. (CGP5-kindled). The increase in the primary afterdischarge duration during kindling was …

Mechanism Of Three-Component Collision To Produce Ultrastable Prna Three-Way Junction Of Phi29 Dna-Packaging Motor By Kinetic Assessment, Daniel W. Binzel, Emil F. Khisamutdinov, Mario Vieweger, Janice Ortega, Jingyuan Li, Peixuan Guo

Nanobiotechnology Center Faculty Publications

RNA nanotechnology is rapidly emerging. Due to advantageous pharmacokinetics and favorable in vivo biodistribution, RNA nanoparticles have shown promise in targeted delivery of therapeutics. RNA nanotechnology applies bottom-up assembly, thus elucidation of the mechanism of interaction between multiple components is of fundamental importance. The tendency of diminishing concern about RNA instability has accelerated by the finding of the novel thermostable three-way junction (3WJ) motif of the phi29 DNA-packaging motor. The kinetics of these three components, each averaging 18 nucleotides (nt), was investigated to elucidate the mechanism for producing the stable 3WJ. The three fragments coassembled into the 3WJ with extraordinary …

Influence Of Key Polymer Attributes, Manufacturing Conditions And Sintering On Abuse Deterrence Of Physical Barrier Type Abuse Deterrent Formulations (Adf), Heather Boyce, Vivek S. Dave, Myke Scoggins, Dan Smith, Steve Byrn, Bhawana Saluja, Wen Qu, Vadim J. Gurvich, Stephen W. Hoag

Pharmacy Faculty/Staff Publications

When sintering us used to treat tablet formulations containing polyethylene oxide (PEO), the polymer particles are able to form stronger bonds thereby increase tablet tensile strength. This increase in strength can make it more difficult for an abuser to break, chew, or grind opioid tablets. A mechanistic study was implemented to understand the key sintering factors that influence tensile strength.

Formulation And Characterization Of The Improved Solubility, In Vivo Bioavailability And Antioxidant Activity Of Apigenin-Phospholipid Complex (Aplc), Sridhar Anand, Darshan R. Telange, Arun T. Patil, Anil M. Pethe, Harshal Fegade, Vivek S. Dave

Pharmacy Faculty/Staff Publications

In the present study a phospholipid based complex of apigenin (APLC) was prepared with a goal of improving its aqueous solubility, dissolution, in vivobioavailability, and antioxidant activity.

Effects Of Target-Controlled Infusion Of High-Dose Naloxone On Pain And Hyperalgesia In A Human Thermal Injury Model: A Study Protocol, Anders D. Springborg, Elisabeth K. Jensen, Bradley K. Taylor, Mads U. Werner

Physiology Faculty Publications

Mu-opioid-receptor antagonists have been extensively studied in experimental research as pharmacological tools uncovering mechanisms of pain modulation by the endogenous opioid system. In rodents, administration of high doses of mu-opioid-receptor antagonists after the resolution of an inflammatory injury has demonstrated reinstatement of nociceptive hypersensitivity indicating unmasking of latent sensitization. In a recent human study, pain hypersensitivity assessed as secondary hyperalgesia area (SHA), was reinstated 7 days after a mild thermal injury, in 4 out of 12 subjects after a naloxone infusion.

The aims of the present study are first, to replicate our previous findings in a larger-sized study; second, to …

Lubricant-Sensitivity Assessment Of Spress® B820 By Near Infrared Spectroscopy: A Comparison Of Multivariate Methods, Vivek S. Dave, Connor Mack, Heather Boyce, Enyioha Ike-Amaechi, Antione Al-Achi, Stephen W. Hoag, Rahul V. Haware

Pharmacy Faculty/Staff Publications

The aim of the present investigation was to compare the predictive performance of PCR and PLS calibration models based on near-infrared spectroscopy (NIRS) data used to monitor lubrication conditions impact on the tablet breaking force (TBF) of SPRESS® B820.

Assessing The Enhancement Of Aqueous Solubility Of Efavirenz Via Lyophilized Milk Based Solid Dispersion Formulations, Nishikant Raut, Pradip Dhore, Suprit Saoji, Vivek S. Dave

Pharmacy Faculty/Staff Publications

No abstract provided.

A Randomized Placebo-Controlled Pilot Study Of The Efficacy And Safety Of D-Cycloserine In People With Chronic Back Pain., Thomas J. Schnitzer, Souraya Torbey, Kristi Herrmann, Gagan Kaushal, Renita Yeasted, A. Vania Apkarian

College of Pharmacy Faculty Papers

BACKGROUND: Few effective pharmacological treatment options exist for chronic back pain, the leading cause of disability in the US, and all are associated with significant adverse effects.

OBJECTIVE: To determine the efficacy and safety of D-cycloserine, a partial agonist to the N-methyl-D-aspartate receptor, in the treatment of chronic low back pain.

METHODS: A total of 41 participants with chronic back pain who met all inclusion and exclusion criteria were enrolled in a double-blind, placebo-controlled randomized pilot trial of D-cycloserine. Treatment was administered orally for six weeks at escalating daily doses of 100 mg, 200 mg, and 400 mg, each for …

An Interprofessional Clinical Integrations Pilot Program: Integrating Third-Year Pharmd Students Into Family Medicine Clinics, Eric Gilliam, Pharmd, Arian Hilsendager, Fnp, Erin Hagerman, Pa, Benjamin Kirkley, Md, Benjamin Chavez, Pharmd, Kari Franson, Pharmd

JCIPE Conference

Purpose: Pilot an interprofessional student placement model by entrusting Doctor of Pharmacy students to deliver value-added patient engagement within interprofessional clinical environments.

Background: Beginning in January 2016, pharmacy education standards mandate students actively engage in early patient care experiences with interprofessional teams, thus necessitating new models by which students collaborate with providers in the provision of patient care.

Intervention: Between May and August 2016, two family medicine clinics are incorporating 65 third-year pharmacy students into shared medical patient care visits during an interprofessional-provider introductory pharmacy practice experience (IP Provider IPPE) pilot program. Students engage with patients and …

National Interprofessional Education Initiatives, Abby A. Kahaleh, Phd, Ms, Mph, Bpharm, Kari L. Franson, Phd, Pharmd

JCIPE Conference

Purpose: The goal of this presentation is to define the IPE activities that meet the national competencies and share strategies for designing, implementing, and assessing IPE programs.

Background: According to the World Health Organization (WHO), interprofessional education is defined as students from 2 or more professions learning about, from, and with each other to enable effective collaborations and improve health outcomes. The institute of Medicine (IOM) reports that IPE must be included in the education and training of health care professionals to enhance the delivery of health care services. Most recently, many accrediting agencies have refined IPE to …

Clinical Impact Of A Novel Interprofessional Dental And Pharmacy Student Tobacco Cessation Education Program On Dental Patients, Matthew Boyd, Pharmd Candidate, Jillian Lykon, Pharmd Candidate, Jacqueline M. Theodorou, Pharmd, Bcps, Melissa E. Rotz, Pharmd, Bcps, Shannon Myers Virtue, Psyd, Elizabeth Waldron, Ba

JCIPE Conference

Objectives:

• To compare the difference between IPE care and standard care (SC) groups regarding dental patients' perceptions of knowledge gained about tobacco cessation, intentions to quit tobacco use, and quit attempts at follow-up.

• To evaluate perceptions of IPE care.

Background:

Based on the link between tobacco use and oral health and the frequent contact between dental providers and patients, the dental clinic is an ideal setting to address tobacco use.1

• Many dentists feel unprepared providing tobacco cessation education, particularly pharmacologic treatment options.1-3

• Pharmacists promote safe and effective pharmacologic treatment options for tobacco dependence and patients’ perceptions …

Designing And Evaluating An Interprofessional Practice Experience Involving Dental And Pharmacy Students, Melissa Rotz, Pharmd, Bcps, Jacqueline Theodorou, Pharmd, Bcps, Maria Fornatora, Dmd, Chizobam Idahosa, Bds, Dds, Ms, Laurie Macphail, Dmd, Phd, Elizabeth Tweddale, Dmd, Shannon Myers Virtue, Psyd

JCIPE Conference

Purpose: To describe the design and evaluation of an innovative interprofessional practice experience involving pharmacy and dental students.

Background: Accreditation standards for pharmacy and dentistry schools mandate that interprofessional education (IPE) is introduced and practiced throughout the curriculum. There is a paucity of data involving interprofessional practice experiences with dental and pharmacy students.

Description of Program: Pharmacy and dental student-teams conduct health and medication histories for patients seen at Temple University’s dental admissions clinic. Additionally, these teams collaborate to conduct tobacco cessation counseling for current tobacco users. This interprofessional practice experience was designed to prepare students to build more effective …

Development, Assessment, And Evolution Of An Interprofessional Activity With Senior Nursing And Pharmacy Students: Application Of Quality Improvement In Interprofessional Education (Ipe), Michelle R. Musser, Pharmd, Bcps, Robin White, Phd, Msn, Rn, Lisa Walden, Med, Mls(Ascp)Cm, Erin Petersen, Pharmd, Bcps, Megan Lieb, Msn, Rn

JCIPE Conference

Purpose: Concurrent development IPE activities and an assessment strategy is essential for informed evolution of such initiatives. This study provides an active example of the progression of IPE at an institution utilizing an active assessment plan.

Background: IPE is advocated as a method to develop students who are prepared for interprofessional practice, which is essential for optimal patient outcomes. While IPE has been integrated in many health professional curricula, focus on assessment is needed to ensure obtainment of educational outcomes and truly prepare students for interprofessional collaboration in the work place.

Description of Intervention/Program: IPE activities were …

Pharmacy Strategic Approaches For Ipe Assessment, Abby A. Kahaleh, Phd, Ms, Mph, Bpharm, Sarah Shrader, Pharmd, Michelle Z. Farland, Pharmd, Jennifer Danielson, Pharmd, Elena Umland, Pharmd

JCIPE Conference

Purpose: The main goal of this presentation is to share pharmacy-specific strategies for assessing the structure, process, and outcomes of IPE programs.

Background: An effective assessment plan includes evaluating each component of the IPE model: Structure, Process, and Outcomes. The structure of IPE contains curriculum, facilities, capacity, and technology. The process encompasses development of faculty/preceptors, in addition to engaging students, patients, and collaborative practices. And the outcomes comprise achieving the educational and clinical goals of an IPE program and meeting its vision and mission. There is a need to provide this critical information in a succinct format as …

Development Of An Inter-Professional Root Cause Analysis Workshop Within A Required Medication Safety Course, Ginah Nightingale, Pharmd, Bcop, Marybeth Pavlik, Rn, Msn, Jason J. Schafer, Pharmd, Mph, Bcps, Aahivp, Elena M. Umland, Pharmd

JCIPE Conference

Purpose: To present the development/delivery of an Interprofessional Root Cause Analysis (RCA) Workshop by colleges of pharmacy and nursing at a health sciences university.

Background: Hospitals and regulatory agencies emphasize the significance of patient safety and recommend that medication/patient safety principles be introduced in health care professions’ education. A college of pharmacy’s required Medication Safety course introduces essential content on principles including culture of medication safety, error reporting systems, medication error causes and technology’s influence on errors. One key course element is completing a team-based RCA. This assignment was completed solely by Pharm.D. students (fall 2009-2014). Given increased …

Assessment Of Ipe Core Competencies During Advanced Pharmacy Practice Clinical Experiences, Elena M. Umland, Pharmd., Gerald Meyer, Pharmd, Mba, Andrea Joseph, Ms, Rph

JCIPE Conference

Purpose: To illustrate incorporation of select interprofessional education collaborative (IPEC) competencies into preceptor evaluations of students for advanced pharmacy practice experiences (APPEs). To describe the tool and evaluate the results obtained.

Background: Interprofessional education (IPE) is a necessary component of pharmacy curricula. Pharmacy students at this health sciences university participate in a required two-year, longitudinal IPE program during their first two program years; some students participate in additional IPE programming throughout the final two program years. To evaluate the success of these experiences, student achievement of IPEC competencies during their APPEs in the curriculum’s final year was measured.

Description of …

The Pharmacy (Organization) Divide: A Focus On The Impact In Pediatric Pharmacy, Chad A. Knoderer, Lisa Lubsch, Kristin C. Klein

Scholarship and Professional Work – COPHS

No abstract provided.