Medicine and Health Sciences Commons^™

Prebriefing: An Effective And Efficient Strategy To Maximize Simulation Based Learning, Ashley Krebs, Susan Lacey

Journal of Interprofessional Practice and Collaboration

Developing and implementing effective teaching methods require careful planning and time-intensive implementation by nursing faculty and their leadership (Fey & Jenkins, 2015). This is especially true when introducing new strategies. Simulation-based learning (SBL) is one such strategy. SBL is an evidence-based approach that enhances student learning and promotes knowledge retention necessary to safely provide care for patients (Kirkman, 2013). However, the adoption and implementation of SBL is highly variable across schools of nursing and other disciplines (Hayden, 2010).

Interprofessional education (IPE) has made significant gains in the past decade with several disciplines mandated by accreditors to provide evidence of IPE …

Spring Into Health: An Interprofessional Education Health Fair, Savannah Parker, Cassie Crew, Savannah Posey

Journal of Interprofessional Practice and Collaboration

The Spring Into Health community health fair was an interprofessional education (IPE) event

hosted by the University of Louisiana Monroe (ULM) College of Pharmacy's Christian

Pharmacists Fellowship International (CPFI) organization. The event included the participation

of several student pharmacy groups, as well as the ULM nursing, dental hygiene, medical

laboratory science, and health studies departments. Every organization involved in the health fair

provided either a health screening or a health education topic to the community of Ouachita

Parish, which is located in northeastern Louisiana. The event was hosted at the Louisiana

Purchase Gardens and Zoo in Monroe, Louisiana, and took …

Collaborative Allied Health And Nursing Interprofessional Health Education: Beginning The Journey, Anita Hazelwood, Lisa Delhomme, Scott Sittig

Journal of Interprofessional Practice and Collaboration

The Allied Health and Nursing Departments within the College of Nursing and Allied Health Professions at the University of Louisiana at Lafayette have begun a journey towards interprofessional health education (IPE) with the vision of offering multiple IPE courses for the allied health and nursing students. The need for interprofessional education in the health professions has been recognized for many years. In 1998, the Pew Health Professions Commission identified the need for interdisciplinary teams as an endeavor to strive for in the 21st century. A variety of terms have been used to describe this pedagogic practice including shared learning, interprofessional …

Impact Of An Educational Intervention On Faculty To Faculty Incivility, Sandy Bailey

Journal of Interprofessional Practice and Collaboration

: Faculty –to- faculty incivility within schools of nursing is a growing problem. Incivility amongst nursing faculty has the potential to effect other nursing faculty, nursing students, the school of nursing, and increase the risk of harm to patients in the clinical setting. A common recommendation for addressing faculty-to-faculty incivility is an educational offering about civility, incivility, and methods to address incivility. Ideally, an educational intervention about incivility can decrease levels of incivility in nursing education thereby increasing the amount of civility within the organization. The purpose of the research was to measure the impact of an educational intervention on …

The Effects Of A Yoga Intervention, Karen Arrant

Journal of Interprofessional Practice and Collaboration

Sleep disturbance and stress in postmenopausal women pose physical, mental, and emotional health hazards. Researchers examined the effect of a yoga intervention on sleep, stress, anxiety, and depression in postmenopausal women. The study employed a randomized, controlled trial with: (1) a treatment group (yoga intervention) and (2) an attention-control group (health education). All participants completed three PROMIS® – Patient-Reported Outcomes Measurement Information System – tools and collected saliva samples before and after the eight-week intervention. The PROMIS® tools measured sleep, anxiety, and depression. Salivary alpha-amylase quantified sleep; salivary cortisol measured stress; and participants self-reported hours of sleep.

Thirty-one women completed …

Exposure To The Rxr Agonist Sr11237 In Early Life Causes Disturbed Skeletal Morphogenesis In A Rat Model, Holly Dupuis, Michael Andrew Pest, Ermina Hadzic, Thin Xuan Vo, Daniel B. Hardy, Frank Beier

Physiology and Pharmacology Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Longitudinal bone growth occurs through endochondral ossification (EO), controlled by various signaling molecules. Retinoid X Receptor (RXR) is a nuclear receptor with important roles in cell death, development, and metabolism. However, little is known about its role in EO. In this study, the agonist SR11237 was used to evaluate RXR activation in EO. Rats given SR11237 from post-natal day 5 to post-natal day 15 were harvested for micro-computed tomography (microCT) scanning and histology. In parallel, newborn CD1 mouse tibiae were cultured with increasing concentrations of SR11237 for histological and whole-mount evaluation. …

Persistent Organic Pollutants (Pops) Increase Rage Signaling To Promote Downstream Cardiovascular Remodeling, Jackson B. Coole, Stephanie S. Burr, Amber M. Kay, Jaime A. Singh, Sandeep Kondakala, Eun Ju Yang, Barbara L.F. Kaplan, George E. Howell, James A. Stewart

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Background: Antimicrobial resistance (AMR) is a global threat and the antimicrobial stewardship program (ASP) is a globally used tool to combat AMR. There is little information on the views among Pakistani physicians regarding AMR and the benefits of hospital antimicrobial stewardship implementation. This study was designed to explore the physicians’ views about ASP. Methods: Qualitative face-to-face and telephonic interviews were conducted by using purposive sampling method with 22 physicians working in seven tertiary care public hospitals of Punjab, Pakistan. All interviews were audio recorded and transcribed verbatim. Qualitative software was used, …

Silver Nanoparticle Synthesis By Acalypha Wilkesiana Extract: Phytochemical Screening, Characterization, Influence Of Operational Parameters, And Preliminary Antibacterial Testing, Adewumi Oluwasogo Dada, Folahan Amoo Adekola, Fehintoluwa Elizabeth Dada, Adunola Tabitha Adelani-Akande, Micheal Oluwasesan Bello, Chidiogo Rita Okonkwo, Adejumoke Abosede Inyinbor, Abimbola Peter Oluyori, Adeniyi Olayanju, Kolawole Oluseyi Ajanaku, Charles Oluwaseun Adetunji

Faculty and Student Publications

© 2019, The Author(s). Introduction: The application of skin bleaching products to inhibit melanogenesis is a common practice within the African diaspora. Despite the adverse health effects of skin bleaching, rigorous studies investigating skin bleaching behavior among these populations in the United States are limited. In our P30 pilot study, we explored predictors of skin bleaching practice intensity among African and Afro-Caribbean women. Methods: In collaboration with our Community Engagement Core, we conducted a cross-sectional study to investigate the relationship between demographic and psychosocial predictors and skin-bleaching-related practice patterns among African and Afro-Caribbean women in New York City. Results: Among …

Determining The Binding Site Of Org27569 Within The Cb1 Receptor, Ayooluwa O. Aderibigbe, Pankaj Pandey, Robert J. Doerksen

Annual Poster Session 2019

Computational studies to determine the binding site of ORG27569, a negative allosteric modulator, within the cannabinoid receptor 1 (CB1) reveal an intracellular binding domain as the most favorable binding site for ORG27569.

The 340b Program, Contract Pharmacies, Hospitals, And Patients: An Evolving Relationship Impacting Health Care Delivery, Morgan Ruley, Morgan Belcher, Hannah Sayre, Alberto Coustasse

Management Faculty Research

The 340B Drug Pricing Program, created by Congress in 1992 through the Veterans Health Care Act, has provided discounted drug prices to hospitals and other health care organizations serving a wide population of low-income patients. Some 340B programs use contract pharmacies, an arrangement whereby the hospital or health care organization signs a contract directly with a pharmacy to provide covered pharmacy services at discounted prices. The federal 340B Drug Pricing Program has provided access to reduced price prescription drugs to more than 35 000 individual health care facilities and sites certified by the US Department of Health and Human Services, …

Development And Implementation Of An Evidence-Based Process For Scarce Resource Allocation, Richard K. Ogden Jr., Daniel L. Millspaugh, Brian O'Neal

Posters

Background: Intravenous immune globulin (IVIG) is a plasma-derived product from pooled donors. It has six FDA approved indications. It is also considered standard of care for a few other conditions in specific populations. Additionally, there is growing non-evidence-based use. Due to a global shortage, IVIG has become increasing difficult to obtain.

. . . .

Conclusions: Development, implementation, and promotion of adherence to an evidence-based criterion allowed our scarce IVIG supply to be sustained. Further refinement of the criteria for use is ongoing, as is an evaluation of IVIG utilization by indication, pre- and post-implementation. This process can be applied …

Long-Term Safety And Efficacy Of Subcutaneous Pasireotide In Patients With Cushing's Disease: Interim Results From A Long-Term Real-World Evidence Study., Luca Manetti, Timo Deutschbein, Jochen Schopohl, Kevin C J Yuen, Michael Roughton, Ulrike Kriemler-Krahn, Libuse Tauchmanova, Ricardo Maamari, Carla Giordano

Articles, Abstracts, and Reports

PURPOSE: Clinical trials have demonstrated the favorable efficacy/safety profile of pasireotide in patients with Cushing's disease (CD). We report interim long-term results of an ongoing real-world evidence study of subcutaneous pasireotide in patients with CD.

METHODS: Adults with CD receiving pasireotide, initiated before (prior-use) or at study entry (new-use), were monitored for ≤ 3 years during a multicenter observational study ( http://clinicaltrials.gov identifier NCT02310269). Primary objective was to assess long-term safety of pasireotide alone or with other CD therapies.

RESULTS: At the time of this interim analysis, 127 patients had received pasireotide (new-use, n = 31; prior-use, n = 96). …

Synthesis Of Bis(Imino)Pyridine Iron(Ii) Complexes And Development Of Bis(Imino)Pyridine Iron(Ii) Catalyzed Carbene Transfer Reactions, Ban Wang

Masters Theses & Specialist Projects

Metal catalysis of symmetric and asymmetric carbene transfer reactions has been widely applied in natural product synthesis and material science over years. Metal carbene can be easily generated from the extrusion of nitrogen under the catalysis of metal complexes to further undergo various organic reactions, O/N/C-H insertions, cycloadditions, and ylide formations. Currently, the dominant effective catalysts for carbene reactions are built with expensive precious metal, for example, rhodium, ruthenium, palladium, gold. Notably, the effective reactivity and enantioselectivity of the dirhodium(II) catalysts are researched and established over the decades. However, the use of precious metal catalysts is the major source of …

Which Factors Influence The Usage And Perceptions Of Medicinal Plants In Kizanda Village (Lushoto District) And Ushongo Village (Tanga District)?, Callie Smith

Independent Study Project (ISP) Collection

The objective of this study was to compare and examine which factors impact usage and perceptions of traditional medicine in Ushongo Mtoni and Kizanda villages. More specifically, this study aimed to gain an understanding of the usages, with a specific focus on gendered usages of medicinal plants in Kizanda village and Ushongo Mtoni village and to try to examine the differences in perceptions towards traditional medicine usage in Kizanda and Ushongo. Additionally, this study aimed to determine if there are any major themes that are constant with medicinal plants in both Ushongo and Kizanda. In order to conduct this study …

Image Anaysis For Predicting Body Weight In Humans, Jeffrey S. Barrett, Chee Ng

Pharmaceutical Sciences Faculty Patents

Systems and methods for determining body weight predictions and human conditions are disclosed. A body weight may be predicted by capturing at least one image of a human, and determining, from the image, a body weight prediction of the human by processing the at least one image with a data processor. The body weight prediction may further be based on an age-based weight factor. A model such as a neural network model may be used to predict body weight.

Nsu Sharks Rx_Fall 2019, Nova Southeastern University

NSU Sharks Rx

Newsletter

Adverse Effects Of Opioid Dependency On Central And Peripheral Aspects Of The Neuromuscular System, Cindy Yang

Student Publications

Prevalence of chronic pain and health care costs have caused an escalation of opioid dependency. The current national crisis involving opioid dependency and drug overdose are growing problems that need to be addressed. Since 2000, there has been an increased awareness of pain relief; more people are looking at alternative ways to induce pain relief and stricter guidelines in prescription of addictive opioid medications (Manchikanti et al., 2012). Despite growing efforts, opioid use and dependency has risen dramatically in the past few years; since 1999, there has been an increase in the number of opioids sold and opioid-related deaths in …

Getting Started As A New Preceptor, Neeloufar Fakourfar, Emmanuelle Schwartzmann

Pharmacy Faculty Articles and Research

Clinical experience in the healthcare field plays a crucial role in shaping future professionals into competent and well-rounded providers. Equally important is the ability to facilitate the learning process of learners to promote self-directed, lifelong learning and critical thinking.1-3 Preceptorship can vary in approach depending on the design of the learning experience: direct instruction, modeling, coaching, mentoring, and facilitiation.4-6 In addition, there are many teaching tools available such as One-Minute Preceptor, layered teaching, providing reflections, and thinking out loud.7-9 To be an effective preceptor, developing skills through self-reflection and seeking out professional development to strengthen areas of weakness are important. …

Collaboration Between Rheumatology Clinic And Specialty Pharmacy To Positively Impact Patient Experience And Hospital Stewardship, Alaina Linafelter, Julia G. Harris, Robert Herr, Stephanie Quinn, Ashley M. Cooper

Posters

Biologic medications are commonly utilized to treat pediatric rheumatic diseases. Being high-cost, most third-party payers require dispensing through a specialty pharmacy. Children's Mercy Hospital Specialty Pharmacy (CMH SP) started acceting patients in March 2015.

The number of patients benefited by the superior service of CMH SP has risen steadily, leading to high patient satisfaction and financial benefits for the hospital.

Clinical Evaluators Take Your Mark, Jodi Polaha, Mckenzie Highsmith, William Lusenhop, Deepu George, Adrian Sandoval

ETSU Faculty Works

• Discuss two implementation outcomes (adoption and reach) and explain why they are important for clinicians to measure and report, with application to own work
• Name sources of data that are accessible to clinicians in health care settings, with consideration of own setting.
• Describe a range of dissemination strategies used to create impact, including new ideas for dissemination of own work.

Research News. Grants, 2019. Volume 3, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July-September 2019

Multiple Sclerosis Outcomes After Cancer Immunotherapy, Catherine R. Garcia, Rani Jayswal, Val R. Adams, Lowell B. Anthony, John L. Villano

Markey Cancer Center Faculty Publications

INTRODUCTION: Neurological immune-related adverse events are a rare but potentially deadly complication after immune checkpoint inhibitor (ICI) treatment. As multiple sclerosis (MS) is an immune-mediated disease, it is unknown how ICI treatment may affect outcomes.

METHODS: We analyzed the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database for pembrolizumab, atezolizumab, nivolumab, ipilimumab, avelumab, and durvalumab 2 years prior their FDA approval until December 31, 2017, to include all cases with confirmed diagnosis/relapse of MS. We also included cases reported in the literature and a patient from our institution.

RESULTS: We identified 14 cases of MS …

Pediatric Surgery Opioid Prescription Follow-Up, Gadison Quick, Nathaniel Aviles, Gabriel Melgarejo, Hunjung Choi, Elizabeth Edmundson

Posters

This quality improvement project is assisting general and orthopedic surgeons in gaining greater clarity when prescribing opioids for specific surgical procedures. Additional surgical services are being added to the project fall of 2019. Opioid prescribing patterns are, and will continue to be, key to all prescribing providers within our organization.

Analysis Of Hpv16 Variants In The Carolina Women’S Care Study And A Comparison Of Gene Expression Profiles Of Exfoliated Cervical Cells From Women Who Either Clear Or Do Not Clear An Hpv16 Infection, Erica Shirlene Green

Theses and Dissertations

Human papillomavirus (HPV) is the etiologic agent for cervical cancer with HPV type 16 (HPV16) being found in about 50% of cervical cancers worldwide. HPVs vary in genomic (DNA) sequence not only between types, but also within types, known as variants. Variants of a particular HPV type may differ by up to 2% in nucleotide sequence in the coding region and up to 5% in the noncoding region. Variants within HPV16 have been identified and grouped into six distinct phylogenetic branches, which segregate geographically: European (E), Asian-American (As.A), African-1 (Af-1), African-2 (Af- 2), Asian (As), and North American (NA). However, …

Susceptibility To Metabolic Disease And Individual Variations In Unfolded Protein Response In Deer Mice (Peromyscus Maniculatus), Amanda Rose Havighorst

Theses and Dissertations

The endoplasmic reticulum is the site where integral membrane and secreted proteins are synthesized and folded, and is also the site of synthesis of steroids, lipids, and other macromolecules. While ER is found in most cell types, hepatocytes in particular contain large amounts of both rough and smooth ER to facilitate their tasks, which include lipoprotein assembly and secretion, cholesterol biosynthesis, and lipid metabolism. As such, stress in the ER – and the cells’ ability to respond to it – plays a key role in disease pathogenesis. In particular, hepatic steatosis, or fatty liver, is linked to ER stress. However, …

Effects Of Dabigatran In Mouse Models Of Aging And Cerebral Amyloid Angiopathy, Neethu Michael, Mher Mahoney Grigoryan, Kelley Kilday, Rachita K. Sumbria, Vitaly Vasilevko, Joanne Van Ryn, David H. Cribbs, Annlia Paganini-Hill, Mark J. Fisher

Pharmacy Faculty Articles and Research

Oral anticoagulants are a critical component of stroke prevention, but carry a risk of brain hemorrhage. These hemorrhagic complications tend to occur in elderly individuals, especially those with predisposing conditions such as cerebral amyloid angiopathy (CAA). Clinical evidence suggests that non-vitamin K antagonist oral anticoagulants are safer than traditional oral anticoagulants. We analyzed whether the anticoagulant dabigatran produces cerebral microhemorrhage (the pathological substrate of MRI-demonstrable cerebral microbleeds) or intracerebral hemorrhage in aged mice with and without hemorrhage-predisposing angiopathy. We studied aged (22 months old) Tg2576 (a model of CAA) and wild-type (WT) littermate mice. Mice received either dabigatran etexilate (DE) …

Glucosamine Hcl-Based Solid Dispersions To Enhance The Biopharmaceutical Properties Of Acyclovir, Darshan R. Telange, Snehal B. Bhagat, Arun T. Patil, Milind J. Umekar, Anil M. Pethe, Nishikant Raut, Vivek S. Dave

Pharmacy Faculty/Staff Publications

The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir and glucosamine HCl were prepared by an ethanol-based solvent evaporation method. The prepared formulations characterized by photomicroscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transforms infrared spectrophotometry (FTIR), powder x-ray diffractometry (PXRD) and drug content analysis. The functional characterization of ACV-SD was performed by aqueous solubility evaluation, dissolution studies, fasted versus fed state dissolution comparison, ex vivo permeability, and stability …

Penicillin Allergy Assessment And Skin Testing In The Outpatient Setting, Wesley D. Kufel, Julie Ann Justo, P. Brandon Bookstaver, Lisa M. Avery

Faculty Publications

Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians. Thus, allergy assessment and penicillin skin testing (PST) are important management strategies to reconcile and clarify labeled penicillin allergies. While PST is more common in the inpatient setting where the results will immediately impact antibiotic management, this process is becoming of increasing importance in the outpatient setting. PST in the outpatient setting allows clinicians to proactively de-label and educate patients accordingly so beta-lactam antibiotics may …

Synthesizing Galactose Modified Polymeric Nanoparticles For Biofilm Inhibition Of Pseudomonas Aeruginosa, Tyler R. Flockton

Theses and Dissertations

Treating patients with antibiotics is becoming harder with the increase in antibiotic resistance. This is due to the widespread antibiotic use in clinical and agricultural settings. With antibiotic resistance outpacing new drugs making it to the market, developing new options to treat bacterial infections is and will be important. We created sugar modified nanoparticles to inhibit the biofilm formation of Pseudomonas aeruginosa.

P. aeruginosa is a gram-negative opportunistic pathogen that infects its host that has a compromised immune system. This makes it one of the most significant bacterial infection in hospitals. P. aeruginosa uses biofilms as an attack mechanism …

Penicillin Allergy Assessment And Skin Testing In The Outpatient Setting, Wesley D. Kufel, Julie Ann Justo, P. Brandon Bookstaver, Lisa M. Avery

Pharmacy Faculty/Staff Publications

Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians. Thus, allergy assessment and penicillin skin testing (PST) are important management strategies to reconcile and clarify labeled penicillin allergies. While PST is more common in the inpatient setting where the results will immediately impact antibiotic management, this process is becoming of increasing importance in the outpatient setting. PST in the outpatient setting allows clinicians to proactively de-label and educate patients accordingly so beta-lactam antibiotics may …