Medicine and Health Sciences Commons^™

Carboxylic Acids And Light Interact To Affect Nanoceria Stability And Dissolution In Acidic Aqueous Environments, Matthew L. Hancock, Eric A. Grulke, Robert Yokel

Nanobiotechnology Center Faculty Publications

Cerium atoms on the surfaces of nanoceria (i.e., cerium oxide in the form of nanoparticles) can store or release oxygen, cycling between Ce³⁺ and Ce⁴⁺; therefore, they can cause or relieve oxidative stress within living systems. Nanoceria dissolution occurs in acidic environments. Nanoceria stabilization is a known problem even during its synthesis; in fact, a carboxylic acid, namely citric acid, is used in many synthesis protocols. Citric acid adsorbs onto nanoceria surfaces, limiting particle formation and creating stable dispersions with extended shelf life. To better understand factors influencing the fate of nanoceria, its dissolution and stabilization have …

Gnetin C For Chemoprevention And Therapy Of Prostate Cancer, Gisella Campanelli

Selected Full-Text Dissertations 2020-

Prostate cancer is common among aging men. Despite current management, it continues to be associated with a high mortality rate. A need, therefore, exists for improved treatment approaches that target every stage of the disease. In this study, we investigated the efficacy of Gnetin C, a resveratrol dimer found abundantly in melinjo (Gnetum gnemon) seeds, across three different treatment modalities. The first involved a Gnetin C-supplemented diet as a chemopreventive strategy in a high-risk transgenic mouse model which overexpresses MTA1 on a background of Pten heterozygosity (R26MTA1; Pten+/f). The second involved the administration of Gnetin C by intraperitoneal (i.p.) injection …

Utilization Of Physiological Based Pharmacokinetic Modeling To Predict Systemic Exposure And Guide Dosing Decisions For Therapeutic Drug Monitoring Of Beta-Lactams In Critically Ill Patients, Hui Wei

Selected Full-Text Dissertations 2020-

Sepsis leads to a continuous pathophysiologic process that dysregulates host response which potentially causes significant organ damage and even death, especially respiratory, renal and cardiac failure. Changes in the clearance and volume of distribution are typically result in pharmacokinetic variabilities and often make it challenging for clinicians to appropriately dose beta-lactam antibiotics. Therapeutic drug monitoring (TDM) is necessary to further optimize beta-lactam pharmacokinetic/pharmacodynamic (PK/PD) parameters to improve clinical outcomes and reduce therapeutic failure.

Cefepime (CEF) and meropenem (MEM) primarily excreted by the kidney, and altered the kidney function of the ICU patients would affect the clearance of the medications. On …

Management Of Patients Treated With Antithrombotic Drugs In Dentistry: Comparison Of Sfco And Baos Recommendations, Meryem Lahlou, Yousef Naji, Ossama Nabih, Ihsane Ben Yahya

Health Sciences

Background Patients on antithrombotic drugs are at risk of thrombosis; when prescribed these medications they develop a risk of haemorrhage. To our knowledge, there is no published global consensus on the management of these patients and only expert panels guidelines exist. Objectives The aims of this study were to (1) compare the clinical guidelines issued by the French Society of Oral Surgery (SFCO) and the clinical guidelines issued by the British Association of Oral Surgery (BAOS), and (2) to summarize the guidelines recommendations. Methods This article is a descriptive comparative review based on published clinical guidelines issued by the French …

2023 Apothecary, Southwestern Oklahoma State University

Apothecary

It is with great honor that we present the 2023 Apothecary issue. This year's Apothecary was made possible by generous financial contributions from many stores, businesses, and Southwestern College of Pharmacy alumni. We greatly appreciate and thank you for your continued support.

The Apothecary staff would like to thank Dr. Les Ramos and Adina Foust. This process would not have been possible without their continuous support, patience, and behind-the-scenes efforts. We also want to thank the SWOSU Design Studio for their hard work in creating this year's fantastic cover and dividers. You always help bring our ideas to life and …

Artificial Intelligence In Dentistry : Knowledge And Perceptions Of Moroccan Students, Manal Elhijazi, Ihsane Benyahya

Health Sciences

Introduction: Artificial intelligence (AI) is a revolution in education, research and health. The aim of this study is to assess the views and perceptions of dental students regarding artificial intelligence and its impact on their future professional practice. Methods: A voluntary anonymous e-questionnaire was sent to all 4th and 5th year dental students of the Faculty of Dentistry after receiving a course on artificial intelligence. The questionnaire consisted of sections to assess students' knowledge of artificial intelligence and its possible applications in dentistry as well as ethical considerations. Statistical analysis of the data was carried out using SPSS version 23 …

Prepubertal Periodontitis In Children: For An Adequate Diagnosis And Optimal Care, F.Z. El Mouatarif, S. Chemlali, M. Hamza, J. Kissa, S. El Arabi

Health Sciences

Prepubertal periodontitis (PP) is a rare and rapid progressive condition found a young cohort of patients that results in destruction of the periodontal support of the primary dentition. Its generalized form, prepubertal periodontitis is often associated with a significant gingival tissue inflammation and fast bone loss with attachment loss leading to the tooth loss. The localized form of PP is characterized by a much more discreet inflammation and slow evolution. It can be associated with a known underlying systemic disease or may occur as part of a recognized syndrome or as an isolated finding. Different treatment modalities can be used …

Biological Parameters And The Histological Response In Rectal Cancer Treated By Neoadjuvant Chemoradiotherapy: A Moroccan Cohort, A. Naim, N. Bouanani, F. Safini, S. Mounaime, Soumaya Rafii, L. Lachker, F. Guessous, M. Khaliss, N. Tawfiq, A. Badou

Health Sciences

Introduction: Multimodal management of rectal cancer, combining neoadjuvant Radio chemotherapy followed by total Mesorectal therapy (TME), has been shown to improve locoregional control. However, the histological response is variable independently of the initial tumor stage. Some recent data suggest the usefulness of the lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in predicting the histological response to neoadjuvant therapy. This study aimed to investigate the correlation between the complete histological response (pCR) after neoadjuvant radio chemotherapy and biological parameters (LMR, NLR and PLR) in rectal cancer patients.

PATIENTS AND METHODS: This retrospective study was conducted in three Moroccan …

Research News, Publications, 2023, Volume 1, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of January 1 through March 31, 2023

Pharmacology Of Disulfiram As An Antibacterial Agent, Yogesh Meka

Theses, Dissertations and Capstones

Disulfiram (Antabuse®) is an oral prescription drug used to treat alcohol abuse disorder (AUD). Disulfiram (DSF) and its metabolites act on the body by inhibiting multiple enzymes involved in alcohol metabolism. This study aims to understand the pharmacology of disulfiram as an antibacterial medication. Previous studies on DSF showed antibiotic activity against multidrug-resistant Staphylococcus aureus strains (MRSA). The initial aim of this study was to decipher the mechanisms involved in inhibiting bacterial growth by DSF, which was done by performing biochemical studies. The studies revealed that DSF had antagonistic effects on redox buffering and energy production. Another aim of this …

Cancer Immunotherapy: A Breakthrough In Patient Care, Abdou-Samad Kone, Nour El Imane Issam Salah, Amina Ghouzlani, Abdallah Badou

Health Sciences

Cancer is one of the world's leading causes of death. Conventional therapies, such as surgical resection, radiotherapy, and chemotherapy, have improved patient management and have shown overwhelming progress. However, the incidence and mortality rates among cancer patients are still extremely high, at approximately 20,5 % and 10,6 % for both sexes, respectively. This may be due to the heterogeneity of tumors, their special microenvironment, and the development of resistance to certain conventional therapies. The concept of immunotherapy provided a new perspective on patient treatment. The interaction of tumor cells with their microenvironment depends on different factors and conditions that promote …

Medication Cost Reduction And Substitution Strategies Through The Mymetrx Program At Catholic Hospice, Ana M. Sanchez Monroig, Tracy Romanello, Joseph Solien, Sanaz Kashan, Angel E. Sanchez Artiles

East Florida Division GME Research Day 2023

Please see supplemental content for full abstract with references.

Introduction: As healthcare costs continue to rise, and with the growing awareness of the potential harms of polypharmacy, there is an ongoing need to explore strategies to optimize medication use in hospice settings. Strategies include deprescribing and medication substitutions, which ensure the safety and comfort of patients but can also lead to significant medication cost reduction.

Objectives: The primary objective of this study was to evaluate the impact of the MyMetRx program on medication cost reduction and medication substitutions within the context of Catholic Hospice. The program aimed to optimize medication …

Influences Of Host Cytokine Signaling On Kshv Infection In Tonsil-Derived B Lymphocytes, Nedaa Alomari

Pharmaceutical Sciences (PhD) Dissertations

Kaposi sarcoma-associated herpesvirus (KSHV) is the etiologic agent of kaposi sarcoma. It is also associated with the B cell lymphoproliferative disorders, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research reveals that KSHV has developed numerous strategies to alter host cytokine signaling activities to facilitate viral persistence and escape host immune surveillance.

Despite three decades of research, there are still many questions in this field awaiting further investigation. This dissertation will investigate host cytokines as factors influencing the establishment of KSHV infection in the human tonsil. We have identified and characterized different cytokines …

Radiation Therapy Of Glioblastoma: Experience Of A Moroccan Center, Hassani Wissal, El Ayachi Zineb, Farhane Fatim-Zahra, Alami Zenab, Bouhafa Touria

Health Sciences

Background: Glioblastomas are the most frequent and aggressive primary brain tumors. Their prognosis remains bleak, despite progress in management and understanding of the different biological mechanisms. Our objective is to highlight the impact of radiotherapy in improving the management of glioblastoma through the experience of the radiotherapy department at Hassan II University Hospital. Materials and Methods: This was a retrospective study analyzing the medical records of patients with glioblastoma over the period from August 2012 to January 2020. The data was analyzed using the epi-info software, therapeutic toxicities evaluated according to CTCAE V.4 scale, and overall survival estimated by the …

To Publish Or Not To Publish Phd Parts Before Its Completion Is Also An Ethical Question, Christos Melidis

Health Sciences

No Abstract for this article type.

Lower Mortality With Andexanet Alfa Vs 4-Factor Prothrombin Complex Concentrate For Factor Xa Inhibitor-Related Major Bleeding In A U.S. Hospital-Based Observational Study, Paul P. Dobesh, Gregory J. Fermann, Mary J. Christoph, Bruce Koch, Eva Lesén, Hungta Chen, Belinda Lovelace, Theresa Dettling, Mark Danese, Julie Ulloa, Sherry Danese, Craig I. Coleman

Journal Articles: Pharmacy Practice

BACKGROUND: Well-designed studies with sufficient sample size comparing andexanet alfa vs 4-factor prothrombin complex concentrate (4F-PCC) in routine clinical practice to evaluate clinical outcomes are limited.

OBJECTIVES: To compare in-hospital mortality in patients hospitalized with rivaroxaban- or apixaban-related major bleeding who were treated with andexanet alfa or 4F-PCC.

METHODS: An observational cohort study (ClinicalTrials.gov identifier: NCT05548777) was conducted using electronic health records between May 2018 and September 2022 from 354 U.S. hospitals. Inclusion criteria were age ≥18 years, inpatient admission with diagnosis code D68.32 (bleeding due to extrinsic anticoagulation), a record of use of the factor Xa inhibitors rivaroxaban or …

Hippocampal Versus Cortical Deletion Of Cholinergic Receptor Muscarinic 1 In Mice Differentially Affects Post-Translational Modifications And Supramolecular Assembly Of Respiratory Chain-Associated Proteins, Mitochondrial Ultrastructure, And Respiration: Implications In Alzheimer's Disease, Mohammad Golam Sabbir, Mamiko Swanson, Robert C. Speth, Benedict C. Albensi

HPD Articles

In a previous retrospective study using postmortem human brain tissues, we demonstrated that loss of Cholinergic Receptor Muscarinic 1 (CHRM1) in the temporal cortex of a subset of Alzheimer's patients was associated with poor survival, whereas similar loss in the hippocampus showed no such association. Mitochondrial dysfunction underlies Alzheimer's pathogenesis. Therefore, to investigate the mechanistic basis of our findings, we evaluated cortical mitochondrial phenotypes in Chrm1 knockout (Chrm1) mice. Cortical Chrm1 loss resulted in reduced respiration, reduced supramolecular assembly of respiratory protein complexes, and caused mitochondrial ultrastructural abnormalities. These mouse-based findings mechanistically linked cortical CHRM1 loss with poor survival of …

Elucidating The Impact Of Western Diet On Bone Marrow Cytokine Signatures: Understanding Poor Outcomes In Susceptibility To Infection And Progression Of Cancer, Lahari Kondeti

Theses, Dissertations and Capstones

Among other disease outcomes, obesity is associated with 1) reduction in long-lasting immune protection and 2) acquisition of cancer. Given our interest in hematopoietic stem and progenitor cell (HSPC) dynamics, we questioned if similar mechanisms in the bone marrow microenvironment contribute to obesity-induced HSPC alterations responsible for 1) decreased immune protection and 2) transformation of HSPCs in the pathogenesis of hematologic malignancies. The negative effects of obesity on immune protection are most notably established in influenza models. Influenza infection susceptibility is increased and influenza vaccine-induced immunity wains in obese individuals. Ongoing studies aim to define mechanisms for waning immunity at …

Implementation And Standardization Of Telehealth Visits In A Specialty Pharmacy Setting, Ivana Wu, Angie Chau, Amber Franck, Adam Saulles

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2023

No abstract provided.

Inpatient Management Of Medication-Assisted Therapies For Opioid Use Disorder, Tracee Mock, Clara Mikhaeil, Emily H. Hsu

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2023

No abstract provided.

Factors Impacting Adherence To Antidiabetic Medications And Health Outcomes In Diabetes Mellitus Patients In Medicare Populations, Kelli Hoang, Kelly Simpson, Danny Wallenslager

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2023

No abstract provided.

Prg4/Cd44/Pp2a Signaling Axis: A Significant Regulator Of Gout Arthritis, Sandy Elsayed

Pharmaceutical Sciences (PhD) Dissertations

Introduction: Gout is a common chronic arthritis caused by monosodium urate (MSU) crystal deposition in joints leading to activation of synovial resident macrophages and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) and reactive oxygen species (ROS) that activate NLRP3 inflammasome. Protein phosphatase-2A (PP2A) may be involved in regulating inflammatory pathways in macrophages. Proteoglycan 4 (PRG4) and its receptor CD44 and its transducer PP2A signaling axis play a biologically significant role in regulating urate crystal inflammation.

Methods: Monocytes and macrophages were primed with TLR2 agonist and stimulated with MSU crystals. Fingolimod (PP2A …

Pharmacy Manager System Implementation Strategies To Mitigate The Cost Of Prescription Errors, Tunde Abiodun Cardozo

Walden Dissertations and Doctoral Studies

AbstractOne of the most frequent medical errors in contemporary medicine is incorrect prescriptions, and the profits from retail pharmacy operations are adversely impacted by the costs associated with prescription errors. Independent pharmacy managers are interested in finding workable strategies to mitigate the cost of prescription errors and increase profit. Using the resource-based theory of competitive advantage (RBTCA), the purpose of this qualitative multiple-case study was to explore strategies some independent pharmacy managers in Texas use to mitigate the cost of pharmacy employee prescription errors and increase profitability. The participants were five independent pharmacy managers who implemented strategies to mitigate the …

Assembly Of Synaptic Protein-Dna Complexes: Critical Role Of Non-Specific Interactions, Sridhar Vemulapalli, Mohtadin Hashemi, Anatoly B. Kolomeisky, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

The synaptic protein-DNA complexes, formed by specialized proteins that bridge two or more distant sites on DNA, are critically involved in various genetic processes. However, the molecular mechanism by which the protein searches for these sites and how it brings them together is not well understood. Our previous studies directly visualized search pathways used by SfiI, and we identified two pathways, DNA threading and site-bound transfer pathways, specific to the site-search process for synaptic DNA-protein systems. To investigate the molecular mechanism behind these site-search pathways, we assembled complexes of SfiI with various DNA substrates corresponding to different transient states and …

Amyloid Cascade Hypothesis For Alzheimer’S Disease. Does It Work Under Physiological Conditions?, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

Plaques in the brain consisting of proteins are a hallmark of diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD). Such aggregates can be assembled spontaneously by specialized proteins such as amyloid beta (Ab) proteins in the case of AD. Numerous in vitro studies made a foundation for the Amyloid Cascade Hypothesis (ACH), according to which the misfolding of proteins leads to their self-assembly into toxic oligomers along with the formation of amyloid fibrils assembled as plaques in the brain. Notably physiological concentration of Ab proteins in the brain is in the low nanomolar concentration, so no spontaneous aggregation of …

Birs Course: Rna Vaccine Manufacture And Assessment Of Regulatory Documents For Rna Vaccines, Stephen R. Byrn, Nathaniel Milton, Kari L. Clase

BIRS Technical Report Papers

This paper is in three segments: (A) Segment on Vaccine Manufacture; (B) Segment on Ready to Use (RTU) Fluid Path for Compounded Sterile Preparations, mRNA Vaccines, and Phage Therapy, (C) Segment on Competency Framework for Addressing Regulatory Review These segments can be used separately or in combination. Additionally, they can be presented in any order. The time devoted to each segment depends on the depth of the course coverage. These segments are interrelated and describe how to make vaccines, how to manufacture vaccines with a point-of-care system built from ready-to-use parts; and how to regulate vaccines. This is a timely …

Swosu Research And Scholarly Activity Fair 2023, Swosu Office Of Sponsored Programs

SWOSU Research and Scholarly Activity Fair Programs

On behalf of the members of the University Research and Scholarly Activity Committee (USRAC) and the Office of Sponsored Programs (OSP) at Southwestern Oklahoma State University (SWOSU) - Welcome to the Thirtieth SWOSU Research and Scholarly Activity Fair! There are 77poster presentations and 2 oral presentations involving over 130 student and faculty researchers, writers, presenters, artists, collaborators, and faculty sponsors encompassing activities from the SWOSU College of Pharmacy; SWOSU School of Nursing & Allied Health Sciences; and SWOSU Departments of Allied Health Sciences; Art, Communication & Theatre; Biological Sciences; Business; Computer Science; Chemistry & Physics; Engineering Technology; Language & Literature; …

Research News, Grants, 2023, Volume 3, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July - September 2023

Evaluation Of The Impact Of The Covid-19 Pandemic On The Teaching Of Otolaryngology And Cervico-Facial Surgery, I. Tahiri, H. Bensouda, O. Haddani, O. El Houari, S. Anajar, L. Taali, A. Hajjij, M. Essaadi, M. Jahidi, F. Benariba, M. Zalagh, F. Guessous, S. Chaouir

Health Sciences

Background: During the Covid-19 pandemic, distance learning is increasingly present in the field of education, particularly in the health sciences. This type of teaching has emerged as the appropriate solution to the problem of knowledge transfer. The objective of this study is to evaluate the impact of distance learning of the ENT (ear, nose and throat) and CFS (cervico-facial surgery) module on students and the impact of the pandemic on their quality of life. Methods: We conducted a survey on students' feelings about distance learning courses, the impact of the pandemic on their lifestyle and the consequences of the protective …

Student Evaluation Of Pre-Clinical Teaching On A Dental Simulator, Manal Elhijazi, Hafsa Elmrini, Ihsane Benyahya

Health Sciences

Context: Student evaluation of teaching (SET) is a pedagogical tool which is part of a quality control process of teaching. Material and methods: An anonymous and voluntary e-questionnaire was sent to all 3rd year students of the Faculty of Dentistry in university Mohamed VI of sciences and health at the end of the academic year 2021-2022 in order to evaluate the progress of practical pre-clinical learning by dental simulator in conservative dentistry. The aim was to evaluate the teaching tools, the organization of the lessons, the content of the program as well as their overall perceptions of this practical pre-clinical …