Medicine and Health Sciences Commons^™

Effect Of Antibiotic Prophylaxis On Surgical Site Wound Infection In Third Molar Surgery: A Meta-Analysis, Mohamed Atif Elkholy, Sayed Rashed Fashkal

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The objective of this meta-analysis is to assess the impact of antibiotic prophylaxis (AP) on surgical site wound infection (SSWI) throughout third molar surgery (TMS).

A meta-analysis was conducted using examinations that compared AP to placebo for TMS from different languages that satisfied the inclusion criteria. Applying dichotomous random or fixed effect models, the findings of these studies were analysed, and the Odd Ratio (OR) was calculated with 95% confidence intervals (CIs).

A total of 18 studies conducted between 2001 and 2023 were included in the present analysis. These studies initially included 4063 individuals with TMS.

A substantial reduction in …

D -∝- Tpgs/ Poloxamer 188 Mixed Micelles For The Oral Delivery Of Azelnidipine: Preparation And In Vitro Evaluation, Ali Kathem Ala Allah, Shaimaa Nazar Abd Alhammid

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Azelnidipine is a calcium channel blocker with low water solubility and high lipophilicity and is intended for treating angina pectoris and hypertension. This study aimed to increase and enhances the solubility of azelnidipine through its incorporation in D - - tocopheryl polyethylene glycol/polyxamer188 (TPGS/P188) micelles for oral administration and substantially increasing the extent of drug absorption.

Nine formulations (A₁-A₉) were prepared by direct dissolution method using a combination of D- - TPGS 1000 succinate and Poloxamer 188. The size of the particle, polydispersity index (PDI), surface charge, and entrapment capacity were measured. The optimum formula …

Evaluation Of Nursing Care Documentation And Administration At Emergency Unite: Comparative Study, Ali Refak Lazem, Huda Baker Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Objectives: to evaluate of nursing care documentation and administration at emergency unite, and find the relationship between Nursing care documentation and administration and demographic characteristic of nurses.

Method: An Observational design study was conducted from the 25 December 2023 to 30 April 2024. The study setting was conducted at the emergency department in AI-Hussein Teaching Hospital, Al-shatra General Hospital in Dhi-Qar governorate/Iraq. Study Sample A convenient sample (non-probability) involving (103 nurses:60 in Al-Hussien Hospital and 43 in Al-Shatra Hospital). The practices were evaluated by using the self-report questionner and observational checklist. The data analysis through descriptive and interferential statistics …

Occurrence And Diversity Of Staphylococcus From Women With Breast Abscess And Mastitis, Rana Adnan M. Al-Wataify, Maysaa S.M. Al-Shukri, Mohend A.N Al-Shalah

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Mastitis is inflammatory that can effect women at every time , it is predominant occur in women during breastfeeding. Staphylococcus are the most common pathogens causative agents of mastitis.The clincal samples were collection from women with different age group from patients who admitted to Al-Hilla General teaching hospital (breast cancer consultation and outpatient clinics) for the period from August2023 to Januray2024.This study included 80 patient suffered from breast infection or mastitis, this result show that 45(56%) from total samples having breast abscesses and 35(44%) having mastitis.The isolating bacterial causes according of total samples that having S.aureus 20(25%), S.epidermides 10 (12.5%),other …

Pharmacoeconomics And Health Technology Assessment - Letter To The Editor, Samar Farid

Bulletin of Faculty of Pharmacy Cairo University

This is letter to the editor

Cellular Uptake And Computational Analysis Of [131i]-Xanthine And [131i]-Hypoxanthine In Human Prostate Cancer Cell Line (Lncap), Hendris Wongso, Isa Mahendra, Yanuar Setiadi, Badra Sanditya Rattyananda, Asep Rizaludin, Ni Made Yuktikamura Galih Pranisuari, Crhisterra Ellen Kusumaningrum

Makara Journal of Science

Potent radiolabelled compounds eligible for therapy of prostate cancer need to be developed. Hence, we developed two candidate therapeutic agents bearing the iodine-131 (¹³¹I) radionuclide, namely, [¹³¹I]-xanthine (3,7-dihydropurine-2,6-dione) and [¹³¹I]-hypoxanthine (1,9-dihydro-6H-purin-6-one). The radiolabelled compounds were subjected to a cellular uptake study, which was accomplished by incubating [¹³¹I]-xanthine and [¹³¹I]-hypoxanthine with the human prostate cancer cell line (LNCaP) for 5, 15, 30, 60, and 90 min. Results showed that the accumulation of both [¹³¹I]-xanthine and [¹³¹I]-hypoxanthine in prostate cancer cells was significantly higher than the …

Phytotherapeutic Approach To Enhance The Hepatoprotective Activity Of Some Edible Plants: Molecular Docking And Nanoformulation, Khaled Nematallah, Amgad Albohy, Noha Swilam

Pharmacy

This study used molecular docking to evaluate phytochemicals from 47 plants against liver fibrosis. It identified potent compounds, prompting further investigation of chamomile, pomegranate, ginseng, and artichoke. Extracts from these plants were characterized and formulated into a self-microemulsifying drug delivery system (SMEDDS). Studies on the herbal formula exhibited around 150% higher flavonoids, 50% higher polyphenols, 178% higher antioxidant activity, and synergistic In-vitro hepatoprotective effects compared to the average results of individual extracts. Both the aqueous suspension and the nanoformulation of the formula offered in-vivo protection against paracetamol-induced hepatotoxicity in mice. The SMEDDS group showed superior outcomes, with no significant differences …

Phytotherapeutic Approach To Enhance The Hepatoprotective Activity Of Some Edible Plants: Molecular Docking And Nanoformulation, Khaled Nematallah, Amgad Abdallah, Noha Swilam

Pharmacy

This study used molecular docking to evaluate phytochemicals from 47 plants against liver fibrosis. It identified potent compounds, prompting further investigation of chamomile, pomegranate, ginseng, and artichoke. Extracts from these plants were characterized and formulated into a self-microemulsifying drug delivery system (SMEDDS). Studies on the herbal formula exhibited around 150% higher flavonoids, 50% higher polyphenols, 178% higher antioxidant activity, and synergistic In-vitro hepatoprotective effects compared to the average results of individual extracts. Both the aqueous suspension and the nanoformulation of the formula offered in-vivo protection against paracetamol-induced hepatotoxicity in mice. The SMEDDS group showed superior outcomes, with no significant differences …

Case Title: Uncovering The Truth: The Unexpected Incidental Discovery Of Metastatic Carcinoid Tumor In An Elderly Patient., Kavitha Chittaragi Dr, Shwetha R. Poojary Dr

Radiology Teaching Files

Carcinoid tumors are rare neuroendocrine neoplasms with varied clinical presentations. We report a case of a 70-year-old female patient who presented with history of loose stools, vomiting, and abdominal pain. Imaging revealed a small hyper-enhancing nodule in the small bowel, multiple liver lesions, and a mesenteric mass, all suggestive of metastatic carcinoid disease. Biopsy confirmed a neuroendocrine tumor. As these tumors can remain indolent for years, early detection and treatment are critical for effective management and better prognosis.

Removal Of Common Antimicrobial Agents By Sustained Low- Efficiency Dialysis, Joanna Q. Hudson Pharmd, Bcps, Fasn, Fccp, Madelyn N. Hilgers Bs, Pharmd Candidate, Elvira O. Gosmanova Md

Faculty Publications

Adequate dosing of antimicrobials is paramount for treating infections in critically ill patients undergoing kidney replacement therapy; however, little is known about antimicrobial removal by sustained low-efficiency dialysis (SLED). The objective was to quantify the removal of cefepime, daptomycin, meropenem, piperacillin–tazobactam, and vancomycin in patients undergoing SLED. Adult patients ≥18 years with acute kidney injury (AKI) or end-stage kidney disease receiving one of the select antimicrobials and requiring SLED were included. Blood and dialysate flow rates were maintained at 250 and 100 mL/min, respectively. Simultaneous arterial and venous blood samples for the analysis of antibiotic concentrations were collected hourly for …

Targeting Ribosome Biogenesis Is A Novel Approach For The Management Of Pancreatic Cancer, Mudassier Ahmad, Haider Ahsan, Carlos Perez, Muhammad Bangash, Andrew Massey, Emmanuel Anning, Manish Tripathi, Dae Kim, Subhash C. Chauhan, Bilal Bin Hafeez

Research Colloquium

Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related deaths in the United States with limited therapeutic options available. Gemcitabine, a deoxycytidine nucleoside analog is currently considered the most effective therapy for PanCa. However, it shows only a marginal survival benefit of six months. Aberrant ribosome biogenesis occurs in most tumor types. We observed that PanCa cells are addicted to ribosome biogenesis, which supports their highly aggressive metastatic phenotypes. Thus, strategically targeting ribosome biogenesis process could be one of the ideal strategies for the prevention and treatment of PanCa. In this study, we elucidated the molecular mechanisms of POLR1A …

An Unusual Case Of Metronidazole-Induced Encephalopathy In A Patient With Hereditary Hemorrhagic Telangiectasia, Tina H. Dao, Kinza Khan, Christopher D. Jackson

Journal of Community Hospital Internal Medicine Perspectives

Metronidazole-induced encephalopathy (MIE) is a rare toxic encephalopathy. We describe a reversible MIE case in a patient with hereditary hemorrhagic telangiectasia (HHT), treated with metronidazole for brain abscess, who developed dizziness, weakness, dysarthria, and severe dysmetria. His Magnetic Resonance Imaging (MRI) brain revealed bilateral, symmetric lesions in bilateral symmetrical regions of increased intensity in the medullary olives, cerebellar dentate nuclei, and the dorsal pons, all characteristic of MIE. Upon metronidazole discontinuation, the patient experienced significant symptom improvement, with subsequent MRI showing resolution of the lesions

Taste Masked Of Eplerenone Using Egg Box Method, Asmaa Mohammed Rashid

Maaen Journal for Medical Sciences

Eplerenone is a selective mineralocorticoid receptor antagonist employed to manage hypertension, central serous retinopathy, and chronic heart failure. It has a highly bitter taste, which reduces patient compliance with the drug.

The aim of this study was masking the very bitter taste of the eplerenone to improve patient compliance especially for geriatric patient.

The medication was encapsulated utilizing the ionic gelation process, in which a 1% w/w sodium alginate solution was utilized to form egg box structures.Two different concentrations of CaCl2 (0.5.1%w/v) were used as cross-linkers, and different drug: polymer ratios were tested. The formulas were evaluated based on their …

Intracellular Islatravir-Triphosphate Half-Life Supports Extended Dosing Intervals, Xiaowei Zang, Wendy Ankrom, Walter K. Kraft, Ryan Vargo, S Aubrey Stoch, Marian Iwamoto, Randolph P Matthews

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Antiretroviral therapy has substantially reduced morbidity, mortality, and disease transmission in people living with HIV. Islatravir is a nucleoside reverse transcriptase translocation inhibitor that inhibits HIV-1 replication by multiple mechanisms of action, and it is in development for the treatment of HIV-1 infection. In preclinical and clinical studies, islatravir had a long half-life (t½) of 3.0 and 8.7 days (72 and 209 hours, respectively); therefore, islatravir is being investigated as a long-acting oral antiretroviral agent. A study was conducted to definitively elucidate the terminal t½ of islatravir and its active form islatravir-triphosphate (islatravir-TP). A single-site, open-label, non-randomized, single-dose phase 1 …

Exploring The Use Of An Interprofessional Education Session For Speech-Language Pathology And Pharmacy Students, Sophia Werden Abrams, Heather Macphee, Linnea Hodge, Justine Hamilton, Ashwini Namasivayam-Macdonald

Teaching and Learning in Communication Sciences & Disorders

Interprofessional education (IPE) occurs when students are provided the opportunity to learn with and from others of related professions to improve the potential for future collaboration. The aim of this study was to explore the perceptions of students about working with professionals from different disciplines before and after their engagement in an interprofessional learning activity and determine any changes in their willingness to work in interprofessional teams.

Doctor of Pharmacy students from the University of Manitoba and Master’s speech-language pathology students from McMaster University participated in an online inter-university and inter-provincial education module. Students were invited to complete the Interprofessional …

Estimation Of The Immunological Markers (Ctla4 And Vegf) Of The Adjuvant Ovarian Cancer In Iraqi Women Patients, Yasir Naeem Khlaif, Mayada Noori Iqbal, Hind Jaber Hassoon

Al-Esraa University College Journal for Medical Sciences

Background: The most frequent cause of death for females with gynecological cancer diagnoses is ovarian cancer (OC). Furthermore, generally speaking, it ranks as the 5^th most frequent cause of death for females. The majority of cases had advanced diagnoses, which worsens the disease's prognosis. Objectives: The aims of the study is to Estimate the immunological markers “cytotoxic T lymphocyte associated antigen 4” (CTLA4) and “Vascular Endothelial Growth Factor” (VEGF) in Adjuvant women (OC). Materials and methods: 90 Adjuvant women OC were included in this study (30 of them were taking (1-6) dose of biotherapy Bevacizumab (Avastin) Group 1 (G1), …

Determination Of The Hematological And Biochemical Parameters Associated With Liver Cancer, Hepatitis Types B, And C In Iraqi Patients, Saja Khudhier Essa Al-Juboori, Shaymaa Ismael Kadhum Al-Juboori

Al-Esraa University College Journal for Medical Sciences

Hepatocellular carcinoma (HCC) is the second most common cancer in humans and the fifth most prevalent worldwide. Although the survival rate of HCC has increased over time, postoperative recurrences remain high after a decade. HCC can be caused by both viral and non-viral diseases. There are two major global risk factors for HCC these are: hepatitis B virus (HBV) and hepatitis C virus (HCV). As part of routine health exams, complete blood counts can detect a variety of disorders, including infections, anemia, immune system disorders, and blood cancers. A complete blood count (CBC) can be used to perform a biochemical …

High-Performance Liquid Chromatography Analytical Techniques For Determining The Various Diabetic Type 2 Medications: A Review Article, Mohammed Abdullah Ahmed, Mohammed J.M. Hassan, Hayder O. Hashim, Ashour H. Dawood

Al-Esraa University College Journal for Medical Sciences

A metabolic illness known as diabetes mellitus (DM) is brought on by the body's decreased secretion and/or activity of the hormone insulin. The condition worsens, pathological alterations in the body, such as nephropathy, retinopathy, and cardiovascular problems, become inevitable. Type I and II DM are the two primary subtypes of DM. Oral hypoglycaemics are used to treat type II diabetes, while insulin replacement therapy is typically used to treat type I diabetes. Patients typically receive dual drug treatments. Despite using oral hypoglycemic medications as monotherapy, have not been able to accomplish their therapeutic goals with first-line therapy.

In the current …

Evaluate Levels Of Nephrin And Kidney Injury Molecule In Diabetic Nephropathy Patients, Ahmed Malik Hassan, Hassan Ali Al-Saadi, Radhwan Mohammed Hussein

Al-Esraa University College Journal for Medical Sciences

Introduction: Diabetes, particularly when uncontrolled for an extended length of time, was already related with a higher risk of complications and progression of both macrovascular and microvascular problems. Diabetic nephropathy is one of the complications of diabetes can be a result from micro vascular effect of diabetes, kidney disease can occur in both type one or type two diabetes patients kidney disease usually affects young and middle-aged patients. Kidney injury molecule and Nephrin is a biomarkers used to diagnosis of early biomarkers in diabetic nephropathy Objective: The aim was effectiveness of KIM-1 and nephrin for diagnosis of diabetic kidney disease …

Characterization Of Irritable Bowel Syndrome Subtype In Iraqi Patients, Ola Amer Jasim, Khalid Mahdi Salih

Al-Esraa University College Journal for Medical Sciences

Irritable Bowel Syndrome (IBS) is a functional disease of gastrointestinal tract (GIT) that affects 10-20% of the population worldwide and is distinguished by abdominal pain/discomfort and changes in bowel habits that is accompanied by diarrhea, constipation, or both. Cross-sectional study was conducted on 50 Iraqi patients with IBS who were presented at private clinics for gastrointestinal diseases (GIDs). The study lasted from November 2021 to May 2022 and aimed to determine the frequency of IBS subtypes among Iraqi patients, as well as the influence of several factors on disease’s initiation, type and severity such as age, gender, and anxiety. The …

Study Of Il-15, Il-11, And Some Physiological Parameters In Aborted Women, Enas Saad Sabih

Al-Esraa University College Journal for Medical Sciences

Objective; The objective of current investigation is TO KNOW THE roles of IL-15 and IL-11 with some physiological indicators in pathophysiology of aborted women.

Methods; This investigation was conducted in the Medical City Hospital's gynecology consultant ‏ for period of March – May 2023. Thirty blood samples were taken from aborted women who visit hospitals and clinics otolaryngology. In addition to thirty blood samples were taken from healthy women who represented as a control group. The levels of IL-11 and IL-15 were detected by enzyme immunoassay (ELISA) (Immunotech, France), and random blood sugar observed by Biorex machine (UK). Levels of …

Incidence Of Crimean-Congo Hemorrhagic Fever (Cchf) In Different Governorates Of Iraq, Ihsan M. Al-Saqur, Amina N. Althwani, Heba N. Safah Hussein, Aubiad H. Noor, Ranna A. Sabar, Dhoha D. Hadi, Shad. H. Haitham

Al-Esraa University College Journal for Medical Sciences

Crimean-Congo hemorrhagic Fever (CCHF) is one of the most important infectious diseases in the world. This disease is considered as a dangerous zoonotic viral disease transmitted from animals to human by Hyalomma ticks. The first case was registered in Iraq in 1979, which led to the death of the patient, her doctor and some of the medical staff in Baghdad/Al-Yarmouq hospital. The current study was conducting on the data of (399) patients suffering from symptoms of hemorrhagic septicemia for two years (2021and 2022) which received from Central Disease Control (CDC) in Baghdad depending on serological test. The results revealed that …

Effect Of Ferritin, Magnesium And Cobalt On Total Viable Count Of Candida Spp. In Normal Pregnant And In-Vitro Fertilized Women, Lina Sami Adham, Abbas Sabri Almizraqchi

Al-Esraa University College Journal for Medical Sciences

Background: A correlation existed between diminished levels of vital mineral elements crucial for antioxidant activity in the bodies of pregnant women and an elevated susceptibility to preeclampsia. Objective: To assess the effect of salivary mineral elements on the salivary total count Candida spp in pregnant, in vitro fertilization pregnant women and control. Materials and Methods: A total of 85 subjects were included in this study, first group consist of (30) normal pregnant women, second group consist of (30) In vitro fertilization (IVF), and third group consist of (25) non-pregnant women, the samples were collected from different clinics …

July / August / September 2024, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the July, August, and September issue of Rural Rocks from the SWOSU College of Pharmacy.

Incorporating Solvation Thermodynamic Mapping In Computer-Aided Drug Design, Yeonji Ji

Dissertations, Theses, and Capstone Projects

Advancements in computational techniques have revolutionized structure-based drug design, substantially improving the efficiency and effectiveness of the drug discovery process by reducing time, costs, and labor requirements. These advancements include various methods, such as investigating small molecule ligands binding to proteins, exploring alternative protein conformations, and solvation mapping on the protein surfaces. Among these methods, understanding the correlation between protein-ligand binding and the role of solvation is important.

A fundamental concept in protein-ligand binding is shape and electrostatic complementarity, which is complicated by the inherent flexibility of proteins. In the absence of small molecule ligands, proteins are complementary to surface …

Challenges And Future Perspective Of Gastroretentive Mucoadhesive Dosage Forms, Rayhan Akbar, Heri Setiawan, Baitha Palanggatan Maggadani, Raditya Iswandana, Kurnia Sari Setio Putri

Pharmaceutical Sciences and Research

Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. …

Application Of Pvp Va 64 And Poloxamer 188/407 In Solid Dispersion Technology For Improving Solubility Of Valsartan, Sulastari Cahyani, Teuku Nanda Saifullah Sulaiman, Marlyn Dian Laksitorini

Pharmaceutical Sciences and Research

Valsartan, Biopharmaceutical Classification System (BCS) class II drug, exhibits pH-dependent solubility in the gastrointestinal tract, which increases at pH levels above 5. Its low solubility results in a bioavailability of only 23%, necessitating efforts to enhance it. This study aims to improve the solubility of valsartan using a solid dispersion system. Polyvinylpyrrolidone/vinyl acetate 64 (PVP VA 64), a hydrophilic polymer, was incorporated to inhibit the recrystallization of valsartan, while poloxamer 188 and poloxamer 407, used as surfactants, aimed to enhance valsartan’s solubility and intrinsic dissolution rate. Valsartan solid dispersions were prepared using the spray drying method, and the optimal formulation …

Recent Updates On Dried Blood Spot And Volumetric Absorptive Microsampling As Microsampling Technique For Antiepileptic Drug Determination: A Systematic Review, Asmiladita Pridilla, Yahdiana Harahap, Denni Joko Purwanto, Baitha Palanggatan Maggadani

Pharmaceutical Sciences and Research

Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS (Volumetric Absorptive Microsampling). Studies were searched through databases, namely Science Direct, Pubmed, and the Google Scholar search engine using pre-determined keywords. Studies published between 2019 and 2024 and used micro-sampling techniques for antiepileptic drug analysis were included. Non-English studies, non-related studies, duplication, and full text unavailable were excluded. Primary sources were used to build a conclusion regarding the purpose …

Biosynthesis Of Agnps Mediated By Equisetum Debile Roxb. Herb Water Extract And Its Potency As An Antioxidant, Yuni Retnaningtyas, Alviani Dwi Karmilasari, Endah Puspitasari

Pharmaceutical Sciences and Research

Silver nanoparticles (AgNPs) are metal nanoparticles currently under development. AgNPs are recognized for their remarkable stability, low reactivity, and advantageous biological properties, including antioxidant activity. Phenolic compounds derived from the Equisetum debile Roxb. (Ed-R) herb have the potential to be explored as bio-reduction and capping agents in the synthesis of silver nanoparticles. The primary objective of this study is to synthesize AgNPs using a water extract from Ed-R herb and to assess their antioxidant activity. The optimal composition for the biosynthesis of AgNPs comprises 10% Ed-R water extract, 8.0 mM AgNO₃, and deionized water in a ratio of …

Global Perspective Of The Risks Of Falsified And Counterfeit Medicines: A Critical Review Of The Literature, Aonghus J. Feeney, Jeffery A. Goad, Gerard T. Flaherty

Pharmacy Faculty Articles and Research

Background

Methods