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Full-Text Articles in Medicine and Health Sciences

Evaluation Of Ep300, A Histone Acetyletransferase, In Patients With Epithelial Ovarian Carcinoma, M. Strigenz, N. Nadkarni, Y. Chin, T. Neff, S. Park, D. Bender, A. Ahmed, Koen De Geest, Michael Goodheart Apr 2013

Evaluation Of Ep300, A Histone Acetyletransferase, In Patients With Epithelial Ovarian Carcinoma, M. Strigenz, N. Nadkarni, Y. Chin, T. Neff, S. Park, D. Bender, A. Ahmed, Koen De Geest, Michael Goodheart

Koen De Geest

No abstract provided.


Lymphoid Enhancing Factor 1 (Lef-1) Overexpression In Epithelial Ovarian, Fallopian Tube And Peritoneal Cancers And Associations With Clinical Factors, A. Clements, D. Engle, D. Shelton, T. Neff, S. Park, D. Bender, A. Ahmed, Koen De Geest, A. Button, J. Engelhardt, Michael Goodheart Apr 2013

Lymphoid Enhancing Factor 1 (Lef-1) Overexpression In Epithelial Ovarian, Fallopian Tube And Peritoneal Cancers And Associations With Clinical Factors, A. Clements, D. Engle, D. Shelton, T. Neff, S. Park, D. Bender, A. Ahmed, Koen De Geest, A. Button, J. Engelhardt, Michael Goodheart

Koen De Geest

No abstract provided.


Metastatic Choriocarcinoma To The Lung Coexistent With A Viable Pregnancy, A. Ahmed, Koen De Geest, T. Van Natta, J. Sorosky Apr 2013

Metastatic Choriocarcinoma To The Lung Coexistent With A Viable Pregnancy, A. Ahmed, Koen De Geest, T. Van Natta, J. Sorosky

Koen De Geest

No abstract provided.


Gog 175: A Randomized Phase Iii Trial Of Iv Carboplatin (Auc 6) And Paclitaxel 175 Mg/M(2) Q 21 Days X 3 Courses Plus Low-Dose Paclitaxel 40 Mg/M(2)/Wk Versus Iv Carboplatin (Auc 6) And Paclitaxel 175 Mg/M(2) Q 21 Days X 3 Courses Plus Observation In Patients With Early-Stage Ovarian Carcinoma, R. Mannel, M. Brady, E. Kohn, P. Hanjani, M. Hiura, R. Lee, Koen De Geest, D. Cohn, B. Monk, H. Michael Apr 2013

Gog 175: A Randomized Phase Iii Trial Of Iv Carboplatin (Auc 6) And Paclitaxel 175 Mg/M(2) Q 21 Days X 3 Courses Plus Low-Dose Paclitaxel 40 Mg/M(2)/Wk Versus Iv Carboplatin (Auc 6) And Paclitaxel 175 Mg/M(2) Q 21 Days X 3 Courses Plus Observation In Patients With Early-Stage Ovarian Carcinoma, R. Mannel, M. Brady, E. Kohn, P. Hanjani, M. Hiura, R. Lee, Koen De Geest, D. Cohn, B. Monk, H. Michael

Koen De Geest

No abstract provided.


Endometrial Cancer: Reviving Progesterone Therapy In The Molecular Age, S. Yang, K. Thiel, Koen De Geest, Kimberly Leslie Apr 2013

Endometrial Cancer: Reviving Progesterone Therapy In The Molecular Age, S. Yang, K. Thiel, Koen De Geest, Kimberly Leslie

Koen De Geest

Endometrial cancer is the most common gynecologic malignancy and represents a major health concern because overall five-year survival rates have not improved in the last three decades. A great deal of research demonstrates that the endometrium is extremely sensitive to hormones, and a shift in the estrogen:progesterone balance is the major cause for the development of endometrial cancer. Progestin-based therapy has proven effective in a subset of patients, particularly in situations where expression of progesterone receptor (PR) is maintained. However, this approach is not routinely used in the clinic in the U.S. for several reasons. For example, many endometrial tumors …


Endometrial Cancer, Kimberly Leslie, K. W. Thiel, Michael Goodheart, Koen De Geest, Y. Jia, S. Yang Apr 2013

Endometrial Cancer, Kimberly Leslie, K. W. Thiel, Michael Goodheart, Koen De Geest, Y. Jia, S. Yang

Koen De Geest

Despite the questions and barriers, the incorporation of molecular therapy into treatment regimens in endometrial cancer is an exciting area of investigation with the potential to improve outcomes. Outside of the development of a reliable screening test for endometrial cancer, converting the disease to a chronic state and improving progression-free survival is our best hope to reverse the concerning trend of decreasing 5-year survival for this disease.


Social Influences On Clinical Outcomes Of Patients With Ovarian Cancer, Susan Lutgendorf, Koen De Geest, David Bender, Amina Ahmed, Michael Goodheart, Laila Dahmoush, , M, Bridget Zimmerman, Frank, J. Penedo Apr 2013

Social Influences On Clinical Outcomes Of Patients With Ovarian Cancer, Susan Lutgendorf, Koen De Geest, David Bender, Amina Ahmed, Michael Goodheart, Laila Dahmoush, , M, Bridget Zimmerman, Frank, J. Penedo

Koen De Geest

PURPOSE Previous research has demonstrated relationships of social support with disease-related biomarkers in patients with ovarian cancer. However, the clinical relevance of these findings to patient outcomes has not been established. This prospective study examined how social support relates to long-term survival among consecutive patients with ovarian cancer. We focused on two types of social support: social attachment, a type of emotional social support reflecting connections with others, and instrumental social support reflecting the availability of tangible assistance. PATIENTS AND METHODS Patients were prospectively recruited during a presurgical clinic visit and completed surveys before surgery. One hundred sixty-eight patients with …


Primary Fallopian Tube Cancer - 30 Years Experience At The University Of Iowa, Alireza Shamshirsaz, Michael Goodheart, Gideon Zamba, David Bender, Thomas Buekers, Koen De Geest Apr 2013

Primary Fallopian Tube Cancer - 30 Years Experience At The University Of Iowa, Alireza Shamshirsaz, Michael Goodheart, Gideon Zamba, David Bender, Thomas Buekers, Koen De Geest

Koen De Geest

No abstract provided.


The Role Of Lymphoid-Enhancing Factor 1 (Lef-1) In Endometrial Gland Morphogenesis, Michael Goodheart, T. Neff, S. Yeun-Park, X. Liu, W. Xie, Koen De Geest, David Bender, T. Buekers, J. Engelhardt Apr 2013

The Role Of Lymphoid-Enhancing Factor 1 (Lef-1) In Endometrial Gland Morphogenesis, Michael Goodheart, T. Neff, S. Yeun-Park, X. Liu, W. Xie, Koen De Geest, David Bender, T. Buekers, J. Engelhardt

Koen De Geest

No abstract provided.


Intraoperative Autologous Blood Transfusion Use During Radical Hysterectomy For Cervical Cancer: Long-Term Follow-Up Of A Prospective Trial, David Engle, Joseph Connor, Peter Morris, David Bender, Koen De Geest, Amina Ahmed, Michael Goodheart Apr 2013

Intraoperative Autologous Blood Transfusion Use During Radical Hysterectomy For Cervical Cancer: Long-Term Follow-Up Of A Prospective Trial, David Engle, Joseph Connor, Peter Morris, David Bender, Koen De Geest, Amina Ahmed, Michael Goodheart

Koen De Geest

No abstract provided.


Microvessel Density And P53 Mutations In Advanced-Stage Epithelial Ovarian Cancer, Niyati Nadkarni, Koen De Geest, Traci Neff, Barry De Young, David Bender, Amina Ahmed, Brian Smith, Anna Button, Michael Goodheart Apr 2013

Microvessel Density And P53 Mutations In Advanced-Stage Epithelial Ovarian Cancer, Niyati Nadkarni, Koen De Geest, Traci Neff, Barry De Young, David Bender, Amina Ahmed, Brian Smith, Anna Button, Michael Goodheart

Koen De Geest

No abstract provided.