Medicine and Health Sciences Commons^™

Evaluation Of Ep300, A Histone Acetyletransferase, In Patients With Epithelial Ovarian Carcinoma, M. Strigenz, N. Nadkarni, Y. Chin, T. Neff, S. Park, D. Bender, A. Ahmed, Koen De Geest, Michael Goodheart

Koen De Geest

No abstract provided.

Lymphoid Enhancing Factor 1 (Lef-1) Overexpression In Epithelial Ovarian, Fallopian Tube And Peritoneal Cancers And Associations With Clinical Factors, A. Clements, D. Engle, D. Shelton, T. Neff, S. Park, D. Bender, A. Ahmed, Koen De Geest, A. Button, J. Engelhardt, Michael Goodheart

Koen De Geest

No abstract provided.

Metastatic Choriocarcinoma To The Lung Coexistent With A Viable Pregnancy, A. Ahmed, Koen De Geest, T. Van Natta, J. Sorosky

Koen De Geest

No abstract provided.

Gog 175: A Randomized Phase Iii Trial Of Iv Carboplatin (Auc 6) And Paclitaxel 175 Mg/M(2) Q 21 Days X 3 Courses Plus Low-Dose Paclitaxel 40 Mg/M(2)/Wk Versus Iv Carboplatin (Auc 6) And Paclitaxel 175 Mg/M(2) Q 21 Days X 3 Courses Plus Observation In Patients With Early-Stage Ovarian Carcinoma, R. Mannel, M. Brady, E. Kohn, P. Hanjani, M. Hiura, R. Lee, Koen De Geest, D. Cohn, B. Monk, H. Michael

Koen De Geest

No abstract provided.

Endometrial Cancer: Reviving Progesterone Therapy In The Molecular Age, S. Yang, K. Thiel, Koen De Geest, Kimberly Leslie

Koen De Geest

Endometrial cancer is the most common gynecologic malignancy and represents a major health concern because overall five-year survival rates have not improved in the last three decades. A great deal of research demonstrates that the endometrium is extremely sensitive to hormones, and a shift in the estrogen:progesterone balance is the major cause for the development of endometrial cancer. Progestin-based therapy has proven effective in a subset of patients, particularly in situations where expression of progesterone receptor (PR) is maintained. However, this approach is not routinely used in the clinic in the U.S. for several reasons. For example, many endometrial tumors …

Endometrial Cancer, Kimberly Leslie, K. W. Thiel, Michael Goodheart, Koen De Geest, Y. Jia, S. Yang

Koen De Geest

Despite the questions and barriers, the incorporation of molecular therapy into treatment regimens in endometrial cancer is an exciting area of investigation with the potential to improve outcomes. Outside of the development of a reliable screening test for endometrial cancer, converting the disease to a chronic state and improving progression-free survival is our best hope to reverse the concerning trend of decreasing 5-year survival for this disease.

Preservation Of Immune Function In Cervical Cancer Patients During Chemoradiation Using A Novel Integrative Approach., Susan Lutgendorf, Elizabeth Mullen-Houser, Daniel Russell, Koen De Geest, Geraldine Jacobson, Laura Hart, David Bender, Barrie Anderson, Thomas Buekers, Michael Goodheart, Michael Antoni, Anil Sood, David Lubaroff

Koen De Geest

Patients receiving chemoradiation for cervical cancer are at risk for distress, chemoradiation-related side-effects, and immunosuppression. This prospective randomized clinical trial examined effects of a complementary therapy, Healing Touch (HT), versus relaxation training (RT) and usual care (UC) for (1) supporting cellular immunity, (2) improving mood and quality of life (QOL), and (3) reducing treatment-associated toxicities and treatment delay in cervical cancer patients receiving chemoradiation. Sixty women with stages IB1 to IVA cervical cancer were randomly assigned to receive UC or 4 ×/weekly individual sessions of either HT or RT immediately following radiation during their 6-week chemoradiation treatment. Patients completed psychosocial …

Social Influences On Clinical Outcomes Of Patients With Ovarian Cancer, Susan Lutgendorf, Koen De Geest, David Bender, Amina Ahmed, Michael Goodheart, Laila Dahmoush, , M, Bridget Zimmerman, Frank, J. Penedo

Koen De Geest

PURPOSE Previous research has demonstrated relationships of social support with disease-related biomarkers in patients with ovarian cancer. However, the clinical relevance of these findings to patient outcomes has not been established. This prospective study examined how social support relates to long-term survival among consecutive patients with ovarian cancer. We focused on two types of social support: social attachment, a type of emotional social support reflecting connections with others, and instrumental social support reflecting the availability of tangible assistance. PATIENTS AND METHODS Patients were prospectively recruited during a presurgical clinic visit and completed surveys before surgery. One hundred sixty-eight patients with …

Diurnal Cortisol Dysregulation, Functional Disability, And Depression In Women With Ovarian Cancer., Aliza Weinrib, Sandra Sephton, Koen De Geest, Frank Penedo, David Bender, Bridget Zimmerman, Clemens Kirschbaum, Anil Sood, David Lubaroff, Susan Lutgendorf

Koen De Geest

BACKGROUND: Multiple alterations in circadian rhythms have been observed in cancer patients, including the diurnal rhythm of the adrenal hormone cortisol. Diurnal cortisol alterations have been associated with cancer-related physiological processes as well as psychological stress. Here we investigate alterations in diurnal cortisol rhythm in ovarian cancer patients, and potential links with depression, life stress, and functional disability.

METHODS: Women (n = 177) with suspected ovarian cancer completed questionnaires and collected salivary cortisol 3× daily for 3 consecutive days before surgery. One hundred women were subsequently diagnosed with ovarian cancer and 77 with benign disease. In addition, healthy women (n …

Primary Fallopian Tube Cancer - 30 Years Experience At The University Of Iowa, Alireza Shamshirsaz, Michael Goodheart, Gideon Zamba, David Bender, Thomas Buekers, Koen De Geest

Koen De Geest

No abstract provided.

A Single-Institution Evaluation Of Factors Important In Fallopian Tube Carcinoma Recurrence And Survival., Alireza Shamshirsaz, Thomas Buekers, Koen De Geest, David Bender, Gideon Zamba, Michael Goodheart

Koen De Geest

OBJECTIVE: The aim of this study was to identify prognostic factors and markers that influence clinical outcomes in patients with primary fallopian tube carcinoma at a single tertiary health care center. These prognostic factors may be of clinical importance and can subsequently be included in future clinical trials. MATERIALS AND METHODS: A retrospective review of our Tumor Registry and Gynecologic Oncology database was conducted to include any patients with a diagnosis of fallopian tube carcinoma between the years 1994 and 2005. We identified clinicopathological data to evaluate factors important in recurrence, disease-specific and overall survival. Kaplan-Meier curves were generated, and …

The Role Of Lymphoid-Enhancing Factor 1 (Lef-1) In Endometrial Gland Morphogenesis, Michael Goodheart, T. Neff, S. Yeun-Park, X. Liu, W. Xie, Koen De Geest, David Bender, T. Buekers, J. Engelhardt

Koen De Geest

No abstract provided.

Intraoperative Autologous Blood Transfusion Use During Radical Hysterectomy For Cervical Cancer: Long-Term Follow-Up Of A Prospective Trial, David Engle, Joseph Connor, Peter Morris, David Bender, Koen De Geest, Amina Ahmed, Michael Goodheart

Koen De Geest

No abstract provided.

Microvessel Density And P53 Mutations In Advanced-Stage Epithelial Ovarian Cancer, Niyati Nadkarni, Koen De Geest, Traci Neff, Barry De Young, David Bender, Amina Ahmed, Brian Smith, Anna Button, Michael Goodheart

Koen De Geest

No abstract provided.

Sleep Disturbance, Cytokines, And Fatigue In Women With Ovarian Cancer., Lauren Clevenger, Andrew Schrepf, Desire Christensen, Koen De Geest, David Bender, Amina Ahmed, Michael Goodheart, Frank Penedo, David Lubaroff, Anil Sood, Susan Lutgendorf

Koen De Geest

Pro-inflammatory cytokines, such as interleukin-6 (IL-6), have been implicated in the underlying processes contributing to sleep regulation and fatigue. Despite evidence for sleep difficulties, fatigue, and elevations in IL-6 among women with ovarian cancer, the association between these symptoms and IL-6 has not been investigated. To address this knowledge gap, we examined relationships between sleep disturbance, fatigue, and plasma IL-6 in 136 women with ovarian cancer prior to surgery. These relationships were also examined in 63 of these women who were disease-free and not receiving chemotherapy one year post-diagnosis. At both time-points, higher levels of IL-6 were significantly associated with …

Social Isolation Is Associated With Elevated Tumor Norepinephrine In Ovarian Carcinoma Patients., Susan Lutgendorf, Koen De Geest, Laila Dahmoush, Donna Farley, Frank Penedo, David Bender, Michael Goodheart, Thomas Buekers, Luis Mendez, Gina Krueger, Lauren Clevenger, David Lubaroff, Anil Sood, Steve Cole

Koen De Geest

Noradrenergic pathways have been implicated in growth and progression of ovarian cancer. Intratumoral norepinephrine (NE) has been shown to increase with stress in an animal cancer model, but little is known regarding how tumor NE varies with disease stage and with biobehavioral factors in ovarian cancer patients. This study examined relationships between pre-surgical measures of social support, depressed mood, perceived stress, anxiety, tumor histology and tumor catecholamine (NE and epinephrine [E]) levels among 68 ovarian cancer patients. We also examined whether associations observed between biobehavioral measures and tumor catecholamines extended to other compartments. Higher NE levels were found in advanced …