Medicine and Health Sciences Commons^™

Expression And Function Of Fgf-4 In Peri-Implantation Development In Mouse Embryos, Daniel A. Rappolee, Claudio Basilico, Yogesh Patel, Zena Werb

Department of Obstetrics and Gynecology Research Publications

One of the earliest events in mammalian embryogenesis is the formation of the inner cell mass (ICM) and the subse- quent delamination of primitive endoderm. We have found that mRNA for fibroblast growth factor (FGF)-4, but not FGF-3, is expressed in preimplantation mouse blastocysts and that the FGF-4 polypeptide is present in ICM cells. ICM-like embryonal carcinoma cells and embryonic stem cells also express FGF-4. Conversely, differentiated embryonal carcinoma cells in the endoderm lineage express FGF-3, but not FGF-4 mRNA. Although mouse embryos expressed FGF-4 mRNA from the 1-cell stage, embryos cultured from the 2-cell through the blastocyst stage in …

Bacteriuria And Pregnancy Outcome: A Prospective Hospital-Based Study In Pakistani Women, Rahat N. Qureshi, Khalid S. Khan, Omar Darr, Nasir Khattak, Bader J. Farooqui, Javed H. Rizvi

Department of Obstetrics & Gynaecology

The prevalence of bacteriuria in Pakistani women and its association with complications of pregnancy was studied. Out of 1579 women, 77 had bacteriuria (4.8%). There was no association of age, gravidity, parity, haemoglobin, pre-eclampsia, mode of delivery, gestational age at delivery, preterm delivery and low birth-weight with presence of bacteriuria. With detection and treatment the pregnancy outcome of women with bacteriuria in pregnancy was the same as that of those without.

Ai : Artificial Insemination Of Sheep, David Windsor

Journal of the Department of Agriculture, Western Australia, Series 4

Artificial insemination (Al) is used widely in the dairy and beef industries and often performed by farmers themselves. By contrast, sheep breeders generally require assistance from vets when frozen semen is to be used. However, recent experiments with frozen semen are indicating that do-it-yourself Al may soon become a reality.

Health Professions Division Catalog 1994-1995, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Penetration Of Piperacillin/Tazobactam Into Gynecologic Tissues Following A Single Loading Dose Prior To Hysterectomy, William F. O'Brien, Shelley George

Obstetrics & Gynecology Faculty Publications

Objective: This study was undertaken to determine plasma and pelvic tissue concentrations of piperacillin/tazobactam following a single intravenous administration.Methods: Plasma and tissue samples were obtained following administration of 3 g of piperacillin and 0.375 g of tazobactam. Concentrations of these agents were determined by chromatography.Results: Plasma concentrations (mean ±SD) for piperacillin/tazobactam were 208 ± 87/27 ± 8 and 95 ± 53/14 ± 2, respectively, at 30 and 60 min after the start of the infusion. The 8:1 ratio between piperacillin and tazobactam in plasma remained constant for up to 96 min. Tissue concentrations yielded a broader range, but …

Gatekeeping Access To Emergency Departments: A Survey Of Hmo Policies, Regina Conway Phillips

Master's Theses

No abstract provided.

Oncolog, Volume 39, Number 03, July-September 1994, Kimberly J. T. Herrick, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Familial cancer syndromes a focus of cancer genetics research
• New test identifies Philadelphia chromosome-positive leukemias

Oncolog, Volume 39, Number 02, April-June 1994, Vickie J. Williams, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Outwitting unknown primary tumors
• Synthetic peptide effectively controls the spread of HIV in human cell cultures
• Biological response modifiers promising adjuvants to cancer therapy

Oncolog, Volume 39, Number 01, January-March 1994, Sunita Patterson, Maureen E. Goode, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Liposomal muramyl tripeptide kills bone cancer cells by stimulating the immune system Gene therapy at M. D. Anderson
• Researcher studies the hemopreventive power of garlic

Oncolog, Volume 39, Number 04, October-December 1994, Linda N. Eppich, Maureen E. Goode, Kathryn L. Hale

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Looking for solutions to ethical problems in the clinic
• Interferon: the evolution of a biological therapy
• Colon cancer registry coordinates treatment, education, and research

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1994), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1994 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective: Our Commitment to Primary Care
• The Consummate Educator and Physician: Fairman Denlinger, DO, ‘53
• Richard S. Koch, DO, ‘38
• Connie McKenzie: Bookkeeping with a Personal Touch
• Cardiology Teaching Facility Opens
• AOA and ACOS Conventions: The Place to be for PCOM Alumni
• Alumni Profile: Kathryn Campanella, DO, '88
• Elders Addresses PCOM
• Class Acts
• Obituaries
• In Memoriam
• Coming Events

Social Security Reform: A Budget Neutral Approach To Reducing Older Women's Disproportional Risk Of Poverty, Richard V. Burkhauser, Timothy M. Smeeding

Center for Policy Research

Perhaps the single greatest achievement of social policy in the United States over the last three decades has been reducing poverty in old age. The transition from work to retirement is no longer economically perilous for the vast majority of older American workers. For most married couples, the risk of falling into poverty even several years after retirement is small. But when one partner of the marriage dies, the survivor faces another much more risky economic transition. The single greatest risk of falling into poverty in old age now comes after the death of a spouse, as the survivor faces …

The Chemistry Of Allergies, Henry Daley

Bridgewater Review

No abstract provided.

Integrative Theories Of Medicine: A (W)Holistic Vision, Kathryn B. Forestal

Master's Theses

No abstract provided.

Complexity Of Fetal Movement Detection Using A Single Doppler Ultrasound Transducer, William A. Russell Jr., Curtis L. Lowery, Patrick J. Baggot, James D. Wilson, Robert Walls, Roger M. Hawk, Pam Murphy

Journal of the Arkansas Academy of Science

The objective of this paper is to discuss the complexity of fetal movement detection encountered during development and implementation of an automated single Doppler ultrasonic transducer based instrument. The single transducer instrument was intended to better quantify the duration, velocity, and magnitude of fetal movements. A Corometrics Model 116 fetal heart rate monitor was modified, and a fetal movement detection algorithm (Russell Algorithm) was developed to detect fetal movements on one and two (data fusion) transducers. A Hewlett-Packard (HP) M-1350-A fetal monitor and the Russell Algorithm were used to detect and record fetal movements concurrently on sixty patients between the …

Bacteriuria And Pregnancy Outcome: A Prospective Hospital-Based Study In Pakistani Women, Rahat Qureshi, Khalid S. Khan, Omar Darr, Nasir Khattak, Javaid H. Rizvi, Bader J. Farooqui

Department of Obstetrics & Gynaecology

The prevalence of bacteriuria in Pakistani women and its association with complications of pregnancy was studied. Out of 1579 women, 77 had bacteriuria (4.8%). There was no association of age, gravidity, parity, haemoglobin, pre-eclampsia, mode of delivery, gestational age at delivery, preterm delivery and low birth-weight with presence of bacteriuria. With detection and treatment the pregnancy outcome of women with bacteriuria in pregnancy was the same as that of those without

The Prevalence Of Behavioural Risk Factors Associated With Sudden Infant Death Syndrome, Ann M. Callaghan

Theses : Honours

Sudden Infant Death syndrome (SIDS) is a major cause of death in the first year of life. In Western Australia (WA), two infants in every thousand live births die from SIDS each year. The aim of this study was to ascertain the prevalence in WA of three risk factors which have been associated with SIDS, namely prone lying, maternal smoking and lack of breast feeding. In addition the study sought to determine the significant influences that encourage change in infant care practices by parents. The study obtained information from child health nurses and midwives regarding the advice they provide on …

Clients' Perceptions Of Preparedness For Discharge Home Following Total Hip Or Knee Replacement Surgery, Cindy H. Nicholson

Masters Theses

This study used a descriptive design to evaluate discharge planning by examining the clients' perception of preparedness for discharge home following total hip or knee replacement surgery. The conceptual framework was based upon the Betty Neuman Systems Model.; This study used Lawton's (1991) "Discharge Preparation Questionairre" to ascertain the clients' perceptions of preparedness in 10 discharge categories. Perceived preparation was measured using a 5 point summated rating scale. The study site was a 42-bed orthopedic unit in a 119 bed acute care hospital in Southeast Michigan. The convenience sample, of 46 adult clients, were interviewed by phone 3 days following …

Basic Fibroblast Growth Factor And Fibroblast Growth Factor Receptor I Are Implicated In The Growth Of Human Astrocytomas., R S Morrison, F Yamaguchi, H Saya, J M Bruner, Alan M. Yahanda Md, Facs, L A Donehower, M Berger

PCI Publications and Projects

Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members, including basic and acidic FGF. The influence of endogenous basic FGF on glioblastoma cell growth in vitro was evaluated using basic FGF-specific antisense oligonucleotides. These studies indicated that human glioblastoma cell growth in vitro, can be inhibited by suppressing basic FGF expression. Human astrocytomas also exhibited changes in FGF receptor (FGFR) expression during the course of their progression from …

Anaemia In Pregnancy - Its Cause In The Underprivileged Class Of Karachi, Saadiya Aziz Karim, Mohammad Khurshid, A.M. Memon, Sadiqua N. Jafarey

Section of Haematology/Oncology

A prospective study of the frequency and type of anaemia amongst poor urban parturients of Karachi was done. It was performed at 2 large teaching hospitals over the time span January to September, 1990. Out of 318 women studied, 104(32.7%) were anaemic (Hb levels <10gm/dl). The type of anaemia was assessed. Iron deficiency predominated and was seen amongst 63.5% of the anaemic population. There was an even distribution of other kinds of anaemia amongst the remainder of the population

Cardiovascular Risk Factors In School Children From Low Middle Income Families In Karachi, Pakistan, Salma H. Badruddin, A. Molla, Mohammad Khurshid, S. Vaz, S. Hassanali

Section of Haematology/Oncology

Serum levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and trigly cerides (TG) were determined on 239 school children aged 5-19 years belonging to lower middle class families. The mean TC, LDL-C, HDL-C and TG ranged from 3.70-4.37 mmol/L, 2.17- 2.70 mmol/L, 0.94-1.14 mmol/L, 1.07-1.26 mmol/L respectively. In general, girls had higher TC, LDL-C and HDL-C levels. There was no significant difference in the TG levels between boys and girls. Thirty-three percent of the girls and 22% of the boys had TC level _4.4 mmol/L, the level at which dietary intervention is recommended …

An Analysis Of Mitochondrial Dna In Rett Syndrome And Other Neurodegenerative Disorders, Catherine Erickson Burgess

Theses and Dissertations in Biomedical Sciences

Mitochondrial dysfunction resulting from mutations on mitochondrial DNA (mtDNA) is being recognized in a growing spectrum of diseases. These diseases, resulting from single base mutations, large deletions, or insertions, have been largely neuromuscular in origin. However, as an understanding of the effects of mtDNA mutations progresses, attention is now focusing on neurodegenerative diseases. Rett Syndrome (RS), a progressive neurodegenerative disease with predominantly female cases, demonstrates morphologic mitochondrial changes, mitochondrial enzyme deficiencies and maternal inheritance (characteristic of mtDNA diseases). No investigation of mtDNA involvement has been previously conducted and, to date, no biological marker exists for this disorder.

Our preliminary studies …

Pattern Of Dyslipoproteinemia In Selected Population Of Karachi, Erum Khan, Ayesha Molla, Naila Kayani, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

Pattern of dyslipoproteinemia was studied ,over a period of 3-1/2 years in 487(394 males, 93 females) cases aged 4 to above 70 years. Type IV hyperlipoproteinemia was most prevalent (36%) followed by type V (15%)

A View Of Hiv--Infection In Karachi, Naila Kayani, Aamir Sheikh, Asif Khan, Chhotoobhai Mithani, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

A prospective study on the prevalence of HIV-l infection in Karachi, Pakistan was conducted over a period of six years (1986-1992). Over 15,000 individualsamples and more than 32,000 donor units of individuals residing in Karachi at the time of sample co llection were tested for HIV-I infection by our screening test EIA which revealed a positivity rate of 0.23% and 0.003% in individual and donor units respectively by Western Blot. We divided patients into four groups A,B,C and D based on the most plausible cause of transmission. The largest number of positive patients belonged to group B, who were of …

The Biomechanical Analysis Of Two Types Of Place Kicks: The Toe And Instep Kicks, Kaylynn Albers

Masters Theses

This study described the biomechanical differences between two styles of the place kick; the toe kick and instep kick. The biomechanical variables included joint angles, velocities, and displacements. Five high school age subjects kicked five trials of the toe kick and five trials of the instep kick at both 20 and 35 yards. The place kicks were filmed with a high speed camera, digitized and analyzed with peak 4.2 computer software.

The findings for joint angles were consistent with those found in the literature. The velocity for the kicking foot and the ball were lower in this study than found …

Co-Sensitization Of Dopamine And Serotonin Receptors Occurs In The Absence Of A Change In The Dopamine D1 Receptor Complex After A Neonatal 6-Ohda Lesion, Li Gong

Electronic Theses and Dissertations

To test whether SKF 38393 could ontogenetically sensitize dopamine (DA) D$\sb1$ receptors and whether this sensitization would be associated with biochemical changes, intact and neonatal 6-hydroxydopamine (6-OHDA)-lesioned rats (200 $\mu$g i.c.v.) were treated daily from birth with SKF 38393 (3.0 mg/kg i.p. x 28 days) or its vehicle. In DA D$\sb1$ neonatally sensitized 6-OHDA rats, enhanced locomotor responses were observed with the first SKF 38393 challenge dose (3.0 mg/kg i.p.) at 6 weeks. This response increased further with weekly SKF 38393 treatments. Enhanced stereotyped behaviors were seen in both lesioned and sensitized rats at 8 weeks. There was no change …

A Comparison Of Four Muscle Relaxant Techniques And Their Incidence Of Postoperative Myalgia In Ambulatory Patients, William James Garske Jr.

Community & Environmental Health Theses & Dissertations

Postoperative myalgia was measured 24 and 72 hours following the administration of four different anesthetic regimens to 36 patients undergoing outpatient or 23-hour admission procedures. Each patient, ASA class I or II, was to undergo procedures of limited duration, 30 to 90 minutes, and surgical stimulation, including procedures such as knee arthroscopy, hernia repair, and breast biopsy. Anesthesia was induced with propofol 1.5 mg/kg, fentanyl 50 mcg, and maintained with O₂ , N₂O, and isoflurane. Group I (n=20), the control, received no muscle relaxant and was maintained with mask ventilation. Group II (n=5) received succinylcholine 1.5 mg/kg …

The Degree Of Exposure To Anesthetic Nitrous Oxide Waste Gas In The Operating Room During Various Surgical Procedures, Kathryn Ann Longworth

Community & Environmental Health Theses & Dissertations

Halsey (1991) summarized the underlying reasons for continuing concern about the problem of waste anesthetic gases. Careful and systematic monitoring studies indicate that individual trends in anesthetic pollution levels are not as low as was confidently predicted 10 years ago, when scavenging devices became commonplace. Second, there are now clear legal requirements for assessment of the situation. It is estimated that each year more than 200,000 health professionals are occupationally at risk of illness as a consequence of chronic exposure to low doses of waste anesthetic gases (Rogers, 1986).

These contaminants are suspected pf being ~eratogenic, carcinogenic, mutagenic, and embryo-lethal. …

Interaoperative Frozen Section Consultation: An Analysis Of Accuracy In A Teaching Hospital., Farrukh Aijaz, Suhail Muzaffar, Akbar Shah Hussainy, Shahid Pervez, Sheema H. Hasan, Hizbullah Sheikh

Department of Pathology and Laboratory Medicine

This Is a retrospective quality assurance study of all frozen sections done at The Aga Khan University Hospital during a six year period (1986 to 1991). There were 1,031 frozen sections out of a cumulative total of 42,985 surgical specimens (2.39%). Nine hundred and seventy-six (94.66%) were concordant. In 92(8.9%) fresh specimens were brought from other hospitals of Karachi, in 37 cases (3.58%) the diagnosis was deferred till the evaluation of permanent paraffin sections and 18 (1,74%) were discordant with 7 (0.67%) false positive and 11(1,06%) false negative. Among the discordant cases, 9 were attributed to misinterpretation, 7 due to …

Diagnosis And Outcome Of Congenital Hyperammonemias, P Mufti, I Ahmed

Department of Paediatrics and Child Health

A total of 21 patients were admitted to Aga Khan University Hospital with suspected congenital hyperammonemias during the period 1989 to 1992, 11 with acidosis and 10 without acidosis. Prominent clinical manifestations included positive family history (76%), onset in the first week of life (67%) and neurological manifestations (76%). Of patients with hyperammonemia and acidosis, 4 had severe metabolic acidosis with anion gap of 30mEq/L and above. Of patients with hyperammonemia without acidosis, 4 had ammonia level ranging from 1600-2000 micrograms/dl. Diagnosis was confirmed in only 1 patient and that was also done abroad. Overall mortality was 71%. These disorders …