Medicine and Health Sciences Commons^™

Nanospiderwebs: Artificial 3d Extracellular Matrix From Nanofibers By Novel Clinical Grade Electrospinning For Stem Cell Delivery, Mohammad Alamein, Qin Liu, Sebastien Stephens, Stuart Skabo, Frauke Warnke, Robert Bourke, Peter Heiner, Patrick Warnke

Qin Liu

Novel clinical grade electrospinning methods could provide three-dimensional (3D) nanostructured biomaterials comprising of synthetic or natural biopolymer nanofibers. Such advanced materials could potentially mimic the natural extracellular matrix (ECM) accurately and may provide superior niche-like spaces on the subcellular scale for optimal stem-cell attachment and individual cell homing in regenerative therapies. The goal of this study was to design several novel “nanofibrous extracellular matrices” (NF-ECMs) with a natural mesh-like 3D architecture through a unique needle-free multi-jet electrospinning method in highly controlled manner to comply with good manufacturing practices (GMP) for the production of advanced healthcare materials for regenerative medicine, and …

A Clinically-Feasible Protocol For Using Human Platelet Lysate And Mesenchymal Stem Cells In Regenerative Therapies, Patrick Warnke, Andreas Humpe, Dirk Strunk, Sebastien Stephens, Frauke Warnke, Jorge Wiltfang, Katharina Schallmoser, Mohammad Alamein, Robert Bourke, Peter Heiner, Qin Liu

Qin Liu

The transplantation of human stem cells seeded on biomaterials holds promise for many clinical applications in cranio-maxillo-facial tissue engineering and regenerative medicine. However, stem cell propagation necessary to produce sufficient cell numbers currently utilizes fetal calf serum (FCS) as a growth supplement which may subsequently transmit animal pathogens. Human platelet lysate (HPL) could potentially be utilized to produce clinical-grade stem cell-loaded biomaterials as an appropriate FCS substitute that is in line with clinically-applicable practice. The goal of this study was to investigate whether HPL can be successfully used to propagate human mesenchymal stem cells (HMSCs) seeded on clinically-approved collagen materials …

Mass Production Of Nanofibrous Extracellular Matrix With Controlled 3d Morphology For Large-Scale Soft-Tissue Regeneration, Mohammad Alamein, Sebastien Stephens, Qin Liu, Stuart Skabo, Patrick Warnke

Qin Liu

Aim: Biomaterials that mimic the nanofibrous architecture of the natural extracellular matrix (ECM) are in the focus for stem cell hosting or delivery in tissue engineering of multilayered soft tissues such as skin, mucosa, or retina. Synthetic nanofibers for such ECM are usually produced by single-syringe electrospinning with only one needle-jet at very low production rates of 0.005–0.008 g·min−1. The aim of this study was to utilize a novel industrial needle-free multijet electrospinning device with the potential for mass production of nanofibrous ECM (NF-ECM) exhibiting a controlled three-dimensional (3D) morphology for large-scale applications such as large area skin regeneration in …

Novel Ceramic Bone Replacement Material Ceraball® Seeded With Human Mesenchymal Stem Cells, Timothy Douglas, Qin Liu, Andreas Humpe, Jörg Wiltfang, Sureshan Sivananthan, Patrick Warnke

Qin Liu

Objectives: Hydroxyapatite (HA) and tricalcium phosphate (TCP) are two very common ceramic materials for bone replacement. A recently developed material for bone replacement is CeraBall®, which is a mixed HA-TCP scaffold available as porous spherical scaffolds of diameter 4 and 6 mm. Before their use as bone replacement materials in vivo, in vitro testing of these scaffolds is necessary. The goal of this study was to characterise 4 and 6 mm CeraBall® scaffolds in vitro with a view to their future use as bone replacement materials. Materials and methods: The proliferation of human mesenchymal stromal cells (hMSCs) seeded on CeraBall® …

Endurance And Fatigue Characteristics Of The Neck Muscles In Patients With Cervical Radiculopathy, Marie Halvorsen, Allan Abbott, Anneli Peolsson, Asa Dedering

Allan D. Abbott

Purpose: The aim of the study was to compare myoelectric manifestation in neck muscle endurance and fatigue characteristics during sub-maximal isometric endurance test in patients with cervical radiculopathy and asymptomatic subjects. An additional aim was to explore associations between primary neck muscle endurance, myoelectric fatigability, and self-rated levels of fatigue, pain and subjective health measurements in patients with cervical radiculopathy.

Methods: Muscle fatigue in the ventral and dorsal neck muscles was assessed in patients with cervical radiculopathy and in an asymptomatic group during an isometric neck muscle endurance test in prone and supine. 46 patients and 34 asymptomatic subjects participated. …

Introduction To Videos On Gout, Michele Meltzer

Michele Meltzer

No abstract provided.

A Double-Blind, Randomized, Placebo Controlled Trial Of Ramelteon For The Treatment Of Insomnia And Mood Stability In Patients With Euthymic Bipolar Disorder, Edward Norris

Edward R Norris MD, FAPA, FAPM

The study was a single-site, double-blind, randomized, placebo-controlled, parallel group study to evaluate the efficacy of adjunctive ramelteon in the treatment of insomnia and mood stability in patients with euthymic bipolar disorder for up to 24 weeks of maintenance treatment. Participants with euthymic bipolar disorder and sleep disturbances were randomized to receive adjunctive ramelteon or placebo in addition to their reular psychiatric medications for up to 24 weeks or until they experienced a relapse (defined as a depressed or manic event).

You Can't Do This To Me! I Have Rights! Refusal Of Care In A Critical Setting, Edward Norris

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Improving Access And Efficient Care For Patients With Psychiatric Illnesses In An Academic Teaching Health System, Michael Kaufmann, Edward Norris, Ralph Primelo, Laurence Karper, Susan Wiley, Gail Stern, D Ezrow, David Dylewski, Rosanne Teders, George Brzostowski, Debbie Salas-Lopez, David Burmeister

Edward R Norris MD, FAPA, FAPM

No abstract provided.

A Family To Remember: Ethics, Boundaries, And Conflict, Ralph Primelo, Edward Norris, Brian Shablin, Tresa Marrow, Jennifer Bednar, Sharon Clark, Stephen Lammers

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Unifying Compensation: The Lehigh Valley Physician Group Compensation Plan Experience, Edward Norris, Michael Rossi

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Alignment Of Lean Management Process To Quality And Safety In A Academic Community Hospital: Psychiatry For The Twenty First Century., Ronald Swinfard, Michael Kaufmann, Ralph Primelo, Laurence Karper, Muhamad Rifai, Edward Norris, Debbie Salas-Lopez, David Burmeister, Gail Stern, David Dylewski, D Ezrow, Rosanne Teders, Courtney Vose

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Nursing Attitudes Regarding Suicidal Patients Before And After Staff Education In Preparation For Hospital-Wide Suicide Assessments, Edward Norris, Ralph Primelo, Gail Stern, Karen Burke, Joanna Bokovoy, Michael Kaufmann, Terry Capuano

Edward R Norris MD, FAPA, FAPM

No abstract provided.

A Multidisciplinary, Resident-Run Clinic For The Treatment Of Hepatitis C In An Underserved, Urban Primary Care Setting, Suzanne J. Templer Do, Joseph L. Yozviak Do, Facp, Vishal Patel Md, Edward Norris Md, Fapm, Eric J. Gertner Md, Mph

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Can Staff Education Change Nursing Attitudes Towards Suicidal Patients, Edward Norris, Ralph Primelo, Gail Stern, Karen Burke, Michael Kaufmann, Carol Foltz, Terry Capuano

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Impact Of Educational Interventions On Insight And Attitudes Toward Medication In Psychiatric Inpatients, Krina Patel, Edward Norris, Julia Correll, Mary O'Connell, Laurence Karper, Michael Kaufmann

Edward R Norris MD, FAPA, FAPM

No abstract provided.

Aldosterone Antagonism With Eplerenone Does Not Adversely Affect Plasma Glucose Levels In Patients With Diabetes Mellitus: Findings From A Post Hoc Analysis Of The Ephesus Trial, Prakash Deedwania Md, Bertram Pitt, Ravi V. Desai Md, Marjan Mujib Md, Mph, Inmaculada B. Aban Phd, J Vincent, E Turgonyi, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

Relationship Between Plasma Glucose And Mortality In Non-Diabetic Patients With Acute Coronary Syndrome And Systolic Heart Failure: Insights From The Ephesus Trial, Prakash Deedwania Md, Ravi V. Desai Md, Marjan Mujib Md, Mph, Bertram Pitt, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

Differential Association Of Insulin Resistance And Metabolic Syndrome With Acute Myocardial Infarction And All-Cause Mortality In Older Adults, Ravi Desai, Mustafa Ahmed, Marjan Mujib, Larry Jacobs, Gregg Fonarow, Gilbert Perry, Wilbert Aronow, Michael Zile, Ali Ahmed

Ravi V Desai MD

No abstract provided.

The Association Of Metabolic Syndrome And Insulin Resistance With Incident Heart Failure Is Independent Of Each Other And Other Risk Factors Including C-Reactive Protein, Ravi V. Desai Md, Prakash Deedwania Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Yan Zhang Ms, Msph, Wilbert S. Aronow Md, Gregg C. Fonarow Md, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

Is The Association Of Left Ventricular Geometry With Cardiovascular Outcomes Independent Of Left Ventricular Mass?, Ravi V. Desai Md, Marjan Mujib Md, Mph, Mustafa I. Ahmed Md, Larry E. Jacobs Md, Gregg C. Fonarow, Wilbert S. Aronow, Michael Zile Md, Ali Ahmed

Ravi V Desai MD

No abstract provided.

Effect Of Left Ventricular Diastolic Dysfunction On Incident Heart Failure And Mortality Is Independent Of Left Ventricular Geometry, Mass And Systolic Function, Ravi V. Desai Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Larry E. Jacobs Md, Gregg Fonarow Md, Gilbert J. Perry, Wilbert S. Aronow Md, Michael Zile Md, Ali Ahmed Md, Mph

Ravi V Desai MD

No abstract provided.

The Association Between Hospital Obstetrical Volume And Maternal Postpartum Complications, Kathy Kyser, Xin Lu, Donna Santillan, Mark Santillan, Stephen Hunter, Alison Cahill, Peter Cram

Stephen K. Hunter

OBJECTIVE: The purpose of this study was to examine the relationship between delivery volume and maternal complications. STUDY DESIGN: We used administrative data to identify women who had been admitted for childbirth in 2006. Hospitals were stratified into deciles that were based on delivery volume. We compared composite complication rates across deciles. RESULTS: We evaluated 1,683,754 childbirths in 1045 hospitals. Decile 1 and 2 hospitals had significantly higher rates of composite complications than decile 10 (11.8% and 10.1% vs 8.5%, respectively; P < .0001). Decile 9 and 10 hospitals had modestly higher composite complications as compared with decile 6 (8.8% and …

The Role Of Lef1 In Endometrial Gland Formation And Carcinogenesis, Dawne Shelton, Hubert Fornalik, Traci Neff, Soo Park, David Bender, Koen Degeest, Xiaoming Liu, Weiliang Xie, David Meyerholz, John Engelhardt, Michael Goodheart

David P Bender

No abstract provided.

The Effects Of Ru-486 On Immune Function And Steroid-Induced Immunosuppression Invitro, Bradley Van Voorhis, Deborah Anderson, Joseph Hill

Bradley J Van Voorhis

No abstract provided.

Expression And Localization Of Inducible And Endothelial Nitric Oxide Synthase In The Rat Ovary - Effects Of Gonadotropin Stimulation In Vivo, Bradley Van Voorhis, Kimberly Moore, Paul Strijbos, Scott Nelson, Sally Baylis, Dana Grzybicki, Carl Weiner

Bradley J Van Voorhis

No abstract provided.

Nitric-Oxide - An Autocrine Regulator Of Human Granulosa-Luteal Cell Steroidogenesis, Bradley Van Voorhis, Melissa Dunn, Gary Snyder, Carl Weiner

Bradley J Van Voorhis

No abstract provided.

Immunohistochemical Localization Of Prostaglandin-H Synthase In The Female Reproductive-Tract And Endometriosis, Bradley Van Voorhis, Phyllis Huettner, Martin Clark, Joseph Hill

Bradley J Van Voorhis

No abstract provided.

Money, Politics And Policy: Lessons From Us Health Care Reform, Nan Schwann

Nanette M Schwann MD

No abstract provided.

Why Did They Die In Cosmetic Surgery, Nan Schwann

Nanette M Schwann MD

No abstract provided.