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Articles 31 - 60 of 978
Full-Text Articles in Medicine and Health Sciences
Prenatal Detection Of Congenital Heart Disease By Basic Ultrasonography At A Tertiary Care Center: What Should Our Expectations Be?, Kimberly Leslie, W. Persutte, J. Drose, R. Lenke, J. Hobbins, M. Manco-Johnson, E. Shaffer, J. Wiggins
Prenatal Detection Of Congenital Heart Disease By Basic Ultrasonography At A Tertiary Care Center: What Should Our Expectations Be?, Kimberly Leslie, W. Persutte, J. Drose, R. Lenke, J. Hobbins, M. Manco-Johnson, E. Shaffer, J. Wiggins
Kimberly K. Leslie
No abstract provided.
Maternal Serum Alpha-Fetoprotein Levels In Ectopic Pregnancies: A Prospective, Controlled Study, S. Lederman, Kimberly Leslie, Y. Lidor, R. Lenke
Maternal Serum Alpha-Fetoprotein Levels In Ectopic Pregnancies: A Prospective, Controlled Study, S. Lederman, Kimberly Leslie, Y. Lidor, R. Lenke
Kimberly K. Leslie
No abstract provided.
Point-Of-Care Electronic Prompts: An Effective Means Of Increasing Compliance And Improving Outcome (Poster), Nanette Schwann Md, Karen Bretz Md, Sherrine Eid Mph, Terry Burger Mba, Bsn, Rn, Ne-Bc, Cic, Deborah Fry Mt (Ascp), Mba, Cic
Point-Of-Care Electronic Prompts: An Effective Means Of Increasing Compliance And Improving Outcome (Poster), Nanette Schwann Md, Karen Bretz Md, Sherrine Eid Mph, Terry Burger Mba, Bsn, Rn, Ne-Bc, Cic, Deborah Fry Mt (Ascp), Mba, Cic
Nanette M Schwann MD
No abstract provided.
Money, Politics, And Policy, Nanette Schwann
Money, Politics, And Policy, Nanette Schwann
Nanette M Schwann MD
No abstract provided.
Point-Of-Care Electronic Prompts: An Effective Means Of Increasing Compliance, Demonstrating Quality, And Improving Outcome (Abstract), Nanette Schwann, Karen Bretz, Anthony Ardire, Frederick Ackler, Paul Evans, Dean Romanchuk, Sherrine Eid, Michelle Beck, Terry Burger, Deborah Fry, Harry Lukens, Thomas Mclouhlin
Point-Of-Care Electronic Prompts: An Effective Means Of Increasing Compliance, Demonstrating Quality, And Improving Outcome (Abstract), Nanette Schwann, Karen Bretz, Anthony Ardire, Frederick Ackler, Paul Evans, Dean Romanchuk, Sherrine Eid, Michelle Beck, Terry Burger, Deborah Fry, Harry Lukens, Thomas Mclouhlin
Nanette M Schwann MD
No abstract provided.
To See Or Not To See: Ultrasound For Peripheral Nerve Blocks, Nanette Schwann
To See Or Not To See: Ultrasound For Peripheral Nerve Blocks, Nanette Schwann
Nanette M Schwann MD
No abstract provided.
Vascular Endothelial Growth Factor Pathway Blockade In Endometrial Cancer, Suzy Davies, Donghai Dai, Kimberly Leslie
Vascular Endothelial Growth Factor Pathway Blockade In Endometrial Cancer, Suzy Davies, Donghai Dai, Kimberly Leslie
Kimberly K. Leslie
No abstract provided.
Cytotoxic Lymphocyte Micrornas As Prospective Biomarkers For Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Kevin Ashton, Mieke Van Driel, Donald Staines, Daniel Peterson, Gunn Atkinson, Sonia Marshall-Gradisnika
Cytotoxic Lymphocyte Micrornas As Prospective Biomarkers For Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Kevin Ashton, Mieke Van Driel, Donald Staines, Daniel Peterson, Gunn Atkinson, Sonia Marshall-Gradisnika
Kevin Ashton
Background: Immune dysfunction associated with a disease often has a molecular basis. A novel group of molecules known as microRNAs (miRNAs) have been associated with suppression of translational processes involved in cellular development and proliferation, protein secretion, apoptosis, immune function and inflammatory processes. MicroRNAs may be implicated in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), where immune function is impaired. The objective of this study was to determine the association between miRNAs in cytotoxic cells and CFS/ME. Methods: Natural Killer (NK) and CD8+T cells were preferentially isolated from peripheral blood mononuclear cells from all participants (CFS/ME, n = 28; mean age = …
Voluntary Running In Mice Beneficially Modulates Myocardial Ischemic Tolerance, Signaling Kinases, And Gene Expression Patterns, Boris Budiono, Louise See Hoe, Jason Peart, Surendran Sabapathy, Kevin Ashton, Luke Haseler, John Headrick
Voluntary Running In Mice Beneficially Modulates Myocardial Ischemic Tolerance, Signaling Kinases, And Gene Expression Patterns, Boris Budiono, Louise See Hoe, Jason Peart, Surendran Sabapathy, Kevin Ashton, Luke Haseler, John Headrick
Kevin Ashton
Exercise triggers hormesis, conditioning hearts against damaging consequences of subsequent ischemia-reperfusion (I/R). We test whether “low-stress” voluntary activity modifies I/R tolerance and molecular determinants of cardiac survival. Male C57BL/6 mice were provided 7-day access to locked (7SED) or rotating (7EX) running-wheels before analysis of cardiac prosurvival (Akt, ERK 1/2) and prodeath (GSK3β) kinases, transcriptomic adaptations, and functional tolerance of isolated hearts to 25-min ischemia/45-min reperfusion. Over 7 days, 7EX mice increased running from 2.1 ± 0.2 to 5.3 ± 0.3 km/day (mean speed 38 ± 2 m/min), with activity improving myocardial I/R tolerance: 7SED hearts recovered 43 ± 3% of …
Longitudinal Investigation Of Natural Killer Cells And Cytokines In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Mieke Van Driel, Donald Staines, Kevin Ashton, Sharni Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra Ramos, Sonya Marshall-Gradisnik
Longitudinal Investigation Of Natural Killer Cells And Cytokines In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Mieke Van Driel, Donald Staines, Kevin Ashton, Sharni Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra Ramos, Sonya Marshall-Gradisnik
Kevin Ashton
Background: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an etiologically unexplained disorder characterised by irregularities in various aspects of the immunological function. Presently, it is unknown whether these immunological changes remain consistent over time. This study investigates Natural Killer (NK) cell cytotoxic activity, NK cell subsets (CD56brightCD16- and CD56dimCD16+) and cytokines, over the course of a12 month period in patients with CFS/ME. Methods: The participants in the study comprised 65 (47.2 ± 11.5 years) CFS/ME participants and 21 (45.2 ±9.3 years) non-fatigued controls. Flow cytometry protocols were used to assess NK subsets and NK cytotoxic activity at various time points that …
Can Staff Education Change Nursing Attitudes Towards Suicidal Patients, Edward Norris, Ralph Primelo, Gail Stern, Karen Burke, Michael Kaufmann, Carol Foltz, Terry Capuano
Can Staff Education Change Nursing Attitudes Towards Suicidal Patients, Edward Norris, Ralph Primelo, Gail Stern, Karen Burke, Michael Kaufmann, Carol Foltz, Terry Capuano
Terry A Capuano MBA, MSN, RN, FACHE, NE-BC
No abstract provided.
Coronary Artery Bypass Graft Surgery: Improving Cost And Quality Outcomes, Terry Capuano
Coronary Artery Bypass Graft Surgery: Improving Cost And Quality Outcomes, Terry Capuano
Terry A Capuano MBA, MSN, RN, FACHE, NE-BC
No abstract provided.
Nursing Attitudes Regarding Suicidal Patients Before And After Staff Education In Preparation For Hospital-Wide Suicide Assessments, Edward Norris, Ralph Primelo, Gail Stern, Karen Burke, Joanna Bokovoy, Michael Kaufmann, Terry Capuano
Nursing Attitudes Regarding Suicidal Patients Before And After Staff Education In Preparation For Hospital-Wide Suicide Assessments, Edward Norris, Ralph Primelo, Gail Stern, Karen Burke, Joanna Bokovoy, Michael Kaufmann, Terry Capuano
Terry A Capuano MBA, MSN, RN, FACHE, NE-BC
No abstract provided.
Developing An Artificial Fallopian Tube: Successful In Vitro Trials In Mice., Stephen Hunter, J. Neeld, J. Scott, D. Olsen, R. Urry, T. Cichocki
Developing An Artificial Fallopian Tube: Successful In Vitro Trials In Mice., Stephen Hunter, J. Neeld, J. Scott, D. Olsen, R. Urry, T. Cichocki
Stephen K. Hunter
This report describes the design and testing of an artificial fallopian tube for the treatment of tubal infertility. Within the device, mouse eggs incubated with sperm were fertilized and a microinfusion pump was used to transport the fertilized ova through the tube. Normal offspring resulted from transfer of the developing embryos into pseudopregnant recipients. These results provide encouraging evidence that an artificial fallopian tube warrants further investigation as a potential alternative to in vitro fertilization.
Molecular Weight Characterization Of Pre- And Postimplant Artificial Heart Polyurethane Materials., Stephen Hunter, D Gregonis, D Colman, J Andrade, T Kessler
Molecular Weight Characterization Of Pre- And Postimplant Artificial Heart Polyurethane Materials., Stephen Hunter, D Gregonis, D Colman, J Andrade, T Kessler
Stephen K. Hunter
No abstract provided.
Single Umbilical Artery: Does Side Matter?, Mark Santillan, Donna Santillan, D. Fleener, B. Stegmann, G. Zamba, Stephen Hunter, J. Yankowitz
Single Umbilical Artery: Does Side Matter?, Mark Santillan, Donna Santillan, D. Fleener, B. Stegmann, G. Zamba, Stephen Hunter, J. Yankowitz
Stephen K. Hunter
INTRODUCTION: The aim of this study was to determine if laterality of an absent umbilical artery (AUA) is associated with specific sonographic findings, chromosomal defects or postpartum birth defects. MATERIALS AND METHODS: In this retrospective cohort study, ultrasound reports and medical records of patients who received an obstetric ultrasound at the University of Iowa Hospitals and Clinics with an identified laterality of the AUA from 1989 to 2007 (n = 405) were reviewed. Rates of sonographic abnormalities between fetuses with a right versus left AUA were compared using Fisher's exact test. Adjustments for confounding were made using logistic regression modeling. …
The Gamete And Embryo Compatibility Of Various Synthetic Polymers., Stephen Hunter, J. Scott, D. Hull, R. Urry
The Gamete And Embryo Compatibility Of Various Synthetic Polymers., Stephen Hunter, J. Scott, D. Hull, R. Urry
Stephen K. Hunter
Several popular and well-characterized polymeric materials were evaluated for their biocompatibility toward the cells unique to reproduction. To accomplish these studies, several in vitro tests were developed that evaluated biocompatibility between the polymers and spermatozoa, ova, and embryos. The data indicated significant differences between the materials with respect to their biocompatibility toward sperm motility, the sperm's ability to penetrate zona-free hamster eggs, and the ability of two-cell mouse embryos to divide. Polytetrafluoroethylene (PTFE-Teflon; PTFE, Chemplast Inc., Wayne, NJ), polyethylene glycol (PEG), and polyhydroxyethyl methacrylate (PHEMA) appear to be the most inert of the materials studied. Polyvinyl chloride (PVC; Tygon-Norton, Akron, …
Surface Modification Of Polyurethane To Promote Long-Term Patency Of Peritoneal Access Devices., Stephen Hunter, D. Gregonis, D. Coleman, B. Hanover, R. Stephen, S. Jacobsen
Surface Modification Of Polyurethane To Promote Long-Term Patency Of Peritoneal Access Devices., Stephen Hunter, D. Gregonis, D. Coleman, B. Hanover, R. Stephen, S. Jacobsen
Stephen K. Hunter
No abstract provided.
Development And Characterization Of An Indoleamine 2,3-Dioxygenase (Ido) Deficient Mouse Model Of Preeclampsia, Mark Santillan, Christopher Pelham, Pimonrat Ketsawatsomkron, Donna Santillan, Baoli Yang, Stephen Hunter, Curt Sigmund
Development And Characterization Of An Indoleamine 2,3-Dioxygenase (Ido) Deficient Mouse Model Of Preeclampsia, Mark Santillan, Christopher Pelham, Pimonrat Ketsawatsomkron, Donna Santillan, Baoli Yang, Stephen Hunter, Curt Sigmund
Stephen K. Hunter
No abstract provided.
Cell Encapsulation As A Potential Nondietary Therapy For Maternal Phenylketonuria, Donna Santillan, Mark Santillan, Stephen Hunter
Cell Encapsulation As A Potential Nondietary Therapy For Maternal Phenylketonuria, Donna Santillan, Mark Santillan, Stephen Hunter
Stephen K. Hunter
OBJECTIVE: The objective of this work was to determine whether cells overexpressing phenylalanine (Phe) hydroxylase (PAH) can significantly reduce Phe in vitro for potential use as a therapy for preventing maternal phenylketonuria. STUDY DESIGN: Human 293T and WRL68 cell lines were transiently and stably transfected to overexpress PAH. Cells were encapsulated within microspheres of sodium alginate. Timed measurements of Phe in media were performed using tandem mass spectrometry. RESULTS: Both nonencapsulated and encapsulated transiently transfected cells overexpressing PAH significantly reduced the Phe concentration in media by approximately 50% in comparison to mock-transfected cells. Cell line clones stably expressing PAH significantly …
Cultural Adaptation Of The Hiv Felt Stigma Scale For Puerto Ricans With Hiv In Allentown, Pa, Julio Jiménez Md, Joseph L. Yozviak Do, Facp, Timothy J. Friel Md, D Adams Psyd, Cynthia Beitler, Eric J. Gertner Md, Mph, E Rivera Ba, M Reyes Ba, L Santiago Phd
Cultural Adaptation Of The Hiv Felt Stigma Scale For Puerto Ricans With Hiv In Allentown, Pa, Julio Jiménez Md, Joseph L. Yozviak Do, Facp, Timothy J. Friel Md, D Adams Psyd, Cynthia Beitler, Eric J. Gertner Md, Mph, E Rivera Ba, M Reyes Ba, L Santiago Phd
Joseph L Yozviak DO, FACP
No abstract provided.
A Multidisciplinary, Resident-Run Clinic For The Treatment Of Hepatitis C In An Underserved, Urban Primary Care Setting, Suzanne J. Templer Do, Joseph L. Yozviak Do, Facp, Vishal Patel Md, Edward Norris Md, Fapm, Eric J. Gertner Md, Mph
A Multidisciplinary, Resident-Run Clinic For The Treatment Of Hepatitis C In An Underserved, Urban Primary Care Setting, Suzanne J. Templer Do, Joseph L. Yozviak Do, Facp, Vishal Patel Md, Edward Norris Md, Fapm, Eric J. Gertner Md, Mph
Joseph L Yozviak DO, FACP
No abstract provided.
Formula Using Routine Biochemical Markers Proved Superior To Forn's And Apri In Predicting Early Vs. Late-Stage Liver Disease In The Hiv/Hcv Co-Infected Host, Margaret Hoffman-Terry Md, Facp, Joseph L. Yozviak Do, Facp, J Mannino, Sharon R. Kimmel Phd, Mha
Formula Using Routine Biochemical Markers Proved Superior To Forn's And Apri In Predicting Early Vs. Late-Stage Liver Disease In The Hiv/Hcv Co-Infected Host, Margaret Hoffman-Terry Md, Facp, Joseph L. Yozviak Do, Facp, J Mannino, Sharon R. Kimmel Phd, Mha
Joseph L Yozviak DO, FACP
No abstract provided.
Clinical Decision Support Workshop: You Can't Have One Without The Order - Practical Cds & Quality Improvement, Donald Levick
Clinical Decision Support Workshop: You Can't Have One Without The Order - Practical Cds & Quality Improvement, Donald Levick
Donald Levick MD
No abstract provided.
Clinical Decision Support: Where To Start, Donald Levick
Clinical Decision Support: Where To Start, Donald Levick
Donald Levick MD
No abstract provided.
Gene Modification Via "Plug And Socket" Gene Targeting., J. Lewis, Baoli Yang, P. Detloff, O. Smithies
Gene Modification Via "Plug And Socket" Gene Targeting., J. Lewis, Baoli Yang, P. Detloff, O. Smithies
Baoli Yang
No abstract provided.
A Common Human Beta Globin Splicing Mutation Modeled In Mice., J. Lewis, Baoli Yang, R. Kim, H. Sierakowska, R. Kole, O. Smithies, N. Maeda
A Common Human Beta Globin Splicing Mutation Modeled In Mice., J. Lewis, Baoli Yang, R. Kim, H. Sierakowska, R. Kole, O. Smithies, N. Maeda
Baoli Yang
The betaIVS-2-654 C-->T mutation accounts for approximately 20% of beta thalassemia mutations in southern China; it causes aberrant RNA splicing and leads to beta0 thalassemia. To provide an animal model for testing therapies for correcting splicing defects, we have used the "plug and socket" method of gene targeting in murine embryonic stem cells to replace the two (cis) murine adult beta globin genes with a single copy of the human betaIVS-2-654 gene. No homozygous mice survive postnatally. Heterozygous mice carrying this mutant gene produce reduced amounts of the mouse beta globin chains and no human beta globin, and have …
T-Cell Specific Avian Tdt: Characterization Of The Cdna And Recombinant Enzyme., Baoli Yang, K. Gathy, M. Coleman
T-Cell Specific Avian Tdt: Characterization Of The Cdna And Recombinant Enzyme., Baoli Yang, K. Gathy, M. Coleman
Baoli Yang
A cDNA clone coding for avian terminal deoxynucleotidyl transferase (TdT) has been isolated and sequenced. The size of this cDNA was 2545 bp with an open reading frame of 1521 bp and a predicted translation product of 58 kDa. Comparison of this TdT sequence with other known TdT sequences has revealed a very high degree of homology at both the DNA and predicted amino acid levels. The chicken TdT cDNA was expressed in a bacterial system and the protein was purified by affinity chromatography. The purified recombinant enzyme, with a specific activity of approximately 1700 U/mg protein, was significantly less …
Fetal Hemorrhage And Platelet Dysfunction In Slp-76-Deficient Mice., J. Clements, J. Lee, B. Gross, Baoli Yang, J. Olson, A. Sandra, S. Watson, S. Lentz, G. Koretzky
Fetal Hemorrhage And Platelet Dysfunction In Slp-76-Deficient Mice., J. Clements, J. Lee, B. Gross, Baoli Yang, J. Olson, A. Sandra, S. Watson, S. Lentz, G. Koretzky
Baoli Yang
The adapter protein SLP-76 is expressed in T lymphocytes and hematopoietic cells of the myeloid lineage, and is known to be a substrate of the protein tyrosine kinases that are activated after ligation of the T-cell antigen receptor. Transient overexpression of SLP-76 in a T-cell line potentiates transcriptional activation after T-cell receptor ligation, while loss of SLP-76 expression abrogates several T-cell receptor-dependent signaling pathways. Mutant mice that lack SLP-76 manifest a severe block at an early stage of thymocyte development, implicating SLP-76 in signaling events that promote thymocyte maturation. While it is clear that SLP-76 plays a key role in …
Syntaxin 4 Heterozygous Knockout Mice Develop Muscle Insulin Resistance., C. Yang, K. Coker, J. Kim, S. Mora, D. Thurmond, A. Davis, Baoli Yang, R. Williamson, G. Shulman, J. Pessin
Syntaxin 4 Heterozygous Knockout Mice Develop Muscle Insulin Resistance., C. Yang, K. Coker, J. Kim, S. Mora, D. Thurmond, A. Davis, Baoli Yang, R. Williamson, G. Shulman, J. Pessin
Baoli Yang
To investigate the physiological function of syntaxin 4 in the regulation of GLUT4 vesicle trafficking, we used homologous recombination to generate syntaxin 4-knockout mice. Homozygotic disruption of the syntaxin 4 gene results in early embryonic lethality, whereas heterozygous knockout mice, Syn4(+/-), had normal viability with no significant impairment in growth, development, or reproduction. However, the Syn4(+/-) mice manifested impaired glucose tolerance with a 50% reduction in whole-body glucose uptake. This defect was attributed to a 50% reduction in skeletal muscle glucose transport determined by 2-deoxyglucose uptake during hyperinsulinemic-euglycemic clamp procedures. In parallel, insulin-stimulated GLUT4 translocation in skeletal muscle was also …