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Articles 43801 - 43830 of 45148

Full-Text Articles in Medicine and Health Sciences

Leukocytosis As A Parameter In Management Of Organophosphate Intoxication, Muhammet Güven, Ayhan Doğukan, Hülya Taşkapan, Mustafa Çeti̇n Jan 2000

Leukocytosis As A Parameter In Management Of Organophosphate Intoxication, Muhammet Güven, Ayhan Doğukan, Hülya Taşkapan, Mustafa Çeti̇n

Turkish Journal of Medical Sciences

No abstract provided.


Detection Of The Sry Gene In A 46,Xy Phenotypic Female By The Pcr-Sscp Method, M. Emi̇n Erdal, I. Ömer Barlas Jan 2000

Detection Of The Sry Gene In A 46,Xy Phenotypic Female By The Pcr-Sscp Method, M. Emi̇n Erdal, I. Ömer Barlas

Turkish Journal of Medical Sciences

No abstract provided.


Sarcomatoid Renal Cell Carcinoma And Its Chromophobe Connection, Ali̇ Kemal Uzunlar, Enver Özdemi̇r, Mehmet Yaldiz, Özden Kaya, Adem Arslan Jan 2000

Sarcomatoid Renal Cell Carcinoma And Its Chromophobe Connection, Ali̇ Kemal Uzunlar, Enver Özdemi̇r, Mehmet Yaldiz, Özden Kaya, Adem Arslan

Turkish Journal of Medical Sciences

No abstract provided.


A Case Of Carbamazepine-Induced Lymphocytic Interstitial Pneumonitis, Ömer Deni̇z, Ergun Tozkoparan, Ahmet İlvan, Faruk Çi̇ftçi̇, Erkan Bozkanat, Samu Öztürk Jan 2000

A Case Of Carbamazepine-Induced Lymphocytic Interstitial Pneumonitis, Ömer Deni̇z, Ergun Tozkoparan, Ahmet İlvan, Faruk Çi̇ftçi̇, Erkan Bozkanat, Samu Öztürk

Turkish Journal of Medical Sciences

No abstract provided.


The Effect Of Levonorgestrel And Melatonin Treatments On Plasma Oxidant-Antioxidant System, And Lipid/Lipoprotein Levels In Female Rats, Kader Köse, Cevad Yazici Jan 2000

The Effect Of Levonorgestrel And Melatonin Treatments On Plasma Oxidant-Antioxidant System, And Lipid/Lipoprotein Levels In Female Rats, Kader Köse, Cevad Yazici

Turkish Journal of Medical Sciences

This study was carried out in order to determine the effects of levonorgestrel (LNG) and progestin derivatives, alone and in combination with melatonin (MEL), on the plasma oxidant-antioxidant system, and also lipid and lipoprotein levels, in the rat model. Female rats were divided into 4 groups according to subcutaneous treatment with LNG (5 mg/kg/day), MEL (25 mg/kg/day) and a LNG-MEL combination (5 mg LNG/25 mg MEL/kg/day) for 5 consecutive days, and a control group. Following the treatment period, malondialdehyde (MDA), conjugated dienes (CD), thiol (SH) and glutathione peroxidase (GPx) values, as the components of the oxidant-antioxidant system, and also triglyceride …


Biological Dosimetry Following X-Ray Irradiation, Münevver Coşkun, Asli Top, Tuncay Orta Jan 2000

Biological Dosimetry Following X-Ray Irradiation, Münevver Coşkun, Asli Top, Tuncay Orta

Turkish Journal of Medical Sciences

Control radiation dose-response curves are necessary in evaluating the absorbed radiation dose of similar radiation quality following radiation accidents or in monitoring the health of both the public and radiation workers. Each biological dosimetry laboratory should establish its own control dose-response data. In this study our aim was to establish control curves for 200 kVp X-rays in our laboratory in order to estimate absorbed radiation doses following exposures. Blood samples from healthy individuals with no radiation working history were irradiated in heparinized tubes at 10 different doses 0.10-5.00 Gy. Cells from irradiated whole blood were incubated in culture containing phytohemagglutinin …


Results Of Acute Cerebral Anoxia In Adults: Is It A Reversal Sign?, Nai̇l Bulakbaşi, Yüksel Pabuşçu, H. Kemal Kurtaran, Cem Tayfun, Mustafa Taşar, Taner Üçöz Jan 2000

Results Of Acute Cerebral Anoxia In Adults: Is It A Reversal Sign?, Nai̇l Bulakbaşi, Yüksel Pabuşçu, H. Kemal Kurtaran, Cem Tayfun, Mustafa Taşar, Taner Üçöz

Turkish Journal of Medical Sciences

Objective: The aim of this study is to describe the results of acute cerebral anoxia in adults as a reversal sign. Methods: We retrospectively examined the CT and MR images of 9 patients in a vegetative state due to acute prolonged anoxia. Each of them had at least one MRI and 4 CT exams 6-12 hours, 10-14 days, 6-8 months and 1 year after the anoxic event. The degree of the cerebral atrophy and the mean density values of cerebral white matter were measured and calculated to demonstrate quantitative changes over time. Results: We detected a diffuse density decrease of …


Tepid Versus Cold Blood Cardioplegia In Patients With Low Preoperative Ejection Fraction, Rahmi̇ Zeybek, Egemen Tüzün, Tayfun Adanir, İhsan İşkesen, Mert Kestelli̇ Jan 2000

Tepid Versus Cold Blood Cardioplegia In Patients With Low Preoperative Ejection Fraction, Rahmi̇ Zeybek, Egemen Tüzün, Tayfun Adanir, İhsan İşkesen, Mert Kestelli̇

Turkish Journal of Medical Sciences

Patients undergoing aortocoronary bypass surgery were randomly assigned to receive cold (+10 ^oC, Group A, n: 36) or tepid (+29 ^oC, Group B, n: 47) blood cardioplegia. The preoperative ejection fraction of all the patients was under 40%. Cardioplegic solution was delivered in antegrade and retrograde fashion in both groups. The myocardial protective effects of these 2 different cardioplegic temperatures were compared in terms of the postoperative cardiac index and left ventricle stroke work index, dopamine and dobutamine requirements in the intensive care unit, intra aortic balloon pump requirement, intensive care unit stay length and mortality ratios. The daily mean …


Tradive Dystonia Or Tardive Myoclonus, Hatice Balaban, Muhi̇tti̇n Cenk Akbostanci, Cem Atbaşoğlu, Ali̇ Kemal Göğüş Jan 2000

Tradive Dystonia Or Tardive Myoclonus, Hatice Balaban, Muhi̇tti̇n Cenk Akbostanci, Cem Atbaşoğlu, Ali̇ Kemal Göğüş

Turkish Journal of Medical Sciences

No abstract provided.


Adsorption Of Iron Or Ferritin By Chitosan, Şi̇nasi̇ Özsoylu Jan 2000

Adsorption Of Iron Or Ferritin By Chitosan, Şi̇nasi̇ Özsoylu

Turkish Journal of Medical Sciences

No abstract provided.


New Frontiers In Tissue Engineering: Applicationsof Tissue Engineering In Cardiovascular Surgery, Serdar Günaydin, Toshiharu Shinoka Jan 2000

New Frontiers In Tissue Engineering: Applicationsof Tissue Engineering In Cardiovascular Surgery, Serdar Günaydin, Toshiharu Shinoka

Turkish Journal of Medical Sciences

Objective: Tissue engineering (TE) is an approach by which cells are grown in vitro onto biodegradable polymers to construct tissues for implantation. Preliminary experimental applications of cardiovascular surgery in our laboratory for creating vascular grafts and valve leaflets through TE are presented and discussed. Material and Methods: Ovine artery and vein segments were harvested, separated into individual cells, expanded in tissue culture and seeded onto synthetic biodegradable tubular scaffolds in 20-day old lambs . After 7 days of in vitro culture, the autologous constructs were used to replace a 2 cm segment of pulmonary artery (N=8) and valve leaflet (N=6). …


Effects Of Tcdd [2,3,7,8-Tetrachlorodibenzo-P-Dioxin(Tcdd)] On The Early Stage Of Pancreaticcarcinogenesis Induced By Azaserine In The Ratpancreas, Haydar Öztas Jan 2000

Effects Of Tcdd [2,3,7,8-Tetrachlorodibenzo-P-Dioxin(Tcdd)] On The Early Stage Of Pancreaticcarcinogenesis Induced By Azaserine In The Ratpancreas, Haydar Öztas

Turkish Journal of Medical Sciences

TCDD (2,3,7,8-tetrachlorodibenzo -p-dioxin), an addictive substance in cigarettes, has been implicated in the pathogenesis of pancreatic carcinoma. This compound has not been tested previously for carcinogenicity towards the pancreas, although TCDD is a known liver carcinogen. The present study was designed to ascertain whether TCDD may have a promoting effect on the development of precursor pancreatic lesions on the rat exocrine pancreas. For this purpose, 30 out of a total of 60 male Leeds rats aged two weeks received a single weekly i.p. injection of azaserine (30 mg/kg body weight) for 5 weeks. The rest of rats (n=30) were used …


Calcium And Phosphate Excretion In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz Jan 2000

Calcium And Phosphate Excretion In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz

Turkish Journal of Medical Sciences

In preeclampsia, alterations in renal function, electrolyte and water metabolism are common findings. Recent studies have suggested that preeclampsia is associated with hypocalciuria. A total of 59 women were included in the present study, 15 of whom were nonpregnant (NP) healthy women, 20 normotensive pregnant women (NTP), and 24 pregnant women with severe preeclampsia (PEP). We compared the three groups in terms of calcium and phosphate excretion, and some parameters of renal function such as serum urea, creatinine and creatinine clearance. Urinary calcium and phosphate levels in the PEP group were significantly lower than in the NP group (p< 0.001 and p< 0.01, respectively) and NTP group (p< 0.001 and p< 0.01, respectively). The serum urea levels were higher in the PEP group than in the NP and NTP (p< 0.001) groups. The same pattern of increase in the PEP group was valid for serum creatinine concentrations as compared with the NP (p< 0.01) and NTP (p< 0.001) levels. The glomerular filtration rate measured by creatinine clearance was lower in preeclamptic women than in normotensive pregnant women (p< 0.01). Patients with preeclampsia had significantly lower (p< 0.001) excretion of calcium than the NP and NTP groups (p< 0.001). Likewise, the phosphate levels were lower in women with preeclampsia than in the NP and NTP groups (p< 0.01). There was no correlation between parameters of renal function and calcium or phosphate excretion. Hypocalciuria and hypophosphateuria were found to be important features of severe preeclampsia and probably indirectly are related to the altered renal function seen in toxemia of pregnancy.


Comparison Of Sister Choromatid Exchangefrequency Between Two Distinct Forms Ofanterior Uveitis, Murat Kaya, İbrahi̇m Koçer, Sitki Öztaş Jan 2000

Comparison Of Sister Choromatid Exchangefrequency Between Two Distinct Forms Ofanterior Uveitis, Murat Kaya, İbrahi̇m Koçer, Sitki Öztaş

Turkish Journal of Medical Sciences

Acute anterior uveitis (AAU) is one of the most prevalent forms of intraocular inflammatory disorders. Although immunological and inflammatory factors are thought to play a part in the pathogenesis of the disease, its real etiology is unknown. AAU is mostly seen in two distinct types; the first one an idiopathic form, and the other frequently associated with a systemic disease such as ankylosing spondylitis (AS) and Behçet's disease (BD). Sister choromatid exchange (SCE) analysis was performed on peripheral lymphocytes from the patients with either idiopathic AAU or AAU associated with a systemic disease, in order to explore the genomic instability …


Clinical Aspects Of Temporomandibular Disorders, Asi̇ye Nehi̇r Özden, Ahmet Ersan Ersoy, Reha Şükrü Ki̇şni̇şçi̇ Jan 2000

Clinical Aspects Of Temporomandibular Disorders, Asi̇ye Nehi̇r Özden, Ahmet Ersan Ersoy, Reha Şükrü Ki̇şni̇şçi̇

Turkish Journal of Medical Sciences

Temporomandibular disorders are common problems in populations presenting signs and symptoms of muscle and joint pain on palpation, limitations in mandibular motion, joint sounds, pain and locking on mandibular function as well as dental, periodontal, occlusal and psychosocial variables. Problems that involve the temporomandibular joint and related structures include myofacial pain-dysfunction, various internal disarrangements of the joint space and degenerative joint diseases. The aim of this study was to evaluate the distribution of age and sex, the frequency of parafunctions, deviations and the cardinal symptoms related to specific disorders of the TMJ. Patients seeking treatment for temporomandibular disorders were reviewed …


Patent Omphalomesenteric Duct, Yeşi̇m Zafer, Şule Yi̇ği̇t, Aydin Türken, Gülsevi̇n Teki̇nalp Jan 2000

Patent Omphalomesenteric Duct, Yeşi̇m Zafer, Şule Yi̇ği̇t, Aydin Türken, Gülsevi̇n Teki̇nalp

Turkish Journal of Medical Sciences

No abstract provided.


A Criterion In The Differential Diagnosis Of Aneurysms Of The Superficial Veins Of The Lower Extremity From Other Cystic Lesions Of The Soft Tissues-The "Apostrophe" Sign, İlgi̇nç Yorulmaz, Egemen Tüzün Jan 2000

A Criterion In The Differential Diagnosis Of Aneurysms Of The Superficial Veins Of The Lower Extremity From Other Cystic Lesions Of The Soft Tissues-The "Apostrophe" Sign, İlgi̇nç Yorulmaz, Egemen Tüzün

Turkish Journal of Medical Sciences

No abstract provided.


Experimentally Developed Secondaryechinococcosis In Pleural And Peritoneal Cavitiesand The Utility Of Serological Tests During Thefollow Up, Kadi̇r Kazez, Mustafa Şahi̇n, Celaletti̇n Vatansev, Yücel Aritaş, Faruk Aksoy, Hüsametti̇n Vatansev Jan 2000

Experimentally Developed Secondaryechinococcosis In Pleural And Peritoneal Cavitiesand The Utility Of Serological Tests During Thefollow Up, Kadi̇r Kazez, Mustafa Şahi̇n, Celaletti̇n Vatansev, Yücel Aritaş, Faruk Aksoy, Hüsametti̇n Vatansev

Turkish Journal of Medical Sciences

Secondary echinococcosis is an important complication of hydatid disease and is not rare in the peritoneal cavity. However, the frequency of secondary hydatidosis in the pleural cavity is not very well known. This study was planned to elicit the frequency of secondary cyst development in the pleural cavity, and to compare this with secondary peritoneal hydatidosis. It was also intended to follow up cyst development by serological tests. Twelve white female Island rabbits were used. The mean weight of the rabbits was 2450±420 g. Cystic fluid containing protoscolex, hydatid sand and germinative membrane homogenate was injected via an 18 F …


Effects Of Gingko Glycosid (Egb 761) On Somevascular Endothelial Functions And Renalhistology In Rabbits With Acute Cyclosporinenephrotoxicity, N. Yilmaz Selçuk, Bi̇rkan Yakan, Mahmut Başoğlu, Cemal Gündoğdu, Ahmet Kiziltunç, H. Zeki̇ Tonbul, Ayla San Jan 2000

Effects Of Gingko Glycosid (Egb 761) On Somevascular Endothelial Functions And Renalhistology In Rabbits With Acute Cyclosporinenephrotoxicity, N. Yilmaz Selçuk, Bi̇rkan Yakan, Mahmut Başoğlu, Cemal Gündoğdu, Ahmet Kiziltunç, H. Zeki̇ Tonbul, Ayla San

Turkish Journal of Medical Sciences

In recent years, Endothelin-1 (ET-1), Platelet Activating Factor (PAF) and thromboxane have been considered responsible for the pathogenesis of acute cyclosporine nephrotoxicity (ACN). The aim of this study was to investigate the effects of the PAF antagonist gingko glycosid (EGb 761) on both renal histology and ET-1 and Nitric Oxide (NO) levels in experimental ACN. This study was carried out on 30 albino rabbits, divided into three groups. They were: group A (n=10) the control, group B (n=10), which was given intravenous cyclosporine (15mg/kg/day) and group C (n=10), which was given oral gingko glycosid (2.5mg/kg/day) in addition to cyclosporine. Plasma …


Effects Of Misoprostol On The Endometrium Ofovariectomized Rats, Ali̇ Suha Sönmez, Mustafa Bi̇ri̇nci̇oğlu, Abdullah Aydin, Ertuğrul Kiliç, Nurhan Şahi̇n Jan 2000

Effects Of Misoprostol On The Endometrium Ofovariectomized Rats, Ali̇ Suha Sönmez, Mustafa Bi̇ri̇nci̇oğlu, Abdullah Aydin, Ertuğrul Kiliç, Nurhan Şahi̇n

Turkish Journal of Medical Sciences

Misoprostol (Cytotec, Searle, England), a prostaglandin E1 analogue, is indicated for protection of peptic disease induced by cyclo-oxygenase inhibitors. Since vaginal bleeding was reported during misoprostol use previously, we hypothesized that misoprostol might cause endometrial stimulation. Therefore, we investigated the effects of misoprostol on the endometrium of ovariectomized (OVX) rats to investigate any endometrial changes. Thirty-two, four month-old, parous female Sprague-Dawley rats were used in this study. All rats underwent ovariectomy at the beginning of the study. Sixty days after the ovariectomy six rats were sacrificed to remove the uterus and the remaining 26 rats were divided into three groups. …


Investigation Of Plaque Formation By Scanningelectron Microscopy, Ece Koparal, Rengi̇n Tütüncü Jan 2000

Investigation Of Plaque Formation By Scanningelectron Microscopy, Ece Koparal, Rengi̇n Tütüncü

Turkish Journal of Medical Sciences

The aim of this study was to investigate plaque formation on natural tooth surfaces by a replica technique, which offers investigation of oral hard tissue surfaces by scanning electron microscopy. This method is recommended in cases where direct investigation is impossible such as when non- extracted teeth are investigated or when extracted teeth are expected to be influenced by the dehydration and drying process. The representative photographs demonstrate the accumulation of plaque in two days.


The Isolation Rate And Antibiotic Resistantpattern Of Helicobacter Pylori In Dyspepticpatients, Esra Ağel, Bengül Durmaz, Mehmet Refi̇k Tevfi̇k, Nergi̇s Aşgin Jan 2000

The Isolation Rate And Antibiotic Resistantpattern Of Helicobacter Pylori In Dyspepticpatients, Esra Ağel, Bengül Durmaz, Mehmet Refi̇k Tevfi̇k, Nergi̇s Aşgin

Turkish Journal of Medical Sciences

In order to determine the isolation rates of Helicobacter pylori in dyspeptic patients, 167 biopsy specimens were examined using different methods, including culturing, microscopy and the rapid urease test. Resistance to commonly used antimicrobials was investigated using the disk diffusion method. Of the 167 specimens, 82(49.1%) were found to be positive for Helicobacter pylori in culture and 72(43 %) were positive in the urease biopsy test. Using Gram staining, Helicobacter pylori were observed in 43 (25.7 %) of the specimens. The resistance rate of the isolates was 53 % for metronidazol, 8% for both clarithromycin and ciprofloxacin, and 4% for …


Serum Carnitine Levels In Patients With Coronaryartery Disease, Serkan Özgi̇rgi̇n, Di̇lek Özmen, Işil Mutaf, Nevbahar Turgan, Hakan Kültürsay, Oya Bayindir, Necla Ni̇şli̇ Jan 2000

Serum Carnitine Levels In Patients With Coronaryartery Disease, Serkan Özgi̇rgi̇n, Di̇lek Özmen, Işil Mutaf, Nevbahar Turgan, Hakan Kültürsay, Oya Bayindir, Necla Ni̇şli̇

Turkish Journal of Medical Sciences

Carnitine is an essential molecule for the transfer of long chain fatty acids through the inner mitochondrial membrane, for beta-oxidation (1). The long chain fatty acids provide a large proportion of the energy requirement of the myocardium. Thus, adequate amounts of tissue carnitine are required to maintain the normal function of the myocardium (2). Experimental studies on acute myocardial ischemia and clinical investigations of patients with congestive cardiac failure have indicated that the myocardial carnitine content was significantly lowered in both conditions, in contrast to raised or normal blood carnitine (3-5). In the present study, alterations in serum carnitine levels …


Alprazolam And Cognitive Behavior Therapy Intreatment Of Panic Disorder, Ahmet Ataoğlu, Mustafa Özkan, Hamdi̇ Tutkun, Abdullah Maraş Jan 2000

Alprazolam And Cognitive Behavior Therapy Intreatment Of Panic Disorder, Ahmet Ataoğlu, Mustafa Özkan, Hamdi̇ Tutkun, Abdullah Maraş

Turkish Journal of Medical Sciences

Panic is an often incapacitating and chronic disorder. Cognitive behaviour therapy (CBT) and alprazolam have been shown to be effective in the treatment of panic disorder. Patients who met the DSM-III-R criteria for panic disorder, were randomized and given 16 weeks of double-blind treatment with CBT (n=16), or alprazolam of up to 6 mg/day (n=18). The 17-item HAM-D and HAM-A scales were administered to all the subjects before and after treatment, which took place over 16 weeks, and the changes in the scores were analyzed. The patients' anxiety levels and numbers of panic attacks were assessed at the beginning of …


Determining Functional Hand Capacity In Textileworkers In Different Departments, Hani̇fegül Taşkiran, Ali̇ Ki̇ti̇ş, Hülya Akdur Jan 2000

Determining Functional Hand Capacity In Textileworkers In Different Departments, Hani̇fegül Taşkiran, Ali̇ Ki̇ti̇ş, Hülya Akdur

Turkish Journal of Medical Sciences

The aim of this study, which was carried out in the Textile Department of the Denizli Printing and Dyeing Industry Inc., was to compare ergonomic work analysis findings in which the functional hand capacity of workers and working conditions were evaluated. A total of 225 textile workers (143 women and 82 men) were included in our study. The working conditions were evaluated by ergonomic work analysis. The functional hand capacities of the workers were evaluated by the Valpar Upper Extremity Range of Motion Test and the Purdue Pegboard Test. The results that were obtained were interpreted by the statistical methods …


Prevalence Of Diabetes Mellitus And Affectedfactors In The District Of Kayseri Health Grouparea, Yusuf Öztürk, Mualla Aykut, Fahretti̇n Keleşti̇mur, Osman Günay, Fevzi̇ye Çeti̇nkaya, Osman Ceyhan, Mücahi̇t Eğri̇ Jan 2000

Prevalence Of Diabetes Mellitus And Affectedfactors In The District Of Kayseri Health Grouparea, Yusuf Öztürk, Mualla Aykut, Fahretti̇n Keleşti̇mur, Osman Günay, Fevzi̇ye Çeti̇nkaya, Osman Ceyhan, Mücahi̇t Eğri̇

Turkish Journal of Medical Sciences

The aim of this study was to determine the prevalence of diabetes mellitus and associated risk factors in rural Kayseri in Central Anatolia and to demonstrate whether glucometers can be used in epidemiological studies. This research was performed in Kayseri in 1994. The research population consisted of 3713 people chosen randomly among men and women of 30 years of age and over. The prevalence of diabetes mellitus was identified as 5.6 %. In addition, the prevalence of diabetes mellitus was found to be higher in men than in women, in people of 50 and over than in people of 49 …


Adult Respiratory Distress Syndrome Caused By Psittacosis, Aysun Yilmazlar, Beri̇n Özcan, Nuray Kaplan, Oya Kutlay Jan 2000

Adult Respiratory Distress Syndrome Caused By Psittacosis, Aysun Yilmazlar, Beri̇n Özcan, Nuray Kaplan, Oya Kutlay

Turkish Journal of Medical Sciences

No abstract provided.


Investigations Of The Absorption And Metabolismof Antioxidant Flavonols, Abdul Aziz Azlina Jan 2000

Investigations Of The Absorption And Metabolismof Antioxidant Flavonols, Abdul Aziz Azlina

Student Works (2000-2009)

Flavonols are polyphenols, secondary plant metabolites commonly found in plants and foods of plant origin. They have widespread biological properties in the human body. The recent discovery of their potential antioxidant activities has prompted extensive research. Flavonols particularly quercetin are potent antioxidants with higher antioxidant properties than the well known antioxidant vitamins C and E. Several epidemiology studies have demonstrated a strong inverse association between flavonoid intake and risk of coronary heart disease. The association with cancer is less defined with only some studies showing an inverse association and others not. In view of their potential to act as antioxidants …


Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd Dec 1999

Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide, (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone, (POBN), and (TEMPO) spin-trapping derivatives thereof. …


Increased Severity Of Murine Infection With Toxioplasma Gondii Following Vitaman E And Selenium Supplementatoin, Susan Mccarthy Dec 1999

Increased Severity Of Murine Infection With Toxioplasma Gondii Following Vitaman E And Selenium Supplementatoin, Susan Mccarthy

Masters Theses & Specialist Projects

At present, toxoplasmosis is one of the most common opportunistic infections in immunocompromised patients. The need for a reliable experimental model is crucial not only for achieving a better understanding of the pathophysiology of this infection but also for developing a better method to evaluate new therapeutic regimens. This study was organized to determine if the antioxidants vitamin E and selenium would provide a beneficial effect in mice chronically infected with Toxoplasma gondii. In the first phase of the study, 35 female Swiss Webster mice were infected with oocysts of the Me49 strain of Toxoplasma gondii while receiving diets supplemented …