Medicine and Health Sciences Commons^™

Commentary: Teratology In The 20th Century Environmental Causes Of Congenital Malformations In Humans And How They Were Established By Harold Kalter, Robert L. Brent

The Selected Works of Robert Brent

No abstract

Utilization Of Juvenile Animals Studies To Determine The Human Effects And Risks Of Environmental Toxicants During Postnatal Developmental Stages, Robert L. Brent

The Selected Works of Robert Brent

Toxicology studies utilizing animals and in-vitro cellular or tissue preparations have been used to study the toxic effects and mechanism of action of drugs and chemicals and to determine the effective and safe dose of drugs in humans and the risk of toxicity from chemical exposures. Testing in animals could be improved if animal dosing using the mg/kg basis was abandoned and drugs and chemicals were administered to compare the effects of pharmacokinetically and toxicokinetically equivalent serum levels in the animal model and human. Since alert physicians or epidemiology studies, not animal studies have discovered most human teratogens and toxicities …

Hepatic Disposition Of Cyclosporine A In Isolated Perfused Rat Livers, Reza Mehvar, Anjaneya Chimalakonda

Pharmacy Faculty Articles and Research

PURPOSE. To develop an isolated perfused rat liver model to study the hepatic disposition of cyclosporine A (CyA) in both sexes.

METHODS. Livers were isolated from male (n = 6) and female (n = 7) rats and perfused with a physiological buffer in a single-pass manner. A bolus 1-mg dose of CyA was injected into the inlet catheter and periodical samples (0-15 min) were collected from the outlet perfusate. The concentrations of CyA in the outlet perfusate, collected bile (0-15 min), and liver tissue (at the end of perfusion) were quantitated by HPLC and subjected to statistical moment analysis. …

Visual Enhancing Of Tactile Perception In The Posterior Parietal Cortex, Tony Ro, Ruth Wallace, Judith Hagedorn, Alessandro Farnè, Elizabeth Pienkos

Publications and Research

The visual modality typically dominates over our other senses. Here we show that after inducing an extreme conflict in the left hand between vision of touch (present) and the feeling of touch (absent), sensitivity to touch increases for several minutes after the conflict. Transcranial magnetic stimulation of the posterior parietal cortex after this conflict not only eliminated the enduring visual enhancement of touch, but also impaired normal tactile perception. This latter finding demonstrates a direct role of the parietal lobe in modulating tactile perception as a result of the conflict between these senses. These results provide evidence for visual-to-tactile perceptual …

Phosphorylation Of Vesicular Stomatitis Virus Phosphoprotein P Is Indispensable For Virus Growth†, Subash C. Das, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

The phosphoprotein (P) of vesicular stomatitis virus (VSV) is an essential subunit of the viral RNAdependent RNA polymerase (RdRp) complex. It is phosphorylated at two different domains. Using defective interfering (DI) RNA or minigenomic RNA templates, we previously demonstrated that phosphorylation within the amino-terminal domain I is essential for transcription, whereas phosphorylation within the carboxyterminal domain II is necessary for replication. For the present study, we examined the role of the phosphorylation of residues in these domains in the life cycle of VSV. Various mutant P coding sequences were inserted into a full-length cDNA clone of VSV, and the virus …

The Nuclear Pore Complex And The Dead Box Protein Rat8p/Dbp5p Have Nonessential Features Which Appear To Facilitate Mrna Export Following Heat Shock, Christiane Rollenhagen, Christine A. Hodge, Charles N. Cole

Dartmouth Scholarship

Nuclear pore complexes (NPCs) play an essential role in RNA export. Nucleoporins required for mRNA export in Saccharomyces cerevisiae are found in the Nup84p and Nup82p subcomplexes of the NPC. The Nup82p subcomplex contains Nup82p, Rat7p/Nup159p, Nsp1p, Gle1p/Rss1p, and Rip1p/Nup42p and is found only on the cytoplasmic face of NPCs. Both Rat7p and Gle1p contain binding sites for Rat8p/Dbp5p, an essential DEAD box protein and putative RNA helicase. Rip1p interacts directly with Gle1p and is the only protein known to be essential for mRNA export after heat shock but not under normal growth conditions. We report that in cells lacking …

Relationship Between Static Mobility Of The First Ray And First Ray, Midfoot, And Hindfoot Motion During Gait, Mary K. Allen, Tyler J. Cuddeford, Ward M. Glasoe, Lisa M. Dekam, Pamela J. Lee, Kelli J. Wagner, H. John Yack

Faculty Publications - College of Physical Therapy

The relationship between a static measure of dorsal first ray mobility and dynamic motion of the first ray, midfoot, and hindfoot during the stance phase of walking was investigated in healthy, asymptomatic subjects who represented the spectrum of static flexibility. Static first ray mobility of 15 subjects was measured by a load cell device and ranged from stiff (3.1 mm) to lax (8.0 mm). Using three-dimensional motion analysis, mean first ray dorsiflexion/eversion and mid-/hindfoot eversion peak motion, time-to-peak, and eversion excursion were evaluated. Subjects with greater static dorsal mobility of the first ray demonstrated significantly greater time-topeak hindfoot eversion and …

Amelioration Of Proteolipid Protein 139–151-Induced Encephalomyelitis In Sjl Mice By Modified Amino Acid Copolymers And Their Mechanisms, Joel N.H. Stern, Zsolt Illés, Jay Reddy, Derin B. Keskin, Eric Sheu, Masha Fridkis-Hareli, Hiroyuki Nishimura, Celia F. Brosnan, Laura Santambrogio, Vijay K. Kuchroo, Jack L. Strominger

Jay Reddy Publications

Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by ≈30%. In the present study, copolymers with modified amino acid compositions (based on the binding motif of myelin basic protein 85–99 to HLA-DR2) have been developed with the aim of suppressing multiple sclerosis more effectively. The enhanced efficacy of these copolymers in experimental autoimmune encephalomyelitis (EAE) induced in SJL/J mice with proteolipid protein 139–151 was demonstrated by using three protocols: (i) simultaneous administration of autoantigen and copolymer (termed prevention), (ii) …

Incremental Genetic K-Means Algorithm And Its Application In Gene Expression Data Analysis, Yi Lu, Shiyong Lu, Farshad Fotouhi, Youping Deng, Susan J. Brown

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

In recent years, clustering algorithms have been effectively applied in molecular biology for gene expression data analysis. With the help of clustering algorithms such as K-means, hierarchical clustering, SOM, etc, genes are partitioned into groups based on the similarity between their expression profiles. In this way, functionally related genes are identified. As the amount of laboratory data in molecular biology grows exponentially each year due to advanced technologies such as Microarray, new efficient and effective methods for clustering must be developed to process this growing amount of biological data.

Results

In this paper, we propose a new clustering …

Do Recent Data From The Seychelles Islands Alter The Conclusions Of The Nrc Report On The Toxicological Effects Of Methylmercury?, Alan H. Stern, Joseph L. Jacobson, Louise Ryan, Thomas A. Burke

Wayne State University Associated BioMed Central Scholarship

Abstract

In 2000, the National Research Council (NRC), an arm of the National Academy of Sciences, released a report entitled, "Toxicological Effects of Methylmercury." The overall conclusion of that report was that, at levels of exposure in some fish- and marine mammal-consuming communities (including those in the Faroe Islands and New Zealand), subtle but significant adverse effects on neuropsychological development were occurring as a result of in utero exposure. Since the release of that report, there has been continuing discussion of the public health relevance of current levels of exposure to Methylmercury. Much of this discussion has been linked to …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

President's Message, David J. Stroup

Journal of the South Carolina Academy of Science

No abstract provided.

Scas Officers And Council Members 2004 - 2005

Journal of the South Carolina Academy of Science

No abstract provided.

Bioinformatics: An Undergraduate Research/Teaching Tool., Abhishek Agrawal, Valgene L. Dunham

Journal of the South Carolina Academy of Science

No abstract provided.

Building New Culture Media For Assisted Reproductive Technology., Mary N. Egbuniwe, H. Lee Higdon Iii, William R. Boone

Journal of the South Carolina Academy of Science

No abstract provided.

An Investigation Of The Acetabulum, The Femoral Head And The Ligament Of Femoral Head In Human Fetuses, İsmi̇han İlknur Uysal, Ahmet Salbacak, Mustafa İsmai̇l Sefa Kapicioğlu, Mustafa Büyükmumcu, Muzaffer Şeker, Aynur Emi̇ne Çi̇çekci̇başi

Turkish Journal of Medical Sciences

We investigated the morphometric characteristics of the acetabulum, the ligament of the femoral head (LFH) and the femoral head, and the relationships among them in 30 spontaneously aborted human fetuses. The maximum length and width of the LFH, the transverse and vertical diameters of the femoral head and the acetabulum, the height of the femoral head and the depth of the acetabulum were measured and the existence of any relationship among them was assessed statistically. The acetabulum was circular in 58.4% of cases and oval in 41.6%. The diameter of the femoral head was less than that of the acetabulum …

The Assessment Of A Family With Myotonic Dystrophy, Ayşe Fi̇li̇z Koç, Suzan Zorludemi̇r, Yakup Sarica

Turkish Journal of Medical Sciences

KOÇ^1, Suzan ZORLUDEMİR^2, Yakup SARICA^1 ^1Department of Neurology, Faculty of Medicine, Çukurova University Adana - Turkey ^2Department of Pathology, Faculty of Medicine, Çukurova University Adana - Turkey

Serum Adenosine Deaminase Levels In Patients With Brucellosis And In Healthy Subjects, Sali̇h Cesur, Kadi̇rhan Sunguroğlu, Kamruddi̇n Ahmed, Deni̇z Tezeren, Nagehan Oran Keseci̇, Sebahat Aksaray

Turkish Journal of Medical Sciences

The aim of this study was to determine the serum adenosine deaminase ( ADA ) levels in patients with brucellosis and compare them with the results of healthy individuals. Forty- eight subject were enrolled in this study : 34 patients with brucellosis and 14 healthy individuals. Serum ADA activity was assessed by spectrophotometer in patients with brucellosis and statistically compared with that of healthy individuals. A normal range of serum ADA was considered 5-35 IU/l. Serum ADA levels were also compared with Brucella agglutinations titers and serum C reactive protein (CRP). Serum ADA levels were found to be significantly higher …

Persistent Müllerian Duct Syndrome With Transverse Testicular Ectopia: A Case Report With Literature Review, Mustafa Fuat Açikalin, Özgül Paşaoğlu, Baran Tokar, Di̇lek İlgi̇ci̇, Hüseyi̇n İlhan

Turkish Journal of Medical Sciences

Fuat AÇIKALIN^1, Özgül PAŞAOĞLU^1, Baran TOKAR^2, Dilek İLGİCİ^1, Hüseyin İLHAN^2 ^1Department of Pathology, Faculty of Medicine, Osmangazi University, Eskişehir - Turkey ^2Department of Pediatric Surgery, Faculty of Medicine, Osmangazi University, Eskişehir - Turkey

Common Anorectal Conditions, Pravin J. Gupta

Turkish Journal of Medical Sciences

No abstract provided.

Leiomyoma Of The Ureter In A Child (The Youngest Reported Case) (Case Report), Bengü Çobanoğlu, İbrahi̇m H. Özercan, Orhan Yalçin, Ertürk Ergi̇n

Turkish Journal of Medical Sciences

BANOĞLU^1, İbrahim H. ÖZERCAN^1, Orhan YALÇIN^2, Ertürk ERGİN^2 ^1Department of Pathology, Faculty of Medicine, University of Fırat, Elazığ - Turkey ^2Department of Urology, Faculty of Medicine, University of Fırat, Elazığ - Turkey

Intravenous Dexmedetomidine Sedation For Spinal Anesthesia In The Prone Knee-Chest Position For Lumbar Laminectomy Surgery, Berri̇n Günaydin, Zerri̇n Özköse, Belde Tarhan

Turkish Journal of Medical Sciences

ÜNAYDIN^{1,2}, Zerrin ÖZKÖSE^1, Belde TARHAN^3 ^1Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Beşevler, 06500, Ankara - Turkey ^2Department of Pharmacology, Faculty of Medicine, Gazi University, Beşevler, 06500, Ankara - Turkey ^3Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Beşevler, 06500, Ankara - Turkey

Pituitary Abscess Simulating Macroadenoma, Gülgün Yilmaz Ovali, Serdar Tarhan, Hüseyi̇n Şentürk, Petek Bayindir, Yüksel Pabuşçu

Turkish Journal of Medical Sciences

ILMAZ OVALI , Serdar TARHAN, Hüseyin ŞENTÜRK, Petek BAYINDIR, Yüksel PABUŞÇU Department of Radiology, Faculty of Medicine, Celal Bayar University, Manisa - Turkey

What The Hittites’ Tablets Tell Us? A Short Historical View Of Deafness On The Basic Of Genetics, Berna Arda, Murat Aksu

Turkish Journal of Medical Sciences

No abstract provided.

Effect Of Zinc Deficiency On Zinc And Carbohydrate Metabolism In Genetically Diabetic (C57bl/Ksj Db+/Db+) And Non-Diabetic Original Strain (C57bl/Ksj) Mice, Zine Kechrid, Noureddine Bouzerna

Turkish Journal of Medical Sciences

Our aim was to investigate the effect of low dietary zinc intake on zinc and carbohydrate metabolism in type II diabetes. Male, 4–5-week-old, genetically diabetic (C57B/LKsJdb+/db+) and nondiabetic original strain (C57BL/KsJ) mice were fed a diet containing 1 mg of Zn/kg (low zinc groups) or 54 mg of Zn/kg (control groups) for 27 days. Food intake and body weight gain were recorded regularly. On day 28, after an overnight fast, the animals were sacrificed and blood glucose, serum insulin concentrations, liver glycogen contents, and zinc levels in the femur and pancreas were determined. The consumption of the low zinc diet …

Lafora Body Disease: Clinical, Electrophysiological And Histopathological Findings, Ayşe Fi̇li̇z Koç, Hacer Bozdemi̇r, Suzan Zorludemi̇r, Gamze Almak, Ali̇ Özeren

Turkish Journal of Medical Sciences

iz KOÇ^1, Hacer BOZDEMİR^1, Suzan ZORLUDEMİR^2, Gamze ALMAK^1, Ali ÖZEREN^1 ^1Department of Neurology, Faculty of Medicine, Çukurova University, Adana - Turkey ^2Department of Pathology, Faculty of Medicine, Çukurova University, Adana - Turkey

Acute Motor Axonal Neuropathy Developing During Helicobacter Pylori Infection, Ahmet Gödekmerdan, A. Neşe Çitak Kurt, Abdullah Kurt, Ni̇met Kabakuş

Turkish Journal of Medical Sciences

No abstract provided.

Buccal Corticotomy For Closure Of Oroantral Openings: Case Report, Bedretti̇n Cem Şener, Hasan Gari̇p, Faysal Uğurlu, Kami̇l Göker

Turkish Journal of Medical Sciences

n Cem ŞENER, Hasan GARİP, Faysal UĞURLU, Kamil GÖKER Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, 80220 Nişantaşı, İstanbul - Turkey

Extensive Carotid Fibromuscular Dysplasia With Dissections And Aneurysm Of The Ascending Aorta, Zafer Koç, A. Muhteşem Ağildere, Ayşe Fi̇li̇z Koç, Osman Kizilkiliç, Özlem Yalçin

Turkish Journal of Medical Sciences

Ç^1, A. Muhteşem AĞILDERE^2, Filiz KOÇ^3, Osman KIZILKILIÇ^1, Özlem YALÇIN^1 ^1Department of Radiology, Faculty of Medicine, Adana Teaching and Medical Research Center, Başkent University, Adana - Turkey ^2Department of Radiology, Faculty of Medicine, Başkent University, Ankara - Turkey ^3Department of Neurology, Faculty of Medicine, Cukurova University, Adana – Turkey

Alternative Testing Methods - Reproductive Toxicity, Srinivasa Jayachandra, Maxim Pinto, Urban J.A.D'Souza

Turkish Journal of Medical Sciences

No abstract provided.