Medicine and Health Sciences Commons^™

Hemangioma Of The Rib, Gülgün Yilmaz Ovali, Ci̇han Göktan, Serdar Tarhan, Şebnem Örgüç, Semi̇n Ayhan, Osman Saribülbül, Rahmi̇ Zeybek

Turkish Journal of Medical Sciences

ILMAZ OVALI^1, Cihan GÖKTAN^1, Serdar TARHAN^1, Şebnem ÖRGÜÇ^1, Semin AYHAN^2, Osman SARIBÜLBÜL^3, Rahmi ZEYBEK^3 ^1Department of Radiology, Faculty of Medicine, Celal Bayar University, Manisa - Turkey ^2Department of Pathology, Faculty of Medicine, Celal Bayar University, Manisa - Turkey ^3Department of Thoracic Surgery, Faculty of Medicine, Celal Bayar University, Manisa - Turkey

Gastrointestinal Basidiobolomycosis As A Rare Etiology Of Bowel Obstruction, Alireza Fahimzad, Abdollah Karimi, Sedigheh Rafiee Tabatabaei, Mahbubeh Gerami Zadeh

Turkish Journal of Medical Sciences

Basidiobolomycosis is an unusual fungal infection that manifests in the skin and rarely involves the gastrointestinal tract. Gastrointestinal Basidiobolomycosis is rarely reported in the medical literature. We report a 1.5-year-old boy from the south of Iran with bowel obstruction which was diagnosed as gastrointestinal Basidiobolomycosis.

A True Aneurysm Of The Profunda Femoris Artery: A Case Report And The Review Of The Literature, Bumi̇n Deği̇rmenci̇, Erol Bozdoğan, Ali̇ Er, Çağri Şenyücel, Sitki Gülhan, Ramazan Albayrak, Mutlu Sağlam

Turkish Journal of Medical Sciences

True aneurysms of the PFA are uncommon. Rupture risk in true PFA aneurysms are extremely high (42%). Therefore a rapid evaluation and treatment planning is essential. Ultrasonography and color Doppler ultrasonography have priority in diagnosis of these cases. Angiography, CT and CT angiography are performed in conjunction with ultrasonography for planning the procedure before surgical treatment and follow-up after treatment.

Communicating Hydrocephalus In Systemic Lupus Erythematosus, Ramazan Albayrak, Sai̇t Albayram, Hakan Selçuk, Sebahatti̇n Sai̇p, Hali̇t Yilmaz, Ci̇van Işlak

Turkish Journal of Medical Sciences

Central nervous system (CNS) involvement has been recognized as the second leading cause of death in patients with systemic lupus erythematosus (SLE), although hydrocephalus is seen very rarely. We report a case of communicating hydrocephalus in a 24-year-old woman having previously diagnosed SLE without antiphospholipid antibody syndrome or cerebral venous angiographic abnormality. We propose direct damage-thrombosis of small sized venous structures or immune complex deposition within arachnoid villi, which impair cerebrospinal fluid flow, as a possible, yet unproven, pathophysiologic mechanism for hydrocephalus in SLE.

Modulation Of Cell Signaling By Tomoregulins In Embryogenesis And Cancer, Paul William Harms

All ETDs from UAB

Growth factor signals often regulate similar cellular processes both during embryogenesis and in adult homeostasis. Stringent control of these signals ensures proper embryonic development and correct cell physiology in mature individuals. Recently, a family of two members of Tomoregulin (or transmembrane protein with epidermal growth factor-like and two follistatin domains [TMEFF]) was found to interact with transforming growth factor-β (TGF-β) and ErbB signaling pathways, both of which are implicated in development and in cancer biology in the adult. The function as well as the mechanisms of TMEFFs in modulating these two signals has not been elucidated in detail. In this …

Faculty Publications 2005, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 952 publications.

Increased Hexosamine Biosynthesis And Protein O-Glcnac Protect Isolated Rat Heart From Ischemia/Reperfusion Injury, Jia Liu

All ETDs from UAB

Increased levels of protein-associated O-linked N-acetylglucosamine (O-GlcNAc) have been correlated with increased tolerance to stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, increased the tolerance of the heart to ischemia and reperfusion (I/R). Hearts from male rats were isolated and perfused with Krebs-Henseliet buffer containing 5mM glucose, and global, no-flow ischemia was induced for 20min followed by 60 min reperfusion. 20 min pre-treatment with 10 mM glucosamine, which enters the HBP directly, significantly improved functional recovery and decreased cardiac Troponin I release …

Regulation Of Ss-Catenin By Gli1 In Epithelial Transformation, Xingnan Li

All ETDs from UAB

Gli family members-mediated continuous Hedgehog (Hh) pathway activity plays a role in the growth of a number of human cancers, including the common malignancy of skin, basal cell carcinoma (BCC), and other highly aggressive tumor types. However, the mechanism by which Gli proteins act to promote the outgrowth of cancer in response to stimulation of Hh signaling is poorly understood. Identified as zinc finger transcriptional factors, the Gli family of proteins has been shown to be involved in multiple cellular processes through activating its target genes. Therefore, to study the function of Gli target genes is important for our understanding …

Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation, Zhaoli Liu

All ETDs from UAB

Notch1 and KLF4 function in the specification of epithelial cell fates, and each can act as a context-dependent oncogene or tumor suppressor. We report that KLF4 directly regulates transcription of Notch1 and that cleavage of full-length Notch1 to the active intracellular form, N1IC, is necessary for transformation by KLF4. Paradoxically, KLF4 suppresses canonical Notch1-CSL signaling by up-regulating Hairless, an antagonist of this pathway. Dominant-negative inhibitors of the canonical Notch1 signaling pathway do not block transformation of epithelial cells by KLF4, while they greatly reduce the efficiency of transformation by N1IC. Thus, N1IC can transform cells by two distinct mechanisms: the …

Kiss1 Metastasis Suppressor Secretion Is Required For Metastasis Suppression, Kevin T. Nash

All ETDs from UAB

Failure to reduce the number of cancer deaths over the last 50 years is due to the inability to selectively target metastatic disease. Recently, the KISS1 metastasis suppressor has emerged as a promising molecular agent for the management of metastatic disease. Although KISS1 has been implicated in the regulation of the metastatic phenotype in human cancers and in in vivo mouse models, little is known about its mechanism. Recent evidence suggests that KISS1 is a neuropeptide that is processed and secreted to interact with its cognate receptor GPR54 in the hypothalamus to trigger puberty and maintain the reproductive state. However, …

Isoprenoid Analogs As Chemical Genetic Tools To Provide Insights Into Farnesyl Transferase Target Selection And Cellular Activity, Jerry Troutman

University of Kentucky Doctoral Dissertations

Protein farnesylation is an essential post-translational modification required for the function of numerous cellular proteins including the oncoprotein Ras. The farnesyl transferase (FTase) catalyzed reaction is unique because farnesyl diphosphate (FPP), the farnesyl group donor for the reaction, forms a significant portion of a target protein binding site. The major goal of this research was to exploit this unique property of the FTase reaction and determine if changing the structure of the farnesyl donor group would affect FTase protein targeting. A small library of structural analogues of FPP was synthesized. Michelis-Menten steady-state kinetic analyses and competition reactions were used to …

Evidence For Association Between The Hla-Dqa Locus And Abdominal Aortic Aneurysms In The Belgian Population: A Case Control Study, Toru Ogata, Lucie Gregoire, Katrina Ab Goddard, Magdalena Skunca, Gerard Tromp, Wayne D. Lancaster, Antonio R. Parrado, Qing Lu, Hidenori Shibamura, Natzi Sakalihasan, Raymond Limet, Gerald L. Mackean, Claudette Arthur, Taijiro Sueda, Helena Kuivaniemi

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms.

Methods

HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay.

Results

We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there …

Dilemma Of Cancer Screening In Pakistan, Hassan Khan, Mohammad Irfanulhaq Khawaja, Muhammad Rizwanulhaq Khawaja

Medical College Documents

In the scenario of limited resources for implementation of screening programmes in Pakistan, the only practical option for early detection is through mass education about cancers, their risk factors, screening modalities and presentation symptoms.

The Earliest Dipodomyine Heteromyid In North America And The Phylogenetic Relationships Of Geomorph Rodent, Steven J Norris

Faculty, Staff and Student Publications

The proteome of the spirochete bacterium Borrelia burgdorferi, the tick-borne agent of Lyme disease, has been characterized by two different approaches using mass spectrometry, providing a launching point for future studies on the dramatic changes in protein expression that occur during transmission of the bacterium between ticks and mammals.

A Twin Study Of Antisocial Behavior And Depression: Methodology, Etiology, And Comorbidity, Kelly A. Tracy

Theses and Dissertations

The etiological connection between internalizing and externalizing disorders is poorly understood. This manuscript aims to investigate the roles of genes and then environment in the development of Major Depressive Disorder (MDD) and Antisocial Personality Disorder (ASPD) and the nature of their comorbidity in young adults. Data from a sample of 2,291 young adult male and female twins from the Young Adult Follow Up Study (YAFU) of the Virginia Twin Study of Adolescent Behavioral Development (VTSABD) were used to estimate the proportion of variation in these traits that can be accounted for by additive genetic, shared environmental, and unique environmental factors. …

Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure To 1,2:5,6 Dibenzanthracene In B6c3f1 Mice, Denise Marie Hernandez

Theses and Dissertations

Numerous findings have suggested that the increased prevalence of childhood illnesses such as cancer, infection, and allergy may be due to environmental exposures. One such cause may be maternal smoking or passive smoke exposure. Known immunotoxicants in cigarette smoke and environmental pollution include polycyclic aromatic hydrocarbons such as 1,2:5,6 Dibenzanthracene (DBA). The objective of these studies was to evaluate the immunosuppressive effects of DBA on various stages of immune system development. Adult mice were administered DBA daily in corn oil at dose levels of 158, 500, 1580, and 5000 µglkg S.C. for 28 days. Immunosuppression was not observed at levels …

Influence Of The Vitamin D3 Analog Eb 1089 On Senescence And Cell Death Pathways In The Response Of Breast Tumor Cells To Ionizing Radiation, Gerald Alan Demasters

Theses and Dissertations

A senescence-like growth arrest succeeded by rapid recovery of proliferative capacity is observed in MCF-7 breast tumor cells exposed to fractionated radiation (5 x 2Gy) alone. Exposure to the vitamin D3 analog EB 1089 (100nM) prior to irradiation converts the initial growth arrest response to cell death in part through the inhibition of radiation-induced senescence and promotion of both apoptotic and autophagic cell death. More importantly, EB 1089 was shown to profoundly reduce the rate of recovery following fractionated irradiation. The effect of EB 1089 on the temporal response to radiation is also observed in MCF-7 cells expressing caspase 3, …

Action Of Tyrosyl Dna Phosphodiesterase On 3'-Phosphoglycolate Terminated Dna Strand Breaks, Haritha Tatavarthi

Theses and Dissertations

Free radical-mediated DNA double strand breaks (DSBs) are induced either directly by ionizing radiation or by certain chemicals like bleomycin. These breaks are terminated by 3'-PG (PO4CH2COOˉ) or 3'-phosphate groups formed as a result of fragmentation of deoxyribose. To study the nature of repair of these 3'-blocked breaks, we constructed substrates mimicking free-radical induced DSBs. Human and yeast tyrosyl DNA-phosphodiesterase (Tdpl) efficiently processed substrates with 3'-PGs, in either the presence or absence of magnesium, to give a 3'-phosphate. Gel filtration chromatography and western blotting codmed that the putative enzyme in human extracts that efficiently processed PG was indeed tyrosyl DNA-phosphodiesterase. …

Glutamate Excitotoxicty Activates A Novel Calcium Permeable Ion Channel In Cultured Hippocampal Neurons, Laxmikant Sudhir Deshpande

Theses and Dissertations

Glutamate excitotoxicity is the predominant mechanism implicated in neuronal cell death associated with neurological disorders such as stroke, epilepsy, traumatic brain injury and ALS. Excessive stimulation of NMDA subtypes of glutamate receptors leads to protracted intracellular calcium elevations triggering calcium mediated neurotoxic mechanisms culminating in delayed neuronal cell death. In addition, glutamate excitotoxicity induces a NMDA dependent extended neuronal depolarization mediated by continuous calcium influx that correlates with delayed neuronal death. Attempts to prevent neuronal death by blocking calcium entry into the neurons using calcium channel blockers or NMDA receptor antagonists have failed to provide any beneficial effects in clinical …

Pathological Upregulation Of A Calcium-Stimulated Phosphatase, Calcineurin, In Two Models Of Neuronal Injury, Jonathan Elledge Kurz

Theses and Dissertations

Excitotoxic calcium influx and activation of calcium-regulated systems is a common event in several types of neuronal injury. This mechanism has been the focus of intense research, with the hope that a more complete understanding of how neuronal injury affects calcium-regulated systems will provide effective treatment options. This study examines one such calcium-stimulated enzyme, calcineurin, in the context of two common neurological pathologies, status epilepticus and traumatic brain injury.Status epilepticus was induced by pilocarpine injection. NMDA-dependent increases in calcineurin activity were observed in cortical and hippocampal homogenates. Upon closer examination, the most profound increases in activity were found to be …

The Role Of Gonadal Hormones On Opioid Receptor Protein Density In Arthritic Rats, Matthew Kren

Theses and Dissertations

The majority of research on the endogenous opioid system has focused on various pain assays and the efficacy of different opioid agonists. However, minimal attention has been focused on the effects of gonadal hormones and their impact on the opioid peptide system. The present study was designed to determine the effects of modulation of gonadal hormones on the opioid receptor protein levels in Complete Freund's Adjuvant (CFA)-treated arthritic and non-arthritic male and female Lewis rats. Midbrain and spinal cord tissues were collected for comparison of the μ, δ, and κ receptor protein levels in arthritic and non-arthritic animals. Male gonadectomy …

Characterization Of The Tcof1 Gene Using A Neuroblastoma Cell Line And A Mouse Model, Lin Li

Theses and Dissertations

Treacher Collins syndrome (TCS) is an autosomal dominant craniofacial development disorder and is caused by mutations in the TCOF1 gene. The TCOFl protein treacle is a nucleolar protein and may function in ribosome biogenesis.Previously, we identified downstream candidate genes using microarray analysis after manipulating Tcofl levels in a murine neuroblastoma (NB) cell line. The list of genes includes cell cycle genes as well as the transcription factors Cnbp and Tbx2, which are known to affect the cell cycle through the c-myc and p19-Mdm2-p53-p21 pathways respectively. To further characterize the cellular effects of Tcofl, stably transfected NB cell lines with overexpression …

A Critical Review Of Telomerase Biology And Model Systems For The Study Of Telomerase, Jeremy Charles Aisenberg

Theses and Dissertations

The study of telomere and telomerase biology holds substantial promise in uncovering the molecular process of aging and the treatment of cancers. Studies have shown that telomere shortening is directly linked to cellular aging and that telomerase expression is found in over 85% of human cancers, including 95% of all advanced malignancies. Development of effective model systems to elucidate the molecular mechanisms underlying the role of telomeres and telomerase in the processes aging and cancer is of particular importance. While inbred strains of mice have provided a wealth of information for a variety of pathways and diseases, the mouse model …

The Influence Of Sustained Cb1 Blockade During Adolescence On Breakpoints In A Progressive-Ratio Paradigm, Mayo Jerry Wright Jr.

Theses and Dissertations

The developmental psychopharmacology of cannabinoids is poorly understood and little is known about the developmental consequences of repeated exposure to cannabinoid antagonists. In these experiments, male Long-Evans rats were treated with SR141716A, a cannabinoid antagonist, throughout adolescence and allowed unrestricted access to food. Control groups were treated with vehicle during the same developmental period and allowed either unrestricted access to food or were pair-fed with a member of the SR-treated group. Motivation to work for food was measured in progressive-ratio sessions at varying levels of food deprivation. For rats that consumed fewer calories throughout adolescence, whether because of pharmacological intervention …

Follicular Thyroid Carcinoma In A Patient With Graves' Disease, Mehmet Özdoğan, Ahmet Gürer, Beki̇r Çakir, Si̇bel Orhun, İsmai̇l Gömceli̇, Selma Göğkuş, Raci̇ Aydin

Turkish Journal of Medical Sciences

ZDOĞAN^1, Ahmet GÜRER^1, Bekir ÇAKIR^2, Sibel ORHUN^3, İsmail GÖMCELİ^1, Selma GÖĞKUŞ^1, Raci AYDIN^1 ^1Department of General Surgery, Atatürk Educational and Research Hospital, Ankara - Turkey ^2Department of Endocrinology, Atatürk Educational and Research Hospital, Ankara - Turkey ^3Department of Pathology, Atatürk Educational and Research Hospital, Ankara - Turkey

The Effect Of Erythropoietin In Acute Pancreatitis: An Experimental Study, Ari̇fe Polat Düzgün, Nuretti̇n Kahramansoy, Mahi̇ Balci Özgedi̇k, M. Mahi̇r Özmen, Selda Seçki̇n, Faruk Coşkun

Turkish Journal of Medical Sciences

Background: Although the pathogenesis of acute pancreatitis is not clearly known, the most frequently mentioned factors are proinflammatory cytokines and nitric oxide (NO), which is stimulated by bacterial endotoxins. The relationship of erythropoietin (EPO), which is an erythroid line growth hormone, with proinflammatory cytokines and NO is also not clear. EPO has a well-known general tissue protective effect, yet its role in an inflammatory presentation like that of acute pancreatitis has not been investigated and documented. Therefore, the aim of this study was to investigate the role of EPO in acute pancreatitis. Materials and Methods: 60 Wistar Albino rats were …

In-Vitro Effect Of Phthalate Esters On Retinal Aldolase, Syed Nasir Askari, Meena Zaidi, Nafees Ahmed

Turkish Journal of Medical Sciences

Background and Aim: Phthalate esters used in the manufacture of cosmetics, lubricants, medical devices and wood furnishings enter the human system through various routes and accumulate into tissues to a considerable level. Low levels of plasticizer cause infertility, hypospadias and premature puberty, while high doses of esters can damage the liver and lung. Reports on the ocular effects of these compounds are either not available or very scarce. The present study assessed the impact of dimethyl phthalate (DMP), diethyl-phthalate (DEP) and diethyl hexyl-phthalate (DEHP) on bovine retinal aldolase. Materials and Methods: Retinal aldolase activity of 0.1 ml of 1:10 solution …

A Selective Ideational Apraxic Agraphia For Consonants, Serpi̇l Demi̇rci̇

Turkish Journal of Medical Sciences

Aim: The proposed graphemic area in the dominant hemisphere contains letter representations that are responsible for guiding the skilled movements required for writing and for recognition of the physical features of letters. Dysfunction in this system may cause apraxic agraphia. In this study, writing performance of a right-handed, left hemisphere damaged, 12-year old apraxic agraphic patient with a native language of shallow ortography is analysed. Methods: Writing performance was evaluated with several different word lists, each holding same amount of letters, novel words (non-word), words, functors, and high-imagery and low-imagery words. Non-words were derived from words by changing a single …

Study Of Elements, Antioxidants And Lipid Peroxidation In Hemodialysis Patients, Esma Menevşe, Abdullah Si̇vri̇kaya, Emrah Karagözoğlu, Ali̇ Muhtar Ti̇fti̇k, Süleyman Türk

Turkish Journal of Medical Sciences

Background: During hemodialysis, most of the elements must be kept in a rather narrow physiological range, otherwise life-threatening events may occur. Furthermore, lipid peroxidation in patients may be partly due to the trace element disturbances. It has been mentioned that there are relations between deficiency in trace elements and antioxidant levels. The present study aimed to determine whether there were differences between hemodialysis patients and a healthy group according to selenium, aluminium, malondialdehyde (MDA), reduced form of glutathione (GSH) and superoxide dismutase (SOD) levels. Methods: The study included 47 hemodialysis patients (hemodialysis group). Blood samples were taken before (pre-hemodialysis) and …

Smc3 Knockdown Triggers Genomic Instability And P53-Dependent Apoptosis In Human And Zebrafish Cells., Giancarlo Ghiselli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: The structural maintenance of chromosome 3 (SMC3) protein is a constituent of a number of nuclear multimeric protein complexes that are involved in DNA recombination and repair in addition to chromosomal segregation. Overexpression of SMC3 activates a tumorigenic cascade through which mammalian cells acquire a transformed phenotype. This has led us to examine in depth how SMC3 level affects cell growth and genomic stability. In this paper the effect of SMC3 knockdown has been investigated. RESULTS: Mammalian cells that are SMC3 deficient fail to expand in a clonal population. In order to shed light on the underlying mechanism, experiments …