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Articles 41431 - 41460 of 45190

Full-Text Articles in Medicine and Health Sciences

Handedness Differences In Dental Traumatic Injuries Of Boxers, Saadetti̇n Dağistan, Şenol Dane, Recep Gürsoy, Bi̇nali̇ Çakur, İlhan Şen, Özkan Mi̇loğlu, Abubeki̇r Harorli Jan 2009

Handedness Differences In Dental Traumatic Injuries Of Boxers, Saadetti̇n Dağistan, Şenol Dane, Recep Gürsoy, Bi̇nali̇ Çakur, İlhan Şen, Özkan Mi̇loğlu, Abubeki̇r Harorli

Turkish Journal of Medical Sciences

Aim: Previous studies reported the relation of left-handedness with dental and head traumas in normal population. In the present study, we aimed to investigate the relationship between dental traumas, such as non-vitality and fracture, and left-handedness. Materials and methods: Twenty three Turkish international professional boxers were included in the study. Existence of teeth that had trauma and loss of vitality in these boxers were investigated. Results: The mean number of non-vital teeth was higher in left-handers than in right-handers for right-lower, left-upper, left-lower, and total regions, but not for the right-upper region. However, there were no significant differences between right- …

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Acute Pancreatitis As An Atypical Presentation Of Henoch-Schonlein Purpura And Cystic Fibrosis, Murat Çakir, Beri̇l Di̇lber, Mukaddes Kalyoncu, Embi̇ya Di̇lber, Ayşe Aksoy, Erol Erduran Jan 2009

Acute Pancreatitis As An Atypical Presentation Of Henoch-Schonlein Purpura And Cystic Fibrosis, Murat Çakir, Beri̇l Di̇lber, Mukaddes Kalyoncu, Embi̇ya Di̇lber, Ayşe Aksoy, Erol Erduran

Turkish Journal of Medical Sciences

Acute pancreatitis (AP) is a rare clinical entity in childhood. Two children, aged 10 and 14 years, were hospitalized for acute abdominal pain. Clinical and laboratory findings were compatible with AP. Both patients were given supportive medications. Two days after admission, the first patient had purpuric lesions on both buttocks and lower extremities, and occult bleeding. The clinical picture was consistent with Henoch-Schonlein purpura, with pancreatitis and gastrointestinal involvement. The patient’s clinical condition improved rapidly after administration of prednisolone. The second patient had digital clubbing on physical examination, and positive sweat chloride test results led to the diagnosis of cystic …

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Co-Occurrence Of Internal Carotid Artery Agenesiswith Multicystic Dysplastic Kidney, Gülgün Yilmaz Ovali, Serdar Tarhan, Petek Bayindir, Muzaffer Polat, İpek Akil Jan 2009

Co-Occurrence Of Internal Carotid Artery Agenesiswith Multicystic Dysplastic Kidney, Gülgün Yilmaz Ovali, Serdar Tarhan, Petek Bayindir, Muzaffer Polat, İpek Akil

Turkish Journal of Medical Sciences

Congenital absence of Internal Carotid Artery (ICA) is a rare disorder. This anomaly may be an isolated entity or may be associated with other organ, or system anomalies (1). Multicystic Dysplastic Kidney (MCDK) is a congenital mal-development in which the renal cortex is replaced by numerous cysts of multiple sizes. Urologic and non-urologic anomalies may accompany MCDK (2). In this paper, we detail a case of congenital agenesis of ICA and the existence of MCDK. To our knowledge, this is the first of such a case to be reported regarding the co-occurrence of ICA agenesis and MCDK.

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Epidemiological Risk Factors For Crimean-Congo Hemorrhagic Fever Patients, Ayten Kadanali, Serpi̇l Erol, Zülal Özkurt, Kemaletti̇n Özden Jan 2009

Epidemiological Risk Factors For Crimean-Congo Hemorrhagic Fever Patients, Ayten Kadanali, Serpi̇l Erol, Zülal Özkurt, Kemaletti̇n Özden

Turkish Journal of Medical Sciences

Aim The aim of this study was to evaluate the epidemiological risk factors for Crimean-Congo hemorrhagic fever (CCHF) patients admitted to our hospitals between January 2004- December 2006. Materials and methods: This was a study of 63 CCHF patients whose definitive diagnosis was based on the detection of CCHF virus-specific IgM by ELISA and/or of genomic segments of the CCHF virus by real time polymerase chain reaction (RT-PCR) and 50 healthy controls. Related data were collected prospectively. Results: Twenty-two (50.8%) of the patients were female, and 31 of them (49.2%) were male. The mean age of the patients was 46 …

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Use Of The Shock Index To Diagnose Acute Hypovolemia, Polat Durukan, İbrahi̇m İki̇zceli̇, Okhan Akdur, Seda Özkan, Erdoğan M. Sözüer, Levent Avşaroğullari, Güleser Akpinar Jan 2009

Use Of The Shock Index To Diagnose Acute Hypovolemia, Polat Durukan, İbrahi̇m İki̇zceli̇, Okhan Akdur, Seda Özkan, Erdoğan M. Sözüer, Levent Avşaroğullari, Güleser Akpinar

Turkish Journal of Medical Sciences

Aim : To determine the accuracy of the shock index in the early detection of hemodynamic changes after acute blood loss. Materials and methods: This prospective, observational study was performed on blood donors who were giving 450 mL of blood over 20 min. Vital signs of the volunteers were recorded just before blood donation, and at 1 and 5 min after donation. Shock index was calculated by dividing the heart rate by systolic blood pressure. Results: Fifty healthy donors (mean age 34±9 years) volunteered to participate in the study. Five minute post-donation heart rate (81±12 /min) and diastolic blood pressure …

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The Predictive Role Of Ast Level, Prothrombin Time, And Platelet Count In The Detection Of Liver Fibrosis In Patients With Chronic Hepatitis C, Özlem Kandemi̇r, Gürbüz Polat, Güli̇z Saraçoğlu, Bahar Taşdelen Jan 2009

The Predictive Role Of Ast Level, Prothrombin Time, And Platelet Count In The Detection Of Liver Fibrosis In Patients With Chronic Hepatitis C, Özlem Kandemi̇r, Gürbüz Polat, Güli̇z Saraçoğlu, Bahar Taşdelen

Turkish Journal of Medical Sciences

Aim: We aimed to assess the predictive value of a combination some of basic serum biochemical markers for the diagnosis of clinically significant fibrosis in chronic hepatitis C. Materials and methods: Blood samples from 68 patients with chronic hepatitis C infection were analyzed for aspartate aminotransferase, prothrombin INR, and platelet count. The liver histopathology was evaluated using the Knodell protocol. The relationship between the serum biochemical markers and severity of the stages were examined. Results: A strong association was found between the fibrosis stage and platelet count and GUCI (P < 0.001, P = 0.035 respectively) but not APRI ([AST/ULN] / Platelet count [ ×109 /L]) × 100) (P = 0.052). The relationship between the platelet count

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The Relationship Of Serum Cea And Ca 19-9 Levels To Liver Metastasis And Pancreatic Invasion In Esophageal Cancer, Ati̇la Türkyilmaz, Ati̇lla Eroğlu, Yener Aydin, Nuretti̇n Karaoğlanoğlu Jan 2009

The Relationship Of Serum Cea And Ca 19-9 Levels To Liver Metastasis And Pancreatic Invasion In Esophageal Cancer, Ati̇la Türkyilmaz, Ati̇lla Eroğlu, Yener Aydin, Nuretti̇n Karaoğlanoğlu

Turkish Journal of Medical Sciences

Aim: Previous studies have examined levels of CEA and CA 19-9 in esophageal cancer patients, but have not determined a significant relationship between CEA and CA 19-9 levels and liver metastasis and pancreatic invasion in patients with esophageal cancer. In this study, we compared the serum levels of CEA and CA 19-9 in patients with esophageal cancer with and without liver and pancreatic metastasis. Materials and methods: The serum levels of CEA and CA 19-9 were measured in clinic patients between January 2007 and January 2008, including 10 patients with liver metastasis (4) and pancreas invasion (6), and 40 patients …

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Short Term Outcomes Of The Use Of High Dose Intravenous Methylprednisolone For Acute Optic Neuritis In A Central Anatolian Population, Yasemi̇n Özdamar, Gölge Acaroğlu, Bayazit İlhan, Seyhan S. Özkan, Kuddusi̇ Teberi̇k Jan 2009

Short Term Outcomes Of The Use Of High Dose Intravenous Methylprednisolone For Acute Optic Neuritis In A Central Anatolian Population, Yasemi̇n Özdamar, Gölge Acaroğlu, Bayazit İlhan, Seyhan S. Özkan, Kuddusi̇ Teberi̇k

Turkish Journal of Medical Sciences

Aim: To describe the clinical characteristics and outcome of optic neuritis (ON) cases treated with high dose intravenous methylprednisolone (IVMP) in a tertiary referral clinic in Ankara, Turkey. Materials and methods: Consecutive patients in the past 5 years with acute isolated ON, who were treated with IVMP and had a follow-up of at least 3 months, were reviewed. Symptoms and findings, results of brain magnetic resonance imaging (MRI), etiologies, visual outcomes, and side effects of the treatment were evaluated. Results: Etiological causes could be elicited in 57 (85.1%) of 67 patients; the most common of which was multiple sclerosis (MS). …

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Imaging Liver Transplantation Candidates Using Gadolinium Enhanced Mdct Angiography, Abdul Meci̇t Kantarci, Irmak Durur Subaşi, Bülent Aydinli, Ci̇han Duran, Seli̇m Doğanay, K. Yalçin Polat, Ragi̇be Kantarci, Hayri̇ Oğul, S. Selçuk Atamanalp Jan 2009

Imaging Liver Transplantation Candidates Using Gadolinium Enhanced Mdct Angiography, Abdul Meci̇t Kantarci, Irmak Durur Subaşi, Bülent Aydinli, Ci̇han Duran, Seli̇m Doğanay, K. Yalçin Polat, Ragi̇be Kantarci, Hayri̇ Oğul, S. Selçuk Atamanalp

Turkish Journal of Medical Sciences

Aim: To report our experience with gadolinium enhanced computed tomography angiography (Gd-CTA) for end-stage liver disease patients who are candidates for liver transplantation as an alternative to iodinated contrast enhanced CTA and gadolinium enhanced magnetic resonance (MR) angiography. Materials and methods: Seventeen patients with end-stage liver disease were evaluated with Gd-CTA. The patients were 10 men (58.8%) and 7 women (41.1%) (age range: 37-59 years). Multidetector CT (MDCT) was performed using 16-detector-row CT scanners. 3D images of the celiac artery, superior mesenteric artery, portal vein, and inferior vena cava (IVC) were obtained for thorough assessment using multiple plane reconstruction and …

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The Characteristics Of Suicidal Cases Regarding The Gender, Aysun Balseven Odabaşi, Nursel Türkmen, Recep Fedakar, Ali̇ Riza Tümer Jan 2009

The Characteristics Of Suicidal Cases Regarding The Gender, Aysun Balseven Odabaşi, Nursel Türkmen, Recep Fedakar, Ali̇ Riza Tümer

Turkish Journal of Medical Sciences

Aim: We studied the patterns of suicide in forensic autopsies performed in Bursa province of Turkey to determine gender differences, incidence of suicide, subgroups of the population most vulnerable to such deaths, and suicide methods used. Materials and methods: Nine hundred fifty-five death cases due to suicide underwent forensic autopsy between 1996 and 2005 in Bursa were included into the study. All of the cases were analyzed in terms of age, gender, and method of suicide, time of year, and alcohol use. Results were subjected to discriminant analyses using SPSS 11.0. Results: There were 955 cases, with 682 males (12-95 …

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General Characteristics Of Paternity Test Applicants, Ayşi̇m Tuğ, Gülümser Gülteki̇n Akduman Jan 2009

General Characteristics Of Paternity Test Applicants, Ayşi̇m Tuğ, Gülümser Gülteki̇n Akduman

Turkish Journal of Medical Sciences

Aim: This research was done to fill the gap in research on the social dimensions of paternity testing by determining the reasons for the suspicion and some characteristics of families who applied for a paternity test. Materials and methods: This research was performed with 50 men that applied for paternity testing. The bi-sectional questionnaire was conducted by means of the interview method. The questionnaire comprised questions on age, education, the reason for and duration of paternity suspicion, domestic violence linked to the paternity suspicion, and plans for the future following the test. The data were assessed with SPSS 10.0 and …

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Humoral Immunity And Haemoglobin F (Hbf) Status In Steady State Adult Nigerian Sickle Cell Disease Patients With Asymptomatic Malaria, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola Jan 2009

Humoral Immunity And Haemoglobin F (Hbf) Status In Steady State Adult Nigerian Sickle Cell Disease Patients With Asymptomatic Malaria, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola

Turkish Journal of Medical Sciences

Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a malaria endemic zone to reduce mortality. Haematology Department, University College Hospital, Ibadan, Nigeria. Materials and methods: The levels of HbF, IgG, IgA, IgM, transferin (TRF), C-reactive protein (CRP), and haptoglobin (HPT) were determined in 14 Nigerians having HbAA genotype with malaria parasitaemia (HbAA +MP), 17 Nigerians having haemoglobin AA genotype without malaria parasitaemia (HbAA -MP), 15 Nigerians having haemoglobin SS genotype without malaria parasitaemia (HbSS -MP), …

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Preparation And Characterization Of Some Substituted Benzyl N-Nitrosocarbamates Containing An N-2-(Methylthio)Ethyl Or A Bis(2-Aminoethyl)Sulfide Functionality, Satya Venkata, Eric Shamo, Vladimir Benin Jan 2009

Preparation And Characterization Of Some Substituted Benzyl N-Nitrosocarbamates Containing An N-2-(Methylthio)Ethyl Or A Bis(2-Aminoethyl)Sulfide Functionality, Satya Venkata, Eric Shamo, Vladimir Benin

Chemistry Faculty Publications

The synthesis and characterization of some substituted benzyl N-nitrosocarbamates with an N-2-(methylthio)ethyl or a bis(2-aminoethyl)sulfide functionality is reported, as a part of a long-term goal to design and prepare novel photolabile structures that could be used as substances for controlled release of alkylating and/or crosslinking agents. The synthesis was accomplished by reaction of benzyl chloroformates with the corresponding amines, resulting in the preparation of carbamates. The latter were subsequently nitrosated, utilizing two different N-nitrosation methods, to yield the target structures.

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Seroprevalence Of Hepatitis A Infection In The Turkish Republic Of Northern Cyprus, Zafer Kurugöl, Güldane Koturoğlu, Sadik Akşi̇t, Ti̇jen Özacar Jan 2009

Seroprevalence Of Hepatitis A Infection In The Turkish Republic Of Northern Cyprus, Zafer Kurugöl, Güldane Koturoğlu, Sadik Akşi̇t, Ti̇jen Özacar

Turkish Journal of Medical Sciences

Aims: This study was conducted to determine the seroprevalence of hepatitis A virus (HAV) infection in the Turkish Republic of Northern Cyprus. Materials and Methods: A total of 660 unvaccinated persons 1 to 30 years old were selected for the study with cluster sampling. Information on sociodemographic characteristics was gathered for each participant and, in 641 of them, anti-HAV antibodies were assayed using an enzyme immune assay. Results: Anti-HAV prevalence in the Turkish population under the age of 30 in Northern Cyprus was 23.9%. For the age groups 1-5, 6-10 and 11-15 years, seroprevalence rates were relatively low (11.4, 9.4 …

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Orbital Emphysema Due To Nose Blowing, Mustafa Sever, Tunç Büyükyilmaz Jan 2009

Orbital Emphysema Due To Nose Blowing, Mustafa Sever, Tunç Büyükyilmaz

Turkish Journal of Medical Sciences

Orbital emphysema is a rare ocular emergency in the absence of trauma, sinusitis and/or surgical intervention. We report a case of orbital emphysema in a 29-year-old male caused by forceful blowing of the nose. The patient presented with sudden and painful onset of right periorbital swelling and nose-bleed following forceful blowing of the nose. There was no history of sinusitis, facial trauma or previous surgery. Examination of the patient disclosed crepitant eyelid swelling, ptosis, and mild unilateral exophthalmos and inferomedial strabismus in the neutral position. Otorhinolaryngologic and ophthalmic examinations were accompanied by computerized tomography, which demonstrated areas of emphysema in …

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The Relationship Between Plasma Homocysteine And Early Coronary Collateral Vessel Development After Acute Myocardial Infarction, Telat Keleş, Tahi̇r Durmaz, Ni̇hal Akar Bayram, Murat Akçay, Ekrem Yeter, Hüseyi̇n Ayhan, Engi̇n Bozkurt Jan 2009

The Relationship Between Plasma Homocysteine And Early Coronary Collateral Vessel Development After Acute Myocardial Infarction, Telat Keleş, Tahi̇r Durmaz, Ni̇hal Akar Bayram, Murat Akçay, Ekrem Yeter, Hüseyi̇n Ayhan, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Aim: Homocysteine is known to inhibit endothelial cell proliferation, which is a key event in angiogenesis. Factors responsible for the presence or absence of coronary collateral circulation are poorly understood. Therefore, in this study we investigated the effect of plasma homocysteine level on the early formation of angiographically visible collaterals after acute myocardial infarction. Materials and Methods: The study included 60 patients that had ST-segment elevation myocardial infarction (STEMI). All the patients underwent coronary angiography 1-4 days after admission (mean: 2.3 ± 1.2 days). Patients were graded according to Rentrop classification. Patients with grade 0 or 1 collateral vessels were …

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Evaluation Of Ribavirin Genotoxicity With Sister Chromatid Exchange And Micronuclei Assays In Humans, Abdulgani̇ Tatar, Zülal Özkurt, Ahmet Hacimüftüoğlu, Ahmet Yeşi̇lyurt, Serhat Vançeli̇k Jan 2009

Evaluation Of Ribavirin Genotoxicity With Sister Chromatid Exchange And Micronuclei Assays In Humans, Abdulgani̇ Tatar, Zülal Özkurt, Ahmet Hacimüftüoğlu, Ahmet Yeşi̇lyurt, Serhat Vançeli̇k

Turkish Journal of Medical Sciences

Aim: The main objective of this study was to assess the genotoxicity of ribavirin in 15 patients who were suffering from Crimean-Congo haemorrhagic fever and treated with the therapy dose of the antiviral agent. Materials and Methods: Genotoxicity was evaluated using the cytokinesis-blocked micronucleus (MN) and sister chromatid exchange (SCE) assays in lymphocyte cultures that were prepared from blood samples collected from the 15 patients. The blood samples were taken on day 9 of a 10-day therapeutic regimen of ribavirin and 1 month after the cessation of therapy. Results: In all patients, the frequency of sister chromatid exchanges and the …

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Subcutaneous Mucormycosis In An Immunocompetent Nigerian Child, Edirin Omorigho Yusuf, Alphonsus Ndidi Onyiriuka Jan 2009

Subcutaneous Mucormycosis In An Immunocompetent Nigerian Child, Edirin Omorigho Yusuf, Alphonsus Ndidi Onyiriuka

Turkish Journal of Medical Sciences

A 13-year-old girl presented with a three-month history of generalized blisters on her body following a traumatic injury to her leg with a piece of wood while farming. The lesions were hemorrhagic, itchy and tender on pressure. The patient was non-diabetic, non-leukemic, non-neutropenic, and not previously on immunosuppressive drugs, nor was there any evidence of immunosuppression. Culture and microscopic examination of scrapings from the skin lesions revealed growth of a Mucor spp. She was initially placed on potassium iodide and responded well for about a month, then relapsed. The patient was successfully treated with itraconazole monotherapy.

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Lack Of Association Between Tlr4 Polymorphism And Severe Gram-Negative Bacterial Infection In Neonates, Tuba Turul Özgür, Leman Yel, Şule Yi̇ği̇t, Lütfi̇ye Mesci̇, Özden Sanal, İlhan Tezcan, Gülsevi̇n Teki̇nalp, Fügen Ersoy Jan 2009

Lack Of Association Between Tlr4 Polymorphism And Severe Gram-Negative Bacterial Infection In Neonates, Tuba Turul Özgür, Leman Yel, Şule Yi̇ği̇t, Lütfi̇ye Mesci̇, Özden Sanal, İlhan Tezcan, Gülsevi̇n Teki̇nalp, Fügen Ersoy

Turkish Journal of Medical Sciences

Aim: Gram-negative microorganisms are responsible for a significant percentage of systemic bacterial infections in neonates, which tend to progress to sepsis. Toll-like receptor 4 (TLR4), one of the receptors in the innate immune system, binds to the lipopolysaccharide (LPS) present on gram-negative bacteria. Following ligation, a cascade of cellular signals leads to activation of NF\kappaB, resulting in the generation of such proinflammatory cytokines as TNF\alpha, IL-1, IL-2, and IL-6. These are the mediators of inflammation, which is the cellular response to activation of the innate immune system. As such, TLR4 appears to be a very likely candidate involved in the …

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A New Classification For Ileosigmoid Knotting, S. Selçuk Atamanalp, Gürkan Öztürk, Bülent Aydinli, M. İlhan Yildirgan, Mahmut Başoğlu, Durkaya Ören, Abdul Meci̇t Kantarci Jan 2009

A New Classification For Ileosigmoid Knotting, S. Selçuk Atamanalp, Gürkan Öztürk, Bülent Aydinli, M. İlhan Yildirgan, Mahmut Başoğlu, Durkaya Ören, Abdul Meci̇t Kantarci

Turkish Journal of Medical Sciences

Aim: This study aimed to establish a new classification that will contribute to the treatment and prognosis of ileosigmoid knotting (ISK), which is a combination of ileum volvulus and sigmoid volvulus (SV). Materials and methods: Based on the SV classification in which criteria associated with mortality, such as age over 60 years and the presence of accompanying disease and/or shock, were used, and a new classification was made for ISK. For this classification, the records of 71 patients with ISK, who were treated surgically, were reviewed retrospectively, and unlike in SV classification, rather than the presence of sigmoid gangrene alone, …

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Coxiella Burnetii Seroprevalence In The Rural Part Of Bolu, Turkey*, Oğuz Karabay, Esra Koçoğlu, Gökhan Baysoy, Selami̇ Konyalioğlu Jan 2009

Coxiella Burnetii Seroprevalence In The Rural Part Of Bolu, Turkey*, Oğuz Karabay, Esra Koçoğlu, Gökhan Baysoy, Selami̇ Konyalioğlu

Turkish Journal of Medical Sciences

Aim: This study was performed to determine the seroprevalence of Coxiella burnetii in the rural part of Bolu, a city located in the western part of the Black Sea region of Turkey. Materials and Methods: The study population was chosen by cluster sampling to represent the rural population of the city. Serum samples were collected from the 9 rural districts of Bolu. Blood samples were taken to the laboratory while stored at 4 °C in ice-cooled boxes. The sera were then stored at -20 °C until testing. The presence of IgG antibodies against C. burnetii phase-II antigens in the sera …

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Femoral Neck Fracture Following An Epileptic Seizure, Ahmet Demi̇rcan, Murat Özsaraç, Fi̇kret Bi̇ldi̇k, Ayfer Keleş, Gülbi̇n Aygencel Jan 2009

Femoral Neck Fracture Following An Epileptic Seizure, Ahmet Demi̇rcan, Murat Özsaraç, Fi̇kret Bi̇ldi̇k, Ayfer Keleş, Gülbi̇n Aygencel

Turkish Journal of Medical Sciences

Although the occurrence of dislocations in shoulders is a well-known complication of convulsive activity, femoral fractures are seen very rare. In this study, a case of a femur neck fracture after epileptic seizure was reported. A 49-year-old man presented to the emergency department following a first grand mal seizure. There was no history of trauma and co-morbid disease. Initial physical examination was normal. When the patient was taken to the computerized tomography room, he experienced 2 generalized tonic-clonic seizures. After the post-ictal period, the patient complained of pain on the left hip and left shoulder. Anteroposterior pelvic and shoulder x-rays …

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A Novel Approach For Brachial Plexus Block, Alpaslan Apan, Hülya Başar, Şazi̇ye Şahi̇n, Ünase Büyükkoçak Jan 2009

A Novel Approach For Brachial Plexus Block, Alpaslan Apan, Hülya Başar, Şazi̇ye Şahi̇n, Ünase Büyükkoçak

Turkish Journal of Medical Sciences

Aim: The line from the midpoint of the sternocleidomastoid muscle to the midpoint of the clavicle was considered the surface projection of the brachial plexus in the supraclavicular region in a previous report using radiological and anatomic techniques. The needle insertion site was the point between the clavicular one-third and cervical two-thirds of this line. The aim of the present study was to determine the clinical efficacy of these suggested landmarks. Materials and methods: Brachial plexus block was performed in 60 healthy adult patients undergoing elective surgery on an upper extremity using the above-mentioned new surface landmarks. Results: The characteristics …

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Relapsing Giant Liposarcoma Originating In The Chest Wall, Bülent Di̇nç, Ayhan Di̇nçkan, Ayhan Mesci̇, Taner Çolak, Cumhur Arici, Ali̇han Gürkan Jan 2009

Relapsing Giant Liposarcoma Originating In The Chest Wall, Bülent Di̇nç, Ayhan Di̇nçkan, Ayhan Mesci̇, Taner Çolak, Cumhur Arici, Ali̇han Gürkan

Turkish Journal of Medical Sciences

Liposarcomas are usually seen in the retroperitoneal region and in extremities, but can be seen in the head, neck, inguinal region, and chest wall less frequently. In this report, a relapsing giant liposarcoma weighing 9 kg and with a diameter of 50 cm originating in the chest wall is discussed.

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Treatment Options For Neuropathic Pain, Sara Akre Jan 2009

Treatment Options For Neuropathic Pain, Sara Akre

Honors Program Theses

Neuropathic pain is caused by injury to or disease of the nervous system. It affects many people around the world and is a symptom of several diseases. In the United States, it is estimated that up to 3% of Americans have neuropathic pain, which costs the healthcare system $40 billion annually (Gilron et al. 2006). It is, unfortunately, difficult to ameliorate or eliminate due to the complexity of the nervous system and its plasticity and is, therefore, a chronic condition. Health care professionals continually struggle to treat patients' pain and, since tolerance to painkillers is easily built up, this often …

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Liquid Chromatography-Tandem Mass Spectrometry For The Determination Of Methylprednisolone In Rat Plasma And Liver After Intravenous Administration Of Its Liver-Targeted Dextran Prodrug, Shuang-Qing Zhang, Helen R. Thorsheim, Suman Penugonda, Venkateswaran C. Pillai, Quentin R. Smith, Reza Mehvar Jan 2009

Liquid Chromatography-Tandem Mass Spectrometry For The Determination Of Methylprednisolone In Rat Plasma And Liver After Intravenous Administration Of Its Liver-Targeted Dextran Prodrug, Shuang-Qing Zhang, Helen R. Thorsheim, Suman Penugonda, Venkateswaran C. Pillai, Quentin R. Smith, Reza Mehvar

Pharmacy Faculty Articles and Research

A specific and sensitive liquid chromatography (LC)-tandem mass spectrometric method for quantitative determination of methylprednisolone (MP) in rat plasma and liver was developed and validated using triamcinolone acetonide as an internal standard. Liquid-liquid extraction using tert-butyl methyl ether was used to extract the drug and the internal standard from plasma and liver. The separation of MP was performed on a C(18) column with a mobile phase of acetonitrile:0.5% formic acid aqueous solution (85:15, v/v) over 4 min. The assay was based on the selected reaction monitoring transitions at m/z 375 -> 161 for MP in plasma, 375 -> 357 for …

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Localization Of Deformed Wing Virus (Dwv) In The Brains Of Apis Mellifera (European Honey Bees), Karan Samir Shah Jan 2009

Localization Of Deformed Wing Virus (Dwv) In The Brains Of Apis Mellifera (European Honey Bees), Karan Samir Shah

Honors Theses

The purpose of the current research project is to design a successful in-situ hybridization to identify regions within the brains of honeybees where DWV replicates. The localization of the virus in the brains of the bees can draw a connection between CCDand DWV.In conclusion, these results demonstrate that in bees infected with DWV the virus replicates actively in very important regions of the brain, including neuropils that are responsible for vision and olfaction. This means that the virus could adversely affect the vision and olfaction of the honeybees making it difficult for bees to behave normally.

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Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby Jan 2009

Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby

All ETDs from UAB

cillus anthracis is a gram-positive, spore forming bacterium that causes infection through three routes: cutaneous, gastrointestinal and pulmonary. Historically, anthrax pathogenesis was thought to be initiated via the uptake of spores by resident macrophages, which then transited to the regional lymph nodes. While en-route, the spores germinated and developed into bacilli within the phagolysosome, escaped into the cytoplasm, killed the cell and eventually the host. Following the recent use of B. anthracis as a biological weapon, researchers began to reevaluate anthrax pathogenesis in order to develop novel treatments. One aspect of anthrax pathogenesis that saw renewed interest was the intracellular …

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Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang Jan 2009

Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang

All ETDs from UAB

The fight against cancer has generated wide interest in understanding the genetic mechanisms behind the disease. One group of oncogenes – transcription factors – offers many opportunities for treatment or prevention. Among these transcription factors is KLF4, which functions in post-mitotic epithelial cells to promote differentiation. KLF4 has tumorigenic activity in both in vitro and in vivo models. In analyzing transcripts that were induced by KLF4, we noted the induction of multiple nuclear receptors, including retinoid receptors. Retinoids are well-established as chemopreventive agents, but the mechanisms by which they act to prevent cancer remain unclear. Previous studies have shown that …

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Regulation Of Neural Precursor Cell Apoptosis And Proliferation By Glycogen Synthase Kinase-3, Tae-Yeon Eom Jan 2009

Regulation Of Neural Precursor Cell Apoptosis And Proliferation By Glycogen Synthase Kinase-3, Tae-Yeon Eom

All ETDs from UAB

Neurogenesis is a crucial process for development, plasticity, and regenerative capacity of the developing and adult brain. Impairment of neurogenesis has been implicated in the etiology of psychiatric disorders. Although substantial studies have shown that therapeutic interventions enhance neurogenesis, much less is known about what factors impair neurogenesis. Thus, the present work examined if glycogen synthase kinase-3 (GSK3) has a role in impaired neurogenesis, focusing on apoptosis and proliferation of neural precursor cells (NPCs). This investigation found that GSK3 promotes apoptotic signaling in cultured NPCs subjected to two insults, trophic factor withdrawal and genotoxic stress. Both stimuli activated GSK3, Bax, …

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