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Articles 39241 - 39270 of 45263
Full-Text Articles in Medicine and Health Sciences
Development Of A High-Performance Liquid Chromatography Method For Warfarin Detection In Human Plasma, Yung An Chua, Wan Zaidah Abdullah, Siew Hua Gan
Development Of A High-Performance Liquid Chromatography Method For Warfarin Detection In Human Plasma, Yung An Chua, Wan Zaidah Abdullah, Siew Hua Gan
Turkish Journal of Medical Sciences
Most of the high-performance liquid chromatography (HPLC) methods that have been developed to measure warfarin levels use the preextraction spiked internal standard method. We developed a new liquid-liquid extraction (LLE) and reversed-phase HPLC method that uses a postextraction spiked internal standard for the determination of plasma warfarin. Materials and methods: The effect of varying the 1) mobile phase pH, 2) type and composition of organic solvents, 3) type and concentration of buffer solutions, 4) column temperatures, 5) flow rates, 6) organic modifier, and 7) ultraviolet wavelengths were tested. Results: Optimum separation was achieved by using 30:70 (v/v) acetonitrile and potassium …
Urodynamic Evaluation Of Acute Effects Of Sildenafil On Voiding Among Males With Erectile Dysfunction And Symptomatic Benign Prostate, Fati̇h Rüştü Yalçinkaya, Mürsel Davarci, Soner Akçi̇n, Ahmet Gökçe, Eşref Oğuz Güven, Mehmet İnci̇, Mevlana Derya Balbay
Urodynamic Evaluation Of Acute Effects Of Sildenafil On Voiding Among Males With Erectile Dysfunction And Symptomatic Benign Prostate, Fati̇h Rüştü Yalçinkaya, Mürsel Davarci, Soner Akçi̇n, Ahmet Gökçe, Eşref Oğuz Güven, Mehmet İnci̇, Mevlana Derya Balbay
Turkish Journal of Medical Sciences
To evaluate the acute effects of sildenafil citrate on micturition of men with erectile dysfunction and symptomatic benign prostatic hyperplasia using urodynamic parameters. Materials and methods: Between June and December 2009, a total of 50 patients over the age of 40 participated in the study. The patients were admitted to our hospital with erectile dysfunction and moderate to severe lower urinary symptoms with benign prostatic hyperplasia. To examine the sexual function of the participants, we used the IIEF-5 Sexual Health Inventory for Men questionnaire. Patients were randomly divided into 2 groups: a treatment group and a control group. A basal …
Prevalence And Etiology Of Anemias In The Adult Turkish Population, Ramazan Memi̇şoğullari, Hayri̇ye Ak Yildirim, Taner Uçgun, Meli̇h Engi̇n Erkan, Cemaletti̇n Güneş, Mesut Erbaş, Adem Güngör, Mehmet Emi̇n Yanik
Prevalence And Etiology Of Anemias In The Adult Turkish Population, Ramazan Memi̇şoğullari, Hayri̇ye Ak Yildirim, Taner Uçgun, Meli̇h Engi̇n Erkan, Cemaletti̇n Güneş, Mesut Erbaş, Adem Güngör, Mehmet Emi̇n Yanik
Turkish Journal of Medical Sciences
Anemia is common in the general population and one of the most frequently observed nutritional deficiency diseases in the world today. The aim of this study was to investigate the prevalence and etiology of anemias in a large cohort representing the Turkish nation. Materials and methods: The study population comprised 2187 subjects. Serum iron, iron binding capacity, ferritin, vitamin B12, and folic acid analyses were conducted with autoanalyzers using commercial kits. Results: A total of 565 (25.8%) subjects (423 females and 142 males) were diagnosed as anemic. The prevalence of anemia was 30.0% in female and 18.2% in male participants. …
Heart Rate Recovery In Patients With Obstructive Sleep Apnea Syndrome, Riza Murat Karaşen, Bülent Çi̇ftçi̇, Ahmet Ari̇f Yalçin, Baran Acar, Selma Firat Güven
Heart Rate Recovery In Patients With Obstructive Sleep Apnea Syndrome, Riza Murat Karaşen, Bülent Çi̇ftçi̇, Ahmet Ari̇f Yalçin, Baran Acar, Selma Firat Güven
Turkish Journal of Medical Sciences
To demonstrate the effects of obstructive sleep apnea syndrome (OSAS) on baroregulatory function by using heart rate recovery (HRR) parameters. Materials and methods: Fifty-four moderate and severe OSAS patients were included in the study. HRR was defined as the difference in heart rate between peak exercise and 1 min later; a value of 18 beats/min was considered abnormal. OSAS patients were enrolled in the study as group 1 (normal HRR; n = 12) and group 2 (abnormal HRR, n = 42). Left ventricular ejection fraction (LVEF, %) and other parameters were also measured by echocardiography in both groups. Results: There …
The Oral Health Status Of Healthy And Obese Children In A Turkish Population: A Cross-Sectional Study, Günseli̇ Güven Polat, Sevi̇ Burçak Çehreli̇, Mehmet Emre Taşcilar, Özlem Marti Akgün, Ceyhan Altun, İlker Tolga Özgen
The Oral Health Status Of Healthy And Obese Children In A Turkish Population: A Cross-Sectional Study, Günseli̇ Güven Polat, Sevi̇ Burçak Çehreli̇, Mehmet Emre Taşcilar, Özlem Marti Akgün, Ceyhan Altun, İlker Tolga Özgen
Turkish Journal of Medical Sciences
To compare the oral health status of a group of obese and healthy Turkish children. Materials and methods: The study involved 43 healthy (19 boys and 24 girls, mean age: 9.88) and 53 obese (18 boys and 35 girls, mean age: 10.4) children who were admitted to a pediatric dentistry clinic in 2008 and 2009. The parents were asked to complete a questionnaire concerning medical history and dietary/oral hygiene habits. The number of decayed, missing, and filled permanent teeth (DMFT); number of decayed, missing, and filled primary teeth (dmft); and gingival bleeding index (GBI) scores of patients were recorded. Statistical …
Cyp2c9 Gene Polymorphisms And Warfarin Dose Requirement: A Single-Center Experience In Turkey, Rahşan Yildirim, Mehmet Gündoğdu, Fati̇h Kurnaz, Abdulkadi̇r Yildirim, Hülya Aksoy, Fuat Erdem, İlhami̇ Ki̇ki̇, Emi̇n Murat Akbaş, Serkan Cerrah
Cyp2c9 Gene Polymorphisms And Warfarin Dose Requirement: A Single-Center Experience In Turkey, Rahşan Yildirim, Mehmet Gündoğdu, Fati̇h Kurnaz, Abdulkadi̇r Yildirim, Hülya Aksoy, Fuat Erdem, İlhami̇ Ki̇ki̇, Emi̇n Murat Akbaş, Serkan Cerrah
Turkish Journal of Medical Sciences
In this study, we aimed to evaluate the relationship between genetic structure and daily dose requirement in patients under warfarin therapy presenting at our hospital. Materials and methods: A total of 80 patients (45 female and 35 male) aged between 29 and 80 years (mean age: 59.86 ± 14.46 years), using warfarin for at least 1 month and presenting at Atatürk University Medical Faculty Outpatient Clinic between May 2009 and May 2010, were included in the study. Analysis of CYP2C9 1075 A>C and CYP2C9 430 C>T polymorphisms were performed using polymerase chain reaction (PCR) and the reverse-hybridization method. …
Early Oxidative Status In Adult Patients With Isolated Traumatic Brain Injury, Özgür Söğüt, Hali̇l Kaya, Mehmet Tahi̇r Gökdemi̇r, Leyla Solduk, Mehmet Aki̇f Dokuzoğlu, Mustafa Burak Sayhan, Atilhan Kaya, Abdürrahi̇m Koçyi̇ği̇t
Early Oxidative Status In Adult Patients With Isolated Traumatic Brain Injury, Özgür Söğüt, Hali̇l Kaya, Mehmet Tahi̇r Gökdemi̇r, Leyla Solduk, Mehmet Aki̇f Dokuzoğlu, Mustafa Burak Sayhan, Atilhan Kaya, Abdürrahi̇m Koçyi̇ği̇t
Turkish Journal of Medical Sciences
To investigate oxidative and antioxidative status, as well as the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), reflecting injury severity and neurological outcome during the early posttraumatic period in patients with isolated traumatic brain injury (TBI). Materials and methods: Fifty-one adult patients with TBI and 45 eligible healthy volunteers as control subjects were enrolled. Plasma total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI) were calculated as biomarkers of early oxidative changes in serum using a novel automated method. Results: TOS levels and OSI values were significantly higher in nonsurvivors compared with those …
The Effect Of Rem Sleep Behaviour Disorder On Clinical Severity In Parkinson's Disease, Dursun Aygün, Yakup Türkel, Adem Akkurt, Musa Kazi̇m Onar
The Effect Of Rem Sleep Behaviour Disorder On Clinical Severity In Parkinson's Disease, Dursun Aygün, Yakup Türkel, Adem Akkurt, Musa Kazi̇m Onar
Turkish Journal of Medical Sciences
Differently from previous studies that directly compared Parkinson's disease (PD) patients with and without rapid eye movement (REM) sleep behavioural disorder (RBD) for the stage, severity, and duration of disease, this study investigated the relationship between the duration and clinical severity of disease in PD patients with and without RBD. Materials and methods: This retrospective study consisted of 141 PD patients older than 18 years of age. The clinical diagnosis of RBD was based on the minimal diagnostic criteria of the revised 2001 International Classification of Sleep Disorders. The patients were divided into 2 subgroups, those with and without clinical …
Salter Innominate Osteotomy Or Pemberton Pericapsular Osteotomy In Treatment Of Developmental Dysplasia Of Hip, Naci̇ Ezi̇rmi̇k, Kadri̇ Yildiz
Salter Innominate Osteotomy Or Pemberton Pericapsular Osteotomy In Treatment Of Developmental Dysplasia Of Hip, Naci̇ Ezi̇rmi̇k, Kadri̇ Yildiz
Turkish Journal of Medical Sciences
We aimed to compare the clinical and radiological results of the Salter innominate osteotomy (SIO) and Pemberton pericapsular osteotomy (PPO) in children with bilateral developmental hip dysplasia who had undergone PPO for 1 side and SIO for the other side in a 1-stage operation. Materials and methods: Children with bilateral hip dysplasia who had undergone PPO for 1 side and SIO for the other side in a 1-stage operation were included in this study, and 126 hips of 63 patients were evaluated. Clinical and radiological results were evaluated and compared using the Sutherland Pain Scale, Modified McKay Grading System, and …
Is Grayanotoxin Directly Responsible For Mad Honey Poisoning-Associated Seizures, Abdülkadi̇r Gündüz, Murat Aydin, Metehan Akça, Süha Türkmen, Süleyman Türedi̇, Umut Eryi̇ği̇t, Ali̇ Cansu, Mehmet Yildirim
Is Grayanotoxin Directly Responsible For Mad Honey Poisoning-Associated Seizures, Abdülkadi̇r Gündüz, Murat Aydin, Metehan Akça, Süha Türkmen, Süleyman Türedi̇, Umut Eryi̇ği̇t, Ali̇ Cansu, Mehmet Yildirim
Turkish Journal of Medical Sciences
The aim of this study was to investigate the effects of grayanotoxin on epileptiform activity in rats. Materials and methods: Forty-two male Sprague Dawley rats were equally divided into 1 of 7 groups. Thirty minutes after induction of epileptiform activity induced by penicillin injection, 0.5, 1, 2, 4, or 8 µg of grayanotoxin-III was intracerebroventricularly administered. Epileptiform activity spike frequency and amplitude were converted into numerical data using software following the experiment. Results: Our results show that grayanotoxin reduces epileptiform spike frequency and amplitude in a dose-dependent manner. Five minutes postinjection, grayanotoxin significantly reduced epileptiform activity, especially at higher doses. …
Penetrating Chest Injuries: Analysis Of 99 Cases, Ülkü Yazici, Alkin Yazicioğlu, Ertan Aydin, Koray Aydoğdu, Sadi̇ Kaya, Nuretti̇n Karaoğlanoğlu
Penetrating Chest Injuries: Analysis Of 99 Cases, Ülkü Yazici, Alkin Yazicioğlu, Ertan Aydin, Koray Aydoğdu, Sadi̇ Kaya, Nuretti̇n Karaoğlanoğlu
Turkish Journal of Medical Sciences
To investigate the patterns of penetrating thoracic injuries and techniques used in their management, and to contribute further data on the knowledge of penetrating thoracic trauma. Materials and methods: The records were reviewed of 99 patients seen at our thoracic surgery hospital over a 4-year period. Results: The group comprised 90 male (90.9%) and 9 female (9.1%) patients, with a mean age of 29.0 years. Of these patients, 62 (62.6%) had left-sided, 33 (33.3%) had right-sided, and 4 (4%) had bilateral penetrating injury. Stab wounds comprised 89 cases (89.9%) and the remaining 10 patients (10.1%) suffered gunshot wounds. Intercostal tube …
Sprinting, Isokinetic Strength, And Range Of Motion Of Ankle Joints In Turkish Male And Female National Sprinters May Have A Relationship, Habi̇be Serap İnal, Burçi̇n Erbuğ, Christos Kotzamanidis
Sprinting, Isokinetic Strength, And Range Of Motion Of Ankle Joints In Turkish Male And Female National Sprinters May Have A Relationship, Habi̇be Serap İnal, Burçi̇n Erbuğ, Christos Kotzamanidis
Turkish Journal of Medical Sciences
We aimed to observe the isokinetic muscular strength differences of the ankle-foot complex of sprinters of both sexes to understand the effectiveness of the ankle and subtalar ranges of motion on the sprint performances of elite athletes. Materials and methods: Elite Turkish national sprinters (n = 11; 5 females and 6 males) were assessed regarding their ankle joint isokinetic performance (30°/s and 120°/s), joint ranges, and sprint times. Results: A significant difference was observed between the average power of the right dorsiflexors (P < 0.001) of female athletes and the right invertors (P < 0.05) of male athletes at 120°/s for the 100-m sprint time. The average powers of the right (P < 0.05) and left (P < 0.05) evertors of the male athletes at 30°/s were significantly negatively correlated with sprint time. Additionally, only the plantar flexion range was significant for male athletes' sprint times, and the dominant invertors' peak torque at 120°/s in female athletes was significant (P < 0.05). Conclusion: The strength of the nondominant side dorsiflexors of female athletes and the nondominant invertors of male athletes are important in decreasing the strength asymmetry to disregard the strength of the nondominant side in relation to sprint performance.
One-Stage Management Of Post-Traumatic Tibial Infected Nonunion Using Bone Transport After Debridement, Tang Liu, Xiaodong Yu, Xiangsheng Zhang, Zhihong Li, Wen Zeng
One-Stage Management Of Post-Traumatic Tibial Infected Nonunion Using Bone Transport After Debridement, Tang Liu, Xiaodong Yu, Xiangsheng Zhang, Zhihong Li, Wen Zeng
Turkish Journal of Medical Sciences
To evaluate the results of the management of post-traumatic tibial infected nonunion using bone transport with external fixators. Materials and methods: We retrospectively reviewed a consecutive series of 35 patients from 2000 to 2008 in our hospital who were treated for the post-traumatic tibial nonunion by bone transport with an external fixator. Thirty-two limbs (80%) were in active infected state. The mean amount of bone defect was 3.5 cm (range 1.0 to 7.8 cm) as measured on plain radiographs. The mean leg-length discrepancy was 4.4 cm (range 0 to 8.7 cm). Results: The mean follow-up was 72.5 months (range 35-106 …
High Cerebrospinal Fluid Protein Level In West Nile Virus Ncephalitis: Report Of Five Cases, Oğuz Karabay, Nazan Tuna, Mehmet Yahyaoğlu, Gökçen Kayan
High Cerebrospinal Fluid Protein Level In West Nile Virus Ncephalitis: Report Of Five Cases, Oğuz Karabay, Nazan Tuna, Mehmet Yahyaoğlu, Gökçen Kayan
Turkish Journal of Medical Sciences
An outbreak of West Nile virus (WNV) occurred in Greece, Russia, and Turkey in 2010. We diagnosed 5 WNV encephalitis patients, who presented with high cerebrospinal fluid (CSF) protein level and encephalitis relevant symptoms in the last days of summer or in the first days of autumn. Here, we aimed to present a retrospective analysis of 5 WNV encephalitis cases in Turkey in terms of their clinical and laboratory findings.
Better Marital Adjustment Is Associated With Lower Disease Activity In Early Inflammatory Arthritis, Sally Sabry Mustafa, Karl Julian Looper, Margaret Purden, Phyllis Zelkowitz, Murray Baron
Better Marital Adjustment Is Associated With Lower Disease Activity In Early Inflammatory Arthritis, Sally Sabry Mustafa, Karl Julian Looper, Margaret Purden, Phyllis Zelkowitz, Murray Baron
Turkish Journal of Medical Sciences
The aim of this study was to examine the association between marital adjustment and disease outcomes in patients with early inflammatory arthritis. Materials and methods: Patients with average disease duration of 7.66 ± 3.79 months were recruited from a larger early inflammatory arthritis registry, which recorded sociodemographic data and disease characteristics. The acute phase reactant C-reactive protein (CRP) levels were measured and disease activity was estimated using the Disease Activity Score in 28 joints (DAS28). Patient and spouse perceived marital adjustment was assessed by the Dyadic Adjustment Scale (DAS). Results: The study sample consisted of 73 patients living with their …
The Impact Of Attention Training On Children With Low Vision: A Randomized Trial, Bi̇lge Başakci Çalik, Ali̇ Ki̇ti̇ş, Uğur Cavlak, Atti̇la Oğuzhanoğlu
The Impact Of Attention Training On Children With Low Vision: A Randomized Trial, Bi̇lge Başakci Çalik, Ali̇ Ki̇ti̇ş, Uğur Cavlak, Atti̇la Oğuzhanoğlu
Turkish Journal of Medical Sciences
The purpose of this study was to show the effectiveness of a 6-week attention training program on the cognition, quality of life (QOL), and activities of daily living in children with low vision. Materials and methods: Included in this study were 20 children with low vision, aged 7-12 years. The children were divided into 2 groups. While the first group (n = 10) participated in a 6-week Pay Attention© training program 3 times a week for 30 min, the second group (n = 10) was the control. Before and after the program, all of the participants were evaluated using a …
Serum Nitric Oxide, Asymmetric Dimethylarginine, And Plasma Homocysteine Levels In Active Behçet's Disease, Murat Aydin, Cemi̇le Koca, Sema Uysal, Yüksel Totan, Ramazan Yağci, Ferah Armutcu, Zübeyde Cücen, Muhammet Ramazan Yi̇ği̇toğlu
Serum Nitric Oxide, Asymmetric Dimethylarginine, And Plasma Homocysteine Levels In Active Behçet's Disease, Murat Aydin, Cemi̇le Koca, Sema Uysal, Yüksel Totan, Ramazan Yağci, Ferah Armutcu, Zübeyde Cücen, Muhammet Ramazan Yi̇ği̇toğlu
Turkish Journal of Medical Sciences
Behçet's disease is a relapsing vasculitis characterized by endothelial dysfunction. This study was conducted to determine the levels of nitric oxide (NO) and 2 related parameters, asymmetric dimethylarginine (ADMA) and homocysteine levels, in relation to the pathogenesis of Behçet's disease. Materials and methods: A total of 49 Behçet's patients, comprising 26 patients with the active disease and 23 patients with the inactive disease, and a healthy control group of 24 individuals participated in this study. International Study Group Diagnostic Criteria were followed in the diagnosis of Behçet's disease; patients who had at least 2 signs were considered as having the …
Comparison Of Conventional And Liquid-Based Cytology: Do The Diagnostic Benefits Outweigh The Financial Aspect?, Erdi̇n İlter, Ahmet Mi̇di̇, Berna Hali̇loğlu, Aygen Çeli̇k, Arzu Neşe Yener, İpek Ulu, Hayri̇ye Serpi̇l Bozkurt, Ümi̇t Özeki̇ci̇
Comparison Of Conventional And Liquid-Based Cytology: Do The Diagnostic Benefits Outweigh The Financial Aspect?, Erdi̇n İlter, Ahmet Mi̇di̇, Berna Hali̇loğlu, Aygen Çeli̇k, Arzu Neşe Yener, İpek Ulu, Hayri̇ye Serpi̇l Bozkurt, Ümi̇t Özeki̇ci̇
Turkish Journal of Medical Sciences
We aimed to compare the efficiency of conventional cytology (CC) and new liquid-based cytology (LBC) techniques in the assessment and the accuracy of Pap smears reported as abnormal by histological examinations. Materials and methods: A total of 3488 women who were undergoing routine cervical screening (1308 CC and 2180 LBC) were included in the initial screening. The results were assessed as either satisfactory or unsatisfactory. Satisfactory results were subdivided as negative, atypical squamous cells of undetermined significance (ASCUS), atypical squamous cells for which high-grade lesions could not be excluded (ASC-H), low-grade squamous intraepithelial lesion (LGSIL), high-grade squamous intraepithelial lesion (HGSIL), …
Risk Factors For Mortality In Patients With Nosocomial Staphylococcus Aureus Bacteremia, Ali̇ye Baştuğ, Gülruhsar Yilmaz, Bi̇rcan Kayaaslan, Esragül Akinci, Hurrem Bodur
Risk Factors For Mortality In Patients With Nosocomial Staphylococcus Aureus Bacteremia, Ali̇ye Baştuğ, Gülruhsar Yilmaz, Bi̇rcan Kayaaslan, Esragül Akinci, Hurrem Bodur
Turkish Journal of Medical Sciences
Bloodstream infections (BSIs) due to Staphylococcus aureus have become increasingly common in hospitals worldwide. The aim of this study was to evaluate the risk factors for mortality of nosocomial BSI due to S. aureus. Materials and methods: We analyzed risk factors for mortality of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) bacteremia in a prospective case control study in a 1196-bed tertiary referral medical center. Logistic regression analyses were used to determine risk factors and prognostic factors of mortality. Results: Between July 2006 and January 2009, 176 patients were identified with clinically significant and microbiologically confirmed nosocomial bacteremia …
The Effect Of Palonosetron On Postoperative Nausea And Vomiting In Supratentorial Craniotomy Patients, Hali̇t Madenoğlu, Ci̇han Akdemi̇r, Recep Aksu, Ci̇hangi̇r Bi̇çer, Ayşe Ülgey, Adem Boyaci
The Effect Of Palonosetron On Postoperative Nausea And Vomiting In Supratentorial Craniotomy Patients, Hali̇t Madenoğlu, Ci̇han Akdemi̇r, Recep Aksu, Ci̇hangi̇r Bi̇çer, Ayşe Ülgey, Adem Boyaci
Turkish Journal of Medical Sciences
Postoperative nausea and vomiting (PONV) is a condition that adversely affects postoperative patient comfort. Supratentorial craniotomy patients were therefore monitored to establish the therapeutic efficiency of 2 different doses of palonosetron. Materials and methods: Patients scheduled for elective supratentorial craniotomy were randomly assigned to 3 groups: a control group (n = 30), a 0.05 mg palonosetron group (n = 30), and a 0.075 mg palonosetron group (n = 30). The drugs were given intravenously at the commencement of dura mater closure. Anesthesia maintenance was provided with 1 MAC sevoflurane in a 50% air and O_2 mixture. After the extubation, the …
Comparison Of The Effects Of Intradialytic Parenteral Nutrition Alone And Combined With Anabolic Steroid In Patients Undergoing Hemodialysis Therapy, Abdi̇ Meti̇n Sarikaya, Funda Sari, Ramazan Çeti̇nkaya
Comparison Of The Effects Of Intradialytic Parenteral Nutrition Alone And Combined With Anabolic Steroid In Patients Undergoing Hemodialysis Therapy, Abdi̇ Meti̇n Sarikaya, Funda Sari, Ramazan Çeti̇nkaya
Turkish Journal of Medical Sciences
It has been shown that androgen anabolic steroids and intradialytic parenteral nutrition (IDPN) may have advantages in malnourished hemodialysis patients. We aimed to compare the effects of IDPN and IDPN with added anabolic steroid. Materials and methods: Twenty hemodialysis patients who had albumin of
Histopathological Effects Of S. Xylosus Peptidoglycan In Comparison To E. Coli Lipopolysaccharide In The Urinary Tract Of Mice, Harith Jabbar Fahad Al-Mathkhury, May Talib Flaih, Hiba Khalil Tawfiq
Histopathological Effects Of S. Xylosus Peptidoglycan In Comparison To E. Coli Lipopolysaccharide In The Urinary Tract Of Mice, Harith Jabbar Fahad Al-Mathkhury, May Talib Flaih, Hiba Khalil Tawfiq
Turkish Journal of Medical Sciences
The present work, among other previous studies done in our lab, aimed to highlight the histopathological effect of S. xylosus peptidoglycan in comparison to LPS of E. coli. Materials and methods: One hundred and fifty urine specimens were collected from urinary tract infection patients visiting Baghdad hospitals. The histopathological effects of S. xylosus S24 peptidoglycan was studied in the urinary tract of female mice by injecting 5 animal groups at the following concentrations: 1000, 2000, 3000, 4000, and 5000 µg/mL. Another 5 groups were injected with 10, 25, 50, 75, and 100 ng/mL of E. coli (serotype 0128:B12) LPS. Results: …
Pediculosis Capitis Infestation In School Children Of A Low Socioeconomic Area Of The North Gaza Governorate, Bassam Alzain
Pediculosis Capitis Infestation In School Children Of A Low Socioeconomic Area Of The North Gaza Governorate, Bassam Alzain
Turkish Journal of Medical Sciences
Pediculus capitis, or human head lice, infests people worldwide, although it is most often seen in school-aged children. The aim of this study was to estimate the incidence and the epidemiological factors related to Pediculus capitis infestation among the selected population. Materials and methods: A study conducted from January to March 2010 of 318 females and 282 males up to 13 years of age found a prevalence rate for Pediculus capitis infestation of 53 (16.8%) in the North Gaza Governorate. The study involved 600 children and used multistage, systematic random sampling. Results: Male children had a lower rate of infestation …
Radioimmunotherapy Of Mice Bearing Breast Tumors With ^{177}Lu-Labeled Trastuzumab, Samira Rasaneh, Hossein Rajabi, Shahram Akhlaghpoor, Shahab Sheybani
Radioimmunotherapy Of Mice Bearing Breast Tumors With ^{177}Lu-Labeled Trastuzumab, Samira Rasaneh, Hossein Rajabi, Shahram Akhlaghpoor, Shahab Sheybani
Turkish Journal of Medical Sciences
In the present study, we investigated the therapeutic efficacy of trastuzumab labeled with lutetium-177 (^{177}Lu) in mice bearing breast tumors. Materials and methods: Trastuzumab was labeled with ^{177}Lu via DOTA as a chelator. In vitro and in vivo quality control tests of incorporated activity, immunoreactivity, stability of ^{177}Lu-trastuzumab, biodistribution, and imaging studies were performed. Therapeutic efficacy and dosimetry studies were carried out in mice with breast tumors. Results: The good in vitro and in vivo quality control results suggested that ^{177}Lu-trastuzumab could be used as a radioimmunotherapy agent. Reductions of 81% and 98% in the mean tumor volume for the …
Cerebral Blood Flow During Single Lung Ventilation, Mehmet Muharrem Erol, Si̇bel Kul, Ayşegül Cansu, Celal Teki̇nbaş, Engi̇n Ertürk, Murat Topbaş
Cerebral Blood Flow During Single Lung Ventilation, Mehmet Muharrem Erol, Si̇bel Kul, Ayşegül Cansu, Celal Teki̇nbaş, Engi̇n Ertürk, Murat Topbaş
Turkish Journal of Medical Sciences
Our aim was to show the effect of one-lung ventilation (OLV) on cerebral blood flow (CBF) by measuring carotid blood flow. This technique has been the subject of experimental and clinical studies. Materials and methods: Carotid doppler flows were measured at 4 different times. Peak systolic velocity (PSV) and end diastolic velocity (EDV) were measured and pulsatility index (PI) and resistive index (RI) calculated. Results: There were no significant changes in PSV, PI, RI, or flow volume in the normal or diseased sides at repeated measures (P > 0.05).There was no significant difference between the flow velocities, PIs, RIs, or flow …
Effects Of Androgen On Expression Of Omgp Of The Hibd Neonatal Rat Brain, Manling Liu, Zhankui Li
Effects Of Androgen On Expression Of Omgp Of The Hibd Neonatal Rat Brain, Manling Liu, Zhankui Li
Turkish Journal of Medical Sciences
To investigate the protective effects of testosterone propionate (TP) on hypoxic-ischemic brain damage (HIBD) neonatal rat brain by observing oligodendrocyte myelin glycoprotein (OMgp) expression in the cortex and hippocampus after HIBD. Materials and methods: Rats were randomly divided into 3 groups: TP pretreatment, HIBD control, and a sham treatment group. Rats 7 days old from the TP group and HIBD control group were subjected to HIBD, and OMgp expression in the hippocampus and cerebral cortex of the different doses and groups was observed after hypoxic-ischemic induction at 24 h, 48 h, 72 h, 7 days, and 14 days. Results: The …
Autophagy And Apoptotic Genes Implicated In Alzheimer’S Disease Are Modulated Following Infection Of Neuronal Cells With Chlamydia Pneumoniae, Denah M. Appelt, Ian Kohler, Annette K. Slutter, Juliana Zoga, Susan T. Hingley, Brian J. Balin
Autophagy And Apoptotic Genes Implicated In Alzheimer’S Disease Are Modulated Following Infection Of Neuronal Cells With Chlamydia Pneumoniae, Denah M. Appelt, Ian Kohler, Annette K. Slutter, Juliana Zoga, Susan T. Hingley, Brian J. Balin
Scholarly Posters
Background: The focus of the current studies was to determine the relationship between the molecular mechanisms interconnecting autophagy and apoptosis following Chlamydia pneumoniae infection in neuronal cells. Dysfunctions in apoptosis and autophagy have been implicated in the neurodegeneration associated with Alzheimer’s disease (AD). Autophagy in AD pathogenesis has been shown to play a role in amyloid processing through the endosomal-lysosomal system. Apoptosis may contribute to the neuronal cell loss observed in AD; however, there is limited evidence of the apoptotic process proceeding to terminal completion. Although Aβ1-42 has been shown to induce apoptosis in neurons and may be an early …
Dynamics Of Envelope Evolution In Clade C Shiv-Infected Pig-Tailed Macaques During Disease Progression Analyzed By Ultra-Deep Pyrosequencing, For Yue Tso, Damien C. Tully, Sandra Gonzalez, Christopher Quince, On Ho, Patricia Polacino, Ruth M. Ruprecht, Shiu-Lok Hu, Charles Wood
Dynamics Of Envelope Evolution In Clade C Shiv-Infected Pig-Tailed Macaques During Disease Progression Analyzed By Ultra-Deep Pyrosequencing, For Yue Tso, Damien C. Tully, Sandra Gonzalez, Christopher Quince, On Ho, Patricia Polacino, Ruth M. Ruprecht, Shiu-Lok Hu, Charles Wood
Nebraska Center for Virology: Faculty Publications
Understanding the evolution of the human immunodeficiency virus type 1 (HIV-1) envelope during disease progression can provide tremendous insights for vaccine development, and simian-human immunodeficiency virus (SHIV) infection of nonhuman primate provides an ideal platform for such studies. A newly developed clade C SHIV, SHIV-1157ipd3N4, which was able to infect rhesus macaques, closely resembled primary HIV-1 in transmission and pathogenesis, was used to infect several pig-tailed macaques. One of the infected animals subsequently progressed to AIDS, whereas one remained a nonprogressor. The viral envelope evolution in the infected animals during disease progression was analyzed by a bioinformatics approach using ultra-deep …
Coxsackievirus B3 Infection Leads To The Generation Of Cardiac Myosin Heavy Chain-Α-Reactive Cd4 T Cells In A/J Mice, Arunakumar Gangaplara, Chandirasegaran Massilamany, Deborah M. Brown, Gustavo A. Delhon, Asit K. Pattnaik, Nora Chapman, Noel Rose, David J. Steffen, Jay Reddy
Coxsackievirus B3 Infection Leads To The Generation Of Cardiac Myosin Heavy Chain-Α-Reactive Cd4 T Cells In A/J Mice, Arunakumar Gangaplara, Chandirasegaran Massilamany, Deborah M. Brown, Gustavo A. Delhon, Asit K. Pattnaik, Nora Chapman, Noel Rose, David J. Steffen, Jay Reddy
Jay Reddy Publications
Enteroviruses like coxsackievirus B3 (CVB3) are common suspects in myocarditis/dilated cardiomyopathy patients. Autoimmunity has been proposed as an underlying mechanism, but direct evidence of its role is lacking. To delineate autoimmune response in CVB3 myocarditis, we used IAk dextramers for cardiac myosin heavy chain (Myhc)-α 334–352. We have demonstrated that myocarditis-susceptible A/J mice infected with CVB3 generate Myhc-α-reactive CD4 T cells and such a repertoire was absent in naïve mice as measured by proliferative response to Myhc-α 334–352 and IAk dextramer staining. We also detected Myhc-α 334–352 dextramer+ cells in the hearts of CVB3-infected mice. The autoreactive …
A Lean Surveillance Transformation, Terry Burger Mba, Bsn, Rn, Ne-Bc, Cic, Deborah Fry Mt (Ascp), Mba, Cic, Barbara Versage Rn, Mba, Cphq
A Lean Surveillance Transformation, Terry Burger Mba, Bsn, Rn, Ne-Bc, Cic, Deborah Fry Mt (Ascp), Mba, Cic, Barbara Versage Rn, Mba, Cphq
Department of Medicine
No abstract provided.