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Articles 45241 - 45243 of 45243

Full-Text Articles in Medicine and Health Sciences

Flow Dynamics In Model Aneurysms Associated With Simulated Vasospasm, Takuo Hashimoto, George M. Austin Dec 999

Flow Dynamics In Model Aneurysms Associated With Simulated Vasospasm, Takuo Hashimoto, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Flow Dynamics in Model Aneurysms Associated with Simulated Vasospasm. Takuo Hashimoto, M.D., George M. Austin, M.D. N.D., 23 pg.


Intracranial Aneurysm-Early Diagnosis And Prevention Of Rupture, George M. Austin Dec 999

Intracranial Aneurysm-Early Diagnosis And Prevention Of Rupture, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Intracranial Aneurysm-Early Diagnosis and Prevention of Rupture. George M. Austin. 1 p.


Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry Dec 200

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …