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Articles 38521 - 38550 of 45320

Full-Text Articles in Medicine and Health Sciences

Does Apnea-Hypopnea Index Alone Reflect Obstructive Sleep Apnea Severity?, Ömer Araz, Di̇dem Pulur, Eli̇f Yilmazel Uçar, Mehmet Meral, Ali̇ Meti̇n Görgüner, Meti̇n Akgün Jan 2013

Does Apnea-Hypopnea Index Alone Reflect Obstructive Sleep Apnea Severity?, Ömer Araz, Di̇dem Pulur, Eli̇f Yilmazel Uçar, Mehmet Meral, Ali̇ Meti̇n Görgüner, Meti̇n Akgün

Turkish Journal of Medical Sciences

We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desaturation time under 90% (DTU-90), and mean saturation (MS) levels and the parameters associated with tissue hypoxia. Materials and methods: A total of 144 subjects were included in the study. Blood C-reactive protein levels, blood uric acid levels, and urine microalbumin levels were measured and the urine uric acid/creatinine ratio and urine microalbumin/creatinine ratio were calculated. Results: Our study results suggest that MS and DTU-90, as well as the AHI, are correlated with the parameters reflecting hypoxemia and the other events secondary to hypoxia. Conclusion: MS …

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Effect Of Hepatic Steatosis On Virological Response To Nucleos(T)Ide Analogs Therapy In Patients With Chronic Hepatitis B, Ahmet Karaman, Şebnem Gürsoy, Işin Soyuer, Hati̇ce Karaman, Muhammet Edi̇p Torun, Mustafa Alper Yurci̇, Mevlüt Başkol, Kadri̇ Güven, Ömer Özbakir, Mehmet Yücesoy Jan 2013

Effect Of Hepatic Steatosis On Virological Response To Nucleos(T)Ide Analogs Therapy In Patients With Chronic Hepatitis B, Ahmet Karaman, Şebnem Gürsoy, Işin Soyuer, Hati̇ce Karaman, Muhammet Edi̇p Torun, Mustafa Alper Yurci̇, Mevlüt Başkol, Kadri̇ Güven, Ömer Özbakir, Mehmet Yücesoy

Turkish Journal of Medical Sciences

To evaluate the impact of hepatic steatosis on the outcome of treatment in patients with chronic hepatitis B infection treated with oral antiviral therapy. Materials and methods: The study was designed in Erciyes University Medical Faculty Department of Gastroenterology. Patients who received oral antiviral therapy because of chronic hepatitis B were included in the study. Liver biopsy specimens were re-evaluated and classified according to Brunt’s steatosis classification. Virological response to oral antiviral therapy was compared between patients with and without steatosis. Results: One hundred and nineteen patients were included in the study, of which 36.1% had hepatic steatosis. Virological response …

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Mmp-2, Timp-2, And Mmp-2/Timp-2 Complex Levels In Epidermoid Lung Cancer, Müfi̇de Öncel, Mehmet Aköz, Murat Öncel, Aysel Kiyici, Burhan Api̇li̇oğullari Jan 2013

Mmp-2, Timp-2, And Mmp-2/Timp-2 Complex Levels In Epidermoid Lung Cancer, Müfi̇de Öncel, Mehmet Aköz, Murat Öncel, Aysel Kiyici, Burhan Api̇li̇oğullari

Turkish Journal of Medical Sciences

To investigate serum levels of MMP-2, TIMP-2, and MMP-2/TIMP-2 complex in epidermoid lung cancer and determine whether one of these markers or any combination of them can be used as a prognostic factor and in the management of this disease. Materials and methods: Twenty-eight patients with non-small cell lung cancer and 21 healthy, age-matched individuals participated in this study. MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were measured in the sera of the patients and controls with the ELISA technique. Results: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were significantly elevated in patients with non-small cell lung cancer compared to the controls …

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Neurocognitive Functioning In Young High-Risk Offspring Having A Parent With Bipolar I Disorder, Erdem Deveci̇, Erol Ozan, İsmet Kirpinar, Meltem Oral, Ali̇ Gökhan Daloğlu, Nazan Aydin, Ahmet Öztürk Jan 2013

Neurocognitive Functioning In Young High-Risk Offspring Having A Parent With Bipolar I Disorder, Erdem Deveci̇, Erol Ozan, İsmet Kirpinar, Meltem Oral, Ali̇ Gökhan Daloğlu, Nazan Aydin, Ahmet Öztürk

Turkish Journal of Medical Sciences

To investigate attention, memory, verbal-linguistic ability, and executive functions in symptom-free young offspring having a parent with bipolar I disorder (BD1O) in comparison with healthy controls (CO). Materials and methods: Thirty symptom-free BD1O and 37 CO were recruited. The groups (both all participants and those >=11 years of age) were well-matched for age, sex, IQ, and years of education. The neurocognitive battery included the Rey Auditory Verbal Learning and Memory Test, Controlled Word Association Test, Digit Span Test, Trail Making Test, Auditory Consonant Trigram Test, Wisconsin Card Sorting Test, Stroop Test, and Test of Variables of Attention. Results: The BD1O …

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Assessment Of Left-Ventricular Diastolic Function In Diabetic Patients: The Role Of Cardiac Mr Imaging, İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, Enbi̇ya Aksakal, Hayri̇ Oğul, Ahmet Yalçin, Yeşi̇m Kizrak, Abdulmeci̇t Kantarci Jan 2013

Assessment Of Left-Ventricular Diastolic Function In Diabetic Patients: The Role Of Cardiac Mr Imaging, İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, Enbi̇ya Aksakal, Hayri̇ Oğul, Ahmet Yalçin, Yeşi̇m Kizrak, Abdulmeci̇t Kantarci

Turkish Journal of Medical Sciences

To evaluate the reliability of cardiac magnetic resonance (CMR) imaging in diabetic patients with clinically suspected cardiomyopathy and to compare the consistency of CMR imaging with 2-dimensional echocardiography (2DE). Materials and methods: Twenty-one diabetic patients with clinically suspected cardiomyopathy were evaluated with CMR imaging and 2DE. Two observers for each modality performed the evaluation. Quantitative data (the ejection fraction, end-systolic volume, end-diastolic volume, left-ventricular mass index, and left-atrial volume index) were acquired from both observers. The data were compared for statistical agreement using the Bland-Altman test between the modalities. Results: The CMR examination and 2DE results were consistent with each …

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Effects Of Obstructive Sleep Apnea Syndrome On Temperament And Character, Fatma Fi̇dan, Ömer Özbulut, Apdullah Ayçi̇çek, Ahmet Hakki Aşik, Mehmet Ünlü Jan 2013

Effects Of Obstructive Sleep Apnea Syndrome On Temperament And Character, Fatma Fi̇dan, Ömer Özbulut, Apdullah Ayçi̇çek, Ahmet Hakki Aşik, Mehmet Ünlü

Turkish Journal of Medical Sciences

There are few studies that have evaluated personality characteristics in patients with obstructive sleep apnea syndrome (OSAS). We aimed to evaluate 2 groups, OSAS patients and controls, using a temperament and character inventory (TCI) questionnaire. Materials and methods: Patients with OSAS symptoms and who underwent polysomnography in the sleep laboratory were included in the study. A TCI questionnaire was given to 52 patients. Those whose apnea-hypoapnea index (AHI) was >=10 were included as the OSAS group and those whose score was

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Can Plasma-Free Dna Concentration Be A Diagnostic Tool In Critically Ill Septic Patients?, Başak Ceyda Meço, Fatma Handan Cuhruk, Melek Tulunay, Mehmet Oral, Mustafa Necmetti̇n Ünal Jan 2013

Can Plasma-Free Dna Concentration Be A Diagnostic Tool In Critically Ill Septic Patients?, Başak Ceyda Meço, Fatma Handan Cuhruk, Melek Tulunay, Mehmet Oral, Mustafa Necmetti̇n Ünal

Turkish Journal of Medical Sciences

To investigate the diagnostic value of plasma-free DNA concentration (PF-DNA) in septic patients compared to nonseptic patients and to correlate it with clinical outcome. Materials and methods: Forty-two mechanically ventilated consecutive patients (11 septic, 31 nonseptic) admitted to the intensive care unit (ICU) were recruited. On admission, besides PF-DNA concentration, APACHE II and SOFA scores and serum C-reactive protein (CRP), procalcitonin (PCT), and serum lipid concentrations, together with clinical outcome, were assessed. Plasma samples from 11 volunteers were also collected. Appropriate statistics were used for analysis. Results: Median PF-DNA concentrations on admission were significantly higher in septic patients compared to …

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The Effects Of An Adaptive Directional Beam Microphone On The Mismatch Negativity Responses Of Cochlear Implant Users In Noise, Asuman Erdoğan, Ferda Akdaş Jan 2013

The Effects Of An Adaptive Directional Beam Microphone On The Mismatch Negativity Responses Of Cochlear Implant Users In Noise, Asuman Erdoğan, Ferda Akdaş

Turkish Journal of Medical Sciences

To investigate the effects of noise on mismatch negativity (MMN) responses and the possible benefits of an adaptive directional BEAM microphone in noise during MMN recordings, and to compare the cochlear implant-evoked potential results with normal hearing subjects. Materials and methods: /da/ and /di/ speech stimuli were used to elicit MMN responses in 11 Freedom cochlear implant users and in 11 normal hearing subjects. Speech noise was delivered at 80 dB sound pressure level (-10 dB signal-to-noise ratio). All subjects were tested in quiet and noisy conditions. To compare the microphone effects, MMN responses for the cochlear implant group were …

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Rehabilitation Idea Begins At Sumers, Yusuf Kemal Kemaloğlu, Pinar Yaprak Kemaloğlu, Güven Mengü Jan 2013

Rehabilitation Idea Begins At Sumers, Yusuf Kemal Kemaloğlu, Pinar Yaprak Kemaloğlu, Güven Mengü

Turkish Journal of Medical Sciences

No abstract provided.

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The Dose-Dependent Effect Of Grayanotoxin On The Cardiovascular System, Süha Türkmen, Ülkü Karagöz, Abdülkadi̇r Gündüz, Süleyman Türedi̇, Metehan Akça, Mehmet Yildirim Jan 2013

The Dose-Dependent Effect Of Grayanotoxin On The Cardiovascular System, Süha Türkmen, Ülkü Karagöz, Abdülkadi̇r Gündüz, Süleyman Türedi̇, Metehan Akça, Mehmet Yildirim

Turkish Journal of Medical Sciences

Mad honey (grayanotoxin, GTX) poisoning is caused by a toxin binding to the sodium channels of a cell membrane. This study investigates the dose-dependent effect of GTX on the cardiovascular system. Materials and methods: Twenty-four male Sprague Dawley rats were divided into 4 equal groups. Group 1 was the control group and was administered only saline. GTX-III was administered in doses of 200, 400, and 800 µg/kg for Groups 2, 3, and 4, respectively. After GTX-III injection, blood pressure and heart rate were recorded using an electrophysiological data acquisition system. Results: After 200 µg/kg GTX-III injection, at 31-60 min, the …

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Prevalence Of Carotid Artery Calcification On Panoramic Radiographs In Patients With Renal Stones, İhsan Üstün, Mehmet İnci̇, Abdullah Demi̇rtaş, Yildiray Şi̇şman, Cumali̇ Gökçe, Eli̇f Tarim Ertaş Jan 2013

Prevalence Of Carotid Artery Calcification On Panoramic Radiographs In Patients With Renal Stones, İhsan Üstün, Mehmet İnci̇, Abdullah Demi̇rtaş, Yildiray Şi̇şman, Cumali̇ Gökçe, Eli̇f Tarim Ertaş

Turkish Journal of Medical Sciences

To determine the prevalence of carotid artery calcification (CAC) detected in routine dental radiography (PRs) in patients with kidney stones (KSs) and to investigate the relationship between CAC-atherosclerosis and KSs. Materials and methods: A total of 108 patients with renal stones were included in the present study. A history of renal colic, with confirmed hematuria and voiding of the calculus, radiographic evidence of KSs, or previous surgical and endoscopic removal of KSs, was used to define the nephrolithiasis. KS patients were evaluated by PR in terms of the presence of CAC. Subjects with either unilateral or bilateral CAC on these …

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Prediction Of Neurological Outcome Using Bispectral Index In Patients With Severe Acute Brain Injury, Wang Xifeng, Zhang Lianshuang, Wu Dawei Jan 2013

Prediction Of Neurological Outcome Using Bispectral Index In Patients With Severe Acute Brain Injury, Wang Xifeng, Zhang Lianshuang, Wu Dawei

Turkish Journal of Medical Sciences

To predict consciousness recovery and outcome of patients with severe acute brain injury using the bispectral index (BIS). Materials and methods: A prospective study of 189 brain-injured patients was made when they were without sedatives for at least 24 h. BIS, 95% spectral edge frequency (SEF), burst suppression ratio (SR), total power (TP), spontaneous electromyographic activity (EMG), and signal quality index (SQI) were recorded continuously for 30 min. Neurologic conditions were measured with the Glasgow Coma Score (GCSBIS) when recording BIS. Patients were followed for 30 days after injury to assess consciousness recovery and outcome. Results: There were statistically significant …

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Ankaferd Blood Stopper: Does It Have A Role In Fracture Healing?, Murat Günay, Ramazan Amanvermez, Gökhan Keleş Jan 2013

Ankaferd Blood Stopper: Does It Have A Role In Fracture Healing?, Murat Günay, Ramazan Amanvermez, Gökhan Keleş

Turkish Journal of Medical Sciences

To examine the effect of Ankaferd Blood Stopper (ABS) on bone healing using a rat femur fracture model. Materials and methods: Eight rats were used as a control group (group 1), which was not subjected to fractures. The remaining 48 rats were divided into 6 groups of 8 each. The femoral shaft fractures were produced by cutting with bone scissors. One milliliter of ABS was applied to the fracture region of groups 3 (day 7), 5 (day 21), and 7 (day 45), or rats treated with saline instead of ABS on the fracture region in groups 2 (day 7), 4 …

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Influence Of Alpha Lipoic Acid On Epithelial Apoptosis In Experimental Periodontitis, Adem Kara, Sümeyra Akman, Tevfi̇k Demi̇rci̇, Taner Arabaci, Varol Çanakçi, Bünyami̇ Ünal Jan 2013

Influence Of Alpha Lipoic Acid On Epithelial Apoptosis In Experimental Periodontitis, Adem Kara, Sümeyra Akman, Tevfi̇k Demi̇rci̇, Taner Arabaci, Varol Çanakçi, Bünyami̇ Ünal

Turkish Journal of Medical Sciences

Alpha lipoic acid (ALA) is a powerful antioxidant. Its antiinflammatory effects and apoptotic mechanism have recently been studied in many diseases. This study aimed to investigate the effects of ALA on apoptotic activity in the treatment of periodontitis. Materials and methods: Thirty male Wistar rats were randomly divided into 3 groups: control (without ligature), PED (ligature + placebo, saline; oral gavage), and ALA+PED (ligature + alpha lipoic acid at 50 mg/kg/day in saline; oral gavage). Histological and biochemical analyses were performed on the mandibular first molars of sacrificed rats. Results: Biochemical myeloperoxidase activity in gingivo-mucosal tissue was measured. For immunohistochemical …

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One Single-Tube Pcr Assay To Detect Both Cd17 (A>T) And Ivs-Ii Nt-654 (C>T) Homozygous Mutations Of \Beta-Thalassemia, Qi Liu, Jun-Li Wang, Guo-Can Yang, Xue-Jun Dong, Zong-Xin Wang, Guo-Xing Ge, Xiao-Feng Gu Jan 2013

One Single-Tube Pcr Assay To Detect Both Cd17 (A>T) And Ivs-Ii Nt-654 (C>T) Homozygous Mutations Of \Beta-Thalassemia, Qi Liu, Jun-Li Wang, Guo-Can Yang, Xue-Jun Dong, Zong-Xin Wang, Guo-Xing Ge, Xiao-Feng Gu

Turkish Journal of Medical Sciences

Several methods can be used to detect gene mutations associated with \beta-thalassemia, but it is difficult to achieve reliable and reproducible results. In this study, we introduce a new method, a single-tube multiplex polymerase chain reaction (PCR) assay, to detect both CD17 (A>T) and IVS-II nt-654 (C>T) homozygous mutations. Materials and methods: This new method designs specific primers to diagnose homozygous mutations and normal controls. Results: After PCR amplification, homozygous mutations produce different fragments from normal controls. Conclusion: This study represents an important step towards the development of a novel protocol to diagnose \beta-thalassemia and other diseases that …

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Prevalence Of Type 1 Diabetes Mellitus In School Children 6–18 Years Old In Diyarbakır, Southeastern Anatolian Region Of Turkey, Hüseyi̇n Demi̇rbi̇lek, Mehmet Nuri̇ Özbek Jan 2013

Prevalence Of Type 1 Diabetes Mellitus In School Children 6–18 Years Old In Diyarbakır, Southeastern Anatolian Region Of Turkey, Hüseyi̇n Demi̇rbi̇lek, Mehmet Nuri̇ Özbek

Turkish Journal of Medical Sciences

The frequency of type 1 diabetes mellitus (T1DM) differs according to factors like geographical location, ethnicity, sex, and age. There are few studies investigating T1DM prevalence in the children of Turkey or of the Southeastern Anatolian Region. We aimed to define T1DM prevalence and to investigate geographic and sociodemographic features in school children 6-18 years old living in Diyarbakır. Materials and methods: The number of children with T1DM and the total number of children at the schools were defined in cooperation with the Diyarbakır Provincial Education Directorate. T1DM prevalence was calculated with the obtained data. Results: The number of school …

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The Effect Of Chloroquine Treatment In Malignant Astrocytomas On Prognosis, Turgay Bulut, Mehmet Ali̇ Eki̇ci̇, Bülent Tucer, Seyi̇t Kağan Başarslan, Kağan Kamaşak, Ali̇ Kurtsoy Jan 2013

The Effect Of Chloroquine Treatment In Malignant Astrocytomas On Prognosis, Turgay Bulut, Mehmet Ali̇ Eki̇ci̇, Bülent Tucer, Seyi̇t Kağan Başarslan, Kağan Kamaşak, Ali̇ Kurtsoy

Turkish Journal of Medical Sciences

To investigate the adjuvant role of the antimutagenic agent chloroquine in the treatment of patients with malignant astrocytomas (MAs). Materials and methods: Clinical research was conducted at the Neurosurgery Clinic of the Erciyes University School of Medicine, from September 2003 to April 2007, on 37 patients diagnosed with MA after tumor resection subsequent to craniotomy. Chloroquine treatment was started on a daily dose of 150 mg, additional to the patients' radiotherapy and chemotherapy protocol, and was continued throughout the 43-month surveillance period. A control group was formed of 81 patients with MA after the craniotomy. Results: While the mean survival …

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Determination Of Mitochondrial Fragmentation And Autophagosome Formation In C2c12 Skeletal Muscle Cells, Saadet Türkseven, Antonio Zorzano Jan 2013

Determination Of Mitochondrial Fragmentation And Autophagosome Formation In C2c12 Skeletal Muscle Cells, Saadet Türkseven, Antonio Zorzano

Turkish Journal of Medical Sciences

To investigate the effect of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) on mitochondrial elimination in C2C12 skeletal muscle cells. Materials and methods: C2C12 muscle cells stably expressing Mito-DsRed were treated with DMSO or CCCP at the doses of 10, 20, and 30 µM for 3, 6, and 24 h. After specific treatments, cells were fixed in 4% paraformaldehyde and immunocytochemistry assays were performed using appropriate antibodies to evaluate mitochondrial morphology and autophagosome formation. Total cell lysates were used for western blot assays. Results: CCCP induces mitochondrial fragmentation in C2C12 cells. In response to a mitochondrial uncoupler, endogenous autophagosome formation is significantly increased …

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Association Between Maternal Ghrelin Levels And Hyperemesis Gravidarum, İkbal Kaygusuz, İlknur İnegöl Gümüş, Melahat Yildirim, Hüsametti̇n Erdamar, Aysel Uysal, Serap Aynur Si̇mavli, Abdullah Ayyildiz, Muhammet Ramazan Yi̇ği̇toğlu Jan 2013

Association Between Maternal Ghrelin Levels And Hyperemesis Gravidarum, İkbal Kaygusuz, İlknur İnegöl Gümüş, Melahat Yildirim, Hüsametti̇n Erdamar, Aysel Uysal, Serap Aynur Si̇mavli, Abdullah Ayyildiz, Muhammet Ramazan Yi̇ği̇toğlu

Turkish Journal of Medical Sciences

To investigate serum levels of ghrelin in pregnant women as a potential early marker for hyperemesis gravidarum (HG). Materials and methods: A cross-sectional study was carried out at Fatih University Hospital. Included in the study were 35 women with HG and 31 pregnant women without HG as a control group. The groups were compared in terms of age, gravidity, body mass index (BMI), and fasting serum thyroid-stimulating hormone (TSH) and ghrelin levels. Results: Ghrelin levels of the patients with HG were found to be significantly lower than those in the control group (P = 0.03). No intergroup differences could be …

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Prognostic Factors In Patients With Glioblastoma Multiforme (Clinical Research), Mehmet Ali̇ Eki̇ci̇, Turgay Bulut, Bülent Tucer, Seyi̇t Kağan Başarslan, Ali̇ Kurtsoy Jan 2013

Prognostic Factors In Patients With Glioblastoma Multiforme (Clinical Research), Mehmet Ali̇ Eki̇ci̇, Turgay Bulut, Bülent Tucer, Seyi̇t Kağan Başarslan, Ali̇ Kurtsoy

Turkish Journal of Medical Sciences

To define the independent variables that affect the life spans of patients with glioblastoma multiforme (GBM). Materials and methods: This study was conducted in the neurosurgery clinic of Erciyes University's Faculty of Medicine, lasting from February 2000 to September 2006. A total of 98 patients were diagnosed with GBM after tumor resections. Patients' demographic, neurological, radiological, surgical, and clinical features and adjunct therapies were analyzed retrospectively. Results: Of the 98 patients, 36 (36.7%) were female and 62 (65.4%) were male. There were 15 patients (15.3%) still alive. The median survival time (MST) of the gross total resection and subtotal resection …

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Evaluation Of Early Corneal Topographic Changes In Children With Down Syndrome, Murat Aslankurt, Lokman Aslan, Adnan Aksoy, Muhammed Mustafa Kurt, Murat Özdemi̇r Jan 2013

Evaluation Of Early Corneal Topographic Changes In Children With Down Syndrome, Murat Aslankurt, Lokman Aslan, Adnan Aksoy, Muhammed Mustafa Kurt, Murat Özdemi̇r

Turkish Journal of Medical Sciences

To evaluate early corneal changes using a Scheimpflug imaging (SI) system (Pentacam) in a pediatric population with Down syndrome. Materials and methods: This study was carried out in a prospective and nonrandomized fashion. Twenty-seven children with Down syndrome and 30 healthy subjects were enrolled in the study. Corneal measurements were done using a Scheimpflug topography system. Central corneal thickness (CCT), minimum corneal thickness (CTmin), central corneal power (CP), difference of central corneal power (DCP) between 2 eyes, inferior superior steepening (I-S), and keratoconus indices were tested with a SI device. Results: Mean CCT and CTmin values were significantly lower in …

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The Effects Of Thyroid Hormones On Uroflowmetry Parameters In Asymptomatic Women, Ersi̇n Çi̇mentepe, Mehmet Erol Yildirim, İlkay Beki̇r İncebay, Ayşe Çarlioğlu, Ömer Faruk Karataş, Doğan Ünal Jan 2013

The Effects Of Thyroid Hormones On Uroflowmetry Parameters In Asymptomatic Women, Ersi̇n Çi̇mentepe, Mehmet Erol Yildirim, İlkay Beki̇r İncebay, Ayşe Çarlioğlu, Ömer Faruk Karataş, Doğan Ünal

Turkish Journal of Medical Sciences

To investigate whether there is any association between uroflowmetry parameters and blood levels of thyroid hormones in asymptomatic women. Materials and methods: Included in the study were 110 consecutive female patients with no urinary complaints who had thyroid function tests performed in an endocrinology clinic. Uroflowmetric measurements were performed for each patient in a sitting position. The patients were divided into 3 groups, hypo-, hyper-, and euthyroidism, and were investigated for statistical difference among them regarding maximum flow rate (Qmax), average flow rate (Qave), voided volume (VV), and voiding time (VT). Results: The mean Qmax and Qave values of hypo-, …

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Serum Leptin Levels And Their Proportional Relationship With Pro- And Antiinflammatory Mediators In Aggressive Periodontitis: Preliminary Report, Zuhal Yetki̇n Ay, Recep Sütcü, Havva Koçak, Fatma Yeşi̇m Kirzioğlu Jan 2013

Serum Leptin Levels And Their Proportional Relationship With Pro- And Antiinflammatory Mediators In Aggressive Periodontitis: Preliminary Report, Zuhal Yetki̇n Ay, Recep Sütcü, Havva Koçak, Fatma Yeşi̇m Kirzioğlu

Turkish Journal of Medical Sciences

To investigate the serum level of leptin (OB) and its relationship with pro- and antiinflammatory cytokines/mediators in aggressive periodontitis (AP) patients. Materials and methods: The study population (n = 12) comprised 6 AP patients and 6 periodontally healthy subjects (HC). The fasting venous serum samples were used to determine the OB and the cytokines/mediators belonging to the Th1/Th2/Th17 cells. The correlations among the OB and cytokines/mediators in the serum and clinical periodontal parameters were also investigated. Results: The AP group presented significantly higher serum TGF-\beta1 and IL-2 concentrations (pg/mL) and lower IL-4, IL-5, IL-12, IL-13, and IL-17A concentrations than the …

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Effect Of Polyneuropathy On Development Of Unilateral Diabetic Foot Ulcer, Fatma Cansel Kaleağasi, Kezban Aslan, Hacer Bozdemi̇r, Beki̇r Tamer Teti̇ker Jan 2013

Effect Of Polyneuropathy On Development Of Unilateral Diabetic Foot Ulcer, Fatma Cansel Kaleağasi, Kezban Aslan, Hacer Bozdemi̇r, Beki̇r Tamer Teti̇ker

Turkish Journal of Medical Sciences

This study investigates polyneuropathy in patients with unilateral diabetic foot ulcer by using electrophysiological methods and discusses whether electrophysiological parameters are predictive of diabetic foot ulcer development. Materials and methods: Fifty-two diabetic patients with unilateral diabetic foot ulcers (31 females, 21 males; mean age of 58.5 years) were included in the study. Results: In the upper extremities, motor fibers were affected in 82% and sensorial fibers were affected in 85% of the subjects. In the lower extremities, motor fibers were affected in 90% of the subjects in the injured site and in 79% of the patients in the intact site, …

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Haematological Changes In Malaria-Infected Children In North-West Nigeria, Momodu Imoru, Umar A. Shehu, Uchechukwu Gabriel Ihesiulor, Aminu Haruna Kwaru Jan 2013

Haematological Changes In Malaria-Infected Children In North-West Nigeria, Momodu Imoru, Umar A. Shehu, Uchechukwu Gabriel Ihesiulor, Aminu Haruna Kwaru

Turkish Journal of Medical Sciences

Malaria is prevalent in the tropical and subtropical regions of the world and has been associated with some haematological changes. This study determined the effect of malaria infection on haematological values amongst children in north-western Nigeria. Materials and methods: Fifty-eight malaria-infected children, aged 1–12 years, and 58 age-matched uninfected children were studied between September and December 2011 at Aminu Kano Teaching Hospital, Kano. Blood samples collected were analysed for full blood count using a Swelab Alfa 3-part analyser and malaria parasite test using the field staining technique. Results: There were significantly lower values of haematocrit, haemoglobin concentration, and platelet count …

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Posttonsillectomy Pain Relief And Epithelialization With Honey, Pathma Letchumanan, Raman Rajagopalan, Mohd Yusoff Kamaruddin Jan 2013

Posttonsillectomy Pain Relief And Epithelialization With Honey, Pathma Letchumanan, Raman Rajagopalan, Mohd Yusoff Kamaruddin

Turkish Journal of Medical Sciences

To assess the ability of honey to reduce pain and promote epithelialization on posttonsillectomy wounds. Materials and methods: A prospective randomized control study was conducted on 60 patients undergoing tonsillectomy from November 2007 to September 2008 at University Malaya Medical Centre. The test group received honey application on the tonsillar bed and the control group had placebo applied. The pain relief was analyzed along with the amount of analgesia consumed, and wound epithelialization was monitored and recorded accordingly. Results: Twenty-one patients from each group were finally analyzed after excluding patients that did not complete the study or fit the criteria. …

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Glutaredoxin-2 Is Required To Control Proton Leak Through Uncoupling Protein-3, Ryan J. Mailloux, Jian Ying Xuan, Brittany Beauchamp, Marjorie F. Lou, Mary-Ellen Harper Jan 2013

Glutaredoxin-2 Is Required To Control Proton Leak Through Uncoupling Protein-3, Ryan J. Mailloux, Jian Ying Xuan, Brittany Beauchamp, Marjorie F. Lou, Mary-Ellen Harper

School of Veterinary and Biomedical Sciences: Faculty Publications

Glutathionylation has emerged as a key modification required for controlling protein function in response to changes in cell redox status. Recently, we showed that the glutathionylation state of uncoupling protein-3 (UCP3) modulates the leak of protons back into the mitochondrial matrix, thus controlling reactive oxygen species production. However, whether or not UCP3 glutathionylation is mediated enzymatically has remained unknown because previous work relied on the use of pharmacological agents, such as diamide, to alter the UCP3 glutathionylation state. Here, we demonstrate that glutaredoxin-2 (Grx2), a matrix oxidoreductase, is required to glutathionylate and inhibit UCP3. Analysis of bioenergetics in skeletal muscle …

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Electroporation-Mediated Gene Transfer Directly To The Swine Heart, Barbara Hargrave, Harre Downey, Cathryn Lundberg, Annelise Israel, Yeong-Jer Chen, Richard Heller Jan 2013

Electroporation-Mediated Gene Transfer Directly To The Swine Heart, Barbara Hargrave, Harre Downey, Cathryn Lundberg, Annelise Israel, Yeong-Jer Chen, Richard Heller

Bioelectrics Publications

In vivo gene transfer to the ischemic heart via electroporation holds promise as a potential therapeutic approach for the treatment of heart disease. In the current study, we investigated the use of in vivo electroporation for gene transfer using three different penetrating electrodes and one non-penetrating electrode. The hearts of adult male swine were exposed through a sternotomy. Eight electric pulses synchronized to the rising phase of the R wave of the electrocardiogram were administered at varying pulse widths and field strengths following an injection of either a plasmid encoding luciferase or one encoding green fluorescent protein. Four sites on …

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Different Mechanisms Of Inflammation Induced In Virus And Autoimmune-Mediated Models Of Multiple Sclerosis In C57bl6 Mice., Abhinoy Kishore, Anurag Kanaujia, Soma Nag, A M Rostami, Lawrence C. Kenyon, Kenneth S Shindler, Jayasri Das Sarma Jan 2013

Different Mechanisms Of Inflammation Induced In Virus And Autoimmune-Mediated Models Of Multiple Sclerosis In C57bl6 Mice., Abhinoy Kishore, Anurag Kanaujia, Soma Nag, A M Rostami, Lawrence C. Kenyon, Kenneth S Shindler, Jayasri Das Sarma

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system (CNS). Neurotropic demyelinating strain of MHV (MHV-A59 or its isogenic recombinant strain RSA59) induces MS-like disease in mice mediated by microglia, along with a small population of T cells. The mechanism of demyelination is at least in part due to microglia-mediated myelin stripping, with some direct axonal injury. Immunization with myelin oligodendrocyte glycoprotein (MOG) induces experimental autoimmune encephalomyelitis (EAE), a mainly CD4(+) T-cell-mediated disease, although CD8(+) T cells may play a significant role in demyelination. It is possible that both autoimmune and nonimmune mechanisms such as …

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Exome Sequencing Reveals De Novo Germline Mutation Of The Mammalian Target Of Rapamycin (Mtor) In A Patient With Megalencephaly And Intractable Seizures, Laurie D. Smith, Carol J. Saunders, Darrell L. Dinwiddie, Andrea M. Atherton, Neil A. Miller, Sarah E. Soden, Emily G. Farrow, Ahmed T G Abdelmoity, Stephen F. Kingsmore Jan 2013

Exome Sequencing Reveals De Novo Germline Mutation Of The Mammalian Target Of Rapamycin (Mtor) In A Patient With Megalencephaly And Intractable Seizures, Laurie D. Smith, Carol J. Saunders, Darrell L. Dinwiddie, Andrea M. Atherton, Neil A. Miller, Sarah E. Soden, Emily G. Farrow, Ahmed T G Abdelmoity, Stephen F. Kingsmore

Manuscripts, Articles, Book Chapters and Other Papers

A de novo somatic mutation in the mammalian target of rapamycin (MTOR) has previously been described in one patient with hemimegalencephaly and epilepsy. Here, we present a case of a young girl with megalencephaly and intractable seizures who was found to have an MTOR mutation in multiple cell lineages (p.Cys1483Phe) and, therefore, presumed to be of germline origin. The mutation was detected in peripheral blood DNA by exome sequencing of the patient and her parents, substantiating the utility of this approach for detection of clinically relevant de novo variations.

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