Medicine and Health Sciences Commons^™

Clonal Hematopoiesis Risk Score And All-Cause And Cardiovascular Mortality In Older Adults, Seyedmohammad Saadatagah, Md Mesbah Uddin, Lachelle D Weeks, Abhishek Niroula, Meng Ru, Koichi Takahashi, Lukasz Gondek, Bing Yu, Alexander G Bick, Benjamin L Ebert, Elizabeth A Platz, Pradeep Natarajan, Christie M Ballantyne

Faculty, Staff and Student Publications

IMPORTANCE: Clonal hematopoiesis (CH) with acquired pathogenic variants in myeloid leukemia driver genes is common in older adults but of unknown prognostic value.

OBJECTIVE: To investigate the prevalence of CH and the utility of the CH risk score (CHRS) in estimating all-cause and disease-specific mortality in older adults with CH.

DESIGN, SETTING, AND PARTICIPANTS: This population-based prospective cohort study involved community-dwelling older adults (aged 67-90 years) without hematologic malignant neoplasms (HMs) who were participants in the Atherosclerosis Risk in Communities Visit 5 at 4 US centers: Forsyth County, North Carolina; Jackson, Mississippi; Minneapolis, Minnesota; and Washington County, Maryland. Samples were …

Appelmans Protocol – A Directed In Vitro Evolution Enables Induction And Recombination Of Prophages With Expanded Host Range, Thao Nguyen Vu, Justin Ryan Clark, Eris Jang, Roshan D'Souza, Le Phuong Nguyen, Naina Adren Pinto, Seongjun Yoo, Ricardo Abadie, Anthony William Maresso, Dongeun Yong

Faculty, Staff and Students Publications

Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) present significant healthcare challenges due to limited treatment options. Bacteriophage (phage) therapy offers potential as an alternative treatment. However, the high host specificity of phages poses challenges for their therapeutic application. To broaden the phage spectrum, laboratory-based phage training using the Appelmans protocol was employed in this study. As a result, the protocol successfully expanded the host range of a phage cocktail targeting CRAB. Further analysis revealed that the expanded host range phages isolated from the output cocktail were identified as recombinant derivatives originating from prophages induced from encountered bacterial strains. These findings …

Role Of Cyp3a5 In Prostate Cancer Growth, Ranjana Mitra, Jake Mclean, Ajay P. Singh, Edwin C. Oh

COM Scholarship

No abstract provided.

Fused In Sarcoma Regulates Glutamate Signaling And Oxidative Stress Response, Chiong-Hee Wong, Abu Rahat, Howard C Chang

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Mutations in fused in sarcoma (fust-1) are linked to ALS. However, how these ALS causative mutations alter physiological processes and lead to the onset of ALS remains largely unknown. By obtaining humanized fust-1 ALS mutations via CRISPR-CAS9, we generated a C. elegans ALS model. Homozygous fust-1 ALS mutant and fust-1 deletion animals are viable in C. elegans. This allows us to better characterize the molecular mechanisms of fust-1-dependent responses. We found FUST-1 plays a role in regulating superoxide dismutase, glutamate signaling, and oxidative stress. FUST-1 suppresses SOD-1 and VGLUT/EAT-4 in the nervous system. FUST-1 also regulates synaptic AMPA-type glutamate receptor …

Activation Of Renal Epithelial Na+ Channels (Enac) In Infants With Congenital Heart Disease, Laura Ortmann, Shyam Sundar Nandi, Yulong Li, Hong Zheng, Kaushik K. Patel

Journal Articles: Cellular & Integrative Physiology

INTRODUCTION: This study was designed to measure the concentration and activity of urinary proteases that activate renal epithelial sodium channel (ENaC) mediated Na

METHODS: Urine samples from infants undergoing cardiac surgery were collected at three time points: T1) pre-operatively, T2) 6-8 h after surgery, and T3) 24 h after diuretics. Urine was collected from five heathy infant controls. The urine was tested for four proteases and whole-cell patch-clamp testing was conducted in renal collecting duct M-1 cells to test whether patient urine increased Na

RESULTS: Heavy chain of plasminogen, furin, and prostasin were significantly higher in cardiac patients prior to …

Winona State University Alumni Blog: 2011-2022, Winona State University

Winona State University Blogs

The Winona State University (WSU) Alumni Blog includes articles and entries from May 2011- August 2022. Note: there may be format coding in the document.

Incorporation Of Nutrition Education With Medication Injection To Sustain Weight Loss, Julia Calvelo

Nursing | Senior Theses

Background: Obesity is a widespread occurrence linked to comorbidities. Weight loss and maintenance is crucial to sustain existing health conditions and reduce risk of chronic diseases.

Lack of maintained weight loss is associated with poor education on nutrition, diet, and physical activity literacy. Objective: The purpose of this quantitative experimental study is to determine the efficacy of nutrition education among medication injection to sustain weight loss throughout treatment. It aims to promote comprehension of the aspects of nutrition, dietary habits, and physical education to not only sustain weight loss, but to understand the significance of how these elements contribute to …

The E-Liquid Flavorings Cinnamaldehyde, Vanillin, And Ethyl Vanillin Induce Cellular Stress Responses In Human Proximal Tubule (Hk-2) Epithelial Cells, Ashley J. Cox

Theses, Dissertations and Capstones

The use of electronic nicotine delivery systems (ENDS) has become popular in recent years as an alternative to traditional cigarettes. These devices heat and subsequently vaporize e-liquids for inhalation by the user, which allows for the delivery of ingredients such as flavorings, nicotine, and solvents through the vapor. Flavorings used in e-liquids are “generally recognized as safe” (GRAS) for consumption by the Food and Drug Administration (FDA), however there are currently no recommendations on safety regarding the inhalation of flavoring agents. While research characterizing effects of e-liquids and their flavorings is abundant in lung and respiratory tract models, few studies …

Lipid Genetics In Pregnant Women: Maneuvering The Challenges Of Using Degraded Samples, Kylee Meece

Mahurin Honors College Capstone Experience/Thesis Projects

The results of this project will explore a novel approach to lipid metabolism in pregnant women by exploring the relationship between maternal gene expression of genes critical for fat metabolism, protein expression, and maternal and neonatal outcomes. The study will also examine gene expression in lean pregnant women compared to obese pregnant women, shedding light into the adverse pathology of obesity during pregnancy. These findings may uncover a mechanism related to gene-expression that connects unfavorable maternal fat metabolism to inflammation and/or insulin resistance, which may help to uncover future targets for interventions.

The analysis of lipid gene expression requires the …

The Effects Of Bisphenol S On Glial Cells Of The Peripheral Nervous System, Madeline Solomon, Rachael Sennett, Angela Asirvatham

Student Research Poster Presentations 2024

Schwann cells are glial cells in the peripheral nervous system that maintain nerve function and myelination. Peripheral nerve myelination is dependent on intact Schwann cell proliferation. Schwann cell proliferation can be adversely affected by environmental pollutants such as Bisphenol A (BPA). BPA is an endocrine-disrupting chemical found in plastic water bottles, receipt paper, containers, and many everyday products. Studies on BPA exposure showed that it stimulated cellular proliferation in neural stem cells. A commonly used manufactured derivative of BPA, Bisphenol S (BPS), has posed similar concerns. Previous research has found that BPS promotes the proliferation of MCF-7 breast cancer cells …

Nurse's Knowledge On Mind Diet For Early-Onset Alzheimer's Disease, Audrey Marie Rafols

Nursing | Student Research Posters

Adults with Early Onset Alzheimer's Disease (EOAD), is the less common form of the neurodegenerative disease of Alzheimer's Disease (AD), where EOAD is found in adults younger than 65 years old (Alzheimer's Association, 2024). Characterized by a decline of memory, cognitive decline, loss of ability to perform daily tasks involving mobility and communication, EOAD does not have one significant cause. A combination of risk factors are genetics and lifestyle factors such as heart disease, history of stroke, and high blood pressure are associated with increasing the risk of EOAD (National Institute of Aging, 2024).

Since there is no cure for …

Progression Magazine, 2023-2024, Coastal Carolina University

Progression Magazine

Magazine of the Gupta College of Science at Coastal Carolina University.

A Diagnostic Challenge – Tinu Syndrome, Sophia Lee, Md, Claire Kassakian, Md

Poster Presentations

No abstract provided.

Role Of Plasmapheresis: A Tale Of Two Thyroid Storms, Zhiwei Zhang, Sam Joseph, Donald Eagerton

South Atlantic Division GME Research Day 2024

No abstract provided.

Adolescent Mental Health In The Twenty-First Century, Arthur Maerlander, Patricia Gail Bray

Center for Brain, Biology, and Behavior: Faculty Publications

Conclusion

Parents do not suddenly relinquish medical decision-making to their children and are a vital part of a process construed within the framework of consent and confidentiality laws. In the transition period from childhood to adulthood, adolescents develop unique healthcare needs and concerns at the very time they are gaining autonomy from their parents. Adolescents progress from being recipients of decisions about their care to gradually becoming active participants in their healthcare and emerge as a primary partner in medical decision-making. Building a strong therapeutic alliance with young people can help them become responsible healthcare decision-makers.

Yet while “healthcare,” including …

Associations Of Sex And Sport Contact‑Level With Recovery Timelines Among Collegiate Athletes With Sport‑Related Concussion, Bernadette A. D'Alonzo, Andrea L. C. Schneider, Ian J. Barnett, Christina L. Master, Abigail C. Bretzin, Douglas J. Wiebe, Ivy League-Big Ten Epidemiology Of Concussion Study Investigators

Center for Brain, Biology, and Behavior: Faculty Publications

Background

Growing interest has motivated recent studies to examine differences in recovery after sportrelated concussion (SRC) by sex. However, heterogeneity in study design, participants, and recovery outcomes has led to mixed findings. Further work is needed to evaluate potential differences by sex and to investigate the role of related characteristics, such as sport contact-level, in recovery timelines. This study aimed to investigate whether concussion recovery trajectories differ by sex, considering a priori clinical and demographic covariates, and accounting for the sequence of recovery outcomes. Our secondary question was whether sport contact-level modifies the relationship between sex and time to outcomes. …

Empowering Kokal: A Decolonized, Community-Led Development Model In Homa Bay County, Kenya, Kennedy Miruka

Regis University Student Publications (comprehensive collection)

In Homa Bay County, Kenya, a community-led development initiative called the Power Centre is transforming the fight against poverty and powerlessness. Grounded in principles of decolonization and participatory action, this project addresses the root causes of marginalization by empowering residents of Kokal Village to become active agents of change. Through a robust mixed-methods research approach, the project identifies systemic challenges and leverages existing social networks to build a sustainable, locally-owned model for development. The Power Centre implements a three-pronged strategy, focusing on increasing community participation, strengthening existing groups, and fostering collaborative networks to weave a robust support system. By addressing …

Power Centres: A Collaborative Development Proposal For Addressing Poverty And Related Challenges In Rural Communities In Kenya, Kennedy Okello Miruka, Kennedy Okello Miruka

Regis University Student Publications (comprehensive collection)

In Homa Bay County, Kenya, a community-led development initiative called the Power Centre is transforming the fight against poverty and powerlessness. Grounded in principles of decolonization and participatory action, this project addresses the root causes of marginalization by empowering residents of Kokal Village to become active agents of change. Through a robust mixed-methods research approach, the project identifies systemic challenges and leverages existing social networks to build a sustainable, locally-owned model for development. The Power Centre implements a three-pronged strategy, focusing on increasing community participation, strengthening existing groups, and fostering collaborative networks to weave a robust support system. By addressing …

Food Accessibility Struggles For College Students With Dietary Restrictions, Ella Schleuning

Mahurin Honors College Capstone Experience/Thesis Projects

College is a time when many students experience independence for the first time in their lives. This is the first time they have had to do their laundry on their own, keep their room clean, and maybe most importantly, they are responsible for figuring out where they are going to eat every day, for every meal. The focus of this study is on food accessibility struggles for college students, specifically looking at Western Kentucky University’s (WKU) food on-campus, as well as students with dietary restrictions.

Since college is the first-time students are responsible for their own meals, it can often …

Winona State University Improving Our World Blog: 2013-2022, Winona State University

Winona State University Blogs

The Winona State University (WSU) Improving Our World Blog articles and entries from September 2013-February 2022. Note: there may be format coding in the document.

Winona State University Rochester Blog:2014-2023, Winona State University

Winona State University Blogs

The Winona State University (WSU) Rochester Blog includes articles and entries from May 2014-March 2023. Note: there may be format coding in the document.

Winona State University Campus Life Blog: 2013-2022, Winona State University

Winona State University Blogs

The Winona State University (WSU) Campus Life Blog includes articles and entries from October 2013- October 2022. Note: there may be format coding in the document.

Winona State University Wellness Blog: 2013-2023, Winona State University

Winona State University Blogs

The Winona State University (WSU) Wellness blog includes articles and entries from February 2013-February 2023. Note: there may be format coding in the document.

Factors That Influence The Prevalence Of Food Allergy In Children Born In Industrialized Countries Vs. Developing Countries: A Literature Review & Feasibility Study, Dimitri Miguel Lacson Torres

Nursing | Senior Theses

Background

Food allergy (FA) is known to be more prevalent in industrialized countries compared to developing countries. FA is a chronic disease that can cause a range of symptoms from regional urticaria to lethal anaphylaxis. FA affects 10% of the general population and is more common in children, affecting 8% of children versus 3% of adults (Seth, D. et al., 2020). It is unclear why food allergy is more common in industrialized countries versus developing countries. Research Question What are the influential factors that affect the increasing incidence of food allergy in toddlers born in industrialized countries versus those that …

Role Of Insulin-Like Growth Factor-1 Signaling In Diet-Enhanced Bone Elongation, Cassaundra A. White

Theses, Dissertations and Capstones

Childhood obesity has increased precipitously to the point that almost 20% of children between the ages of 2 and 19 have been diagnosed with obesity. While obesity is a complex metabolic disorder, one contributing factor is diet, particularly a diet high in fat. Among many problems associated with diet-induced obesity, the impact on skeletal health is often overlooked. In addition to increased stress on the skeleton due to excess weight, obesity also disrupts the endocrine and immune systems that, in turn, can secondarily alter skeletal growth. Obesity during the early years of childhood is particularly detrimental because the skeleton is …

Inverse Association Between Exercising Blood Pressure Response And Left Ventricular Chamber Size And Mass In Women Who Habitually Resistance Train, Evan L. Matthews

Research Data

Excel document of research data.

Microvascular Reactivity Is Greater Following Blood Flow Restriction Resistance Exercise Compared To Traditional Resistance Exercise, Michael R. Perlet, Evan L. Matthews

Research Data

Excel document of research data, statistical analysis, and graphs.

Limitations Of Invasive Snake Control Tools In The Context Of A New Invasion On An Island With Abundant Prey, Shane R. Siers, Melia G. Nafus, Jereid E. Calaor, Rachel M. Volsteadt, Matthew S. Grassi, Megan Volsteadt, Aaron F. Collins, Patrick D. Barnhart, Logan T. Huse, Amy A. Yackel Adams, Diane L. Vice

United States Department of Agriculture Wildlife Services: Staff Publications

In October 2020, a new population of invasive brown treesnakes (Boiga irregularis) was discovered on the 33-ha Cocos Island, 2.5 km off the south coast of Guam, United States. Cocos Island is a unique conservation resource, providing refuge for many lizards and birds, including endangered species, which were extirpated from mainland Guam by invasive predators including brown treesnakes. We sought to evaluate the usefulness of toxic baiting with acetaminophen-treated carrion baits and cage trapping, common tools for the control of brown treesnakes on mainland Guam, as potential eradication tools on Cocos Island. We evaluated multiple bait types and …

Site-Specific Space Use And Resource Selection By Black Vultures (Coragyps Atratus) In The Southeastern Usa, Betsy Evans, John S. Humphrey, Eric A. Tillman, Michael L. Avery, Bryan M. Kluever

United States Department of Agriculture Wildlife Services: Staff Publications

North American populations of Black Vultures Coragyps atratus have increased and expanded their distribution in the southern and eastern USA. In conjunction with these patterns has been a rise in human–vulture conflicts. To improve our understanding of space use patterns and better inform management, we evaluated the movements of Black Vultures (n = 23) in the southeastern USA using a long-term GPS tracking database. Our specific objectives were to: (1) quantify home-range sizes in relation to season and geographical study location and (2) examine within-home-range resource selection to identify landscape and anthropogenic factors influencing roost and diurnal space use. …

Antipredator Blood-Squirting Defense In Horned Lizards (Phrynosoma): Chemical Isolation Of Plasma Component(S), Pogonomyrmex Ant Dietary Origin, And Evolution, Wade C. Sherbrooke, Bruce A. Kimball

United States Department of Agriculture Wildlife Services: Staff Publications

North American horned lizards of the genus Phrynosoma are largely myrmecophagous and squirt systemic blood from circumocular sinuses during encounters with certain mammalian predators. The predators react with distinct revulsion. Using bioassay-guided fractionation of blood plasma, we endeavored to identify the source and characteristics of the active chemical compound(s) responsible for this negative oral response. Our results of coyote bioassays and a series of novel mouse bioassay experiments were largely concordant. The active compound(s) was likely plasma-borne with a molecular weight (mw) of between 800 and 1,600. To identify the source of the active compound(s), we noted bioassay responses …