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Articles 9061 - 9090 of 42156
Full-Text Articles in Medicine and Health Sciences
Eradication Of Feral Swine From A Barrier Island In Florida, Usa: An Examination Of Effort And Multi-Method, Multi-Species Population Indexing, Richard M. Engeman, Eric A. Tillman, Betsy A. Evans, John C. Griffin, Garrison Grobaski, Bradley S. Smith, John Stark, Bryan M. Kluever
Eradication Of Feral Swine From A Barrier Island In Florida, Usa: An Examination Of Effort And Multi-Method, Multi-Species Population Indexing, Richard M. Engeman, Eric A. Tillman, Betsy A. Evans, John C. Griffin, Garrison Grobaski, Bradley S. Smith, John Stark, Bryan M. Kluever
United States Department of Agriculture Wildlife Services: Staff Publications
Feral swine (Sus scrofa) were targeted for and successfully eradicated from Saint Vincent Island (SVI), a National Wildlife Refuge (NWR) along the coast of Florida’s panhandle to protect its habitats and uncharacteristically high diversity of wildlife species for barrier islands in the region, including federal and state-listed threatened and endangered species. The eradication effort was initiated in early 2015 and concluded in 2019. A total of 438 feral swine were removed from the Island, 417 by federal control experts and 21 by recreational hunters. In general, the amount of effort needed to eradicate each feral swine slowly increased …
Downed Wood Removal Effects On Survival And Site Fidelity Of Woodrats In A California Oak Woodland, Timothy J. Smyser, Michael A. Hardy, Amy J. Davis, William L. Preston, William D. Tietje
Downed Wood Removal Effects On Survival And Site Fidelity Of Woodrats In A California Oak Woodland, Timothy J. Smyser, Michael A. Hardy, Amy J. Davis, William L. Preston, William D. Tietje
United States Department of Agriculture Wildlife Services: Staff Publications
Owing to the increasing intensity and frequency of wildfires in the western United States, the removal of woody debris (downed dead wood and snags) from fire‐prone landscapes is being evaluated for wildfire mitigation. Consequently, the study of the ecological value of coarse woody debris to sustain dependent species has become of foremost importance. From 2004–2009, we used a before‐after control‐impact (BACI) study design to assess the effects of downed wood removal on a population of big‐eared woodrats (Neotoma macrotis) in an oak woodland (Quercus spp.) in coastal‐central California, USA. Using Pollock's robust design mark‐recapture analyses (with 12 …
High Thermal Quality Rookeries Facilitate High Thermoregulatory Accuracy In Pregnant Female Rattlesnakes, Haley A. Moniz, Jack Henry Buck, Hayley L. Crowell, Scott M. Goetz, Trevor D. Ruiz, Emily N. Taylor, Scott M. Bobacks
High Thermal Quality Rookeries Facilitate High Thermoregulatory Accuracy In Pregnant Female Rattlesnakes, Haley A. Moniz, Jack Henry Buck, Hayley L. Crowell, Scott M. Goetz, Trevor D. Ruiz, Emily N. Taylor, Scott M. Bobacks
United States Department of Agriculture Wildlife Services: Staff Publications
Temperature is a primary factor influencing organismal development, and the fluctuating daily and seasonal thermal regimes of temperate climates may challenge the ability of viviparous reptiles to optimize body temperatures during gestation. Testing how viviparous reptiles navigate highly variable thermal conditions (e.g., relatively cold nights and/or highly fluctuating temperatures) is a powerful way to understand how they use microhabitats for thermoregulatory benefits. We assessed the thermal ecology of pregnant and non-pregnant female prairie rattlesnakes (Crotalus viridis) inhabiting a high-elevation, montane shrubland in northwest Colorado throughout their short summer active season, addressing the thermal consequences of microhabitat selection with …
Characterizing Feral Swine Movement Across The Contiguous United States Using Neural Networks And Genetic Data, Rachael M. Giglio, Courtney F. Bowden, Ryan K. Brook, Antoinette J. Piaggio, Timothy J. Smyser
Characterizing Feral Swine Movement Across The Contiguous United States Using Neural Networks And Genetic Data, Rachael M. Giglio, Courtney F. Bowden, Ryan K. Brook, Antoinette J. Piaggio, Timothy J. Smyser
United States Department of Agriculture Wildlife Services: Staff Publications
Globalization has led to the frequent movement of species out of their native habitat. Some of these species become highly invasive and capable of profoundly altering invaded ecosystems. Feral swine (Sus scrofa × domesticus) are recognized as being among the most destructive invasive species, with populations established on all continents except Antarctica. Within the United States (US), feral swine are responsible for extensive crop damage, the destruction of native ecosystems, and the spread of disease. Purposeful human-mediated movement of feral swine has contributed to their rapid range expansion over the past 30 years. Patterns of deliberate introduction of …
Bayesian Integrated Species Distribution Models For Hierarchical Resource Selection By A Soaring Bird, Ryo Ogawa, Guiming Wang, L. Wes Burger, Bronson Strickland, J. Brian Davis, Fred L. Cunningham
Bayesian Integrated Species Distribution Models For Hierarchical Resource Selection By A Soaring Bird, Ryo Ogawa, Guiming Wang, L. Wes Burger, Bronson Strickland, J. Brian Davis, Fred L. Cunningham
United States Department of Agriculture Wildlife Services: Staff Publications
Migratory birds exhibit seasonal geographic range (hereafter, range) dynamics during the annual cycle. Few studies have examined how migratory birds select their habitats for range occupancy at the species level and space use at the individual level simultaneously. We hypothesized that environmental variables directly related to fitness components would affect the range occupancy probabilities of migrants, whereas environment variables related to movements and flights would affect the space use intensities of migrants. We built Bayesian integrated species distribution models (ISDMs) to evaluate the effects of climate conditions, wind conditions, and landcover compositions on the seasonal range dynamics of American white …
Raccoon Density Estimation From Camera Traps For Raccoon Rabies Management, Amy J. Davis, Wesley C. Dixon, Richard B. Chipman, Amy T. Gilbert, Jacob E. Hill, James C. Beasley, Olin E. Rhodes Jr., Guha Dharmarajan
Raccoon Density Estimation From Camera Traps For Raccoon Rabies Management, Amy J. Davis, Wesley C. Dixon, Richard B. Chipman, Amy T. Gilbert, Jacob E. Hill, James C. Beasley, Olin E. Rhodes Jr., Guha Dharmarajan
United States Department of Agriculture Wildlife Services: Staff Publications
Density estimation for unmarked animals is particularly challenging, yet density estimates are often necessary for effective wildlife management. Raccoons (Procyon lotor) are the primary terrestrial wildlife reservoir for Lyssavirus rabies within the United States. The raccoon rabies variant (RRVV) is actively managed at landscape scales using oral rabies vaccination (ORV) within the eastern United States. To effectively manage RRVV, it is important to know the density of raccoons to appropriately scale the density of ORV baits distributed on the landscape. We compared methods to estimate raccoon densities from camera‐trap data versus more intensive capture‐mark‐recapture (CMR) estimates across 2 …
Mechanosensory Encoding In Ex Vivo Muscle–Nerve Preparations, Stephen N. Housley, Evelyn A. Gardolinski, Paul Nardelli, J'Ana Reed, Mark M. Rich, Timothy C. Cope
Mechanosensory Encoding In Ex Vivo Muscle–Nerve Preparations, Stephen N. Housley, Evelyn A. Gardolinski, Paul Nardelli, J'Ana Reed, Mark M. Rich, Timothy C. Cope
Neuroscience, Cell Biology & Physiology Faculty Publications
Our objective was to evaluate an ex vivo muscle-nerve preparation used to study mechanosensory signalling by low threshold mechanosensory receptors (LTMRs). Specifically, we aimed to assess how well the ex vivo preparation represents in vivo firing behaviours of the three major LTMR subtypes of muscle primary sensory afferents, namely type Ia and II muscle spindle (MS) afferents and type Ib tendon organ afferents. Using published procedures for ex vivo study of LTMRs in mouse hindlimb muscles, we replicated earlier reports on afferent firing in response to conventional stretch paradigms applied to non-contracting, that is passive, muscle. Relative to in vivo …
Assessing The Effectiveness Of Goal-Directed Versus Stimulus Driven Visual Search Training At Improving Goalkeepers’ Penalty Kick Save Responses, Annabelle Treacy
Assessing The Effectiveness Of Goal-Directed Versus Stimulus Driven Visual Search Training At Improving Goalkeepers’ Penalty Kick Save Responses, Annabelle Treacy
Theses, Dissertations and Capstones
Goalkeepers must perceive and analyze many different types of information in a short time to effectively move their bodies to make a save. Skilled goalkeepers enhance their actions by coupling them to information present in their environment. The information in their environment constantly changes, so the goalkeepers must adjust their strategies or positions to match the environmental demands. Goalkeepers use two types of perception and attentional strategies: stimulus-driven and goal-directed. Stimulus-driven perception is fast and compulsory, while goal-directed perception is slower and more methodical. Both visual search strategies direct the goalkeeper’s attention to where it is most needed and can …
Concepts In Animal Parasitology, Chapter 61: Transversotrematidae Witenberg, 1944 (Family): Ectoparasitic Trematodes [Platyhelminthes], Scott C. Cutmore, Thomas H. Cribb
Concepts In Animal Parasitology, Chapter 61: Transversotrematidae Witenberg, 1944 (Family): Ectoparasitic Trematodes [Platyhelminthes], Scott C. Cutmore, Thomas H. Cribb
Concepts in Animal Parasitology
An overview of the family Transversotrematidae Witemberg, 1944, a small but biologically significant group of plagiorchiid digenean trematodes (flukes), including discussion of identification, general morphology, life cycles, host range, and the significance of their evolutionary position and biology.
Chapter 61 in Concepts in Animal Parasitology, by Scott C. Cutmore and Thomas H. Cribb. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap061
Concepts In Animal Parasitology, Chapter 62: Hirudinea (Subclass): Parasitic Leeches, Alejandro Oceguera-Figueroa, Sebastian Kvist
Concepts In Animal Parasitology, Chapter 62: Hirudinea (Subclass): Parasitic Leeches, Alejandro Oceguera-Figueroa, Sebastian Kvist
Concepts in Animal Parasitology
An overview of the parasitic leeches, subclass Hirudinea, including discussion of leeches as parasites, vectors, and hosts, their general morphology, reproduction, zoogeography, classification, phylogeny, medical uses, and preparation of specimens.
Chapter 62 in Concepts in Animal Parasitology, by Alejandro Oceguera-Figueroa and Sebastian Kvist. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap062
Human System Composite Performance Measures: General Systems Performance Theory Insights, Lawrence Disalvi
Human System Composite Performance Measures: General Systems Performance Theory Insights, Lawrence Disalvi
Bioengineering Dissertations - Archive
Composite Performance Measures (CPMs) of human performance are widely employed in applications that range from mundane to life-changing, yet they are frequently presented without explanation or reference to theoretical underpinnings. The conceptual soundness of a widely used CPM approach, based on additive combination of constituent components, has been called into question by Kondraske. He argues the relevance of General Systems Performance Theory (GSPT) and performance capacity envelope concepts when applied to multidimensional CPM measures.
To obtain evidence-based answers to assertions regarding CPM types and rationale employed in medical and non-medical contexts, a Systematic Descriptive Review was conducted. Separately, the GSPT-based …
Thyroid Hemiagenesis Associated With Oncocytic Type Follicular Adenoma With Kras Mutation - A Case Report, Sam Joseph, Zhiwei Zhang, Donald Eagerton, Rana Hoda
Thyroid Hemiagenesis Associated With Oncocytic Type Follicular Adenoma With Kras Mutation - A Case Report, Sam Joseph, Zhiwei Zhang, Donald Eagerton, Rana Hoda
South Atlantic Division GME Research Day 2024
No abstract provided.
Effects Of Food Bar Chewing Duration On The Physiologic, Metabolic, And Perceptual Responses To Moderate-Intensity Running, Thomas R. Geaney, Zachary A. Sievert, J. David Branch, Patrick B. Wilson
Effects Of Food Bar Chewing Duration On The Physiologic, Metabolic, And Perceptual Responses To Moderate-Intensity Running, Thomas R. Geaney, Zachary A. Sievert, J. David Branch, Patrick B. Wilson
Exercise Science Faculty Publications
Purpose
Chewing duration can affect food particle size, gastric processing, and postprandial glycemia, but these effects have not been investigated with exercise. This study examined how the chewing duration of a food bar impacts glycemic and metabolic responses, gastrointestinal (GI) symptoms, psychological affect, and performance during endurance running.
Methods
This randomized, unblinded, crossover study had 15 males (35.2 ± 7.4 years, VO2peak: 56.1 ± 5.2 ml/kg/min) attend three laboratory visits. Visit 1 required a VO2peak test, 10 min familiarization run at 60% VO2peak, and familiarization time-to-exhaustion (TTE) test (10 min at 90% VO2peak, followed by …
Probable Extirpation Of The Jackrabbit (Lepus Californicus) From Arkansas, D.B. Sasse
Probable Extirpation Of The Jackrabbit (Lepus Californicus) From Arkansas, D.B. Sasse
Journal of the Arkansas Academy of Science
The black-tailed jackrabbit (Lepus californicus) was first documented in Arkansas during the modern era in Franklin County in 1927. Over the next few decades records were reported from multiple counties in northwest Arkansas and the species was locally common in Benton, Crawford, and Washington counties in the 1950s. The last Arkansas record documented in the scientific literature was from 1968 and since then there have only been three credible reports, with the last being from the late 1980s. The Arkansas Game and Fish Commission solicited reports of jackrabbits from the public and failed to find evidence of them from a …
Ultrastructure Of The Biflagellated Spermatozoon In The Western Siren, Siren Nettingi (Caudata: Sirenidae), Using Scanning Electron Microscopy, S.E. Trauth
Journal of the Arkansas Academy of Science
I investigated the ultrastructure of the biflagellated spermatozoon of the Western Siren, Siren nettingi, using scanning electron microscopy from salamanders collected in northeastern Arkansas. My primary goal in this study was to reveal the general morphology of the distinctive sperm cell components (two axonemes, two undulating membranes, and two axial fibers), which run nearly the entire length of the spermatozoon. These remarkable gamete structures are found in members of the salamander family Sirenidae and do not conform to spermatozoal ultrastructure of any other salamander species. Moreover, the biflagellated sperm are the end product of an extraordinary assemblage of complex maturation …
History And Distribution Of The Wood Stork (Mycteria Americana) In Arkansas, R. Tumlison, L. Serviss
History And Distribution Of The Wood Stork (Mycteria Americana) In Arkansas, R. Tumlison, L. Serviss
Journal of the Arkansas Academy of Science
Wood Storks (Mycteria americana) were thought to be common visitors to Arkansas in the early 1900s, but observations declined mid-century. Surveys of citizen science data and other online sources indicate that numbers of unique observations and total counts of birds have increased since 2000. Storks do not breed here, but have been reported in 34 of 75 counties, and appear mostly in August and September. Birds apparently originate from Mexico. Number of observations have increased since 2016, but many of those observations include only a few birds rather than larger flocks.
An Annotated Checklist Of The Camel Crickets (Insecta: Orthoptera: Rhaphidophoridae) Of Arkansas, H.W. Robison, C.T. Mcallister
An Annotated Checklist Of The Camel Crickets (Insecta: Orthoptera: Rhaphidophoridae) Of Arkansas, H.W. Robison, C.T. Mcallister
Journal of the Arkansas Academy of Science
A total of 14 native species of camel crickets and one introduced taxon representing three genera (Ceuthophilus, Phrixocnemis, and Diestrammena) of the orthopteran family Rhaphidophoridae, are herein reported from Arkansas. The most diverse genus was Ceuthophilus, with 13 native species, while Phrixocnemis had one native species, and Diestrammena, formerly Tachycines, was represented by one introduced species. This updated checklist is intended to be of use to entomologists, naturalists, professional biologists, and resource managers in evaluating the biodiversity of Arkansas. State distributional maps are provided for each species listed by county, and habitats are discussed in which each species was taken …
Fish Leeches Of Arkansas, D.J. Richardson, W.E. Moser, C.T. Mcallister, S.P. Lawson, H.W. Robison
Fish Leeches Of Arkansas, D.J. Richardson, W.E. Moser, C.T. Mcallister, S.P. Lawson, H.W. Robison
Journal of the Arkansas Academy of Science
Recent collection within Arkansas greatly enlarges the knowledge concerning hosts and distributions of fish leeches within the state. The natural history of the 6 species of fish leeches known from Arkansas (Placobdella montifera, Placobdella pediculata, Cystobranchus klemmi, Cystobranchus verrilli, Myzobdella lugubris, and Myzobdella reducta) is reviewed and updated and molecular data are provided.
Boiling Behind Bars: Exploring The Hidden Toll Of Extreme Heat On Mental Health In Texas Prisons, Sandra K. Miller
Boiling Behind Bars: Exploring The Hidden Toll Of Extreme Heat On Mental Health In Texas Prisons, Sandra K. Miller
Social Work Theses - Archive
The State of Texas supports the largest prison system in the US and held 132,859 people in 100 units scattered across the state as of December 2023. Approximately 70% of Texas prison beds are not air conditioned, despite the state’s reputation for dangerously hot, humid summers. The State has officially recorded temperatures inside Texas prison facilities as high as 120 degrees with heat index values of over 150. Although there is a growing body of research on the negative physiological and psychological consequences of extreme heat among the general public, little is known about the physical and emotional toll of …
Sympathetic-Cardiovascular Stress Reactivity In Adults With Major Depressive Disorder, Ashley Darling
Sympathetic-Cardiovascular Stress Reactivity In Adults With Major Depressive Disorder, Ashley Darling
Kinesiology Dissertations - Archive
Major depressive disorder (MDD) is a mood disorder characterized by persistently depressed mood and/or anhedonia that causes significant functional impairment in daily life. MDD affects nearly 15% of adults in their lifetime, and since 2019, prevalence estimates have increased up to ~30% in young adults (18-25 years old). In addition to its debilitating effects on daily functioning, epidemiological studies link MDD to ~3 times greater risk of cardiovascular disease (CVD), followed by accelerated CVD progression and mortality. Although the mechanisms contributing to MDD-CVD comorbidity are unclear, there is evidence of stress system dysfunction in adults with MDD.
Accordingly, the aim …
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin
Biology Dissertations - Archive
Mycobacteria encompass many pathogenic species known to cause severe disease in humans. A well-known example is Mycobacterium tuberculosis (Mtb), the causative agent of the lung disease tuberculosis, which kills millions of humans worldwide yearly. Pathogenic mycobacteria like Mtb are challenging to treat because of their innate ability to adapt to environmental stress. Their unique cell physiology and conserved stress responses allow them to combat biological insults, regulate growth, and regulate genes involved in stress; all these responses increase tolerance to antibiotics. The current therapies to treat mycobacterial infections are lengthy and, at times, unsuccessful, partly due to antibiotic tolerance. A …
Employers’ Perceptions Of And Experiences Working With Residency-Trained Athletic Trainers, C E. Welch Bacon, J M. Cavallario, L E. Eberman, J J. Wetherington, F Q. Pecha, B L. Van Lunen
Employers’ Perceptions Of And Experiences Working With Residency-Trained Athletic Trainers, C E. Welch Bacon, J M. Cavallario, L E. Eberman, J J. Wetherington, F Q. Pecha, B L. Van Lunen
Clinical Practice in Athletic Training
Context: Athletic trainers (ATs) who complete accredited residency training in a specialty area are considered clinical specialists, yet more information is needed to determine whether they are practicing within the higher capacity expected of a specialist. While some quantitative evidence demonstrating the value of residency-trained ATs on patient satisfaction, patient throughput, and the financial impact specific to the physician practice setting exists, residency training is not limited to only ATs who want to provide services in physician practice. Moreover, as accredited athletic training residency programs continue to emerge, it is increasingly important to understand key stakeholders’ perceptions of residency-trained ATs …
Program And Proceedings: Nebraska Academy Of Sciences 1880–2024, 144th Anniversary Year, One Hundred-Thirty-Fourth Annual Meeting
Nebraska Academy of Sciences: Programs and Proceedings
Program
Aeronautics and Space Science
Aeronautics and Space Science Poster Session
Anthropology: Humans Past and Present
Maiben Lecture: "Platte Basin Timelapse: A Watershed in Motion," Grant Reiner
Applied Science and Technology
Biological Sciences
Biomedical Sciences
Chemistry
Earh Sciences
Environmental Sciences
Physics
Science Education
Incorporating Sex-Diverse And Gender-Inclusive Perspectives In Higher Education Biology Courses, Breanne N. Harris, A Kelsey Lewis, Sam L. Sharpe, Teri J. Orr, Christopher T. Martine, Chloe C. Josefson
Incorporating Sex-Diverse And Gender-Inclusive Perspectives In Higher Education Biology Courses, Breanne N. Harris, A Kelsey Lewis, Sam L. Sharpe, Teri J. Orr, Christopher T. Martine, Chloe C. Josefson
Faculty Journal Articles
Inclusive teaching is teaching in a way that reaches all students in the classroom; this is beneficial for everyone, particularly for those with minoritized identities. Instructors play a critical role in scaffolding how students are exposed to and learn science content in the classroom. In this manuscript, we discuss how biology instructors can make their classrooms more inclusive with regard to sex and gender diversity content. Many topics in biology are based on androcentric, heteronormative, and oppressive framing, even though those lenses are more reflective of our own history and culture than they are of the diversity we see in …
Quantum Dots' Toxicity: A Multi-Level Investigation On The Impact Of Quantum Dots On The Actin Cytoskeleton, Nhi Le
Graduate Theses/Dissertations
Quantum dots (QDs) are fluorescence nanomaterials with unique optical and physical properties. As such, they are highly sought after for their potential use in several biomedical and industrial applications. Despite their vast potential, recent studies have suggested that quantum dots are toxic to cells. Yet, the mechanism of quantum dots’ toxicity remains unclear. As such, my thesis aims to comprehensively examine the mechanism of quantum dots’ toxicity, emphasizing how quantum dots disrupt the actin cytoskeleton. In this study, I used RNA sequencing and mass spectrometry to investigate the influence of CdSe/ZnS QDs on the transcriptomic proteomic level of Saccharomyces cerevisiae …
Nanotoxicology Of Cdse/Zns Quantum Dot Alternatives In Thle-2 And Hepg2 Liver Cells, Seth Harris
Nanotoxicology Of Cdse/Zns Quantum Dot Alternatives In Thle-2 And Hepg2 Liver Cells, Seth Harris
Graduate Theses/Dissertations
Fluorescent nanoparticles known as quantum dots (QDs) have unique properties that make them useful in biomedicine. Specifically, CdSe/ZnS QDs, while good at fluorescing, show toxicity. Due to this, safer alternatives have been developed. This study uses an XTT viability assay, ROS fluorescent imaging, and apoptosis to investigate the effect of QD alternatives InP/ZnS, CuInS2/ZnS, and carbon dots (NCD) in liver cells. The liver is a possible destination for accumulation of QDs making it an appropriate model for testing. A cancerous liver cell line known as HepG2, and an immortalized liver cell line known as THLE-2 were used. At …
Assessing The Utility Of Breast Cancer Polygenic Risk Scores And Association With Clinical Factors In A Population Of Breast Cancer Patients, John L. Slunecka
Assessing The Utility Of Breast Cancer Polygenic Risk Scores And Association With Clinical Factors In A Population Of Breast Cancer Patients, John L. Slunecka
Dissertations and Theses
INTRODUCTION: Breast cancer (BC) is the most common cancer among women and is classified as a complex disease. Advances in population genomics have led to the development of polygenic risk scores (PRSs) with the potential to enhance current risk models, but replication is often limited. OBJECTIVE: We sought to assess the predictive capabilities of two high-powered BC PRSs in a sample population selected for breast cancer. In addition, the capacity of the PRSs to predict clinical variables that could improve BC screening and treatments was explored. METHODS: Two published PRS algorithms (313 vs 3820) were used to score female subjects …
What Influences Trust In And Understanding Of Clinical Trials? An Analysis Of Information And Communication Technology Use And Online Health Behavior From The Health Information National Trends Survey, Aurora Occa, Allison S. Merritt, Allison Leip, Jerod L. Stapleton
What Influences Trust In And Understanding Of Clinical Trials? An Analysis Of Information And Communication Technology Use And Online Health Behavior From The Health Information National Trends Survey, Aurora Occa, Allison S. Merritt, Allison Leip, Jerod L. Stapleton
UK CARES Faculty Publications
Background: Using information and communication technologies to seek, discuss, and share health-related information influences people’s trust and knowledge of several health practices. However, we know little about the associations between individuals’ information and communication technology use and their perceptions of trust and knowledge of clinical trials. Examining these associations may lead to the identification of target audiences and channels for developing effective educational interventions and campaigns about clinical trials.
Methods: In this study, we analyzed Health Information National Trends Survey data to document perceptions of clinical trial-related knowledge and trust that were recently added as questions in this annual national …
Cancer Research Provides A Model For Advancing Clinical Trials In Dementia In The Era Of Disease-Modifying Alzheimer’S-Type Dementia Therapies, Gregory Jicha, Thomas Tucker, Susanne Arnold, Peter T. Nelson
Cancer Research Provides A Model For Advancing Clinical Trials In Dementia In The Era Of Disease-Modifying Alzheimer’S-Type Dementia Therapies, Gregory Jicha, Thomas Tucker, Susanne Arnold, Peter T. Nelson
Neurology Faculty Publications
Dementia and cancer are multifactorial, widely-feared, age-associated clinical syndromes that are increasing in prevalence. There have been major breakthroughs in clinical cancer research leading to some effective treatments, whereas the field of dementia has achieved comparatively limited success in clinical research. The lessons of cancer research may help those in the dementia research field in confronting some of the dilemmas faced when the clinical care regimen is not entirely safe or efficacious. Cancer clinical trials have assumed that untreated individuals with cancer are at high risk for morbidity and mortality after primary diagnoses. Thus, patients deserve a choice of clinical …
Nalfurafine Promotes Myelination In Vitro And Facilitates Recovery From Cuprizone + Rapamycin-Induced Demyelination In Mice, Ross Van De Wetering, Rabia Bibi, Andy Biggerstaff, Sheein Hong, Bria Pengelly, Thomas E. Prisinzano, Anne C. La Flamme, Bronwyn M. Kivell
Nalfurafine Promotes Myelination In Vitro And Facilitates Recovery From Cuprizone + Rapamycin-Induced Demyelination In Mice, Ross Van De Wetering, Rabia Bibi, Andy Biggerstaff, Sheein Hong, Bria Pengelly, Thomas E. Prisinzano, Anne C. La Flamme, Bronwyn M. Kivell
Markey Cancer Center Faculty Publications
The kappa opioid receptor has been identified as a promising therapeutic target for promoting remyelination. In the current study, we evaluated the ability of nalfurafine to promote oligodendrocyte progenitor cell (OPC) differentiation and myelination in vitro, and its efficacy in an extended, cuprizone-induced demyelination model. Primary mouse (C57BL/6J) OPC-containing cultures were treated with nalfurafine (0.6–200 nM), clemastine (0.01–100 μM), T3 (30 ng/mL), or vehicle for 5 days. Using immunocytochemistry and confocal microscopy, we found that nalfurafine treatment increased OPC differentiation, oligodendrocyte (OL) morphological complexity, and myelination of nanofibers in vitro. Adult male mice (C57BL/6J) were given a diet con- taining …