Medicine and Health Sciences Commons^™

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Milestones Leading To The Development Of Spinal Surgery In The Late 19th Century, D. J. Canale

Henry Ford Hospital Medical Journal

The significant amount of spinal surgery in neurological practice today prompts a survey of the historical development of surgical treatment of disorders of the spine. Any discussion tracing the events leading to modern surgical practice must necessarily contain the contributions of men of medicine through the centuries; therefore, neurosurgery as practiced today is greatly indebted to the efforts of courageous and dedicated men in world history extending to the early Egyptians. Overcoming seemingly insurmountable barriers of prejudice bred of ignorance, societal customs, and religious tradition, these fathers of medicine have contributed the knowledge and experimental evidence which form the cornerstone …

The Treatment Of Chronic Pain: Program Of The Community Hospital Rehabilitation Center For Pain, Karl L. Manders

Henry Ford Hospital Medical Journal

After approximately three years' experience, the use of multiple modality treatment appears to be the most advantageous for individuals who have not responded satisfactorily to routine medical and surgical treatment. Alleviation of pain, discontinuance of narcotic medication, and return to both social and vocational activities has been accomplished in most patients of this center for the treatment of chronic pain.

Chemothalamolysis In The Treatment Of Hemiballismus — Simplified Knighton's Technique, Salvador Gonzalez-Cornejo

Henry Ford Hospital Medical Journal

Three cases are reported in which the author used Knighton's simplified technique to make lesions in the ventrolateral nucleus of the thalamus. This controlled the involuntary movements of hemiballismus. One patient died of a myocardial infarction due to marked hypotension and an episode of postoperative bleeding in the upper gastrointestinal tract.

Selective Cerebral Arteriography And The Cat Scan In Acoustic Tumors, Donald C. Austin

Henry Ford Hospital Medical Journal

Increasing experience with selective cerebral arteriography in the diagnostic evaluation of acoustic tumors has led to a more rational determination of the proper surgical approach to the lesion. It also predicts the necessity for staging the surgical procedure, reduces the potential for intraoperative complications and rules out other types of angle lesions and the possible necessity for performing a preoperative, concomitant or postoperative shunting procedure. The CAT scan has added an important screening procedure in predicting the presence of an angle lesion, determining the need for further diagnostic studies and evaluating the possible presence or absence of a recurrent tumor …

Subarachnoid And Intracerebral Hemorrhage Due To The Rupture Of An Arteriovenous Malformation And Aneurysm In The Same Patient. Report Of Two Cases, F. Gomez-Mendez

Henry Ford Hospital Medical Journal

Two cases are reported of coexistent intracranial aneurysm and arteriovenous malformation. Both lesions ruptured within one week in one patient and within three months in the other. The rarity of such occurrences is discussed and the surgical operative procedures used are described. One patient is doing well except for some weakness of the right leg and mild dysphasia. The second patient died three months postoperatively, probably because of rupture of the aneurysm. No autopsy was obtained.

Progressive Ataxia And Hearing Loss (Left) In A 23-Year-Old Man. A Clinico-Pathological Conference, Jose Bebin

Henry Ford Hospital Medical Journal

As part of the scientific program honoring Robert 5. Knighton, M.D., a clinical pathological conference was conducted by Dr. Jose Bebin. Following presentation of the protocol, comments from several discussants included diagnoses of a primary neoplastic process in the brain stem, angioma of the pons, neoplasm or cyst of the posterior fossa, possible angioma on the left side of the brain stem, a viral cerebellitis, an ependymoma, or a medulloblastoma. Together with the case presentation the author offers autopsy findings and a discussion and review of the literature.

Atlantoaxial Dislocations: A Retrospective Study Of 35 Cases, Arturo Paz-Esquerre

Henry Ford Hospital Medical Journal

Of 35 patients with CI-C2 dislocations, 37% (13 cases) had a history of rheumatoid arthritis, 11% (4 cases) had trauma as well as rheumatoid arthritis, and 25.7% (9 cases) had severe motor deficit quadriparesis or quadriplegia. One patient, representing 2.8% of the total, had a brain contusion related to closed head trauma.

Effect Of Cold Exposure On Serum Levels Of Corticosteroid-Binding Globulin In Male And Virgin Female Rats, Erik R. Larsen

Masters Theses

No abstract provided.

Demonstration Of Unique Mycelial Components In Candida Albicans, David Jon Mancuso

Biological Sciences Theses & Dissertations

Mycelial (M) and blastopore (B) cell homogenates of Candida albicans strain BJ85 were compared to detect and recover unique M components. Qualitative differences in the protein and lipid content of Mand B homogenates were suggested by discontinuous polyacrylamide gel electrophoresis (DPAGE). In addition, a quantitative and possibly qualitative shift in the protein content during germ tube formation was implied by DPAGE. Unique M components were detected using both DPAGE and immunoelectrophoretic (IE) techniques. One unique M component by DPAGE, four by IE, and two by combined DPAGE and IE techniques were suggested. Of these three methods, only DPAGE and the …

The Effects Of Inducing Functional Class Iii Malocclusion On Actively Growing Rat Mandibles, Aarin Chu

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Three Linked Enzyme Loci In Fishes: Implications In The Evolution Of Vertebrate Chromosomes, D C Morizot, D A Wright, M J Siciliano

Faculty, Staff and Student Publications

A three-point linkage group comprised of loci coding for adenosine deaminase (ADA), glucose-6-phosphate dehydrogenase (G6PDH), and 6-phospho-gluconate dehydrogenase (6PGD) is described in fish of the genus Xiphophorus (Poeciliidae). The alleles at loci in this group were shown to assort independently from the alleles at three other loci--isocitrate dehydrogenase 1 and 2, and glyceraldehyde-3-phosphate dehydrogenase 1. Alleles at the latter three loci also assort independently from each other. Data were obtained by observing the segregation of electrophoretically variant alleles in reciprocal backcross hybrids derived from crosses between either X. helleri guentheri or X. h. strigatus and X. maculatus. The linkage component …

Acute Onset Of Bulbar And Ocular Paralysis: An Isolated Case, With Differential Diagnosis, Aziz Aghdassi, Robert D. Teasdall

Henry Ford Hospital Medical Journal

The diagnosis of botulism should be considered in all patients with the acute onset of cholinergic dysfunction and muscle weakness. The pupils are usually dilated, paralysis of ocular and bulbar muscles invariably occurs along with weakness of limb and axial muscles. This diagnosis is supported by the presence of a neuromuscular block and confirmed by the detection of toxin. Although the clinical presentation in this patient supported this diagnosis and a neuromuscular defect was present, no botulinum toxin was found. Not until Clostridium botulinum, type B organisms were cultured was the diagnosis of "probable botulism" made in this patient. Myasthenia …

Salicylate Effect On Platelets And Vascular Thrombosis In Rheumatoid Arthritis, Gilbert B. Bluhm, Jeanne M. Riddle, Donald G. Pica, Gordon D. Langejans

Henry Ford Hospital Medical Journal

Platelet surface activation was surveyed by electron microscopy (EM) in 40 patients with classical rheumatoid arthritis (RA) without clinical evidence of recent intravascular coagulation. Increased platelet surface activity (PSA) was noted in 8 of 25 females and 8 of 15 males (16 of 40 or 40%). Abnormal PSA failed to correlate with either the presence of rheumatoid nodules or the titer of rheumatoid factor. Hyperactive platelet populations, however, did tend to correlate with a serum urate level above 5 mg% (7 of 12 vs 9 of 28). Neither "low" nor "anti-inflammatory" levels of serum salicylate appear to afford protection from …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Quinidine-Induced Hepatitis And Thrombocytopenia, Mohsin Alam, Wolf F. C. Duvernoy, Sol D. Pickard, Paul L. Aronsohn

Henry Ford Hospital Medical Journal

Quindlne-induced hepatitis has received more attention only recently whereas quinidine-induced thrombocytopenia is well recognized. Over the past two years the authors saw four patients with quinidine-hepatitis accompanied by malaise, anorexia, fever in two patients and marked elevation of liver enzymes in all. Two patients had associated quinidine-induced thrombocytopenia of 81,000 and 6,600 platelets / cu mm, respectively. Liver biopsy in two patients revealed small foci of hepatocellular necrosis, Kupffer cell hyperplasia and Kupffer cells containing lipochrome. In one patient noncaseous granulomatous lesions were seen. Symptoms subsided and laboratory tests returned to normal rapidly on withdrawal of quinidine. In one patient, …

Diagnostic Ultrasound In Gynecology, Manojkumar H. Shah, Chang Y. Lee, James J. Karo, Bruce H. Drukker

Henry Ford Hospital Medical Journal

The accuracy of diagnostic ultrasound in 484 gynecologic patients was evaluated. In 97% of them, the ultrasonic findings were either diagnostic or confirmatory of the final clinical condition. The ultrasonic procedure was useful in the evaluation of pelvic or adnexal masses, confirmation and assessment of early pregnancy, location of lost Intrauterine contraceptive devices, diagnosis of tubo-ovarian abscess and hydatidiform mole. The ultrasonic study aided in developing a precise surgical approach as well as reducing the number of operative procedures performed only for diagnosis. In 3%, the ultrasonic studies were misleading, indicating the limitations of the procedure and reinforcing the need …

The Incidence Of Retrolental Fibroplasia, R. Michael Nisbet

Henry Ford Hospital Medical Journal

With the increased use of oxygen to treat the respiratory distress syndrome, retrolental fibroplasia was encountered in more infants. One hundred consecutive premature infants were screened for ocular disease and a diagnosis of retrolental fibroplasia was made in six infants. A profile of a "high risk" infant emerged as one with a birth weight less than 1,500 grams who suffers from the respiratory distress syndrome and multiple apneic spells. During the examinations many other ocular abnormalities were found which prove the value of such screening.

X-Linked Diseases With Cataract, Philip J. Howard

Henry Ford Hospital Medical Journal

X-linked cataracts are a rare group and appear as a complication of other disease. Changes in the lens are difficult to visualize and the family history may alert the examiner to the possibility of cataractous changes. This paper is a review of 13 sex-linked conditions with cataract as a possible complication. Cataracts may be present in an occasional case or in some instances in every case. Short abstracts follow of Fabry's disease, glucose 6-dehydrogenase deficiency, myotonic dystrophy, ectodermal hypohidriotic dysplasia, oculocerebral syndrome, keratosis follicularis spinulosa decalvans with cataract, Norrie disease, incontinenti pigmenti, hypoparathyroidism due to a sex-linked recessive trait, pseudohypopara-thyroidism, …

Clinical Uses Of Biofeedback: A Review Of Recent Research, Richard M. Lee, Scott E. Baldwin, Julia A. Lee

Henry Ford Hospital Medical Journal

Biofeedback refers to a special type of operant conditioning (ie, a category of learning) in which subjects acquire control over physiological processes through the feedback of information. Its methodology is based upon principles of behavioral science developed in the laboratory through experimentation. It has been conclusively demonstrated that humans (and other animals) can learn to control such actions as EKG parameters, blood pressure, body temperature, EEG, individual motor units, and glandular secretions. Clinically, biofeedback has been applied to a wide variety of psycho-physiologic disorders in which a measurable response requires alteration. The best established applications are tension and migraine headaches, …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Ultrasonic Versus Hand Filing Of The Human Root Canal System, Howard W. Scholz Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

A comparison was made of ultrasonic filing versus hand filing using three solutions to flood the canals of 24 extracted human maxillary central incisors. A modified PR-30 Cavitron insert was used in a Cavitron 1010 unit for the ultrasonic filing. The clinical crown was removed with a diamond saw and water spray at the cemento-enamel junction. The two major groups were ultrasonic filing versus hand filing; the three subgroups were solution/solvents - 10% EDTA, 2.0% NaOCl, and distilled water.

After filing, the roots were grooved longitudinally with a high speed bur and cracked opened with a mallet and chisel. The …

Human Placental Alkaline Phosphatase And Steroid Metabolism By Rat Adrenals, Allen G. Meier

Loma Linda University Electronic Theses, Dissertations & Projects

Human placental alkaline phosphatase was purified by butanol extraction, methanol precipitation and chromatography on DEAE-cellulose. The pH optimum was found to be 10.9. The enzyme was competitively inhibited by di-ethyl-p-nitrobenzyl-phosphonate and copper sulfate. An increase in enzymatic activity occurred in the presence of the phosphate ion (HPO₄) and ATP.

The enzyme was crystallized from a 40% saturated solution of ammonium sulfate and shown to be homogeneous by sedimentation analysis. Homogeneity of the enzyme was also demonstrated using poly-acrylamide-gel-electrophoresis. At a pH of 7.5% the electrophoretic pattern yielded a single band and showed no significant contamination.

The metabolic transformation …

The Effect Of Endodontic Therapy On The Incidence Of Radiation Caries In Dogs, James A. Abbott

Loma Linda University Electronic Theses, Dissertations & Projects

Endodontic therapy was evaluated as a possible control or prevention modality of radiation type dental caries in dogs. Two adult male dogs with permanent dentitions had endodontic therapy performed on alternating teeth in each jaw. The nontreated teeth served as controls.

The dogs were irradiated with 7000 rad Cobalt-60 radiation fractionated over an eight week period. The dogs were killed at 60 and 182 days post-irradiation. The teeth were removed from the jaws and immersed in methylene blue dye, sectioned, and the dye penetration pattern photographed. Diffusion of the dye into the tooth structure was quantified and statistically analyzed.

A …

Intraoperative Transanal Fiberoptic Colonoscopy: Report Of Six Cases, Thomas A. Fox Jr., Peter A. Haas

Henry Ford Hospital Medical Journal

Intraoperative transanal fiberoptic colonoscopy is presented as an alternative to transcolonic procedures to remove colonic polyps, or to excise or biopsy other intraluminal lesions. This method should be considered when the standard transanal colonoscopy has failed. The results with this procedure have been excellent. The method also can be applied to patients who have colonic lesions and are to undergo elective procedures such as hysterectomy and cholecystectomy.

Early Vagotomies At Henry Ford Hospital: An Historical Vignette And A Follow-Up, James C. Gruenberg, Conrad R. Lam

Henry Ford Hospital Medical Journal

Over a one-year period beginning in April, 1946, nine transthoracic vagotomies were done at the Henry Ford Hospital. Three of the patients had had a partial gastrectomy previously and the operation was done for recurrent bleeding from marginal ulcers. Thirty years later, an attempt was made to ascertain the present condition of these patients. Long term follow-ups were possible on six patients and follow-ups of one, six and 14 years on the others. All nine patients had immediate relief of ulcer pain and cessation of bleeding if present. No subsequent drainage operation was required for the six patients with primary …

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Clinical Variations Of Hereditary Spastic Paraplegia In Four Families, Davood M. Danadoost, Charles E. Jackson, Robert D. Teasdall

Henry Ford Hospital Medical Journal

Hereditary spastic paraplegia was diagnosed in 19 patients belonging to four families. All had spastic gait and upper motor neuron signs in lower limbs. In family A, the disease was expressed in this manner, although one member had muscle wasting in an upper limb. There was additional involvement of the posterior columns in six of the eight affected members of family B and cerebellar ataxia was noted in upper limbs of three of them. Posterior columns were also involved in three of the four affected members of family C. The disease was transmitted in these three families by an autosomal …

Technetium Pyrophosphate Myocardial Scanning In Acute Myocardial Infarction, Arunkumar N. Mehta, Sidney Goldstein, Daniel S. Marks, Albert Kasenter, William R. Eyler

Henry Ford Hospital Medical Journal

Technetium 99m pyrophosphate (99mTCPyP) accumulates in recently infarcted myocardium and can be detected by external imaging techniques. This study was performed to evaluate the ability of this isotope to identify the presence of acute myocardial infarction. In 82 patients admitted to a coronary care unit with chest pain of varying etiology, scan was positive in all 13 patients with acute transmural myocardial infarction and in 23 of 27 patients with nontransmural myocardial infarction. The scan was negative in 37 of 42 patients without evidence of recent infarction. Four of the remaining five patients in this group had unstable angina pectoris. …