Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (10094)
- TÜBİTAK (3209)
- University of Nebraska - Lincoln (2869)
- Henry Ford Health (2151)
- University of Kentucky (1592)
-
- Old Dominion University (843)
- The Jackson Laboratory (738)
- Boise State University (673)
- Virginia Commonwealth University (614)
- Aga Khan University (585)
- Chapman University (549)
- University of Arkansas, Fayetteville (541)
- Universitas Indonesia (535)
- University of Nevada, Las Vegas (470)
- Loma Linda University (466)
- Bowling Green State University (464)
- Department of Primary Industries and Regional Development, Western Australia (450)
- City University of New York (CUNY) (437)
- University of South Carolina (413)
- Brigham Young University (412)
- Nova Southeastern University (373)
- WellBeing International (357)
- Himmelfarb Health Sciences Library, The George Washington University (356)
- University of Texas Rio Grande Valley (272)
- Thomas Jefferson University (270)
- Dartmouth College (268)
- Wright State University (255)
- Santa Clara University (253)
- Rowan University (249)
- Wayne State University (243)
- Keyword
-
- Humans (6696)
- Animals (2603)
- Female (2573)
- Male (2079)
- Mice (1879)
-
- Middle Aged (1168)
- Adult (1160)
- Aged (1053)
- Neoplasms (782)
- Tumor (761)
- Mutation (589)
- Cell Line (572)
- Cell Line, Tumor (566)
- Carcinoma (556)
- Immunotherapy (530)
- Retrospective Studies (524)
- Cancer (520)
- Biomarkers (510)
- Child (467)
- COVID-19 (440)
- Tumor Microenvironment (426)
- Obesity (408)
- Receptors (377)
- Inflammation (376)
- Adolescent (375)
- Lung Neoplasms (371)
- Leukemia (365)
- Treatment Outcome (341)
- Mice, Inbred C57BL (338)
- Aged, 80 and over (336)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (7585)
- Turkish Journal of Veterinary & Animal Sciences (3209)
- Henry Ford Hospital Medical Journal (2151)
- Faculty, Staff and Students Publications (1548)
- International Journal of Physical Activity and Health (660)
-
- United States Department of Agriculture Wildlife Services: Staff Publications (592)
- Dissertations and Theses (Open Access) (526)
- Nebraska Beef Cattle Reports (441)
- Children’s Nutrition Research Center Staff Publications (425)
- Loma Linda University Electronic Theses, Dissertations & Projects (410)
- Biology and Medicine Through Mathematics Conference (370)
- School of Veterinary and Biomedical Sciences: Faculty Publications (333)
- Kesmas (322)
- Theses and Dissertations (317)
- Journal of the Department of Agriculture, Western Australia, Series 4 (307)
- Electronic Theses and Dissertations (290)
- Pharmacy Faculty Articles and Research (271)
- Nebraska Center for Virology: Faculty Publications (270)
- Brigham Young University Science Bulletin, Biological Series (260)
- Publications and Research (258)
- Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association (250)
- Department of Pathology and Laboratory Medicine (249)
- Research Day (234)
- Dartmouth Scholarship (231)
- Osmosis Magazine (227)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (217)
- Biological Sciences Faculty Publications (216)
- Markey Cancer Center Faculty Publications (213)
- Trematoda Taxon Notebooks (212)
- BioMedicine (207)
- Publication Type
Articles 42061 - 42061 of 42061
Full-Text Articles in Medicine and Health Sciences
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Nebraska Center for Virology: Faculty Publications
Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …