Medicine and Health Sciences Commons^™

The Effects Of Ligula Intestinalis Plerocercoids On The Growth Features Of Tench, Tinca Tinca, Mehmet Borga Ergönül, Ahmet Altindağ

Turkish Journal of Veterinary & Animal Sciences

A total of 272 specimens of tench (Tinca tinca L., 1758) caught in Lake Mogan (Ankara) were examined for the presence of the plerocercoids of Ligula intestinalis, and growth parameters such as age composition, age-length, age-weight and weight-length relationship and condition factor were calculated seperately for both infected and non-infected fish. The only marked difference was observed in value b between infected (2.745) and non-infected (3.014) fish.

Pathological And Phytochemical Investigation Of Neuronal Lipofuscinosis Caused By Asphodelus Aestivus In Sheep: I. Pathological Findings, Serap Bi̇ri̇nci̇oğlu, İhsan Çaliş, Hamdi̇ Avci, Bengi̇ Baba Erdağ

Turkish Journal of Veterinary & Animal Sciences

A severe neurologic syndrome accompained by intense neuronal pigmentation was described in sheep exposed to Asphodelus aestivus in Turkey. The clinical signs were similar in all the sheep affected, and the condition was usually characterized by progressive paresis, ataxia and convulsion. At necropsy, yellowish-brown discoloration in the brain and spinal cord were consistently seen. A microscopical examination revealed abundant yellowish-brown pigment granules in the cytoplasm of the larger neurons. Similar pigment granules were also observed in extraneuronal tissues. The histochemical features of the pigments were consistent with those of lipofuscin. The available evidence suggests that the tissue pigmentation was related …

Isolation And Serotyping Of Ornithobacterium Rhinotracheale From Poultry, Süheyla Türkyilmaz

Turkish Journal of Veterinary & Animal Sciences

The aims of this study were the isolation of Ornithobacterium rhinotracheale from poultry and serotyping of the isolates and field sera by agar gel precipitation (AGP) test. For the isolation 257 chickens and 214 turkeys were used and for the AGP test 333 chickens and 250 turkeys were used. O. rhinotracheale was isolated from the sinus discharge of 3 broiler breeders at 37, 42 and 46 weeks of age. It was determined that 3 isolates were O. rhinotracheale serotype I having cross reactions with serotype L. Of 333 sera examined 86 were found seropositive in chickens by AGP test. It …

Live Weights Of Kıvırcık Ewes And Lambs In Some Periods Under Extensive Management Conditions, İbrahi̇m Cemal, Orhan Karaca, Tufan Altin, Mustafa Kaymakçi

Turkish Journal of Veterinary & Animal Sciences

The aims of the present study were to evaluate the growth characteristics of Kıvırcık sheep and describe non-genetic factors influencing their expression. Data were collected from 6 flocks including a nucleus flock and 5 breeders’ flocks (2 in mountainous and 3 in lowland villages). Flocks raised in extensive conditions were kept in pastures throughout the year. The body weight of ewes at parturition and the birth and weaning weight of lambs were recorded during 2 lambing seasons (1999-2000 and 2000-2001). The least-squares mean of ewe body weight at parturition was 42.2 kg. Lambing season, flock and age of ewe were …

Faecal Carriage Of Listeria Monocytogenes In Stray Dogs In Bursa Province, Turkey, A. Levent Kocabiyik, Cengi̇z Çeti̇n, Cüneyt Özakin

Turkish Journal of Veterinary & Animal Sciences

The faecal carriage rate of Listeria monocytogenes in stray dogs in Bursa province, Turkey, was determined from 82 faecal samples by bacteriological methods. L. monocytogenes was isolated from only one (1.22%) of the samples examined. The isolate was serotyped as 1/2b. It was concluded that stray dogs could be a reservoir of the organism as well as a source of human listeriosis in Turkey. This is the first report on the isolation of L. monocytogenes from a dog in this country.

Some Histochemical Properties Of The Ceruminous Glands In The Meatus Acusticus Externus In Cats And Dogs, Zi̇ya Özcan

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to determine some histochemical properties of the ceruminous glands located in the meatus acusticus externus in cats and dogs. Ten cats and 10 dogs of various breeds were used as the study materials. To determine the properties of the secretions of the ceruminous glands in the meatus acusticus externus of cats and dogs, the periodic acid Schiff (PAS) stain was used for neutral mucosubstances and glycogen, while the Alcian blue stain (pH 2.5) was applied for the presence of acidic mucosubstances. The diastase reaction was applied to confirm the presence of glycogen. In dogs, positive staining …

Vaccine-Associated Feline Sarcoma (Vafs) With Multiple Recurrences In A Turkish Van Cat, Yilmaz Aydin, Babür Bi̇li̇r

Turkish Journal of Veterinary & Animal Sciences

Vaccine-associated feline sarcoma (VAFS) with multiple recurrences was diagnosed in the specimens at the injection site of a Turkish Van cat that had been vaccinated four months previously. The original tumor consisted of two compartments each 2.5 cm and 3.5 cm in diameter. It recurred five times following surgery and local recurrences necessitated five more radical resections within two years. Euthanasia was performed when pleural effusion developed, but evidence of metastatic disease was not observed. This article reports the first case of a vaccine-associated feline sarcoma in a Turkish Van cat clinically diagnosed as prominent evidence of postvaccinal sarcoma from …

Aspergillosis And Gastric Impaction In An Ostrich, Azi̇z Arda Sancak, Jale Paracikoğlu

Turkish Journal of Veterinary & Animal Sciences

It is inevitable to encounter many diseases of ostriches in Turkey as a consequence of the rapid expansion of ostrich farming and flocks in this country. Aspergillus fumigatus was isolated from the lungs and air sacs of a 3-month-old, male, blue-neck ostrich. In postmortem examination, the ingestion of a large amount of gravel was noted. The accumulated gravel had led to an occlusion of the passage between the proventriculus and gizzard. This work appears to be the first report of aspergillosis and gastric impaction developing together and leading to death in an ostrich.

Abortion Due To Streptococcus Equi Subspecies Zooepidemicus In A Mare, A. Levent Kocabiyik, Gürsel Sönmez, Mi̇hri̇ban Ülgen, Cüneyt Özakin, Esra Kocakaya, Ayli̇n Alasonyalilar

Turkish Journal of Veterinary & Animal Sciences

The organs of an aborted equine fetus were examined histopathologically and microbiologically. Diffuse, mild cellular infiltration of neutrophils, lymphocytes and plasma cells was observed in the lamina propria of the intestine. In addition, bacterial colonies were seen in the intestinal content, wall of intestine and liver. Streptococcus equi subsp. zooepidemicus was isolated in pure culture from all organs. This is the first report of the isolation of S. equi subsp. zooepidemicus from an aborted equine fetus in Turkey.

Unilateral Uterine Prolapse In A Cat, Ni̇hat Özyurtlu, Duygu Kaya

Turkish Journal of Veterinary & Animal Sciences

Unilateral uterine prolapse that occurred immediately after parturition was diagnosed in a 15-month-old cat brought to the clinics of the Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Ankara University. Depending on clinical and ultrasonographic examination findings, the other uterine horn was though to be invaginated into the prolapsed horn. To purpose of treatment, ovariohysterectomy was performed. During laparotomy, the non-pregnant right uterine horn was seen to be invaginated into the pregnant uterine horn.

Characterization Of Migrating Cells From Ventricular Zone (Vz) To Distant Limbic Structures After Multiple Neonatal Seizures, Melissa Corcia

Seton Hall University Dissertations and Theses (ETDs)

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Biomarkers For Placental Abnormality, Cathal Mccarthy

Doctoral

Obstetrical complications including recurrent miscarriage, pre-eclampsia and intrauterine growth restriction (IUGR) affect 1%-5% of pregnant women (Younis and Samueloff 2003). Dysfunctional trophoblasts, impaired development of spiral arteries, imbalance in systems controlling the dilation and contraction of spiral arteries, placental fibrin clots and intervillous thrombosis are all possible factors that can result in an insufficient placental circulation. The combination of the hypercoagulable state of pregnancy and presence of genetic thrombophilic markets has the potential to induce placental thrombosis and cause placental insufficiency with subsequent obstetrical complications. The initial part of the research work involved examining the relationship between four common genetic …

Using Technology To Teach Technology: Design And Evaluation Of Bilingual Online Physician Education About Electronic Medical Records, Sarah R. Edmonson, Adol Esquivel, Pallavi Mokkarala, Craig W. Johnson, Cynthia L. Phelps

Faculty, Staff and Student Publications

The "EMR Tutorial" is designed to be a bilingual online physician education environment about electronic medical records. After iterative assessment and redesign, the tutorial was tested in two groups: U.S. physicians and Mexican medical students. Split-plot ANOVA revealed significantly different pre-test scores in the two groups, significant cognitive gains for the two groups overall, and no significant difference in the gains made by the two groups. Users rated the module positively on a satisfaction questionnaire.

Predicting Childhood Sexual Or Physical Abuse: A Logistic Regression Geo-Mapping Approach To Prevention, Roland K. Tadoum, Kamila Smolij, Michelle A. Lyn, Craig W. Johnson

Faculty, Staff and Student Publications

This study investigates the degree to which gender, ethnicity, relationship to perpetrator, and geomapped socio-economic factors significantly predict the incidence of childhood sexual abuse, physical abuse and non- abuse. These variables are then linked to geographic identifiers using geographic information system (GIS) technology to develop a geo-mapping framework for child sexual and physical abuse prevention.

Identification Of Fatty Acid Oxidation Disorder Patients With Lowered Acyl-Coa Thioesterase Activity In Human Skin Fibroblasts, Mary Hunt, Jos Ruiter, Petra Mooyer, Carlo W T Van Roermond, Rob Ofman, Lodewig Ijlst, Ronald J A Wanders

Articles

Background: Acyl-CoA thioesterases are enzymes that hydrolyze acyl-CoAs to the free fatty acid and coenzyme A (CoASH). These enzymes have been identified in several cellular compartments and are thought to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. However, to date no patients deficient in acyl-CoA thioesterases have been identified. Design: Acyl-CoA thioesterase activity was measured in human skin fibroblasts. Western blot analysis was used to determine Type-II acyl-CoA thioesterase protein levels in patients. Results: Activity was found in human fibroblasts with all saturated acyl-CoAs from C4:0- to C18:0-CoA, with highest activity detected with lauroyl-CoA and myristoyl-CoA (C12:0 …

Gene Therapy And Targeted Toxins For Glioma, James Curtin, Gwendalyn King, Marianela Candolfi, Kurt Kroeger, Pedro Lowenstein, Maria Castro

Articles

The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of nine to twelve months from diagnosis to death. Current treatment modalities are unable to significantly prolong survival in patients diagnosed with glioblastoma. As such, glioma is an attractive target for developing novel therapeutic approaches utilizing gene therapy. This review will examine the available preclinical models for glioma including xenographs, syngeneic and genetic models. Several promising therapeutic targets are currently being pursued in pre-clinical investigations. These targets will be reviewed by mechanism of action, i.e., conditional cytotoxic, targeted …

Regulatory Role Of Glycogen Synthase Kinase 3 For Transcriptional Activity Of Add1/Srebp1c, Kang Ho Kim, Min Jeong Song, Eung Jae Yoo, Sung Sik Choe, Sang Dai Park, Jae Bum Kim

Faculty, Staff and Student Publications

Adipocyte determination- and differentiation-dependent factor 1 (ADD1) plays important roles in lipid metabolism and insulin-dependent gene expression. Because insulin stimulates carbohydrate and lipid synthesis, it would be important to decipher how the transcriptional activity of ADD1/SREBP1c is regulated in the insulin signaling pathway. In this study, we demonstrated that glycogen synthase kinase (GSK)-3 negatively regulates the transcriptional activity of ADD1/SREBP1c. GSK3 inhibitors enhanced a transcriptional activity of ADD1/SREBP1c and expression of ADD1/SREBP1c target genes including fatty acid synthase (FAS), acetyl-CoA carboxylase 1 (ACC1), and steroyl-CoA desaturase 1 (SCD1) in adipocytes and hepatocytes. In contrast, overexpression of GSK3beta down-regulated the transcriptional …

Respiratory Symptoms In Relation To Residential Coal Burning And Environmental Tobacco Smoke Among Early Adolescents In Wuhan, China: A Cross-Sectional Study, C. Anderson Johnson, Jiang Xia, Päivi M. Salo, Yan Li, Grace E. Kissling, Edward L. Avol, Chunhong Liu, Stephanie J. London

CGU Faculty Publications and Research

Background

Cigarette smoking and coal burning are the primary sources of indoor air pollution in Chinese households. However, effects of these exposures on Chinese children's respiratory health are not well characterized.

Methods

Seventh grade students (N = 5051) from 22 randomly selected schools in the greater metropolitan area of Wuhan, China, completed an in-class self-administered questionnaire on their respiratory health and home environment.

Results

Coal burning for cooking and/or heating increased odds of wheezing with colds [odds ratio (OR) = 1.57, 95% confidence interval (CI): 1.07–2.29] and without colds (OR = 1.44, 95% CI: 1.05–1.97). For smoking in the home, …

Bronchial Airway Epithelial Cell Denudation In The Pathogenesis Of Asthma: The Role Of Il-4 And Il-13, Gail Ramirez-Icaza

All-Inclusive List of Electronic Theses and Dissertations

Asthma is characterized by infiltration and shedding of the bronchial epithelium. The Th2 cytokines IL-4 and IL-13 are involved in the cellular recruitment and infiltration seen in asthma. The effects ofIL-4 and IL-13 on cell-matrix interactions, gap formation, increased monolayer permeability and epithelial shedding are unknown. Experiments described in this report test the hypothesis that bronchial airway epithelial cells (BAEC) express paxillin, a structural focal adhesion protein, and down-regulation of paxillin by Th2 cytokines lead to BAEC hyperpermeability. Furthermore, the hypothesis that the Th2 cytokines IL-4 and IL-13 could down-regulate the adherens junction proteins Pcatenin and E-cadherin in BAEC, and …

Arkansas Animal Science Department Report 2004, Zelpha B. Johnson, D. Wayne Kellogg

Arkansas Agricultural Experiment Station Research Series

No abstract provided.

Association Of Dc-Sign Promoter Polymorphism With Increased Risk For Parenteral, But Not Mucosal, Acquisition Of Human Immunodeficiency Virus Type 1 Infection, Maureen P. Martin, Michael M. Lederman, Holli B. Hutcheson, James J. Goedert, George W. Nelson, Yvette Van Kooyk, Roger Detels, Susan Buchbinder, Keith Hoots, David Vlahov, Stephen J. O'Brien, Mary Carrington

Biology Faculty Articles

There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired …

Enterotoxin B Subunit Lectins As Adjuvants For Improvement Of Mucosal Vaccine, Nak-Won Choi

Loma Linda University Electronic Theses, Dissertations & Projects

In comparison with whole organism vaccines, subunit vaccines may be safer for immunization but may lack sufficient immunogenicity to provide complete immunity to the pathogen. To resolve this problem, bacterial and plant enterotoxin B subunit adjuvants containing a variety of receptor-binding properties were used to enhance the immunogenicity of rotavirus subunit vaccines. Enterotoxin B subunit adjuvants were employed to enhance protection against virus infection. Pentameric cholera toxin B subunit (CTB), shiga toxin-1 B subunit (STB) and monomeric ricin toxin B subunit (RTB) molecules were genetically linked to a 90 amino acid peptide from the simian rotavirus (SA11) nonstructural protein NSP4 …

The Potential Role Of Ledgf/P75 In Prostate Cancer, Tracy Ruth Daniels

Loma Linda University Electronic Theses, Dissertations & Projects

The serum autoantibody repertoire from cancer patients is currently being exploited for the identification of tumor associated antigens (TAA) and the design of TAA arrays. Such arrays would facilitate autoantibody profiling and potentially aid in the serological diagnosis and prognosis of tumors. The goal of this study was to identify and characterize prostate-specific TAA. We observed that while the general frequency and titers of autoantibodies in PCa patients were relatively similar to those in matched controls, significant differences could be detected between the two groups in the autoantibody response to the lens epithelial-derived growth factor p75 (LEDGF/p75). LEDGF/p75 is a …

P14arf : A P53-Independent Tumor Suppressor, Monte W. Miller

Loma Linda University Electronic Theses, Dissertations & Projects

Many genetic alterations at the CDKN2A locus on human chromosome 9 have been shown to be at least partially responsible for transformation of cells to a cancerous phenotype. This locus encodes two proteins, p16 and p14, that play a pivotal role in tumor surveillance.

Breakdowns in the p14 pathway have been estimated to be present in approximately 40% of human cancers and only recently have its binding partners and effects begun to be defined. Its interaction with the p53 pathway, which is estimated to be inactivated or mutated in 50% of all cancers, makes it difficult to determine its own …

The Effect Of Topical Fluorides On The Microleakage Of Sealants, N. Jared Nation

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The purpose of this study was to evaluate the possible microleakage found in two groups of sealants; a group bonded with a dentin bonding agent (DBA), and a group bonded without a DBA after exposure to a variety of topical fluorides.

Materials and Methods: Extracted, human molars were placed into 8 groups. Half of the groups contained sealants that were bonded with a DBA and the other remaining groups of sealants were bonded without a DBA. There were two control groups, one that had sealants bonded with a DBA and the other had sealants bonded without a DBA, but …

The Effect Of Naocl, Ca(Oh)2, Mta And Mtad On Root Dentin Fracture Resistance, Sunil Ilapogu

Loma Linda University Electronic Theses, Dissertations & Projects

Various materials are used for the treatment of immature teeth that have been subjected to trauma or decay. It is not well established what effect these materials may have on the immature root dentin. A concern would be the resistance to fracture of the remaining root dentin. The purpose of this study was to compare the resistance of fracture of bovine teeth treated with sodium hypochlorite, calcium hydroxide, gray MTA and gray MTA in conjunction with MTAD after certain periods of time. One hundred and ninety five freshly extracted, intact bovine incisors were prepared using a modified Haapasalo and Orstavik …

Muscle Vibration's Effect On The Threshold Frequency Of An Electrically Induced Muscle Cramp, Joshua D. Williamson

All-Inclusive List of Electronic Theses and Dissertations

Objective: The purpose of this study was to evaluate the effect of muscle vibration on the threshold frequency of an electrically-induced muscle cramp of the flexor hallucis brevis. Design and setting: This study used a 2 x 2 factorial design study. The independent variables consisted of treatment ( control and vibration) and time (pretest and post-test). The dependent variable was the threshold frequency of an electrically induced muscle cramp. Subjects: 16 healthy individuals, aged 21.6 ± 8.0 years, free from any lower extremity neurological, muscular, or vascular pathology were used in this study. Methods: Subjects reported on three consecutive days …

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Selected Works Temporary Series

No abstract provided.

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Departmental Papers (Biology)

No abstract provided.

Evaluating Forensic Dna Evidence: Essential Elements Of A Competent Defense Review, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.