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Articles 42091 - 42093 of 42093
Full-Text Articles in Medicine and Health Sciences
Inoculation—Vaccination, Frank S. Billings
Inoculation—Vaccination, Frank S. Billings
School of Veterinary and Biomedical Sciences: Faculty Publications
When one comes to discuss this question with the members of the profession as he casually meets them, he is often surprised to find how uncertain and clouded the prevailing ideas are upon the subject. In fact, the majority of physicians do not seem to have any clear conception of the act connected with the words “ inoculation ” and “ vaccination.”
Human Complement Protein C8: The “Hole” Story, James M. Sodetz
Human Complement Protein C8: The “Hole” Story, James M. Sodetz
Journal of the South Carolina Academy of Science
No abstract provided.
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Nebraska Center for Virology: Faculty Publications
Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …