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Articles 1 - 30 of 206
Full-Text Articles in Medicine and Health Sciences
Multisystem Inflammatory Syndrome In Children (Mis-C): Is There A Relationship To Typhus?, Juliana Hager, Juliana Hager, Jacob Smith
Multisystem Inflammatory Syndrome In Children (Mis-C): Is There A Relationship To Typhus?, Juliana Hager, Juliana Hager, Jacob Smith
Research Colloquium
The United Kingdom first reported in April 2020 a group of eight previously healthy children with a link to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that presented with systemic inflammation and multi-organ involvement, now named multisystem inflammatory syndrome in children (MIS-C). The Centers of Disease Control and Prevention (CDC) have reported over 1000 cases since the primary discovery as of October 2020 with 20 total deaths. [1] The clinical features of MIS-C have been previously compared to inflammatory syndromes including Kawasaki disease (KD) and toxic shock syndrome (TSS). We describe the clinical presentation and management for 3 pediatric cases with …
Neurotropic Manifestations As A Potential Risk Factor For Schizophrenia Following In Utero Exposure To Sars-Cov-2, Mir Ali R Talpur, Omar H. Elsayed, Rif S. El-Mallakh
Neurotropic Manifestations As A Potential Risk Factor For Schizophrenia Following In Utero Exposure To Sars-Cov-2, Mir Ali R Talpur, Omar H. Elsayed, Rif S. El-Mallakh
The University of Louisville Journal of Respiratory Infections
Background: COVID-19 infection is associated with neurologic and psychiatric morbidity that suggests a direct effect of the virus or secondary effect of an inflammatory process. These neuropsychiatric consequences may increase the likelihood of schizophrenia in the offspring of women who become infected with COVID-19 during their pregnancy.
Methods: We performed a directed narrative review of the literature focusing on the proposed pathophysiological processes that lead to schizophrenia and known pathological consequences of COVID-19 infection.
Results: Schizophrenia in adult offspring has been associated with maternal infections during pregnancy by a wide range of respiratory and neurotropic pathogens. Spikes in the incidence …
Exploring The Possible Phenomenon Of Viral Interference Between The Novel Coronavirus And Common Respiratory Viruses, Spencer Deleveaux, Alexandria Clarke-Kregor, Xavier Fonseca-Fuentes, Essam Mekhaiel
Exploring The Possible Phenomenon Of Viral Interference Between The Novel Coronavirus And Common Respiratory Viruses, Spencer Deleveaux, Alexandria Clarke-Kregor, Xavier Fonseca-Fuentes, Essam Mekhaiel
Journal of Patient-Centered Research and Reviews
At the peak of the 2021 wave of the SARS-CoV-2 alpha variant in North America, there was concern for a superimposed wave of viral respiratory infections. There was, however, an apparent shift in the usual epidemiology of these pathogens, especially during the traditional influenza season from approximately October 2020 to March 2021. This article seeks to briefly describe the epidemiology of notable respiratory pathogens during the first wave of the COVID-19 pandemic and to focus on one possible factor for the trends observed. There are many contributory elements to the observed viral trends, but in particular, we present a synopsis …
Generation Of Chimeric Rhinoviruses Presenting Sars-Cov-2 Broadly Neutralizing Epitopes And Their Antigenicity Characterization, Danish Ansari
Generation Of Chimeric Rhinoviruses Presenting Sars-Cov-2 Broadly Neutralizing Epitopes And Their Antigenicity Characterization, Danish Ansari
Biotechnology Theses
The global COVID pandemic is not yet fully under control as there were over 21 million new cases of SARS-CoV-2 infections and over 50,000 deaths globally as of January of 2022. A heavily mutated variant of concern, Omicron is responsible for most of these cases which demands an urgency for a new vaccine. NIH reports over 180 vaccine candidates that use various strategies currently in development. However, a recurring concern with these vaccines is that the continuous viral mutations decrease the efficacy of vaccines. Therefore, we proposed to construct a human rhinovirus (HRV) based chimeric virus containing highly conserved, broadly …
Factors Contributing To Ventilator Dependent Days In Covid-19, Isaac Ginsberg, Samantha Eteve, Bryan Lunt, Kenneth Krell
Factors Contributing To Ventilator Dependent Days In Covid-19, Isaac Ginsberg, Samantha Eteve, Bryan Lunt, Kenneth Krell
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
Corrigendum: Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar
Corrigendum: Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar
Research outputs 2022 to 2026
In the published article, there was an error in the legend for Figure 1 as published. The figure legend did not indicate that it has been adapted from Plowright et al. (2017). Copyright permission was obtained from Springer Nature to adapt Figure 1 from Plowright et al. (2017). The corrected legend appears below. Figure 1. Zoonotic risk distribution, pathway to spillover, and the multimodal role of the determinants of spillover. The zoonotic risk is demonstrated by the accumulated distribution of reservoir hosts and vectors that play a role in the pathway to spillover. The risk of spillover is determined by …
Effects Of Transcranial Direct Current Stimulation On Adults With Post-Acute Covid-19 Syndrome, Isaac Min, Aaron Schurger
Effects Of Transcranial Direct Current Stimulation On Adults With Post-Acute Covid-19 Syndrome, Isaac Min, Aaron Schurger
Student Scholar Symposium Abstracts and Posters
Since its detection in December 2019, coronavirus disease 2019 (COVID-19), the viral disease caused by the SARS-CoV-2 novel coronavirus, has had prominent effects on human health and mortality. Studies in previous infections of SARS-CoV and MERS-CoV have found evidence of persistent symptoms in recovered patients, such as lethargy and shortness of breath. Similar residual symptoms have also been seen in recovered COVID-19 patients beyond four weeks of the initial onset of symptoms — collectively termed post-acute COVID-19 syndrome (PACS). These symptoms include deficits in working memory. Preliminary studies done in the United States and Europe have shown a significant portion …
Gender, Monastic Life, And The Lay Community During The Pandemic, Stephen Covell, Diane Riggs, Cameron Borg
Gender, Monastic Life, And The Lay Community During The Pandemic, Stephen Covell, Diane Riggs, Cameron Borg
Modules for Teaching Pandemic Response and Religion in the USA
The following teaching module is designed for high school and college level instructors who seek to teach a lesson on the impact the COVID-19 pandemic had on the monastic life of both Buddhists and Catholics. The teaching module features a lesson plan, case studies, and assignments that can be incorporated as the instructor sees fit. This teaching module was created by Wester Michigan University's Department of Comparative Religion.
Coronavirus (Covid-19) And Religious Holidays In The U.S., Stephen Covell, Diane Riggs, Cameron Borg, Jarrett Stalinger, Jacob Riccioni
Coronavirus (Covid-19) And Religious Holidays In The U.S., Stephen Covell, Diane Riggs, Cameron Borg, Jarrett Stalinger, Jacob Riccioni
Modules for Teaching Pandemic Response and Religion in the USA
The following teaching module is designed for high school and college level instructors who seek to teach a lesson on the impact the COVID-19 pandemic had on the celebration of religious holidays, such as Ramadan, Passover, and Easter. The teaching module features a lesson plan, case studies, and assignments that can be incorporated as the instructor sees fit. This teaching module was created by Western Michigan University's Department of Comparative Religion.
Orthodox Jewish Women And Ritual Purity During The Pandemic, Stephen Covell, Diane Riggs, Cameron Borg
Orthodox Jewish Women And Ritual Purity During The Pandemic, Stephen Covell, Diane Riggs, Cameron Borg
Modules for Teaching Pandemic Response and Religion in the USA
The following teaching module is designed for high school and college level instructors who seek to teach a lesson on the impact the COVID-19 pandemic has had on Jewish women and their ritual purity. The teaching module features a lesson plan, case studies, and assignments that can be incorporated as the instructor sees fit. This teaching module was created by Western Michigan University's Department of Comparative Religion.
Ulnar Nerve Palsy As Covid-19 Sequelae In 3 Patients, Cristina Terhoeve, Ryan Bliss, Rasheed Ahmad
Ulnar Nerve Palsy As Covid-19 Sequelae In 3 Patients, Cristina Terhoeve, Ryan Bliss, Rasheed Ahmad
School of Medicine Faculty Publications
The pathophysiology and treatment of COVID-19 have been at the forefront of medical research this past year. While great strides have been made in our knowledge of the disease, there is still much that is unknown. More than one-third of patients with COVID-19 present with symptoms involving the nervous system. The reason for this is unclear, although several theories have been postulated. In this case study, we present 3 patients with severe ulnar nerve dysfunction following treatment for COVID-19 in the intensive care unit. We discuss reasons why this may have occurred, the etiology of which is likely multifactorial. We …
Public Policy And Religion In The Pandemic: U.S. Constitution And The First Amendment, Stephen Covell, Diane Riggs, Cameron Borg
Public Policy And Religion In The Pandemic: U.S. Constitution And The First Amendment, Stephen Covell, Diane Riggs, Cameron Borg
Modules for Teaching Pandemic Response and Religion in the USA
The following teaching module is designed for high school and college level instructors who seek to teach a lesson on the impact the COVID-19 pandemic had on the relationship between church and state. The teaching module features a lesson plan, case studies, and assignments that can be incorporated as the instructor sees fit. This teaching module was created by Western Michigan University's Department of Comparative Religion.
“Hiccups” With Covid-19 Management, Yong W. Lee, Jacob Psomiadis, Sarah Akbani, Marvin Lopez-Medal, Aisha Miller
“Hiccups” With Covid-19 Management, Yong W. Lee, Jacob Psomiadis, Sarah Akbani, Marvin Lopez-Medal, Aisha Miller
Advances in Clinical Medical Research and Healthcare Delivery
Hiccups, medically referred as singultus, is a condition that results from involuntary contraction of the diaphragm and intercostal muscles. Singultus is usually a self-limiting condition which typically lasts less than 48 hours but in rare cases, can persist greater than 48 hours. This is a case of a 48 year-old male who was prescribed dexamethasone for COVID-19 but developed intractable singultus for two weeks. Patient was unable to tolerate diet due to intractable singultus leading to vomiting. He underwent various non-pharmacological maneuvers and pharmacotherapy without resolution. Dexamethasone- induced hiccups have been reported as an under recognized side effect of dexamethasone. …
Development Of A Bamlanivimab Infusion Process In The Emergency Department For Outpatient Covid-19 Patients, Danny Pham, Sandy Wong, Christina T. Nguyen, Stephen C. Lee, Kimberly J. Won
Development Of A Bamlanivimab Infusion Process In The Emergency Department For Outpatient Covid-19 Patients, Danny Pham, Sandy Wong, Christina T. Nguyen, Stephen C. Lee, Kimberly J. Won
Pharmacy Faculty Articles and Research
The coronavirus disease 2019 (COVID-19) pandemic has prompted the creation of new therapies to help fight against the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Bamlanivimab is a SARS-CoV-2 monoclonal antibody that is administered as an intravenous infusion to ambulatory patients with mild or moderate COVID-19, but a concern that arose was deciding the optimal location for patients to receive the medication. This report describes the development and implementation of a bamlanivimab infusion center in the emergency department of three hospitals in Orange County, California, shortly after bamlanivimab received emergency use authorization. As a result, a total of 601 …
Examining The Healthcare Journeys Of African American Individuals With Type 2 Diabetes Amid Covid-19, Lei Edmerson
Examining The Healthcare Journeys Of African American Individuals With Type 2 Diabetes Amid Covid-19, Lei Edmerson
Honors Theses
The overall purpose of this study is to explore the pandemic experience of African American’s with Type 2 Diabetes. This study was done to highlight a specific group of people who live with a chronic illness and the steps they took to ensure their safety during a pandemic. The COVID- 19 pandemic had been shown to adversely and disproportionately impact minorities and those with diabetes in regards to mortality rates. This study aims to bring light to the stories of those dealing with more than just the pandemic. It wanted to explore how they made it thus far, and if …
Ua94/6/1 Pandemic Personal Narrative, Leah Painter
Ua94/6/1 Pandemic Personal Narrative, Leah Painter
Student/Alumni Personal Papers
COVID-19 personal narrative written by student Leah Painter for History 241 class.
Wellness Review 2021, Part 1, Martin Huecker, Brian A. Ferguson, Jacob Shreffler
Wellness Review 2021, Part 1, Martin Huecker, Brian A. Ferguson, Jacob Shreffler
Journal of Wellness
Introduction: This article presents a curated selection of the wellness literature from January to June of 2021. JWellness editors offer a summary of recent publications within the wellness domain to seek an understanding of both burnout prevention and, more importantly, thriving in the medical profession.
Methods: For the interval of Jan 1 to June 30, 2021, a UofL librarian queried PubMed for empirical research studies, review articles, and editorials related to healthcare professional wellness. Excluding papers related to COVID-19 (due to extensive prior coverage) and editorials/commentaries, the editors narrowed to 43 articles (systematic reviews, meta-analyses, general reviews, and clinical trials) …
Voices From A Prison Pandemic: Lives Lost From Covid-19 At Lakeland Correctional, Kimberly Thomas
Voices From A Prison Pandemic: Lives Lost From Covid-19 At Lakeland Correctional, Kimberly Thomas
Articles
Coronavirus tore through jails and prisons like wildfire. In some states, more than half of the people incarcerated there tested positive for COVID-19; nearly 400,000 people in prison across the United States have tested positive. For people in prison, COVID-19 brought the loss of close friends, solitary confinement, loss of connection with family and programming, lack of information, and fear of contracting the virus. It has also reminded those who are incarcerated of the one-dimensional way in which people in prison are perceived. As stated by one collaborator, Cory Souders, "[s]o many men and women who come to prison are …
Variances In Bcg Protection Against Covid-19 Mortality: A Global Assessment, Zouina Sarfraz, Azza Sarfraz, Krunal Pandav, Sarabjot Singh Makkar, Saman Hasan Siddiqui, Gaurav Patel, Tania Platero-Portillo, Bishnu Mohan Singh, Mohamed Iburahim Haja Maideen, Deepika Sarvepalli, Muzna Sarfraz
Variances In Bcg Protection Against Covid-19 Mortality: A Global Assessment, Zouina Sarfraz, Azza Sarfraz, Krunal Pandav, Sarabjot Singh Makkar, Saman Hasan Siddiqui, Gaurav Patel, Tania Platero-Portillo, Bishnu Mohan Singh, Mohamed Iburahim Haja Maideen, Deepika Sarvepalli, Muzna Sarfraz
Department of Paediatrics and Child Health
The BCG vaccine is known to impart nonspecific immunological benefits alongside conferring protection to tuberculosis in endemic regions. It is also known to protect against bladder cancer and other respiratory tract infections. During the coronavirus disease 2019 (COVID-19) pandemic, the BCG vaccine has gained attention due to its role in conferring protective immunity. We demonstrate the potential immunological protective mechanisms that play a role against COVID-19. We conduct a global assessment of the countries that have the highest and lowest mortality rates determined by an a priori methodology. Lastly, we discuss the potential limitations of incorporating BCG vaccines as potential …
Follow These Procedures For Cleaning Fruits And Vegetables, Celina Wille, Teresa Hunsaker
Follow These Procedures For Cleaning Fruits And Vegetables, Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 prevention messages available in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment. This infographic provides facts about cleaning fruits and vegetables.
How To Clean Electronic Items To Prevent Coronavirus (Covid-19), Celina Wille, Teresa Hunsaker
How To Clean Electronic Items To Prevent Coronavirus (Covid-19), Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 prevention messages developed in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment.This infographic provides facts about cleaning electronics.
Follow These Procedures For Cleaning Fruits And Vegetables - Sturdy Fruits And Vegetables, Celina Wille, Teresa Hunsaker
Follow These Procedures For Cleaning Fruits And Vegetables - Sturdy Fruits And Vegetables, Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 prevention messages developed in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment. This fact sheet provides information about cleaning sturdy fruits and vegetables such as green beans, asparagus, cucumbers, and melons.
How Long Can The Coronavirus (Covid-19) Survive?, Celina Wille, Teresa Hunsaker
How Long Can The Coronavirus (Covid-19) Survive?, Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 prevention messages developed in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment. This fact sheet provides information about the survival times of the virus.
What Can You Do To Prevent Spreading The Coronavirus (Covid-19)?, Celina Wille, Teresa Hunsaker
What Can You Do To Prevent Spreading The Coronavirus (Covid-19)?, Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 prevention messages in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment. This fact sheet provides information on practices to prevent disease.
Follow These Procedures For Cleaning Fruits And Vegetables - Lettuce And Other Leafy Greens And Root Vegetables, Celina Wille, Teresa Hunsaker
Follow These Procedures For Cleaning Fruits And Vegetables - Lettuce And Other Leafy Greens And Root Vegetables, Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 prevention messages developed in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment. This fact sheet provides information about cleaning lettuce and other leafy greens and root vegetables.
Follow These Procedures For Cleaning Fruits And Vegetables - Tender Fruits And Vegetables, Celina Wille, Teresa Hunsaker
Follow These Procedures For Cleaning Fruits And Vegetables - Tender Fruits And Vegetables, Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 Prevention messages developed in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment. This fact sheet provides information about cleaning tender fruits and vegetables such as tomatoes, ripe stone fruits, mushrooms, and berries.
What Household Cleaning Products Effectively Prevent The Coronavirus (Covid-19)?, Celina Wille, Teresa Hunsaker
What Household Cleaning Products Effectively Prevent The Coronavirus (Covid-19)?, Celina Wille, Teresa Hunsaker
All Current Publications
This infographic is part of a series of eight graphically depicted COVID-19 prevention messages in English and Spanish, covering virus survival times, personal prevention practices, use of homemade cleaning products, and techniques to maintain a virus-free personal and home environment. This fact sheet provides information about household cleaning products that prevent disease.
County Youth Athletics Response To Covid-19 Pandemic, Elise Schaller
County Youth Athletics Response To Covid-19 Pandemic, Elise Schaller
Dissertations
Problem: To ensure safe participation in youth athletics and prevent COVID-19 transmission during the COVID-19 pandemic, St. Louis County Department of Public Health (DPH) implemented Youth Sports Guidelines on October 14, 2020. This project aimed to identify level of adherence to precautions listed in the guidelines at six county public high school athletic events.
Methods: An observational descriptive study design was used to monitor guideline adherence at high school athletic events. Two observers tallied violations by participants and spectators to Youth Sports Guidelines at St. Louis County public high school athletic events. Six high-frequency contact (basketball and wrestling) events …
Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease And Implications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz
Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease And Implications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz
Department of Paediatrics and Child Health
Background/aim: Since the outbreak of the COVID-19, numerous therapies to counteract this severe disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 patients and the methodologies of ongoing clinical trials are explored.
Materials and methods: A systematic search adhering to PRISMA guidelines was conducted in PubMed, Cochrane Central, medRxiv, and bioRxiv using the following keywords: “Tocilizumab,” “Actemra,” “COVID-19.” An additional subsearch was conducted on Clinicaltrials.gov to locate ongoing tocilizumab trials.
Results: A total of 13 studies were included in the meta-analysis comprising 2120 patients. The treatment group had lower mortality compared to the control group (OR = 0.42, …
Effect Of Clinical Isolate Or Cleavage Site Mutations In The Sars-Cov-2 Spike Protein On Protein Stability, Cleavage, And Cell-Cell Fusion, Chelsea T. Barrett, Hadley E. Neal, Kearstin Edmonds, Carole L. Moncman, Rachel Thompson, Jean M. Branttie, Kerri Beth Boggs, Cheng-Yu Wu, Daisy W. Leung, Rebecca E. Dutch
Effect Of Clinical Isolate Or Cleavage Site Mutations In The Sars-Cov-2 Spike Protein On Protein Stability, Cleavage, And Cell-Cell Fusion, Chelsea T. Barrett, Hadley E. Neal, Kearstin Edmonds, Carole L. Moncman, Rachel Thompson, Jean M. Branttie, Kerri Beth Boggs, Cheng-Yu Wu, Daisy W. Leung, Rebecca E. Dutch
Molecular and Cellular Biochemistry Faculty Publications
The trimeric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) is the sole viral protein responsible for both viral binding to a host cell and the membrane fusion event needed for cell entry. In addition to facilitating fusion needed for viral entry, S can also drive cell-cell fusion, a pathogenic effect observed in the lungs of SARS-CoV-2-infected patients. While several studies have investigated S requirements involved in viral particle entry, examination of S stability and factors involved in S cell-cell fusion remain limited. A furin cleavage site at the border between the S1 and S2 subunits (S1/S2) has …