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Full-Text Articles in Medicine and Health Sciences

Non-Surgical Correction Of Craniofacial Microsomia With Occlusal Plane Canting, Tzu-Pin Su, Huei-Mei Tsai, Chia-Yi Pan, Yuen-Yung Tsang, Yu-Ling Cheng Dec 2020

Non-Surgical Correction Of Craniofacial Microsomia With Occlusal Plane Canting, Tzu-Pin Su, Huei-Mei Tsai, Chia-Yi Pan, Yuen-Yung Tsang, Yu-Ling Cheng

Taiwanese Journal of Orthodontics

An adult woman suffered moderate complications of cranio-facial microsomia (CFM) with different severity on both sides of the face. This anomaly leads to short ramal height, condylar pathology, chin deviation and facial asymmetry. The malformed dental arch, open bite and severe canting of the occlusal plane were the reasons for the patient to request the therapy. Orthodontic treatment was performed with pre-adjusted edgewise system assisted by temporal anchorage devices (TADs). These modalities were executed through leveling of the occlusal plane. The improvement was noticed for both better oral function and esthetics.


Vertical Maxillary Excess Complicated With Mutilated Dentition Treated By An Interdisciplinary Approach, Shao-Ching Su, Huei-Mei Tsai, Ming-Jeaun Su, Yi-Min Liu Dec 2020

Vertical Maxillary Excess Complicated With Mutilated Dentition Treated By An Interdisciplinary Approach, Shao-Ching Su, Huei-Mei Tsai, Ming-Jeaun Su, Yi-Min Liu

Taiwanese Journal of Orthodontics

Vertical skeletal dysplasia can lead to excessive lower facial height and maxillary teeth elongation with gum exposure. Patients usually have long face, steep mandibular plane angle, usually with mandibular retrognathism. The clinical manifestations include narrow nose, narrow upper dental arch, excessive incisal display, a significant backward and downward rotated mandible as well as vertical maxillary excess (VME). Traditional classifications which mainly based on sagittal jaw relation is inadequate in describing the vertical skeletal discrepancy. The patient also suffered from multiple missing posterior teeth, that requires an interdisciplinary dental care. The main treatment objectives are to normalize overjet and overbite, improve …


Surgery First And Atypical Extraction For A Skeletal Class Iii With Severe Anterior Open Bite And Severe Crowding— Three-Year Stability, Sutthinee Ruschasetkul, Thatchawee Borikanphanitphaisan, Yi-Chin Wang Dec 2020

Surgery First And Atypical Extraction For A Skeletal Class Iii With Severe Anterior Open Bite And Severe Crowding— Three-Year Stability, Sutthinee Ruschasetkul, Thatchawee Borikanphanitphaisan, Yi-Chin Wang

Taiwanese Journal of Orthodontics

This case report features a successful combined surgical-orthodontic treatment of a patient with skeletal Class III malocclusion with severe anterior open bite and severe mandibular crowding. Clinical examination revealed concave profile with long-face deformity caused by retrognathic maxilla and excessive vertical growth of mandible, maxillary crowding despite absence of maxillary first premolars, mandibular incisor retroclination, deep curve of Spee, and blocked-out mandibular canines. The treatment involved surgery-first approach with extraction of lower right first premolar and atypical extraction of lower left canine due to its poor periodontal support. Harmonized facial profile, pleasing smile, good occlusal interdigitation as well as skeletal …


Clinical Effectiveness Of Using Clear Aligners In Orthodontic Treatment, Chih-Ling Lin, Yi-Chin Wang, Yuh-Jia Hsieh, Yun-Fang Chen, Yu-Chih Wang Dec 2020

Clinical Effectiveness Of Using Clear Aligners In Orthodontic Treatment, Chih-Ling Lin, Yi-Chin Wang, Yuh-Jia Hsieh, Yun-Fang Chen, Yu-Chih Wang

Taiwanese Journal of Orthodontics

Purpose: To assess the clinical treatment effectiveness of clear aligners in orthodontic tooth movements.

Methods: The database of Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, and Scopus were searched from Jan 2015 to Jan 2020. The National Institute for Health and Clinical Excellence assessment tool was used for the methodological quality of included studies.

Results: The literature review yielded 166 articles after removal of duplicates, and an additional 2 articles were included from hand search of the bibliographies of included articles and relevant reviews. Fifteen studies were included in the systematic review. One study was randomized …


Effect Of Angular Insertion Of Orthodontic Miniscrews On Primary Stability, Prajak Jariyapongpaiboon, Jirawan Chartpitak Dec 2020

Effect Of Angular Insertion Of Orthodontic Miniscrews On Primary Stability, Prajak Jariyapongpaiboon, Jirawan Chartpitak

Taiwanese Journal of Orthodontics

Purpose: Infrazygomatic crest (IZC) miniscrews have useful clinical applications. They are applied with angular insertion to the bone surface. However, appropriate angles for the maximum stability of the miniscrew have not yet been well documented. This study aimed to compare the primary stability of different angles of orthodontic miniscrew insertion by analyzing maximum insertion torque (MIT) and pull out strength (PS).

Materials and methods: Sixty miniscrew implants were divided into 3 groups which underwent different angular insertion, with 20 samples in each group. Three pairs of bearing devices were constructed with an angulation of 30, 40 or 50 degrees. An …


Care And Maintenance Of Dental Restorations, Ibeth Erazo Dec 2020

Care And Maintenance Of Dental Restorations, Ibeth Erazo

Publications and Research

Contributing to the longevity of the restoration by minimizing the effects of surface corrosion, maintaining the esthetic appearance and the smooth surface characterization, and contributing to gingival health by lessening the potential for plaque retention are the principal reasons for taking care of dental restorations. However, during oral hygiene routine procedures and prevention treatments, these desired effects are not always achieved. In many cases, the restorative materials are not identified in a patient’s record leading to damage during oral hygiene performance by dental professionals. Therefore, it is important to be able to recognize the different restorative materials and employ the …


Dysphagia And Masticatory Performance As A Mediator Of The Xerostomia To Quality Of Life Relation In The Older Population., Ting-Yu Lu, Jen-Hao Chen, Je-Kang Du, Ying-Chun Lin, Pei-Shan Ho, Chien-Hung Lee, Chih-Yang Hu, Hsiao-Ling Huang Dec 2020

Dysphagia And Masticatory Performance As A Mediator Of The Xerostomia To Quality Of Life Relation In The Older Population., Ting-Yu Lu, Jen-Hao Chen, Je-Kang Du, Ying-Chun Lin, Pei-Shan Ho, Chien-Hung Lee, Chih-Yang Hu, Hsiao-Ling Huang

School of Public Health Faculty Publications

Background: The impact of poor oral health on older adults' quality of life is a public health problem. In this study, the mediating effects of dental status, occlusal condition, dysphagia, and masticatory performance on the association between xerostomia and oral health-related quality of life (OHRQoL) were assessed in the older adult population.Methods: Stratified cluster sampling was used to recruit 1076 community-dwelling adults aged 65 years and older from Kaohsiung, Taiwan. Community care centers were randomly selected according to their geographic classifications (urban, rural, or mountainous areas). Assessments of dental status and occlusal condition were performed by dentists. Information on demographics, …


Relation Of Oral Ulcers To Quality Of Life: A Cross-Sectional Study, Enji Ahmed, Ayat Gaml Abdelnasser, Mai Zakaria, Soheir Gafar Dec 2020

Relation Of Oral Ulcers To Quality Of Life: A Cross-Sectional Study, Enji Ahmed, Ayat Gaml Abdelnasser, Mai Zakaria, Soheir Gafar

Dentistry

Oral ulcers affect many dental patients; impairing their lives physically, psychologically, and socially. Due to the absence of information about oral ulcers in our population, the authors undertook a pilot study to obtain a more complete picture of prevalence of oral ulcers, its probable risk factors and its burden on the quality of life. Materials and methods The authors performed a cross‑sectional study with 605 adult dental patients. All patients filled a questionnaire inquiring about the risk factors. An oral examination was performed to each participant to determine presence or absence of oral ulcers; and the type of the oral …


Biomaterials In Valvular Heart Diseases, Bita Taghizadeh, Laleh Ghavami, Hossein Derakhshankhah, Ehsan Zangene, Mahdieh Razmi, Mehdi Jaymand, Payam Zarrintaj, Nosratollah Zarghami, Mahmoud Reza Jaafari, Matin Moallem Shahri, Adrineh Moghaddasian, Lobat Tayebi, Zhila Izadi Dec 2020

Biomaterials In Valvular Heart Diseases, Bita Taghizadeh, Laleh Ghavami, Hossein Derakhshankhah, Ehsan Zangene, Mahdieh Razmi, Mehdi Jaymand, Payam Zarrintaj, Nosratollah Zarghami, Mahmoud Reza Jaafari, Matin Moallem Shahri, Adrineh Moghaddasian, Lobat Tayebi, Zhila Izadi

School of Dentistry Faculty Research and Publications

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient's quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach …


Predicting Dental Student's Performance On National Board Dental Examination (Nbde) Part I: Exploring Demographic Factors, Dental Admission Test (Dat) Factors, Pre-Program Academic Factors, And Dental Program Academic Performance., Wei-Shao Lin Dec 2020

Predicting Dental Student's Performance On National Board Dental Examination (Nbde) Part I: Exploring Demographic Factors, Dental Admission Test (Dat) Factors, Pre-Program Academic Factors, And Dental Program Academic Performance., Wei-Shao Lin

Electronic Theses and Dissertations

Dental students need to successfully challenge a national licensure examination to be able to practice dentistry. Dental educators currently have difficulty in identifying candidates who are at risk of failing this examination. This non-experimental quantitative study examined existing dental student data from the 2017, 2018, and 2019 graduating classes, using a retrospective and correlational approach to identify possible markers for at risk students. Demographic factors, dental admission test (DAT) factors, pre-program academic factors, dental program academic performance, and National Board Dental Examination (NBDE) Part I performance. A series of independent t-tests and One-Way analysis of variances (ANOVAs) were used to …


Radiographic Evaluation Of Bone And Mucosa Using Low-Dose Cbct With Radiopaque X-Resin Stent Versus Ct And Ridge Mapping: A Validity Study, Enji Ahmed, Nader Nabil Riskallah, Mushira Muhammed Dahaba, Eman Abdelaziz Ahmed Dec 2020

Radiographic Evaluation Of Bone And Mucosa Using Low-Dose Cbct With Radiopaque X-Resin Stent Versus Ct And Ridge Mapping: A Validity Study, Enji Ahmed, Nader Nabil Riskallah, Mushira Muhammed Dahaba, Eman Abdelaziz Ahmed

Dentistry

Aim: To compare the abilities of computed tomography (CT), cone beam computed tomography (CBCT) with X-resin and ridge mapping and to measure the thickness of bone and soft tissue during implant planning, which allows increasing the success criteria of implant placement. Materials and Methods: This validity study included a total of 96 samples chosen from 20 patients undergoing implant surgeries (mandible and maxilla) aged between 25 and 50 years. Measurements of bone and mucosa were done by using three techniques, which are the CT, CBCT with X-resin, and finally ridge mapping at 4 points that are 3, 4, 5, and …


Influence Of Blood Contamination On The Bond Strength And Biointeractivity Of Biodentine Used As Root-End Filling, Shehabeldin Mohamed Saber Prof.Dr. Dec 2020

Influence Of Blood Contamination On The Bond Strength And Biointeractivity Of Biodentine Used As Root-End Filling, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To evaluate the influence of blood contamination on the bond strength and apatite forming ability of Biodentine used as root-end filling material. Methodology: Eighty (n = 80) extracted single-rooted, sound human maxillary anterior teeth were prepared and obturated. Then, the roots were resected, retrograde cavities were prepared and Biodentine was inserted as the root-end filling material. Teeth were then randomly divided into 2 equal groups (n = 40) according to the setting environment of Biodentine i.e., group A where setting took place in human blood and group B where setting took place in deionized water (control group). Teeth were …


Disparities In Oral Health: Socioeconomic Status And Policies To Increase Access To Primary Dental Care, Mckenzie Nutter Dec 2020

Disparities In Oral Health: Socioeconomic Status And Policies To Increase Access To Primary Dental Care, Mckenzie Nutter

Theses/Capstones/Creative Projects

Primary dental care is a patient-centered service consisting of routine dental checkups. The oral cavity is the first point of entrance to the body for many harmful pathogens. Therefore, primary dental care is essential to not only prevent and treat conditions in the mouth, but to also reduce the number of systemic diseases in the rest of the body. However, people with higher incomes or wealth have increased access to primary dental care. People with low socioeconomic status have decreased access to primary dental care, at least in part due to difficulties in paying for separate dental insurance. Disparities in …


Assessing Nurse Practitioners' Knowledge And Clinical Practice With Regard To The Oral-Systemic Link, Angela Haynes Dec 2020

Assessing Nurse Practitioners' Knowledge And Clinical Practice With Regard To The Oral-Systemic Link, Angela Haynes

Electronic Theses and Dissertations

Nurse Practitioners (NPs) comprise a significant portion of the U.S. primary care workforce and play an essential role in patients' health awareness, prevention strategies, disease management, and in providing appropriate provider referrals. Nurse Practitioners receive education on the oral-systemic connection, yet there have been limited studies on the clinical practice of NPs assessing the oral cavity to evaluate the condition of the teeth and the oral tissues. The purpose of this study was to explore the nurse practitioners’ knowledge and practice habits of assessing the oral cavity for diseases or abnormalities in the mouth that can, in turn, affect overall …


Attitudes Of Virginia Dental Hygienists Toward Dental Therapists, Helene Mesina Burns Dec 2020

Attitudes Of Virginia Dental Hygienists Toward Dental Therapists, Helene Mesina Burns

Dental Hygiene Theses & Dissertations

Problem: The purpose of this study was to determine the opinions and attitudes of Virginia dental hygienists toward dental therapists (DTs) and to determine if current education level and years of practice affected opinions regarding education requirements for DTs. Methods: After IRB approval, a 22-item questionnaire was distributed online to a convenience sample of 910 Virginia dental hygienists. Questions assessed attitudes of participants toward the DT using a seven-point Likert-type scale ranging from 1 (strongly disagree) to 7 (strongly agree). Additionally, participants were asked to respond to demographic questions and open-ended questions about potential advantages and/or disadvantages to DTs. Independent …


A Dynamic Mechanical Method To Assess Bulk Viscoelastic Behavior Of The Dentin Extracellular Matrix, Yvette Alania, Mariana Cavalcante Dos Reis, Joo-Won Nam, Rasika S. Phansalkar, James Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo Dec 2020

A Dynamic Mechanical Method To Assess Bulk Viscoelastic Behavior Of The Dentin Extracellular Matrix, Yvette Alania, Mariana Cavalcante Dos Reis, Joo-Won Nam, Rasika S. Phansalkar, James Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

To develop a protocol for assessment of the bulk viscoelastic behavior of dentin extracellular matrix (ECM), and to assess relationships between induced collagen cross-linking and viscoelasticity of the dentin ECM.

Methods

Dentin ECM was treated with agents to induce exogenous collagen cross-linking: proanthocyanidins (PACs) from Vitis vinifera – VVe, PACs from Pinus massoniana - PMe, glutaraldehyde – (GA), or kept untreated (control). A dynamic mechanical strain sweep method was carried out in a 3-point bending submersion clamp at treatment; after protein destabilization with 4 M urea and after 7-day, 6-month, and 12-month incubation in simulated body fluid. Tan δ, …


Dental Sealants And Restorative Treatment For First Molars Among Medicaid Enrollees, Christopher Okunseri, Brian D. Hodgson, Elaye Okunseri, Raul Garcia, Alexis D. Visotcky, Aniko Szabo Dec 2020

Dental Sealants And Restorative Treatment For First Molars Among Medicaid Enrollees, Christopher Okunseri, Brian D. Hodgson, Elaye Okunseri, Raul Garcia, Alexis D. Visotcky, Aniko Szabo

School of Dentistry Faculty Research and Publications

Objectives

To assess the association between dental sealant placement and subsequent restorative treatment of permanent first molars over time.

Methods

We analysed Wisconsin Medicaid claims data from 2001 to 2009 for children aged 6-16 years. Children entered the study cohort at age 6 and were censored if Medicaid eligibility was lost for >31 days. A fixed effects analysis via a Cox proportional hazards model, stratified by individual, was used to estimate the time-averaged and time-dependent effects of sealant placement on dental treatment defined as any restorative, endodontic or surgical procedure.

Results

A total of 185,262 children with permanent first molars …


Epidemiology Of Male Breast Cancer, Santhi Konduri, Maharaj Singh, George Bobustuc, Richard Rovin, Amin Kassam Dec 2020

Epidemiology Of Male Breast Cancer, Santhi Konduri, Maharaj Singh, George Bobustuc, Richard Rovin, Amin Kassam

School of Dentistry Faculty Research and Publications

Background

Due to its rarity, few studies have characterized the epidemiology of male breast cancer. The purpose of this study was to determine survival and risk factors for male breast cancer in a large U.S. population.

Methods

In this study, 19,795 male patients with breast cancer were identified from the National Cancer Database (2004–2014). Patient demographics, tumor characteristics and treatments were analyzed by using descriptive statistics. We used multivariate Cox regression and Kaplan Meier analysis.

Results

Over 10 years, the incidence of male breast cancer increased from 7.2% to 10.3%, while mortality decreased from 11% to 3.8%. Socioeconomic factors predicting …


Serum Levels Of Vitamin C And Vitamin D In A Cohort Of Critically Ill Covid-19 Patients Of A North American Community Hospital Intensive Care Unit In May 2020: A Pilot Study, Cristian Arvinte, Maharaj Singh, Paul E. Marik Dec 2020

Serum Levels Of Vitamin C And Vitamin D In A Cohort Of Critically Ill Covid-19 Patients Of A North American Community Hospital Intensive Care Unit In May 2020: A Pilot Study, Cristian Arvinte, Maharaj Singh, Paul E. Marik

School of Dentistry Faculty Research and Publications

Background

The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of vitamin C and vitamin D as a risk-assessment tool, and therapeutic option, in COVID-19.

Objective

The objective of this pilot study was to measure serum vitamin C and vitamin D levels in a cohort of patients with critical COVID-19 illness in our community hospital ICU, correlate with other illness risk factors (age, BMI, HgbA1c, smoking status), generate hypotheses, and …


Graphite/Gold Nanoparticles Electrode For Direct Protein Attachment: Characterization And Gas Sensing Application, Javad Shabani Shayeh, Yahya Sefidbakht, Meisam Omidi, Fatemeh Yazdian, Lobat Tayebi Dec 2020

Graphite/Gold Nanoparticles Electrode For Direct Protein Attachment: Characterization And Gas Sensing Application, Javad Shabani Shayeh, Yahya Sefidbakht, Meisam Omidi, Fatemeh Yazdian, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this work, graphite/gold nanoparticles (G/AuNPs) were synthesized through a facile chemical method, and its potential application for direct protein attachment for electrochemical detection of carbon monoxide (CO) was investigated. The preparation of G/AuNPs electrodes was optimized by synthesizing the nanoparticles in different concentration of HAuCl4.3H2O at various temperatures. The G/AuNPs electrode was subsequently modified by four types of mercaptopropionic acid, including 1-mercaptopropionic, 3-mercaptopropionic, 6-mercaptopropionic, and 11-mercaptopropionic acid, to achieve the best structure for protein attachment. Visible absorption and electrochemical studies showed that 3-mercaptopropionic acid possesses the best performance regarding the electrical conductivity between electrode and …


J Mich Dent Assoc December 2020 Dec 2020

J Mich Dent Assoc December 2020

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

  • A cover story on “The Dentist’s Role in Recognizing Sleep-Related Breathing Disorders: A Two-Part Series”.
  • The “2020 Author/Title Index to the Journal of the Michigan Dental Association”.
  • News you need, Editorial and regular department articles on MDA Foundation activities, Dentistry and the Law, Staff Matters, and component news.

This issue also includes three articles reprinted …


Using Cone-Beam Computed Tomography To Evaluate Apical Transportation And Centering Ability Of Waveone, Oneshape And Tornado Rotary Systems: A Clinical Study, Alaaeldeen O. Mais, Amr M. Abdallah, Essam Osman Nov 2020

Using Cone-Beam Computed Tomography To Evaluate Apical Transportation And Centering Ability Of Waveone, Oneshape And Tornado Rotary Systems: A Clinical Study, Alaaeldeen O. Mais, Amr M. Abdallah, Essam Osman

BAU Journal - Creative Sustainable Development

This clinical study was aimed to evaluate apical transportation and centering ability of WaveOne, OneShape files and Tornado rotary system using Cone-beam computed tomography (CBCT). Lower molars with a curving angle of buccal canals extending from 15°-45° in 24 patients were arbitrarily divided into three groups (n=8) rendering to the rotary systems used: Group 1, Tornado system, Group 2, WaveOne rotary system, and Group 3, OneShape rotary system. CBCT was used as a diagnostic method to evaluate centering ratio and canal transportation at 2, 5 and 8 mm from apical foramen. One-way analysis of variance and post hoc Tukey tests …


Stress Analysis Comparing Effect Of Two Different Cad-Cam Implant Superstructure Materials (In-Vitro Study), Noura Turky Saad, Essam Osman, Ahmed M. Abdelhamid, Mohamed Shokry, Ehab A. Farghaly Nov 2020

Stress Analysis Comparing Effect Of Two Different Cad-Cam Implant Superstructure Materials (In-Vitro Study), Noura Turky Saad, Essam Osman, Ahmed M. Abdelhamid, Mohamed Shokry, Ehab A. Farghaly

BAU Journal - Creative Sustainable Development

Purpose: This study was conducted to evaluate the micro-strain around dental implant using two different CAD/CAM crown fabricated materials through strain gauge analysis. Materials and Methods: Five dental implants were fixed in a 5 previously drilled solid rigid polyurethane test blocks in the edentulous area with neighboring abutments mesial and distal printed out using special 3D Dental printer, Cyanoacrylate adhesive was then used to fix the printed-out part on to the polyurethane test blocks, creating the bounded saddle replicas. Ten CAD/CAM screw retained crowns were fabricated; five Enamic crowns from vita enamic blocks, and five zirconia crowns from presintered katana …


Persistent Palatal Hypertrophy Associated With Rapid Maxillary Expansion Procedure: Report Of A Rare Case, Mehmet Melih Omezli, Damla Torul, Tolunay Avci Nov 2020

Persistent Palatal Hypertrophy Associated With Rapid Maxillary Expansion Procedure: Report Of A Rare Case, Mehmet Melih Omezli, Damla Torul, Tolunay Avci

BioMedicine

Maxillary transversal deficiency (MTD) is a common skeletal problem. If not treated on time, MTD evolve to a more complex malocclusion. This problem can affect facial growth and development. Rapid maxillary expansion (RME) procedure frequently used for the management. This technique is usually successful in young individuals but as the age advances and the articulations of the maxilla with surrounding facial bones get more rigid, it becomes ineffective. Undesirable side effects or results have been reported after use of RME in skeletally mature patients such as buccal tipping of posterior teeth, extrusion, periodontal tissue recession, fenestration of buccal cortex, necrosis …


Role Of Metabolism In Bone Development And Homeostasis, Akiko Suzuki, Mina Minamide, Chihiro Iwaya, Kenichi Ogata, Junichi Iwata Nov 2020

Role Of Metabolism In Bone Development And Homeostasis, Akiko Suzuki, Mina Minamide, Chihiro Iwaya, Kenichi Ogata, Junichi Iwata

Faculty, Staff and Student Publications

Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such …


Targeting Trimeric And Tetrameric Proanthocyanidins Of Cinnamomum Verum Bark As Bioactives For Dental Therapies, Joo-Won Nam, Rasika S. Phansalkar, David C. Lankin, James Mcalpine, Ariene A. Leme-Kraus, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli Nov 2020

Targeting Trimeric And Tetrameric Proanthocyanidins Of Cinnamomum Verum Bark As Bioactives For Dental Therapies, Joo-Won Nam, Rasika S. Phansalkar, David C. Lankin, James Mcalpine, Ariene A. Leme-Kraus, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

The present study elucidated the structures of three A-type tri- and tetrameric proanthocyanidins (PACs) isolated from Cinnamomum verum bark to the level of absolute configuration and determined their dental bioactivity using two therapeutically relevant bioassays. After selecting a PAC oligomer fraction via a biologically diverse bioassay-guided process, in tandem with centrifugal partition chromatography, phytochemical studies led to the isolation of PAC oligomers that represent the main bioactive principles of C. verum: two A-type tetrameric PACs, epicatechin-(2β→O→7,4β→8)-epicatechin-(4β→6)-epicatechin-(2β→O→7,4β→8)-catechin (1) and parameritannin A1 (2), together with a trimer, cinnamtannin B1 (3). Structure …


Proanthocyanidin Block Arrays (Pacbar) For Comprehensive Capture And Delineation Of Proanthocyanidin Structures, Shuxi Jing, Wayne E. Zeller, Daneel Ferreira, Bin Zhou, Joo-Won Nam, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli Nov 2020

Proanthocyanidin Block Arrays (Pacbar) For Comprehensive Capture And Delineation Of Proanthocyanidin Structures, Shuxi Jing, Wayne E. Zeller, Daneel Ferreira, Bin Zhou, Joo-Won Nam, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Proanthocyanidins (PACs) are near-ubiquitous and chemically complex metabolites, prototypical of higher plants. Their roles in food/feed/nutrition and ethnomedicine are widely recognized but poorly understood. With the analysis of evidence that underlies this challenge, this perspective identifies shortcomings in capturing and delineating PAC structures as key factors. While several groups have forwarded new representations, a consensus method that captures PAC structures concisely and offers high integrity for electronic storage is required to reduce confusion in this expansive field. The PAC block arrays (PACBAR) system fills this gap by providing precise and human- and machine-readable structural descriptors that capture PAC metabolomic structural …


Ada News - 11/16/2020, American Dental Association, Publishing Division Nov 2020

Ada News - 11/16/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Oral Health Literacy Status Of School Staff Members In Southern Minnesota, Gabrielle Sullivan Nov 2020

Oral Health Literacy Status Of School Staff Members In Southern Minnesota, Gabrielle Sullivan

Dental Hygiene ETDs

Purpose:

This study evaluated the oral health literacy OHL of school staff in Southern Minnesota. OHL is the degree to which individuals can understand health information. Dental caries is the most common chronic disease in school aged children, and school staff members spend a large portion of the day with children. Therefore, it is important for all school staff members to have a moderate or higher OHL status.

Methods:

The survey used a convenience sample of school staff in 3 different schools in southern Minnesota and used the REALD-30 OHL instrument with slight modification, to simplify data collection.

Results:

Fifty …


Drug-Delivery Ca-Mg Silicate Scaffolds Encapsulated In Plga, A. Jadidi, E. Salahinejad, E. Sharifi, Lobat Tayebi Nov 2020

Drug-Delivery Ca-Mg Silicate Scaffolds Encapsulated In Plga, A. Jadidi, E. Salahinejad, E. Sharifi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca7MgSi4O16) porous scaffolds were fabricated by a foam replica method, loaded with vancomycin hydrochloride and encapsulated in poly lactic-co-glycolic acid (PLGA) coatings. Field emission scanning electron microscopy, Archimedes porosimetry and Fourier-transform infrared spectroscopy were used to characterize the structure of the scaffolds. The drug delivery kinetics and cytocompatibility of the prepared scaffolds were also studied in vitro. The bare sample exhibited a burst release of vancomycin and low biocompatibility …