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Full-Text Articles in Medicine and Health Sciences

Synergistic Effects Of Conductive Pva/Pedot Electrospun Scaffolds And Electrical Stimulation For More Effective Neural Tissue Engineering, Ali Babaie, Behnaz Bakhshandeh, Ali Abedi, Javad Mohammadnejad, Iman Shabani, Abdolreza Ardeshirylajimi, Seyed Reza Moosavi, Javid Amini, Lobat Tayebi Nov 2020

Synergistic Effects Of Conductive Pva/Pedot Electrospun Scaffolds And Electrical Stimulation For More Effective Neural Tissue Engineering, Ali Babaie, Behnaz Bakhshandeh, Ali Abedi, Javad Mohammadnejad, Iman Shabani, Abdolreza Ardeshirylajimi, Seyed Reza Moosavi, Javid Amini, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Fabrication and optimization of conductive scaffolds capable of inducing proper intercellular connections through electrical signals is critical for neural tissue engineering. In this research, electrospun conductive PVA (Polyvinyl alcohol)/PEDOT(poly(3,4-ethylenedioxythiophene)) scaffolds were fabricated in different compositions. Conductivity of electrospinning solutions and electrospun scaffolds were measured. Morphology and topography, mechanical properties and water contact angle of scaffolds were analyzed. Chemistry of scaffolds were studied using FTIR analysis, while biocompatibility and cellular interactions with scaffolds were tested using MTT assay and cellular attachment and spreading testing. Our results show improvements in PEDOT-containing scaffolds, in terms of physiochemical properties, and cell viability compared to …


Dental Practice During Covid-19 Pandemic: Risks And Measures, Eman Kheir, Nada Hashim Nov 2020

Dental Practice During Covid-19 Pandemic: Risks And Measures, Eman Kheir, Nada Hashim

International Arab Journal of Dentistry

In December 2019, the novel coronavirus was discovered for the first time in Wuhan, China. On the 9th of January 2020, following a fast progression of the infection, the World Health Organization announced the finding to be a novel coronavirus that was named SARS-CoV-2. Dentistry has a very special working environment that puts it on the top of the lists of hazardous professions. The inherent nature of dental procedures might represent a transmission path for the virus. The spread of the disease can be prevented by taking strict measures before, during and after each dental procedure. The aim of this …


Clinician’S Corner Tooth Transposition: The Clinical Features And Management A Case Report, Emad Hussein Nov 2020

Clinician’S Corner Tooth Transposition: The Clinical Features And Management A Case Report, Emad Hussein

Journal of the Arab American University مجلة الجامعة العربية الامريكية للبحوث

Tooth transposition is a rare developmental dental anomaly of unknown etiology. It exhibits a clinical challenge due to the presence of 2 teeth in a narrow buccolingual thickness of bone that had interchanged in position; care should be taken to avoid root proximity during movement of the transposed teeth during orthodontic treatment. The acceptance of tooth transposition could be considered the safest method of treatment on the root structure and the surrounding periodontium of the transposed teeth. Correction of tooth transposition could be tried in cases of maxillary lateral incisor canine transposition to avoid adverse effects on esthetics.


Ada News - 11/02/2020, American Dental Association, Publishing Division Nov 2020

Ada News - 11/02/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Blood Pressure Monitoring Following Individual Carpules Of Anesthetic Utilizing Computer-Controlled Anesthetic Delivery, Kristi M. Soileau, Adam E. Degenova, Qingzhao Yu Nov 2020

Blood Pressure Monitoring Following Individual Carpules Of Anesthetic Utilizing Computer-Controlled Anesthetic Delivery, Kristi M. Soileau, Adam E. Degenova, Qingzhao Yu

School of Dentistry Faculty Publications

To date, no study has evaluated blood pressure following administration of each carpule given for dental procedures using a computerized dental anesthesia system. Blood pressures taken prior to performing invasive periodontal procedures were compared with those readings measured following delivery of each of up to three consecutive carpules of Marcaine or Xylocaine in varying order. Pressure differences were also adjusted for age, sex, race, and whether a prescribed anxiolytic was taken beforehand. Neither systolic nor diastolic blood pressures changed significantly as compared to initial blood pressure readings. However, compared with Whites, Hispanics, and Middle Easterners, Blacks had significantly higher systolic …


Ada Code Of Ethics (November 2020), American Dental Association Nov 2020

Ada Code Of Ethics (November 2020), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.


Dental Practice Success Special Issue: Infection Control (November 2020), American Dental Association, Publishing Division Nov 2020

Dental Practice Success Special Issue: Infection Control (November 2020), American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.


Dental Practice Success Special Issue: Infection Control (November 2020), American Dental Association, Publishing Division Nov 2020

Dental Practice Success Special Issue: Infection Control (November 2020), American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.


Correlation Between Root Surface Strain And Apical Micro-Cracks Produced During Canal Preparation With Thermally Treated Single Or Multi-File Niti Systems, Shehabeldin Mohamed Saber Prof.Dr. Nov 2020

Correlation Between Root Surface Strain And Apical Micro-Cracks Produced During Canal Preparation With Thermally Treated Single Or Multi-File Niti Systems, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To determine the apical root surface strain (RSS) generated during shaping with thermally treated file NiTi systems, and its association with the development of apical microcracks. Methodology: Twenty extracted human mandibular molars with severely curved mesial roots having two separate canals were prepared using XP-Endo Shaper files (Group A: XPS in mesio-buccal canals) and Hyflex CM files (Group B: HCM in mesio-lingual canals). Pre-instrumentation images of apical surface of each root were obtained with Environmental Scanning Electron Microscope (ESEM). Root surface strain (RSS) generated during canal preparation was measured as micro-strain (ìstrain) using electrical strain gauges fixed on apical …


Antibacterial Potential Of Nano-Particulate Intracanal Medications On A Mature E. Faecalis Biofilm In An Ex Vivo Model, Shehabeldin Mohamed Saber Prof.Dr. Nov 2020

Antibacterial Potential Of Nano-Particulate Intracanal Medications On A Mature E. Faecalis Biofilm In An Ex Vivo Model, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To investigate and compare the antibacterial and antibiofilm activity of Chlorhexidine Digluconate functionalized Hydroxyapatite Nanoparticles and silver Nanoparticles as intracanal medicaments on a mature E. faecalis biofilm model in root canals of extracted teeth. Methodology: Sixty-eight human maxillary central incisors were mechanically prepared, sterilized, infected with E. faecalis, and then incubated for 28 days under anaerobic conditions to develop a mature E. faecalis biofilm. Eight teeth were used to monitor biofilm formation and maturation over the incubation period with field emission scanning electron microscopy (Fe SEM), while the other 60 teeth were divided into two experimental groups (n=20) in …


Molar-Incisor Hypomineralization Studies, Azza Tagelsir Ahmed, Brian D. Hodgson, E. Angeles Martinez-Mier Nov 2020

Molar-Incisor Hypomineralization Studies, Azza Tagelsir Ahmed, Brian D. Hodgson, E. Angeles Martinez-Mier

School of Dentistry Faculty Research and Publications

The problem of demarcated hypomineralization defects of the permanent first molars (molar-incisor hypomineralization [MIH]) has been an emerging issue for oral health professionals around the globe. Yet, the first set of US-based epidemiologic data on MIH took as long as 2 decades from the time when MIH was first described by Weerheijm and colleagues.1 In response to the June JADA article titled “Prevalence of Molar-Incisor Hypomineralization and Other Enamel Defects and Associated Sociodemographic Determinants in Indiana,” (Tagelsir Ahmed A, Soto-Rojas AE, Dean JA, Eckert GJ, Martinez-Mier EA, JADA. 2020;151[7]: 491-501), we attempt to highlight some of the challenges encountered …


A New Phantom To Evaluate The Tissue Dissolution Ability Of Endodontic Irrigants And Activating Devices, Kimia Khoshroo, Brinda Shah, Alexander Johnson, John Baeten, Katherine Barry, Mohammadreza Tahiri, Mohamed Ibrahim, Lobat Tayebi Nov 2020

A New Phantom To Evaluate The Tissue Dissolution Ability Of Endodontic Irrigants And Activating Devices, Kimia Khoshroo, Brinda Shah, Alexander Johnson, John Baeten, Katherine Barry, Mohammadreza Tahiri, Mohamed Ibrahim, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Abstract

Objective

The aim of this study was to introduce a gelatin/bovine serum albumin (BSA) tissue standard, which provides dissolution properties identical to those of biological tissues. Further, the study evaluated whether the utilization of endodontic activating devices led to enhanced phantom dissolution rates.

Materials and Methods

Bovine pulp tissue was obtained to determine a benchmark of tissue dissolution. The surface area and mass of samples were held constant while the ratio of gelatin and BSA were varied, ranging from 7.5% to 10% gelatin and 5% BSA. Each sample was placed in an individual test tube that was filled with …


Plga-Coated Drug-Loaded Nanotubes Anodically Grown On Nitinol, F. Davoodian, E. Salahinejad, E. Sharifi, Z. Barabadi, Lobat Tayebi Nov 2020

Plga-Coated Drug-Loaded Nanotubes Anodically Grown On Nitinol, F. Davoodian, E. Salahinejad, E. Sharifi, Z. Barabadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This study evaluates the use of nanotubes (NTs) as a matrix for local drug delivery modified by a biodegradable polymeric coating on medical-grade nitinol (NiTi alloy) surfaces. For this purpose, NiTi was anodized within parameters that promote the formation of NTs, ultrasonicated, annealed and impregnated with vancomycin hydrochloride. To improve bioperformance, poly(lactic-co-glycolic acid) (PLGA) was also deposited on the drug-loaded NTs. The samples were characterized in terms of structure, wettability, drug delivery, corrosion and cytocompatibility. Scanning electron microscopy and water contact angle measurements signify the formation of open-top homogeneous NTs of 600– 700 nm in length and ~30 nm in …


Nano-Hydroxyapatite And Nano-Hydroxyapatite/Zinc Oxide Scaffold For Bone Tissue Engineering Application, Fatemeh Heidari, Reza Bazargan-Lari, Mehdi Razavi, Farahnaz Fahimipour, Daryoosh Vashaee, Lobat Tayebi Nov 2020

Nano-Hydroxyapatite And Nano-Hydroxyapatite/Zinc Oxide Scaffold For Bone Tissue Engineering Application, Fatemeh Heidari, Reza Bazargan-Lari, Mehdi Razavi, Farahnaz Fahimipour, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This research aims to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by ZnO for bone tissue engineering applications. HA and ZnO were developed using sol‐gel and precipitation methods respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), atomic absorption (AA), and atomic force microscopy (AFM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ZnO scaffolds possess higher …


N Y State Dent J November 2020 Nov 2020

N Y State Dent J November 2020

The New York State Dental Journal

The New York State Dental Journal (NYSDJ) is produced by the New York State Dental Association (NYSDA) six times a year, in January, March, April, July, September and November. Each issue features clinical and scientific articles written by researchers and practitioners from around the globe and is subject to review by a panel of specialists convened by the Editor.

Issues include cover and feature articles alongside regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.


J Mich Dent Assoc November 2020 Nov 2020

J Mich Dent Assoc November 2020

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

  • Feature articles on how “Routine Blood Lead Testing During Pregnancy Empowers Future Dental Caries and Neurotoxicity Research”, how to “Recoup Your Dues and More with MDA-Endorsed Programs”, and your “2021 MDA Membership Benefits Guide”.
  • News you need, Editorial and regular department articles on MDA Foundation activities, Dentistry and the Law, Staff Matters, 10-Minute EBD, Headquarters …


Ethics In Clinical Research On Application Of Virtual Articulators In Dentistry, Dugagjin Sokoli, Merita Sveqla, Burim Kiseri, Kujtim Shala Oct 2020

Ethics In Clinical Research On Application Of Virtual Articulators In Dentistry, Dugagjin Sokoli, Merita Sveqla, Burim Kiseri, Kujtim Shala

UBT International Conference

Just like any other medical research field, the investigation on the use of virtual articulators in dentistry has its ethical implications. Research ethics in oral and medical investigations are critical internationally. The privacy of any participant in the research is a non-negotiable and justice is crucial at all times during the research. We researched on various online research platforms and selected 12 research papers, out of 197, that treat the ethics in research in medical and dental clinical research. We identified 10 ethical issues that needs to be considered while doing clinical research on application of virtual articulators in dentistry. …


The Importance Of Digital Genealogical Coding For Family Medicine, Naser Kamberi, Hyzer Rizani, Festim Kamberi, Smajl Rizani Oct 2020

The Importance Of Digital Genealogical Coding For Family Medicine, Naser Kamberi, Hyzer Rizani, Festim Kamberi, Smajl Rizani

UBT International Conference

This study was conducted on a sample of 8000 individuals interviewed in 97 households in some settlements, such as: Presevo, Zhunica, Rahovica, Miratovc, Raince, Norche and some other villages. The material is sorted by generations in order to detect the type of inheritance in the family. In this paper we followed genetic diseases, inheritance of biomorphological traits, blood groups, and all these qualities are presented with codes. For example, birth order, generation, adjective code, personal code of wife and husband identifying spouses. Based on this data, a computer program is formed to form genetic trees in the family. Therefore, this …


In Vitro Effect Of Etching Time And Polymerization Duration On The Shear Bond Strengths To Dentin, Xhevdet Aliu, Nexhmije Ajeti, Kastriot Meqa, Fisnik Aliu, Merita Sveqla, Lumturije Asllani Oct 2020

In Vitro Effect Of Etching Time And Polymerization Duration On The Shear Bond Strengths To Dentin, Xhevdet Aliu, Nexhmije Ajeti, Kastriot Meqa, Fisnik Aliu, Merita Sveqla, Lumturije Asllani

UBT International Conference

The effect of dentine etching time with H 3 PO 4 37% (20 and 60 sec) and composite polymerization duration (60 and 180 sec) on the shear bond strengths to dentin was evaluated in vitro. Dentine was treated with H 3 PO 4 37% in duration of 20 and 60 sec, before (Syntac ® ) was applied. The composite was polymerized for 60 and 180 sec. Data were analyzed with Anova and Tuckey test. Mean values for the first group (etching 20 sec / polymerization 60 sec) were 63.8 ± 3.7 N, for the second group (E 60 sec / …


International Conference On Dental Science, University For Business And Technology - Ubt Oct 2020

International Conference On Dental Science, University For Business And Technology - Ubt

UBT International Conference

UBT Annual International Conference is the 9th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …


Advent Of Computer Assisted Surgery And Its Application In Oral And Maxillofacial Surgery, Lobna Abdrlaziz, Ahmed Abozekry Oct 2020

Advent Of Computer Assisted Surgery And Its Application In Oral And Maxillofacial Surgery, Lobna Abdrlaziz, Ahmed Abozekry

Future Dental Journal

Computer-assisted surgery (CAS) represents a surgical concept and set of methods, that use computer technology for surgical planning, and for guiding or performing surgical interventions.

Advances in imaging techniques can greatly improve the treatment outcome and enhance the success rate of surgical procedures. This review article updates the information on surgical navigation system and its application in maxillofacial surgery.


Effect Of Nylon And Acetal Denture Base Material On Candida Ablicans Count For Partial Denture Cases, Mohamed Ali El Hariri, Mohamed Ezzat El Sayed Oct 2020

Effect Of Nylon And Acetal Denture Base Material On Candida Ablicans Count For Partial Denture Cases, Mohamed Ali El Hariri, Mohamed Ezzat El Sayed

Future Dental Journal

No abstract provided.


Comparative Evaluation Of Piezotome Versus Periotome Extractions Of Non- Restorable Endodontically Treated Teeth: A Randomized Clinical Trial, Lydia Melek, Marwa G. Noureldin Oct 2020

Comparative Evaluation Of Piezotome Versus Periotome Extractions Of Non- Restorable Endodontically Treated Teeth: A Randomized Clinical Trial, Lydia Melek, Marwa G. Noureldin

Future Dental Journal

Aim: The study was intended to evaluate the efficacy of piezotome versus periotome extractions of non-re- storable endodontically treated teeth in relation to prevention of marginal bone loss, operating time of the procedure, and postoperative sequalae. Methods: Forty-two patients with age range of 30–55 years requiring extraction of maxillary single rooted teeth that failed endodontically were randomly divided into two equal groups, a piezotome group and a periotome group. Clinical assessment was performed through measuring the marginal bone loss, time taken for extraction, postoperative pain and any complications related to the extraction procedure. The data was recorded then analyzed using …


Vital Tooth Bleaching Using Different Techniques: A Clinical Evaluation, Ana Rita Barcessat, Nalia Cecilia Gurgel, Niklaus Ursus Wetter Oct 2020

Vital Tooth Bleaching Using Different Techniques: A Clinical Evaluation, Ana Rita Barcessat, Nalia Cecilia Gurgel, Niklaus Ursus Wetter

Future Dental Journal

Objectives: This clinical trial aimed to evaluate dental color stabilization after different bleaching techniques. Methods: Four dental bleaching techniques were tested in 60 healthy volunteers aged from 25 to 35 years randomly assigned to four groups. Group 1 (G1): conventional in-office bleaching using 35% hydrogen peroxide. Group 2 (G2): in-office application of 3% hydrogen peroxide followed by in-office bleaching using 35% hy- drogen peroxide. Group 3 (G3): in-office application of 3% hydrogen peroxide and activation with a light emitting diode (LED) lamp. Group 4 (G4): at-home bleaching using 10% carbamide peroxide. The color of canines and incisors was scored using …


Modified Tunnel Technique For Management Of Gingival Recession In Esthetic Zone Using Acellular Dermal Matrix Versus Connective Tissue Graft, Rania Fahmy, Maha R. Taalab Oct 2020

Modified Tunnel Technique For Management Of Gingival Recession In Esthetic Zone Using Acellular Dermal Matrix Versus Connective Tissue Graft, Rania Fahmy, Maha R. Taalab

Future Dental Journal

Gingival recession often results in major aesthetic problems. Further complains of increased root surface sen- sitivity and root caries could also be encountered. Numerous techniques have been described for the manage- ment of recession. The development of the tunnel technique represents an important esthetic advancement in managing recession defects. This study was performed to compare between the use of Acellular Dermal Matrix (ADM) and connective tissue graft (CTG) under a modified tunnel technique for management of gingival re- cession in the esthetic zone. Sixteen Miller class I and II recession defects were equally divided for treatment with the two donor …


Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez Oct 2020

Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

Objective: This study focused on documenting characteristics of the gingival transcriptome during various stages of periodontitis targeting genes associated with apoptotic and autophagic pathways and changes that specifically associate with features of the oral microbiome.

Methods: Macaca mulatta (n = 18; 12–23 years) were examined at baseline and 0.5, 1, and 3 months of disease progression, as well as 5 months with clinical disease resolution. 16S sequencing and microarray analyses examined changes in the microbiome and gingival transcriptome, respectively, at each time point from every animal.

Results: Specific patterns of apoptotic and autophagic genes were identified related to the …


Ada News - 10/19/2020, American Dental Association, Publishing Division Oct 2020

Ada News - 10/19/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez Oct 2020

Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez

Dental Medicine Faculty Research

Objective: This study focused on documenting characteristics of the gingival transcriptome during various stages of periodontitis targeting genes associated with apoptotic and autophagic pathways and changes that specifically associate with features of the oral microbiome. Methods: Macaca mulatta (n = 18; 12-23 years) were examined at baseline and 0.5, 1, and 3 months of disease progression, as well as 5 months with clinical disease resolution. 16S sequencing and microarray analyses examined changes in the microbiome and gingival transcriptome, respectively, at each time point from every animal. Results: Specific patterns of apoptotic and autophagic genes were identified related to the initiation …


Noninvasive Temporal Detection Of Early Retinal Vascular Changes During Diabetes, Mohammad A. Saghiri, Andrew Suscha, Shoujian Wang, Ali M. Saghiri, Christine M. Sorenson, Nader Sheibani Oct 2020

Noninvasive Temporal Detection Of Early Retinal Vascular Changes During Diabetes, Mohammad A. Saghiri, Andrew Suscha, Shoujian Wang, Ali M. Saghiri, Christine M. Sorenson, Nader Sheibani

All Dugoni School of Dentistry Faculty Articles

Diabetes associated complications, including diabetic retinopathy and loss of vision, are major health concerns. Detecting early retinal vascular changes during diabetes is not well documented, and only few studies have addressed this domain. The purpose of this study was to noninvasively evaluate temporal changes in retinal vasculature at very early stages of diabetes using fundus images from preclinical models of diabetes.Non-diabetic and Akita/+ male mice with different duration of diabetes were subjected to fundus imaging using a Micron III imaging system. The images were obtained from 4 weeks- (onset of diabetes), 8 weeks-, 16 weeks-, and 24 weeks-old male Akita/+ …


A Tri-Component Knee Plug For The 3rd Generation Of Autologous Chondrocyte Implantation, Lobat Tayebi, Zhanfeng Cui, Hua Ye Oct 2020

A Tri-Component Knee Plug For The 3rd Generation Of Autologous Chondrocyte Implantation, Lobat Tayebi, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

Here, we report a newly designed knee plug to be used in the 3rd generation of Autologous Chondrocyte Implantation (ACI) in order to heal the damaged knee cartilage. It is composed of three components: The first component (Bone Portion) is a 3D printed hard scaffold with large pores (~ 850 µm), made by hydroxyapatite and β-tricalcium phosphate to accommodate the bony parts underneath the knee cartilage. It is a cylinder with a diameter of 20 mm and height of 7.5 mm, with a slight dome shape on top. The plug also comprises a Cartilage Portion (component 2) which is a …