Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Genetics and Genomics (3)
- Computational Biology (2)
- Medicine and Health Sciences (2)
- Agriculture (1)
- Bioinformatics (1)
-
- Biology (1)
- Biostatistics (1)
- Biotechnology (1)
- Entomology (1)
- Genetics (1)
- Genomics (1)
- Longitudinal Data Analysis and Time Series (1)
- Medical Sciences (1)
- Microarrays (1)
- Molecular Genetics (1)
- Physical Sciences and Mathematics (1)
- Plant Sciences (1)
- Statistical Methodology (1)
- Statistics and Probability (1)
- Survival Analysis (1)
- Institution
- Publication
- Publication Type
- File Type
Articles 1 - 5 of 5
Full-Text Articles in Systems Biology
Genetically Distinct Behavioral Modules Underlie Natural Variation In Thermal Performance Curves, Gregory W. Stegeman, Scott E. Baird, William S. Ryu, Asher D. Cutter
Genetically Distinct Behavioral Modules Underlie Natural Variation In Thermal Performance Curves, Gregory W. Stegeman, Scott E. Baird, William S. Ryu, Asher D. Cutter
Biological Sciences Faculty Publications
Thermal reaction norms pervade organismal traits as stereotyped responses to temperature, a fundamental environmental input into sensory and physiological systems. Locomotory behavior represents an especially plastic read-out of animal response, with its dynamic dependence on environmental stimuli presenting a challenge for analysis and for understanding the genomic architecture of heritable variation. Here we characterize behavioral reaction norms as thermal performance curves for the nematode Caenorhabditis briggsae, using a collection of 23 wild isolate genotypes and 153 recombinant inbred lines to quantify the extent of genetic and plastic variation in locomotory behavior to temperature changes. By reducing the dimensionality of the …
Functional Analysis Of Synthetic Gene Circuits Controlling A Protein Pump In Yeast, Junchen Diao
Functional Analysis Of Synthetic Gene Circuits Controlling A Protein Pump In Yeast, Junchen Diao
Dissertations & Theses (Open Access)
Synthetic biology aims to build biological devices to understand living systems and explore new applications. Synthetic gene circuits such as genetic switches, oscillators and logic gates are at the core of many synthetic biology applications. These gene circuits often include a sensor/regulator protein capable to detect small molecules and then transduce them into a regulatory signal to generate measurable output. Similar signal transduction networks are also abundant in nature. However, in many natural and engineered scenarios, the output also affects the regulator/sensor protein. How such interactions between the regulator/sensor and the output affect synthetic gene circuit function has not been …
Clustering With Exclusion Zones: Genomic Applications, Mark Segal, Yuanyuan Xiao, Fred Huffer
Clustering With Exclusion Zones: Genomic Applications, Mark Segal, Yuanyuan Xiao, Fred Huffer
Mark R Segal
Methods for formally evaluating the clustering of events in space or time, notably the scan statistic, have been richly developed and widely applied. In order to utilize the scan statistic and related approaches, it is necessary to know the extent of the spatial or temporal domains wherein the events arise. Implicit in their usage is that these domains have no “holes”—hereafter “exclusion zones”—regions in which events a priori cannot occur. However, in many contexts, this requirement is not met. When the exclusion zones are known, it is straightforward to correct the scan statistic for their occurrence by simply adjusting the …
High-Level Resistance To Bacillus Thuringiensis Toxin Cry1ac And Cadherin Genotype In Pink Bollworm, Aaron J. Gassmann, Robert W. Biggs, Jeffrey A. Fabrick, Bruce E. Tabashnick, Timothy J. Dennehy, Yves Carriere, Shai Morin
High-Level Resistance To Bacillus Thuringiensis Toxin Cry1ac And Cadherin Genotype In Pink Bollworm, Aaron J. Gassmann, Robert W. Biggs, Jeffrey A. Fabrick, Bruce E. Tabashnick, Timothy J. Dennehy, Yves Carriere, Shai Morin
Aaron J. Gassmann
Resistance to transgenic cotton, Gossypium hirsutum L., producing Bacillus thuringiensis (Bt) toxin Cry1Ac is linked with three recessive alleles of a cadherin gene in laboratory-selected strains of pink bollworm, Pectinophora gossypiella (Saunders), a major cotton pest. Here, we analyzed a strain (MOV97-R) with a high frequency of cadherin resistance alleles, a high frequency of resistance to 10 μg of Cry1Ac per milliliter of diet, and an intermediate frequency of resistance to 1,000 μg of Cry1Ac per ml of diet. We selected two strains for increased resistance by exposing larvae from MOV97-R to diet with 1,000 μg of Cry1Ac per ml …
Comparative Mapping Of Arabidopsis Thaliana And Brassica Oleracea Chromosomes Reveals Islands Of Conserved Organization, Stanley P. Kowalski, Tien-Hung Lan, Kenneth A. Feldmann, Andrew H. Patterson
Comparative Mapping Of Arabidopsis Thaliana And Brassica Oleracea Chromosomes Reveals Islands Of Conserved Organization, Stanley P. Kowalski, Tien-Hung Lan, Kenneth A. Feldmann, Andrew H. Patterson
Law Faculty Scholarship
The chromosomes of Arabidopsis thaliana and Brassica oleracea have been extensively rearranged since the divergence of these species; however, conserved regions are evident. Eleven regions of conserved organization were detected, ranging from 3.7 to 49.6 cM in A. thaliana, spanning 158.2 cM (24.6%) of the A. thaliana genome, and 245 cM (29.9%) of the B. oleracea genome. At least 17 translocations and 9 inversions distinguish the genomes of A. thaliana and B. oleracea. In one case B. oleracea homoeologs show a common marker order, which is distinguished from the A. thaliana order by a rearrangement, indicating that the lineages of …