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Articles 1 - 5 of 5
Full-Text Articles in Systems Biology
Identifying Novel Molecular Targets To Induce Ferroptosis In Drug-Tolerant Cancer Cells Through Computational Modeling, Haris J. Rana
Identifying Novel Molecular Targets To Induce Ferroptosis In Drug-Tolerant Cancer Cells Through Computational Modeling, Haris J. Rana
Biological Sciences Undergraduate Honors Theses
Ferroptosis is an iron-dependent, reactive oxygen species (ROS)-driven form of regulated cell death in which the cell membrane is degraded by lipid peroxidation. It is regulated by multiple enzymes, such as glutathione peroxidase 4 (GPX4), which prevents membrane degradation by reducing lipid peroxides and protecting cells from oxidative damage. When inhibitors like RSL3 target GPX4, lipid peroxides build up, and toxic ROS compromises membrane integrity. Traditional anticancer treatments, such as most chemotherapies, aim to eliminate tumor cells by damaging DNA and triggering apoptosis. However, resistance to apoptosis is a “hallmark of cancer,” often resulting in treatment failure. As a distinct …
Of Biodiversity, Boundaries, And Distribution: The Myxomycetes Of The Philippines And Beyond, Sittie Aisha Bustamante Macabago
Of Biodiversity, Boundaries, And Distribution: The Myxomycetes Of The Philippines And Beyond, Sittie Aisha Bustamante Macabago
Graduate Theses and Dissertations
This dissertation contains a compilation of independently performed studies primarily focusing on the myxomycetes (plasmodial slime molds) from the Philippines and integrating local and worldwide data to demonstrate regional and global trends. The major themes include the following: (I) a review of the diverse group of spore-producing amoeboid protists, including the myxomycetes; (II-IV) diversity assessments in three different groups of islands in the Philippine archipelago; (V) mapping the myxomycetes found in the Philippines for databasing and analyzing the geocoded data; (VI) a study on regional boundaries, including the Philippines, using myxomycete species composition; and, (VII) creating a global species distribution …
Sampling Terrestrial Arthropod Biodiversity: A Case Study In Arkansas, Michael Joseph Skvarla
Sampling Terrestrial Arthropod Biodiversity: A Case Study In Arkansas, Michael Joseph Skvarla
Graduate Theses and Dissertations
The Interior Highlands is a biodiversity hotspot, with at least 200 known endemic species, but is understudied compared to hotspots, such as the Southern Appalachians. In order to begin to rectify this issue, a nine month study was conducted from mid-March through early December at a 4 ha site at Steel Creek, Buffalo National River, in Newton County, Arkansas. Thirteen collecting methods were employed, including three colors of Lindgren funnel trap, five colors of pan trap, Malaise traps, canopy traps with upper and lower collectors, pitfall traps, and Berlese-Tullgren extraction of leaf litter, which resulted in the collection of 1311 …
Systematics Of Testudacarine Torrent Mites (Parasitengona: Torrenticolidae), Joseph Charles O'Neill
Systematics Of Testudacarine Torrent Mites (Parasitengona: Torrenticolidae), Joseph Charles O'Neill
Graduate Theses and Dissertations
Thirteen new species of Testudacarus (Torrenticolidae: Testudacarinae) are described, four species are redescribed, and the status of previously problematic species are addressed. For Testudacarinae this represents the first published: 1) descriptions from multiple specimens (therefore providing ranges); 2) colored photographs; 3) explicit illustrations and discussion of sexual dimorphism within the subfamily; 4) genetic data. A comprehensive literature review is also included.
Sampling Local Fungal Diversity In An Undergraduate Laboratory Using Dna Barcoding, A. H. Harrington, A. F. Bigott, B. W. Anderson, M. J. Boone, S. M. Brick, J. F. Delsol, R. A. Hotchkiss, R. A. Huddleston, E. H. Kasper, J. J. Mcgrady, M. L. Mckinnie, M. V. Ottenlips, N. E. Skinner, K. C. Spatz, A. J. Steinberg, F. Van Den Broek, C. N. Wilson, A. M. Wofford, A. M. Willyard
Sampling Local Fungal Diversity In An Undergraduate Laboratory Using Dna Barcoding, A. H. Harrington, A. F. Bigott, B. W. Anderson, M. J. Boone, S. M. Brick, J. F. Delsol, R. A. Hotchkiss, R. A. Huddleston, E. H. Kasper, J. J. Mcgrady, M. L. Mckinnie, M. V. Ottenlips, N. E. Skinner, K. C. Spatz, A. J. Steinberg, F. Van Den Broek, C. N. Wilson, A. M. Wofford, A. M. Willyard
Journal of the Arkansas Academy of Science
Traditional methods for fungal species identification require diagnostic morphological characters and are often limited by the availability of fresh fruiting bodies and local identification resources. DNA barcoding offers an additional method of species identification and is rapidly developing as a critical tool in fungal taxonomy. As an exercise in an undergraduate biology course, we identified 9 specimens collected from the Hendrix College campus in Conway, Arkansas, USA to the genus or species level using morphology. We report that DNA barcoding targeting the internal transcribed spacer (ITS) region supported several of our taxonomic determinations and we were able to contribute 5 …