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Systems Biology Commons

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Illinois State University

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Articles 1 - 30 of 36

Full-Text Articles in Systems Biology

Data-Driven Modeling Of Dynamics And Adaptation In Mapk Pathway, Elisha Erzoah, Maria Emelianenko, Mariaelena Pierobon Nov 2025

Data-Driven Modeling Of Dynamics And Adaptation In Mapk Pathway, Elisha Erzoah, Maria Emelianenko, Mariaelena Pierobon

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Reconstructing Gene Regulatory Networks From Time-Series Data In Knime, Raina Robeva Nov 2025

Reconstructing Gene Regulatory Networks From Time-Series Data In Knime, Raina Robeva

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


[Kadel] Robust Basins, Fragile Attractors: A New View On Boolean Network Dynamics, Claus Kadelka Nov 2025

[Kadel] Robust Basins, Fragile Attractors: A New View On Boolean Network Dynamics, Claus Kadelka

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


[Kadel] Understanding Aging In Worms Using Boolean Modeling, Brandilyn Stigler Nov 2025

[Kadel] Understanding Aging In Worms Using Boolean Modeling, Brandilyn Stigler

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


[Kadel] A Multilevel Extension Of Boolean Networks Captures Topologically-Stable Hybrid Attractors, Kishore Hari Nov 2025

[Kadel] A Multilevel Extension Of Boolean Networks Captures Topologically-Stable Hybrid Attractors, Kishore Hari

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


An Agent-Based Model Of Microglia And Neuron Interaction: Implications In Neurodegenerative Disease, Cheyenne Ty, Amanda Case, Emmanuel Mezzulo, Abigail Penland, Kamila Larripa Jan 2025

An Agent-Based Model Of Microglia And Neuron Interaction: Implications In Neurodegenerative Disease, Cheyenne Ty, Amanda Case, Emmanuel Mezzulo, Abigail Penland, Kamila Larripa

Spora: A Journal of Biomathematics

Whether immune cells protect or harm the brain is an open question depending on context, and their role is implicated in multiple diseases such as Alzheimer's disease, dementia, and other neurological disorders. Microglia, a specific type of immune cell in the central nervous system, play a key role in homeostasis, and genes associated with an elevated risk of Alzheimer's disease correspond with deficiencies in their behavior. We created an agent-based model that incorporates inflammatory signaling, chemotaxis, and phagocytosis of damaged neurons and allows the exploration of crucial pathways in the maintenance of brain health. We specifically investigated pathways related to …


Leveraging Quantitative Systems Pharmacology For Dose Optimization In Oncology Drug Development, Blerta Shtylla Nov 2024

Leveraging Quantitative Systems Pharmacology For Dose Optimization In Oncology Drug Development, Blerta Shtylla

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Kreig: Quantifying The Relationship Between Sars-Cov-2 Viral Load And Infectiousness, Aurelien Marc Nov 2024

Kreig: Quantifying The Relationship Between Sars-Cov-2 Viral Load And Infectiousness, Aurelien Marc

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Study Of Different Treatment Strategies In Epidemic Models Using Nonlinear Model Predictive Control, Hector Puebla, Luis A. Ricardez-Sandoval, Priti Kumar Roy Nov 2024

Study Of Different Treatment Strategies In Epidemic Models Using Nonlinear Model Predictive Control, Hector Puebla, Luis A. Ricardez-Sandoval, Priti Kumar Roy

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Modelling Saccharomyces Cerevisiae For The Production Of Fermented Beverages, Paul A. Valle Dr., Yolocuauhtli Salazar Dr., Luis N. Coria Dr., Oscar N. Soto Dr., Jesus B. Paez Dr. Nov 2024

Modelling Saccharomyces Cerevisiae For The Production Of Fermented Beverages, Paul A. Valle Dr., Yolocuauhtli Salazar Dr., Luis N. Coria Dr., Oscar N. Soto Dr., Jesus B. Paez Dr.

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Msis-Kadelka: Modularizing The Control Search For Biological Systems, David Murrugarra Nov 2023

Msis-Kadelka: Modularizing The Control Search For Biological Systems, David Murrugarra

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Msis-Kadelka: Algebraic Methods For Inferring Discrete Models Of Biological Networks, Brandilyn Stigler Nov 2023

Msis-Kadelka: Algebraic Methods For Inferring Discrete Models Of Biological Networks, Brandilyn Stigler

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Msis-Kadelka: Canalization Reduces The Nonlinearity Of Regulation In Biological Networks, Claus Kadelka, David Murrugarra Nov 2023

Msis-Kadelka: Canalization Reduces The Nonlinearity Of Regulation In Biological Networks, Claus Kadelka, David Murrugarra

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Modularity And Boolean Network Decomposition, Matthew Wheeler Nov 2022

Modularity And Boolean Network Decomposition, Matthew Wheeler

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


The Nonlinearity Of Regulation In Biological Networks, Santosh Manicka, Kathleen Johnson, Michael Levin, David Murrugarra Nov 2022

The Nonlinearity Of Regulation In Biological Networks, Santosh Manicka, Kathleen Johnson, Michael Levin, David Murrugarra

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Modularity In Gene Regulatory Networks, Mehak Kapoor, Claus Kadelka Nov 2022

Modularity In Gene Regulatory Networks, Mehak Kapoor, Claus Kadelka

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Effective Dose Fractionation Schemes Of Radiotherapy For Prostate Cancer, Jose Alvarez, Kathleen M. Storey, Pavitra Kannan, Heyrim Cho Mar 2022

Effective Dose Fractionation Schemes Of Radiotherapy For Prostate Cancer, Jose Alvarez, Kathleen M. Storey, Pavitra Kannan, Heyrim Cho

Spora: A Journal of Biomathematics

Radiation therapy remains as one of the main cancer treatment modalities. Typical regimens for radiotherapy comprise a constant dose administered on weekdays, and no radiation on weekends. In this paper, we examine adaptive dosages of radiation treatment strategies for heterogeneous tumors using a dynamical system model that consist of radiation-resistant and parental populations with unique interactive properties, namely, PC3 and DU145 prostate cancer cell lines. We show that stronger doses of radiation given in longer time intervals, while keeping the overall dosage the same, are effective in PC3 cell lines, but not in DU145 cell lines. In addition, we tested …


Machine Learning-Based Risk Factor Analysis And Prevalence Prediction Of Intestinal Parasitic Infections, Ahmet Ay Nov 2021

Machine Learning-Based Risk Factor Analysis And Prevalence Prediction Of Intestinal Parasitic Infections, Ahmet Ay

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Identification Of Control Targets In Boolean Networks Via Computational Algebra, Alan Veliz-Cuba Nov 2021

Identification Of Control Targets In Boolean Networks Via Computational Algebra, Alan Veliz-Cuba

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Building Model Prototypes From Time-Course Data, David Murrugarra, Alan Veliz-Cuba Nov 2021

Building Model Prototypes From Time-Course Data, David Murrugarra, Alan Veliz-Cuba

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Chemoimmunotherapy Treatment Strategies On A Mathematical Model Of Cancer Evolution, Sandra M. Lopez, Yolocuauhtli Salazar, Paul A. Valle Nov 2021

Chemoimmunotherapy Treatment Strategies On A Mathematical Model Of Cancer Evolution, Sandra M. Lopez, Yolocuauhtli Salazar, Paul A. Valle

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Mathematical Model Describing The Behavior Of Biomass, Acidity, And Viscosity As A Function Of Temperature In The Shelf Life Of Yogurt, Manuel Alvarado, Paul A. Valle, Yolocuauhtli Salazar Nov 2021

Mathematical Model Describing The Behavior Of Biomass, Acidity, And Viscosity As A Function Of Temperature In The Shelf Life Of Yogurt, Manuel Alvarado, Paul A. Valle, Yolocuauhtli Salazar

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Neural Network Controller Vs Pulse Control To Achieve Complete Eradication Of Cancer Cells In A Mathematical Model, Joel A. Quevedo, Sergio A. Puga, Paul A. Valle Nov 2021

Neural Network Controller Vs Pulse Control To Achieve Complete Eradication Of Cancer Cells In A Mathematical Model, Joel A. Quevedo, Sergio A. Puga, Paul A. Valle

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


The Role Of Mathematics In 21st Century Medicine, Reinhard Laubenbacher Nov 2021

The Role Of Mathematics In 21st Century Medicine, Reinhard Laubenbacher

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Reconstructing Mathematical Models With Chaotic Attractors Via Genetic Algorithms, Luis A. Ramirez Islas, Paul A. Valle Nov 2021

Reconstructing Mathematical Models With Chaotic Attractors Via Genetic Algorithms, Luis A. Ramirez Islas, Paul A. Valle

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Estimating The Number Of Discrete Models Of Biological Networks, Brandilyn Stigler Nov 2020

Estimating The Number Of Discrete Models Of Biological Networks, Brandilyn Stigler

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Mathematical Modelling And In Silico Experimentation To Estimate The Quantity Of Covid-19 Infected Individuals In Tijuana, México, Karla A. Encinas, Luis N. Coria, Paul A. Valle Nov 2020

Mathematical Modelling And In Silico Experimentation To Estimate The Quantity Of Covid-19 Infected Individuals In Tijuana, México, Karla A. Encinas, Luis N. Coria, Paul A. Valle

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Mathematics Saves Lives: Models And Signals Enabling Medicine And Biology, Raina Robeva Oct 2019

Mathematics Saves Lives: Models And Signals Enabling Medicine And Biology, Raina Robeva

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Network Reconstruction Using Computational Algebra And Gene Knockouts, Matthew Macauley Oct 2019

Network Reconstruction Using Computational Algebra And Gene Knockouts, Matthew Macauley

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Petri Nets As A Unifying Tool To Link Physiologically Based Toxicokinetic (Pbtk) Models To Adverse Outcome Pathways (Aops), Ian Edhlund Oct 2019

Petri Nets As A Unifying Tool To Link Physiologically Based Toxicokinetic (Pbtk) Models To Adverse Outcome Pathways (Aops), Ian Edhlund

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.