Animal Experimentation and Research Commons^™

The Rate Of The Healing Process In Venous Thrombi Produced By A Sclerosing Agent With Special Attention To Endothelial Lining, Kiyoshi Tanaka

Loma Linda University Electronic Theses, Dissertations & Projects

Despite extensive clinical and experimental investigations of venous thrombosis, relatively little is known about the early phases of healing of the venous thrombus. Soon after its discovery heparin has become the most popular agent for the prevention and treatment of venous thrombosis, but there are a number of unanswered questions regarding the most satisfactory treatment for venous thrombosis.

One area of controversy has been the duration of anticoagulation therapy for acute venous thrombosis. If the anticoagulant is discontinued too soon, the thrombus may continue to propagate. Prolonged anticoagulant therapy exposes the patient to the risk of serious hemorrhage. The objective …

Isolation And Chemico-Physiologic Characterization Of A Parotid Hormone Activity From Porcine Glands, Jean-Marc Tieche

Loma Linda University Electronic Theses, Dissertations & Projects

For the past decade, evidence has accumulated which suggests that the resistance of the teeth to dental decay is in part under systemic control. It was shown that the resistance is accomplished through the optimal operation of a dentinal fluid transport mechanism which is believed to be hormonally controlled by the hypothalamic-parotid gland endocrine axis. Although circumstantial evidence for such an endocrine function was strong, the isolation of a parotid hormone which stimulates the dentinal fluid transport mechanism remained to be accomplished.

Using modern biochemical techniques, a methodology was designed to isolate and purify the hormone from porcine parotid glands. …

Effects Of Cariogenic And Noncariogenic Diets On The Concentration Of The Parotid Hormone Releasing Factor In Rat Hypothalami, Melva Joan Brown

Loma Linda University Electronic Theses, Dissertations & Projects

Hypothalamic and cortical extracts from various cariogenically grouped rats which had been maintained on either a Purina diet or a high sucrose diet (HSD) for three months were infused intravenously into 28 days old rats to determine if there was a titer of parotid hormone releasing factor (PRF) capable of facilitating fluid movement (FM) in the teeth. The hypothalamic and cortical extracts obtained from Purina-fed rats with 0-caries and the hypothalamic extracts from BSD-fed rats conclusively demonstrated FM stimulatory ability. Other Purina-fed groups were essentially biologically ineffective, however, extracts from HSD-fed caries groups including scores 11-40 demonstrated extremely potent FM …

The Effect Of Insulin, Fluoride And Methyl Xanthines On The Hypothalamic-Parotid Gland Endocrine Axis, Reagan Ondler

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine the effect of insulin and fluoride on dentinal fluid movement (FM) in high-sucrose fed rats as mediated through the hypothalamic-parotid gland endocrine axis. In conjunction with the fluoride study, the possible involvement of cAMP was examined through the use of several methyl xanthines which are recognized as phosphodiesterase inhibitors.

Twenty-one day old, male Sprague Dawley rats were maintained on a high-sugar diet (62% sucrose) for 8-9 days at which time intravenous or arterial infusions of insulin, fluoride or the methyl xanthines were performed. Additional procedures included collecting plasma from rats which had …

Bone Regeneration Over Submerged Dental Roots In Dogs, Roger Lee Plata

Loma Linda University Electronic Theses, Dissertations & Projects

Nonendodontically treated roots were submerged 1.5 to 2.0 mm. below the alveolar crest in three dogs. Twelve roots were treated in this manner. Regeneration of alveolar bone can be seen in three weeks with complete bone coverage in five weeks. A complete lamina dura can be seen around the amputated roots.

Bone failed to regenerate over two of the twelve roots. In one case there was delayed healing due to the early loss of some sutures. A sinus tract developed connecting the oral environment with the contents of the pulp. This led to bone resorption and a necrotic pulp. In …

The Effects Of Crowding On The Diurnal Ascorbic Acid Levels Of Albino Rats, Mary Jo Barr

Masters Theses

The adrenal physiology of the albino rat was studied through the measurement of adrenal ascorbic acid levels. A cyclic phenomenon was observed which follows the diel periodicity of the animal. Ascorbic acid values were found to be characteristically higher in males than in females. A similar difference was also seen in populations divided into young animals (body weight less than 175 grams) and old animals (body weight greater than 175 grams). Crowding, induced by manipulating the area of cage space per gram of body weight, was observed to be a definite stressor and caused the adrenal ascorbic acid levels to …

The Effects Of Acute Stress On Adrenal Ascorbic Acid Levels, Robert Joseph Collier

Masters Theses

The diurnal rhythm of adrenal ascorbic acid (DAR) displays an inverse relationship to the diurnal rhythm of circulating levels of plasma corticosteroids. Alloxan monohydrate, 175 mg/kg body weight was given subcutaneously to albino rats to determine the effect of the diabetic state on the DAR. A total of 200 female albino rats were divided into two study groups. Study Group I was composed of 150 animals divided into populations of 15, each including 3 controls. Study Group II was composed of populations of 5, each group containing all controls or all alloxinated rats. The populations of 15 were sacrificed at …

Cardioregulatory Role Of The Abdominal Ganglion Of Aplysia Californica, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.

The principal results are listed below.

1. Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for …

Periosteal Circulation And Its Contribution To The Nutrition Of Compact Bone, Jean Elaine Tassell

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

The Pacemaker Function Of The Small Intestine, Robert W. Hasselbrack

Loma Linda University Electronic Theses, Dissertations & Projects

New evidence is presented to clarify to some extent the significance of the gradient of rhythmicity in the small intestine of the unanesthetized dog. The gradient of rhythmicity was studied on five dogs prepared with duodenal fistulas. Rhythmic contractions were recorded from the small intestine by a small rubber balloon. The gradient of rhythmicity was found to decrease in a stepwise manner as the distance from the pylorus is increased. Roughly, the rhythmic contractions were found to be 18 to 19 per minute in the duodenum and 14 to 15 per minute in the ileum. In the terminal ileum there …

The Lungs And Respiration In The Frog, Peter P. Strassburg

Bachelors’ Theses

In a wide sense, respiration is sometimes defined as the gaseous exchange constantly taking place between an organism and its environment. Essentially it is concerned with the intake of oxygen and the output of carbon dioxide but it also includes any other gas exchange that might occur. Small organisms take oxygen directly from the air or from the watery medium surrounding them into all parts of their structures. They also give off carbon dioxide from all their parts directly into the surrounding medium. They can do this successfully because they are small enough to have every cell in direct or …