Animal Experimentation and Research Commons^™

The Validity Of Animal Experiments In Medical Research, Gill Langley

Gill Langley, PhD

Other animals, such as mice, rats, rabbits, dogs and monkeys, are widely used as surrogates for humans in fundamental medical research. This involves creating disorders in animals by chemical, surgical or genetic means, with the aim of mimicking selected aspects of human illnesses. It is a truism that any model or surrogate is not identical to the target being modelled. So, in medical research, experiments using animals or cell cultures or even healthy volunteers instead of patients (being the target population with the target illness) will inevitably have limitations, although these will be greater or lesser depending on the model.

Prolonged Pain Research In Mice: Trends In Reference To The 3rs, Jonathan Balcombe, Hope Ferdowsian, Lauren Briese

Jonathan Balcombe, PhD

This literature review documents trends in the use of mice in prolonged pain research, defined herein as research that subjects mice to a source of pain for at least 14 days. The total amount of prolonged pain research on mice has increased dramatically in the past decade for the 3 pain categories examined: neuropathic, inflammatory, and chronic pain. There has also been a significant rise in the number of prolonged mouse pain studies as a proportion of all mouse studies and of all mouse pain studies. The use of transgenic mice has also risen significantly in prolonged pain research, though …

Cancerous Contradictions: The Mis-Regulation Of Human Carcinogens Based On Animal Data, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Jonathan Balcombe, PhD

The regulation of human exposures to potential carcinogens constitutes society’s most important use of animal carcinogenicity data. However, for environmental contaminants of greatest U.S. concern, we found that in most cases (58.1%; 93/160) the U.S. Environmental Protection Agency (EPA) considered the animal data inadequate to support a classification of probable human carcinogen or noncarcinogen.

The World Health Organisation’s International Agency for Research on Cancer (IARC) is a leading international authority on carcinogenicity assessments. For chemicals lacking human exposure data (the great majority), IARC classifications of identical chemicals were significantly more conservative than EPA classifications (p

Laboratory Routines Cause Animal Stress, Jonathan P. Balcombe, Neal D. Barnard, Chad Sandusky

Jonathan Balcombe, PhD

Eighty published studies were appraised to document the potential stress associated with three routine laboratory procedures commonly performed on animals: handling, blood collection, and orogastric gavage. We defined handling as any non-invasive manipulation occurring as part of routine husbandry, including lifting an animal and cleaning or moving an animal's cage. Significant changes in physiologic parameters correlated with stress (e.g., serum or plasma concentrations of corticosterone, glucose, growth hormone or prolactin, heart rate, blood pressure, and behavior) were associated with all three procedures in multiple species in the studies we examined. The results of these studies demonstrated that animals responded with …

Observing The Unwatchable Through Acceleration Logging Of Animal Behavior, Danielle D. Brown, Roland Kays, Martin Wikelski, Rory Wilson, A. Peter Klimley

Methodology and Animal Models in Research

Behavior is an important mechanism of evolution and it is paid for through energy expenditure. Nevertheless, field biologists can rarely observe animals for more than a fraction of their daily activities and attempts to quantify behavior for modeling ecological processes often exclude cryptic yet important behavioral events. Over the past few years, an explosion of research on remote monitoring of animal behavior using acceleration sensors has smashed the decades-old limits of observational studies. Animal-attached accelerometers measure the change in velocity of the body over time and can quantify fine-scale movements and body postures unlimited by visibility, observer bias, or the …

Unintended Facilitation Between Marine Consumers Generates Enhanced Mortality For Their Shared Prey, F. Joel Fodrie, Matthew D. Kenworthy, Sean P. Powers

University Faculty and Staff Publications

We manipulated predator densities and prey vulnerability to explore how interactions between two predators affect overall mortality of their shared prey. Our threemember study system included eastern oysters (Crassostrea virginica) and two of its major consumers: southern oyster drills (Stramonita haemastoma) and stone crabs (Menippe adina). Field experiments demonstrated that drills and crabs foraging together generated higher than expected oyster mortality based on each species operating independently, even though crabs also killed some drills. In subsequent laboratory trials, we experimentally mimicked the handling of oysters by foraging crabs and confirmed that crabs facilitated drills by breeching oyster valves, thereby granting …

The Ethical Limits Of Domestication: A Critique Of Henry Heffner’S Arguments, Colin Allen, Marc Bekoff, Lori Gruen

Experimentation Collection

Henry E. Heffner argues that “animals bred for research are properly viewed as animals who have successfully invaded the laboratory niche, relying heavily on kin selection to perpetuate their genes.” (1999, p. 134). This view of human–animal interactions is the cornerstone of his defense of animal experimentation in two widely-distributed papers (Heffner 1999, 2001). We argue that Heffner’s defense lacks adequate attention to ethical distinctions and principles.

Refinements In Rabbit Husbandry, The Bvaawf/Frame/Rspca/Ufaw Joint Working Group On Refinement

Breeding of Laboratory Research Animals Collection

The aims of this report are to identify the needs of domesticated rabbits and to present information on ways in which the current systems of housing rabbits can be improved for the benefit of all concerned: the animal, the scientist, the animal technician and the breeder.

In recent years an increasing number of establishments have changed from standard caging to group housing systems, despite the traditionally-held view that mature rabbits cannot be housed together. In this report group housing in floor pens is discussed in detail (Section 2), with both the advantages and disadvantages of this system presented. It is …

Life History, Ecology, And Morphology Of The Ravine Salamander, Plethodon Richmondi, Ronnie D. Jewell

Theses, Dissertations and Capstones

The distribution of P. richmondi and P. cinereus has been of interest to herpetologist for many years. Plethodon cinereus is found throughout the state except for part of the Allegheny Plateau Province where P. richmondi occurs. There is a somewhat abrupt end to their ranges where they overlap which does not appear to be influenced by elevational differences, vegetation patterns, or general climatic changes. The propose of this study was to determine if temperature and/or moisture are limiting the distribution of P. richmondi and P. cinereus in West Virginia. The natural history of P. richmondi has not in West Virginia …

How Rabbit Poisoning Methods Work, S H. Wheeler

Journal of the Department of Agriculture, Western Australia, Series 4

While the "rabbit plauges" of the past are a distant memory for most farmers, rabbit numbers must still be controlled in many parts of Western Australia. Rabit control techniques rely heavily on poisoning, which given the right conditions can kill a high percentage of rabbits at risk.

Recent research by the Agricultural Protection Board has been aimed at determining how different poisons, baits and poisoning methods work. By knowing in detail how each method works and what influences its results, we can choose the best control method for a particular place and time, avoid costly failures, and increase the effectiveness …

Feral Donkeys : An Assessment Of Control In The Kimberley, S H. Wheeler

Journal of the Department of Agriculture, Western Australia, Series 4

Feral donkeys are one of the major limitations to increased pastoral production in many parts of the Kimberley area of Western Australia, where they compete with cattle for food. In addition donkeys are aggressive animals, driving cattle from watering points and better grazing areas. They eliminate perenial plants by overgrazing and therefore reduce the carrying capacity of the range.

Originally introduced as draught animals, donkeys were released when cars arrived; since then they have bred up to large numbers in many areas.

For several years the Agricultural Protection Board has undertaken a programme of donkey shooting from helicopters. Since this …

Breeding And Use Of Nonhuman Primates In The Usa, Joe R. Held

International Journal for the Study of Animal Problems

Several species of nonhuman primates, each possessing specific characteristics of particular value, are used by the United States biomedical community in various health-related activities. These animals are man's closest relatives and are indispensable in understanding and controlling human health problems. The destruction of primate habitats and embargoes on the export of primates from source countries have decreased the supply of these animals. The inadequate and erratic supply of these resources threatens the continuation of many ongoing and new activities contributing to improving human health. In the U.S., a program has been developed to meet the health needs of primates:

1) …

Breeding And Use Of Nonhuman Primates In The Usa, Joe R. Held

Experimentation Collection

Several species of nonhuman primates, each possessing specific characteristics of particular value, are used by the United States biomedical community in a wide variety of health-related activities. These animals are man's closest relatives and are indispensable in the effort to understand and control human health problems.

The destruction of primate habitats and embargoes on export of primates from source countries have decreased the supply of these animals. Continuation of many ongoing and new activities contributing to the improvement of human health is threatened by inadequate and erratic supply of these resources. In the U.S., a program has been developed to …

The Intestinal Platyhelminths Of Southwestern And Central West Virginia Amphibia And Relationships Between The Degree Of Infestation And Habitat Of Amphibians And Sex Of Host, Stanley B. Mills

Theses, Dissertations and Capstones

In April and May, 1977, 397 (14 species) amphibians were collected from southwestern and central West Virginia and examined for parasites. Five species of trematodes and two species of cestodes were found from 93 hosts. The total of 397 amphibians was subdivided, for convenience, into six categories of amphibians; aquatic male and female, terrestro-aquatic male and female, and terrestrial male and female. Nine of 24 (37.5%). female aquatic amphibians was the highest incidence found, while terrestro-aquatic females contained the highest mean number (6.0) worms per incidence, and parasite loads of host. Hosts, each platyhelminth specimen are given.

The Medina Pig Research Station, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Before the Department of Agriculture's Medina Pig Research Station was established in 1964, pig production research had been carried out on Denmark Research Station, Muresk Agricultural College and in some commercial herds.

However, with increasing specialisation in the pig industry better facilities were needed. Medina Research Station provides such facilities, allowing it to carry out research to provide detailed information of immediate practical value for both extensive and intensive pig production enterprises.

Super Spreader Distributes Snail Baits, G D. Rimes, W. M. O'Donnell

Journal of the Department of Agriculture, Western Australia, Series 4

THE problem of distributing snail bait on broad acres has been overcome by simple modifications to a conventional super spreader.

Pig Husbandry Research In Western Australia, N W. Godfrey

Journal of the Department of Agriculture, Western Australia, Series 4

IN the past it has not been possible to undertake research work with pigs on any appreciable scale in Western Australia.

A small herd has been maintained at Denmark Research Station for some years as a demonstration side-line unit, run in conjunction with the dairy herd.

A number of very useful trials have been carried out with the Denmark herd, but its size has limited the comprehensiveness of the type of research work that could be undertaken.

Pig Research Projects For W.A, W J O Wilkie

Journal of the Department of Agriculture, Western Australia, Series 4

The Medina Pig Research Unit now being developed by the Department of Agriculture will be an important addition to pig research facilities in Australia.

The primary function of the unit will be to serve the needs of the pig industry in Western Australia.

In this article, Animal Husbandry Officer W. J. Wilkie, B.V.Sc, discusses some aspects of research to be carried out.

Poisoning Rabbits From The Air, C D. Gooding

Journal of the Department of Agriculture, Western Australia, Series 4

AERIAL baiting gives spectacular kills of rabbits in country which cannot be effectively treated by conventional means, and has been widely adopted in New Zealand and other States in Australia.

Here Mr. Gooding reports on developments in aerial baiting in Victoria, and suggests practical applications in Western Australia.

The Success Of The Rabbit 'Killer' Trials, A R. Tomlinson

Journal of the Department of Agriculture, Western Australia, Series 4

SUCCESS well beyond what was anticipated has been achieved in a two year trial of a modified version of the rabbit "killer" method.

In the "killer" method, trained officers are employed to kill rabbits instead of to inspect and supervise the activities of farmers and, in fact, these officers do all the actual work of destruction.

This system was advocated by the W.A. Royal Commission which reported on Vermin Control in this State in 1944, and it was used successfully in New Zealand.

These trials were applied only to poisoning and not to overall destruction measures. The main object was …

Vermin Control In W.A, A R. Tomlinson

Journal of the Department of Agriculture, Western Australia, Series 4

THE annual report of the Agriculture Protection Board of W.A. for 1958-1959 indicated that while vermin control had continued at a relatively high standard throughout the State, most of the animal and bird pests were at the lowest level within the memory of most people.

However, there were ample warnings that any relaxation in control work could have rapid and serious consequences.

Free Feeding For The Control Of Rabbits, C Marshall

Journal of the Department of Agriculture, Western Australia, Series 4

IN common with most other farm work, the control of rabbits calls for a high degree of skill, patience and perseverance.

There is no short cut to success, and if results are required we must be prepared to give of our best.

Failures of control works are experienced at various times, and the reasons can generally be traced back to something we have failed to do or some short cut we have tried to take.

However, we should not lose heart from one failure. During normal farming procedure, if a farmer's crop fails he does not give up planting in …