Systems and Integrative Physiology Commons^™

Cancer Cachexia: Metabolic Changes That Occur In Oxidative Capacity And Carbohydrate And Lipid Metabolism Of The Liver, Sarah Ramey

Health, Human Performance and Recreation Undergraduate Honors Theses

BACKGROUND: Cancer cachexia is defined as cancer-associated muscle wasting, and is a cancer side effect that dramatically affects cancer prognosis, is thought to be at least partially mediated by increased energy expenditure, and is directly responsible for the death of 20-40% of all cancer patients. Although the liver is known to be a predominant regulator of whole body metabolism, there is little known about its relationship to the development of cancer cachexia. PURPOSE: The purpose of this exploratory study was to investigate alterations in liver metabolism by examining measures of hepatic glycogen storage, oxidative phenotype and lipid content throughout the …