Physiology Commons^™

Cardiovascular Responses To Unilateral, Bilateral, Upper, And Lower Limbs Resistance Exercises, Jean L. S. De Oliveira, Leonardo C. R. Lima, Renan V. Barreto, Witalo Kassiano, José De O. V. Neto, Júlio C. C. N. Filho, Túlio Banja, Robson S. De Matos, Cláudio De O. Assumpção

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 1154-1164, 2023. The effects of different resistance exercises on cardiovascular responses remain elusive. Therefore, the present study aimed to investigate acute cardiovascular responses to unilateral and bilateral upper and lower limb resistance exercise. Young healthy males (n = 22; 26.9 ± 5.4 years, 170.0 ± 6.0 cm, 77.0 ± 10.8 kg) participated in the present study. Four experimental sessions were carried out, each consisting of one of the four exercises: unilateral and bilateral knee extension, unilateral and bilateral biceps curl. Cardiovascular responses (heart rate; HR, systolic blood pressure; SBP, and rate-pressure product; RPP) …

Hemodynamics And Arterial Stiffness In Response To Oral Glucose Loading In Individuals With Type Ii Diabetes And Controlled Hypertension, Yu Lun Tai, Smaran Marupudi, Gabriel A. Figueroa, Ryan D. Russell

Health & Human Performance Faculty Publications and Presentations

Introduction: Type 2 diabetes (T2D), the fastest growing pandemic, is typically accompanied by vascular complications. A central hallmark of both T2D and vascular disease is insulin resistance which causes impaired glucose transport and vasoconstriction concomitantly. Those with cardiometabolic disease display greater variation in central hemodynamics and arterial elasticity, both potent predictors of cardiovascular morbidity and mortality, which may be exacerbated by concomitant hyperglycemia and hyperinsulinemia during glucose testing. Thus, elucidating central and arterial responses to glucose testing in those with T2D may identify acute vascular pathophysiologies triggered by oral glucose loading.

Aim: This study compared hemodynamics and arterial stiffness to …

The Effects Of Traditional Versus Ability-Based Physical Training On The Health And Fitness Of Custody Assistant Recruits, Karly Rodas, Joseph Dulla, Matthew R. Moreno, Ashley Bloodgood, Megan Mcguire, Robin (Rob) Marc Orr, J. Jay Dawes, Robert G. Lockie

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 1641-1660, 2022. This study investigated traditional training (TT) versus ability-based training (ABT) in custody assistant recruits. Retrospective analysis was conducted on two recruit classes who completed an 8-week academy. The TT group (18 males, 13 females) followed a physical training model where recruits completed the same exercises with the same intensity; the ABT group (17 males, 12 females) had exercises tailored towards their ability. Pre- and post-academy, recruits were assessed in: body mass; body fat percentage (BF%); resting heart rate (RHR); blood pressure (BP); waist circumference (WC); waist-to-hip ratio (WHR); grip strength; push-ups; sit-ups; …

Is It Safe For Hemodialysis Patients To Seek Gains With Less Pain? Acute Hemodynamic Response To Intradialytic Blood Flow Restriction Training, Rony Nobre, Rodrigo Cardoso, Aline Araujo, Rafael Orcy, Jeniffer Aquino, Larissa Ribeiro, Rafaela Catto, Ana Carolina Conteratto, Airton Rombaldi, Maristela Bohlke

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 434-441, 2022. Considering that the hemodynamic safety is a major concern about intradialytic exercise with blood flow restriction, this analysis was performed to compare the blood pressure (BP) behavior during the first two hours of hemodialysis (HD) between sessions with no exercise (control group, CG), low/moderate intensity aerobic exercise with blood flow restriction (BFRE) and conventional aerobic exercise (AE). Adult patients with chronic kidney disease on HD at a university hospital were randomly assigned and submitted to a 12-week intradialytic training with BFRE or AE compared with the CG group. The main outcomes of …

Pulmonary Capillary Recruitment And Distention In Mammalian Lungs: Species Similarities, David Langleben, Benjamin D. Fox, Stylianos E. Orfanos, Michele Giovinazzo, John D. Catravas

Bioelectrics Publications

Pulmonary arterial pressure rises minimally during exercise. The pulmonary microcirculation accommodates increasing blood flow via recruitment of pulmonary capillaries and, at higher flows, by distention of already perfused capillaries. The flow transition range between recruitment and distention has not been studied or compared across mammalian species, including humans. We hypothesised that the range would be similar. Functional pulmonary capillary surface area (FCSA) can be estimated using validated metabolic techniques. We reviewed data from previous studies in three mammalian species (perfused rabbit lungs and dog lung lobes, and exercising humans) and generated blood flow-FCSA curves over a range of flows. We …

Isometric Exercise Training: A Review Of Hypothesized Mechanisms And Protocol Application In Persons With Hypertension, Jacquelyn Rickson, Stephen A. Maris, Samuel A.E. Headley

International Journal of Exercise Science

International Journal of Exercise Science 14(2): 1261-1276, 2021. According to the American Heart Association 116.4 million, or 46% of US adults are estimated to have hypertension. Although, traditional moderate intensity aerobic exercise training is associated with reducing blood pressure by 5-8 mmHg, barriers to this modality of exercise training exist. Thus, the purpose of this review is to evaluate the mechanisms and incorporation of isometric exercise training (IET) as an adjunctive mode of exercise in a population with HTN. Based upon the articles reviewed from the years 2000-2020 which incorporated IET and provided clear protocols lasting 4 or more weeks, …

Role Of Nhe3 In The Intestine And Thick Ascending Limb Of The Kidneys, Jianxiang Xue

USF Tampa Graduate Theses and Dissertations

The sodium-hydrogen exchanger isoform 3 (NHE3, SLC9A3) mediates most Na+/H+ exchange in the gastrointestinal tract and the kidney, where it plays crucial roles in Na+ and fluid absorption as well as acid-base homeostasis. Whole body NHE3 knockout (NHE3-/-) mice show overt absorptive defects in both the intestine and kidneys. Genetic mutations of NHE3 gene in humans are associated with congenital sodium diarrhea (CSD). In the kidneys, NHE3 is expressed in the proximal tubule (PT) and the thick ascending limb (TAL). Whole kidney-specific (PT and TAL) NHE3 knockout (NHE3Pax8cre) mice and PT-specific NHE3 knockout (PT-NHE3-/-) mice have shown the importance of …

Relationships Among Metabolic-Risk, Body Fatness, And Muscular Fitness In Young Obese Latino Children, Justin J. Merrigan, Sina Gallo, Jennifer B. Fields, Robyn Mehlenbeck, Margaret T. Jones

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 488-500, 2020. Given the high prevalence of obesity in Latino children and potential health risks, the purpose of this study was to: 1) evaluate relationships among metabolic-risk, fitness, and body fatness; 2) determine sex differences in cardio-metabolic risk factors and fitness of obese children of Latino descent. Sixty children (boys, n= 39, 7.8 ± 1.5 years; girls, n= 21, 7.2 ± 1.5 years; body mass index, 97.8 ± 2.5^thpercentile) completed assessments of height, weight, and body fat, prior to fasted blood draws and a battery of fitness tests. Cardio-metabolic markers …

Nanoformulation Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, Prevents Its Acute Hypotensive Response, Sarah L. Schlichte, Svetlana Romanova, Kenichi Katsurada, Elizabeth A. Kosmacek, Tatiana K. Bronich, Kaushik K. Patel, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Journal Articles: Cellular & Integrative Physiology

Scavenging superoxide (O₂^•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer. While few SOD mimics have transitioned to clinical trials, MnTnBuOE-2-PyP⁵⁺ (BuOE), a manganese porphyrin SOD mimic, is currently in clinical trials as a radioprotector for cancer patients; thus, providing hope for the use of SOD mimics in the clinical setting. However, BuOE transiently alters cardiovascular function including a significant and precipitous decrease in blood pressure. To limit BuOE's acute hypotensive action, we developed a mesoporous silica nanoparticle …

Sympathetic Neural Responses To Acute Thermal Sensations, Hannah August Cunningham

Dissertations, Master's Theses and Master's Reports

The influence of thermal stimuli on the sympathetic nervous system is variable and largely depends on the change in temperature and timing of the stimuli. Core temperature changes yield increased muscle sympathetic nerve activity (MSNA) while changes in skin temperature yield variable MSNA responses. The MSNA responses to acute heating or cooling sensations remains unclear. Twenty-three participants (11 women, 12 men; age 24±1 years, BMI 26±1 kg/m²) underwent a thermal protocol that included four trials each of cool sensation threshold, warm sensation threshold, and heat pain (12 total trials). Continuous blood pressure (finger plethysmography), heart rate (electrocardiography), and …

Comparison Of College Student Hypertension Prevalence Between The Jnc7 And Acc/Aha Diagnostic Criteria, Kadiatu Kamara, Oliver W A Wilson, Zack Papalia, Melissa Bopp, C M. Bopp

International Journal of Exercise Science

International Journal of Exercise Science 12(3): 898-903, 2019. Hypertension is highly prevalent and associated with non-communicable diseases and increased premature mortality risk. However, the impact of the new hypertension diagnostic criteria on the prevalence of hypertension diagnoses has yet to be examined among college students. The purpose of this study was to compare the prevalence of hypertension between the JNC7 and the ACC/AHA hypertension diagnostic criteria among college students. The blood pressure of 5,945 college students was assessed, and chi-square tests for independence examined differences between JNC7 and ACC/AHA criteria. The mean age of participants was 21.30 ± 1.05 years, …

Emerging Roles Of The Membrane Potential: Action Beyond The Action Potential, Lina Abdul Kadir, Michael Stacey, Richard Barrett-Jolley

Bioelectrics Publications

Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as ion channel research shifts beyond these tissues, it became clear that the RMP is a feature of virtually all cells studied. The RMP is maintained by the cell's compliment of ion channels. Transcriptome sequencing is increasingly revealing that equally rich compliments of ion channels exist in both excitable and non-excitable tissue. In this review, we discuss a range of critical roles …

Functional Changes Associated With Shroom3 Deficiency And Mutation: Implications In Renal Pathophysiology And Disease, Doyun Ko

Electronic Thesis and Dissertation Repository

Chronic kidney disease (CKD) is a substantial global health burden that has recently been linked to the genetic locus SHROOM3 by several genome-wide association studies. Shroom3 is an actin-binding protein that is necessary for inducing apical constriction in epithelial cells. Our lab has previously shown that Shroom3 is critical for proper kidney development and loss of Shroom3 produces symptoms associated with CKD. As hypertension is both a leading cause and comorbidity of CKD, I hypothesized that loss of Shroom3 confers increased susceptibility to hypertension. Using a high-salt induced model of hypertension, I show that Shroom3 deficient mice do not become …

Sympatho-Excitatory Response To Pulmonary Chemosensitive Spinal Afferent Activation In Anesthetized, Vagotomized Rats, Julia A. Shanks, Zhiqiu Xia, Steven J. Lisco, George J. Rozanski, Harold D. Schultz, Irving H. Zucker, Han-Jun Wang

Journal Articles: Cellular & Integrative Physiology

The sensory innervation of the lung is well known to be innervated by nerve fibers of both vagal and sympathetic origin. Although the vagal afferent innervation of the lung has been well characterized, less is known about physiological effects mediated by spinal sympathetic afferent fibers. We hypothesized that activation of sympathetic spinal afferent nerve fibers of the lung would result in an excitatory pressor reflex, similar to that previously characterized in the heart. In this study, we evaluated changes in renal sympathetic nerve activity (RSNA) and hemodynamics in response to activation of TRPV1-sensitive pulmonary spinal sensory fibers by agonist application …

Extreme Conditioning Program Induced Acute Hypotensive Effects Are Independent Of The Exercise Session Intensity, Ramires Alsamir Tibana, Leonardo Mesquita Almeida, Ivo Vieira De Sousa Neto, Nuno Manoel Frade De Sousa, Jeeser Alves De Almeida, Belmiro Freitas De Salles, Claudio Melibeu Bentes, Fabricio Azevedo Voltarelli, Scott Collier, Jonato Prestes

International Journal of Exercise Science

International Journal of Exercise Science 10(8): 1165-1173, 2017. The aim of the study was to determine the acute systolic (SBP) and diastolic (DBP) blood pressure, rating of perceived exertion (RPE) and heart rate (HR) responses following two intense training sessions (24 hours apart). Nine male extreme conditioning program (ECP) practitioners with more than 6 months of experience (age 26.7 ± 6.6 years; body mass 78.8 ± 13.2 kg; body fat 13.5 ± 6.2 %) completed two experimental ECP sessions. Cardiovascular variables were measured before, immediately after and every 15 min during a 45 min recovery following each experimental session. Compared …

Effects Of The Boy Scouts Of America Personal Fitness Merit Badge On Cardio-Metabolic Risk, Health Related Fitness And Physical Activity In Adolescents Boys, Justin Maxwell, Ryan D. Burns, Timothy A. Brusseau

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 964-976, 2017. A growing number of adolescents are more sedentary and have fewer formal opportunities to participate in physical activity. With the mounting evidence that sedentary time has a negative impact on cardio-metabolic profiles, health related fitness and physical activity, there is a pressing need to find an affordable adolescent physical activity intervention. One possible intervention that has been overlooked in the past is Boy Scouts of America. There are nearly 900,000 adolescent boys who participate in Boy Scouts in the United States. The purpose of this research study was to evaluate the effect …

Blood Pressure And Cardiovascular Health Has Relationship With Age In Adults During Adulthood, Allyson K. Getty, Jessica M. Lenzo, Tia R. Wisdo, Joyann E. Oakman, Christina M. Cromwell, Jessica A. Hill, Lauren N. Chavis, Deborah L. Feairheller, Phd

International Journal of Exercise Science

International Journal of Exercise Science 10(5): 798-806, 2017. Efforts to combat cardiovascular disease (CVD) have proven effective, especially in the population aged 55-74 years. However, less research has been conducted in younger populations to determine at what age CVD risk develops. The purpose of this study is to compare cardiovascular health markers in adults, specifically CVD risk between younger adults aged 18-22 and a slightly older group of adults in middle adulthood aged 23-54. Cardiovascular health measures were collected from a group of adults; 13 younger adults (20.2±0.9 yrs) and 10 adults in middle adulthood (42.9±10.1 yrs). All participants were …

Body Size Predicts Cardiac And Vascular Resistance Effects On Men's And Women's Blood Pressure, Joyce M. Evans, Siqi Wang, Christopher Greb, Vladimir Kostas, Charles F. Knapp, Qingguang Zhang, Eric S. Roemmele, Michael B. Stenger, David C. Randall

Biomedical Engineering Faculty Publications

Key Points Summary

• We report how blood pressure, cardiac output and vascular resistance are related to height, weight, body surface area (BSA), and body mass index (BMI) in healthy young adults at supine rest and standing.
• Much inter-subject variability in young adult's blood pressure, currently attributed to health status, may actually result from inter-individual body size differences.
• Each cardiovascular variable is linearly related to height, weight and/or BSA (more than to BMI).
• When supine, cardiac output is positively related, while vascular resistance is negatively related, to body size. Upon standing, the change in vascular resistance is positively related to size. …

Hypotensive Responses Of Reciprocal Supersets Versus Traditional Resistance Training In Apparently Healthy Men, Claudio Melibeu Bentes, Pablo B. Costa Corresponding Author, Victor Gonçalves Corrêa Neto, Roberto Simão, Gabriel Andrade Paz, Marianna Maia, Tiago Figueiredo, Gabriel Rodrigues Neto, Jefferson S. Novaes, Humberto Miranda

International Journal of Exercise Science

International Journal of Exercise Science 10(3): 434-445, 2017. The purpose of this study was to compare the hypotensive responses of reciprocal supersets (SS) versus traditional training (TRAD) methods. Thirteen men with at least five years of recreational experience in resistance training (RT) volunteered for the study. When completing the TRAD protocol, participants performed the following exercises separately in sequence: chest press (CP), low row (LR), leg extension (LE), leg curl (LC), pull down (PD), and shoulder press (SP). The SS method required participants to complete the same exercises as in the TRAD protocol, but exercises were coupled such that muscles …

An Acute Bout Of A Controlled Breathing Frequency Lowers Sympathetic Neural Outflow But Not Blood Pressure In Healthy Normotensive Subjects, Shannon Mcclain, Alexa Brooks, Sara Jarvis

International Journal of Exercise Science

International Journal of Exercise Science 10(2): 188-196, 2017 Controlled or paced breathing is often used as a stress reduction technique but the impact on blood pressure (BP) and sympathetic outflow have not been consistently reported. The purpose of this study was to determine whether a controlled breathing (12 breaths/min, CB) rate would be similar to an individual’s spontaneous breathing (SB) rate. Secondly, would a CB rate of 12 breaths/min alter heart rate (HR), BP, and indices of muscle sympathetic nerve activity (MSNA). Twenty-one subjects (10 women, 11 men) performed two trials: SB, where the subject chose a comfortable breathing rate; …

The Effects Of Beetroot Juice On Vo2max And Blood Pressure During Submaximal Exercise, Jose M. Perez

Electronic Theses and Dissertations

Supplementation with beetroot juice (BR) has been shown to reduce blood pressure (BP) at rest and improve several performance parameters during submaximal and maximal exercise. BR effects on BP during submaximal exercise have not been investigated. Furthermore, the effects of BR on VO₂max are inconclusive. The purpose of this study was to investigate the effects of BR on VO₂max and BP during submaximal exercise. 20 healthy, recreationally trained volunteers (age 21.8±2.35 years, weight 75.10±10.62 kg, height 177.4±6.39 cm) participated in this study, which had a double-blind placebo controlled randomized crossover design. Participants began supplementation with either …

Carotid Artery Imt, Blood Pressure, And Cardiovascular Risk Factors In Males And Females, Christina M. Cromwell, Kristin R. Aichele, Joyann E. Oakman, Michael P. Neal, Jessica M. Lenzo, Avery N. Perez, Naomi L. Bye, Erica L. Santaniello, Jessica A. Hill, Rachel C. Evans, Karla A. Thiele, Lauren N. Chavis, Allyson K. Getty, Tia R. Wisdo, Deborah L. Feairheller, Phd

International Journal of Exercise Science

International Journal of Exercise Science 9(4): 482-490, 2016. Previous studies have investigated carotid artery intima-media thickness (IMT) and blood pressure and found a direct correlation between the two. It is known that adult females have better cardiovascular health than males until a certain stage of life, yet limited research has examined gender differences in vascular function. Thus, the purpose of this study was to investigate vascular structure and function, blood pressure, and blood glucose/cholesterol levels in relation to gender differences in young healthy adults. On three separate days, 44 adults (26.30 ±11.9yrs; 24M, 20F) completed a carotid IMT ultrasound, a …

Passive Hyperthermia Therapy Similarly Reduces Arterial Blood Pressure In Obese Type 2 Diabetic And Healthy Individuals, Eric Rivas

International Journal of Exercise Science: Conference Proceedings

Diabetes which is associated with impaired glycemic control, can damage macro and microvasculature, and impair vascular relaxation (i.e., endothelial dysfunction). The high thermal conductance of hot water will cause thermoregulatory adjustments that increase cardiac output, heart rate and stroke volume while reducing central venous pressure. This project tested the hypothesis that an acute bout of hot water hyperthermia will reduce arterial blood pressure during and following the exposure, but the response will be attenuated in obese type 2 diabetics. Eleven obese type 2 diabetics (T2D) (50.1 ± 12 y, 45 ± 7.1% fat mass, 7.5 ± 1.8% HbA1C) and nine …

The Effect Of Multiple Sclerosis On Carotid Baroreflex Control Of Heart Rate And Blood Pressure, Dustin R. Allen, Mu Huang, David M. Keller, Scott L. Davis

International Journal of Exercise Science: Conference Proceedings

Multiple sclerosis (MS) is marked by conduction abnormalities within the central nervous system that can lead to impaired blood pressure regulation. However, the impact of this disease on dynamic neural control—responsiveness and timing (i.e., latency)—of blood pressure has not been examined. Utilizing a variable neck chamber system, we tested the hypothesis that patients with MS (MS: n=4) exhibit an altered response following baroreflex perturbation compared to sex and age matched healthy controls (CON: n=4). At rest, 5-sec pulses of neck suction (NS; -60 Torr) and neck pressure (NP; +40 Torr) were applied to simulate carotid hypertension and hypotension, respectively. Mean …

Leptin Regulates Cd16 Expression On Human Monocytes In A Sex-Specific Manner, Joseph G. Cannon, Gyanendra Sharma, Gloria Sloan, Christiana Dimitropoulou, R. Randall Baker, Andrew Mazzoli, Barbara Kraj, Anthony Mulloy, Miriam Cortez-Cooper

School of Medical Diagnostics & Translational Sciences Faculty Publications

Fat mass is linked mechanistically to the cardiovascular system through leptin, a 16 kDa protein produced primarily by adipocytes. In addition to increasing blood pressure via hypothalamic-sympathetic pathways, leptin stimulates monocyte migration, cytokine secretion, and other functions that contribute to atherosclerotic plaque development. These functions are also characteristics of CD16-positive monocytes that have been implicated in the clinical progression of atherosclerosis. This investigation sought to determine if leptin promoted the development of such CD16-positive monocytes. Cells from 45 healthy men and women with age ranging from 20 to 59 years were analyzed. Circulating numbers of CD14++16++ monocytes, which are primary …

The Relationship Between High-Salt And Estrogen On Blood Pressure Under Basal And Stressed Conditions In The Female Offspring Of Sprague Dawley Rats That Were Subjected To High Or Normal Salt Diets During Pregnancy, Brandon G. Wilkinson, Dr. James Porter

Journal of Undergraduate Research

Cardiovascular disease (CVD) is the number one leading cause of death in the United States. High blood pressure (hypertension) is a form of CVD and affects nearly 1 in 3 American adults. Men are more likely than women to develop hypertension until 45 years of age. However, percentages of women diagnosed with hypertension rise to exceed that of men around 45-54 years of age.1 This trend in hypertension is a clear age-related sex dimorphism. The trend suggests that following the onset of menopause, women have a higher risk of hypertension, a risk that continues to rise with age.2-3 Current research …

Exercise Blood Pressures Are Lower After Aquatic Compared To Land Treadmill Training, Alex T. Carradine, Brad S. Lambert, Nicolas P. Greene, Travis W. Constanzo, Steven E. Martin, Stephen F. Crouse

International Journal of Exercise Science: Conference Proceedings

Exercise blood pressures are lower after aquatic compared to land treadmill training

Alex T. Carradine¹, Brad S. Lambert¹, Nicolas P. Greene², Travis W. Constanzo¹, Steven E. Martin¹, Stephen F. Crouse (FACSM)¹. Texas A&M University, College Station, TX. ²University of Virginia, Charlottesville, VA.

Traditional treadmill training has been shown to moderately decrease exercise blood pressures but the degree to which aquatic running alters exercise blood pressures has not been fully investigated. PURPOSE: To compare the exercise blood pressure responses after land treadmill (LTM) training to an equivalent …

Effect Of Low Maternal Aldosterone On Offspring Cardiovascular Development, Travis Dean Mckee

All Graduate Theses, Dissertations, and Other Capstone Projects

Maternal conditions are well known to affect fetal cardiovascular development. This study was designed to investigate in spontaneously hypertensive rats (SHR), the effects of maternal aldosterone suppression on the development of hypertension in the offspring. A sham procedure or a right adrenalectomy combined with cryodestruction of the zona glomerulosa of the left adrenal gland was performed on SHR females. The rats were mated and male offspring were implanted at 11-13 weeks of age with a PA-C40 remote monitoring device placed into the femoral artery to record cardiovascular parameters for 4 weeks. Systolic (mmHg), diastolic (mmHg), and mean blood pressure (mmHg), …

Blood Volume Unloading Reduces Cerebral Blood Flow, Taylor Drury, Darren Warburton, Aaron Phillips, Shannon Bredin

International Journal of Exercise Science: Conference Proceedings

Introduction: Cerebral autoregulation (CA) has been understood for over 50 years to maintain constant cerebral blood flow (CBF) over a wide range of arterial blood pressures (60-150 mmHg), and blood volumes. The original work, which published this relationship, however, was derived from a limited number of studies focused primarily on clinical populations. Since that time, it has been applied to healthy individuals and is a mainstay of almost all physiology textbooks. Recent evidence, however, has suggested that CBF in healthy individuals is not independent of alterations in blood pressure and volume, indicating a possible absence of cerebral autoregulation. Lower body …

Effect Of Dimethylarginine Dimethylaminohydrolase In The Development Of Salt Sensitivity, Samar Abdulla Nasser

Wayne State University Dissertations

Salt sensitivity is associated with a rise in blood pressure (BP) occurring during sodium loading and/or a fall in BP during sodium restriction that exceeds random fluctuations in BP. Salt sensitivity is more common in African American than Caucasian hypertensives and is also present, in normotensive African Americans. The mechanism or mechanisms resulting in salt-sensitive hypertension are multiple and include both activation of the renin angiotensin system via increases in angiotensin II and reductions in the endogenous vasodilator, nitric oxide (NO). An important means of NO downregulation is through asymmetric dimethylarginine (ADMA), an endogenous NO inhibitor, which is largely metabolized …