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Articles 61 - 71 of 71
Full-Text Articles in Physiology
Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction In A Mouse Model That Exhibits Age-Dependent Progression Of Alzheimer's Disease-Related Pathology, Adam D. Bachstetter, Christopher M. Norris, Pradoldej Sompol, Donna M. Wilcock, Danielle Goulding, Janna H. Neltner, Daret St. Clair, D. Martin Watterson, Linda J. Van Eldik
Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction In A Mouse Model That Exhibits Age-Dependent Progression Of Alzheimer's Disease-Related Pathology, Adam D. Bachstetter, Christopher M. Norris, Pradoldej Sompol, Donna M. Wilcock, Danielle Goulding, Janna H. Neltner, Daret St. Clair, D. Martin Watterson, Linda J. Van Eldik
Sanders-Brown Center on Aging Faculty Publications
Overproduction of proinflammatory cytokines in the CNS has been implicated as a key contributor to pathophysiology progression in Alzheimer's disease (AD), and extensive studies with animal models have shown that selective suppression of excessive glial proinflammatory cytokines can improve neurologic outcomes. The prior art, therefore, raises the logical postulation that intervention with drugs targeting dysregulated glial proinflammatory cytokine production might be effective disease-modifying therapeutics if used in the appropriate biological time window. To test the hypothesis that early stage intervention with such drugs might be therapeutically beneficial, we examined the impact of intervention with MW01-2-151SRM (MW-151), an experimental therapeutic that …
Exercise Ameliorates Disruption Of The Dystrophin-Associated Glycoprotein Complex And Fibrosis In The Aging Rat Heart, Yang Lee, Jeffrey M. Hord, Hyo-Bum Kwak, Jong-Hee Kim, John M. Lawler
Exercise Ameliorates Disruption Of The Dystrophin-Associated Glycoprotein Complex And Fibrosis In The Aging Rat Heart, Yang Lee, Jeffrey M. Hord, Hyo-Bum Kwak, Jong-Hee Kim, John M. Lawler
International Journal of Exercise Science: Conference Proceedings
The dystrophin-glycoprotein complex (DGC) is localized and integrated into the cell membrane. The DGC provides a mechanical link between the cellular cytoskeleton and the extracellular matrix (ECM). In cardiac muscle, disruption of DGC might be involved in mediating cardiac remodeling that occurs with aging, cardiomyopathy, and heart failure through transforming growth factor-beta (TGF-ß). Decorin is a small leucine-rich proteoglycan closely related to the DGC component that binds to collagen. Decorin reduces fibrosis via inhibition of TGF-ß and myofibroblast formation. PURPOSE: To test the hypothesis that exercise training (ET) would alleviate age-related disruption of localization in DGC proteins (dystrophin, α-syntrophin, and …
Increase In Muscle Power Induced By Periodized Resistance Training In Elderly Women, Cláudio De Oliveira Assumpção, João Bartholomeu Neto, Christiano Bertoldo Urtado, Maria Imaculada L. Montebelo
Increase In Muscle Power Induced By Periodized Resistance Training In Elderly Women, Cláudio De Oliveira Assumpção, João Bartholomeu Neto, Christiano Bertoldo Urtado, Maria Imaculada L. Montebelo
International Journal of Exercise Science: Conference Proceedings
Resistance training (RT) has been recommended to prevent muscle force and power decrease induced by aging. Neuromuscular tests are important tools to analyze muscle force function. The objective of the present study was to analyze the behavior of lower limb muscle power of elderly women submitted to 12 weeks of periodized RT. 16 women aged 65.5±3.6 years with a minimum of one year of previous experience in strength training were selected, they performed 24 sessions of RT divided in 3 mesocycles (MA, MB and MC), of 8 sessions each, with a session frequency of twice a week. The MA with …
Aging, Neuromuscular Decline, And The Change In Physiological And Behavioral Complexity Of Upper-Limb Movement Dynamics, S. Morrison, K. M. Newell
Aging, Neuromuscular Decline, And The Change In Physiological And Behavioral Complexity Of Upper-Limb Movement Dynamics, S. Morrison, K. M. Newell
Rehabilitation Sciences Faculty Publications
Aging is characterized by a general decline in physiological and behavioral function that has been widely interpreted within the context of the loss of complexity hypothesis. In this paper, we examine the relation between aging, neuromuscular function and physiological-behavioral complexity in the arm-hand effector system, specifically with reference to physiological tremor and isometric force production. Experimental findings reveal that the adaptive behavioral consequences of the aging-related functional decline in neurophysiological processes are less pronounced in simple motor tasks which provides support for the proposition that the motor output is influenced by both extrinsic (e.g., task related) and intrinsic (e.g., coordination, …
Store-Operated Ca(2+) Entry (Soce) Contributes To Normal Skeletal Muscle Contractility In Young But Not In Aged Skeletal Muscle, Angela M. Thornton, Xiaoli Zhao, Noah Weisleder, Leticia S. Brotto, Sylvain Bougoin, Thomas M. Nosek, Michael B. Reid, Brian Hardin, Zui Pan, Jianjie Ma, Jerome Parness, Marco Brotto
Store-Operated Ca(2+) Entry (Soce) Contributes To Normal Skeletal Muscle Contractility In Young But Not In Aged Skeletal Muscle, Angela M. Thornton, Xiaoli Zhao, Noah Weisleder, Leticia S. Brotto, Sylvain Bougoin, Thomas M. Nosek, Michael B. Reid, Brian Hardin, Zui Pan, Jianjie Ma, Jerome Parness, Marco Brotto
Physiology Faculty Publications
Muscle atrophy alone is insufficient to explain the significant decline in contractile force of skeletal muscle during normal aging. One contributing factor to decreased contractile force in aging skeletal muscle could be compromised excitation-contraction (E-C) coupling, without sufficient available Ca(2+) to allow for repetitive muscle contractility, skeletal muscles naturally become weaker. Using biophysical approaches, we previously showed that store-operated Ca(2+) entry (SOCE) is compromised in aged skeletal muscle but not in young ones. While important, a missing component from previous studies is whether or not SOCE function correlates with contractile function during aging. Here we test the contribution of extracellular …
Neuromuscular Adaptations In Elderly Adults Are Task-Specific During Stepping And Obstacle Clearance Tasks., Matthew Bice, Nicholas J. Hanson, James A. Eldridge, Paul Reneau, Douglas W. Powell
Neuromuscular Adaptations In Elderly Adults Are Task-Specific During Stepping And Obstacle Clearance Tasks., Matthew Bice, Nicholas J. Hanson, James A. Eldridge, Paul Reneau, Douglas W. Powell
International Journal of Exercise Science
Elderly adults have a diminished movement capacity due to physiological and neurological declines associated with advancing age. Previous research suggests that elderly adults use altered neuromuscular patterns to conduct activities of daily living (ADLs). Limited research has addressed these altered activation strategies in obstacle clearance, stair ascent and stair descent. The purpose of this study was to compare neuromuscular activation patterns in young and elderly adults during these tasks. Eleven young and 10 healthy elderly adults performed five downward stepping, upward stepping and obstacle clearance trials. Surface EMG was measured from the quadriceps, hamstrings, gastrocnemius and tibialis anterior muscles. A …
Changes In The Proliferation Of The Subventricular Zone Neural Stem Cell Pool Throughout Aging In The Murine Brain, Olayinka Edwards
Changes In The Proliferation Of The Subventricular Zone Neural Stem Cell Pool Throughout Aging In The Murine Brain, Olayinka Edwards
Honors Scholar Theses
Previous studies regarding subventricular zone (SVZ) neural stem cells (NSCs) have either observed global changes in the SVZ niche containing NSCs or an impure NSC population. By imaging wholemount preparations of mouse brains and staining with molecular markers specific for proliferating NSC nuclei, the study was able to give a more accurate depiction of the SVZ NSC population than its predecessors. This study will quantify the percentage of proliferating NSCs at various ages of adult murine brain development in order to elucidate a possible correlation between NSC division kinetics and the declining neurogenic output witnessed with aging.
Mip/Mtmr14 And Muscle Aging, Scott K. Powers, Michael B. Reid
Mip/Mtmr14 And Muscle Aging, Scott K. Powers, Michael B. Reid
Physiology Faculty Publications
No abstract.
Alterations In The Cellular Composition Of The Mouse Bladder Following Ovariectomy, Partial Bladder Outlet Obstruction, And Aging, Diane Holly Smith
Alterations In The Cellular Composition Of The Mouse Bladder Following Ovariectomy, Partial Bladder Outlet Obstruction, And Aging, Diane Holly Smith
Honors Scholar Theses
Detrusor underactivity (DU) increases susceptibility to urinary retention and accordingly further complicates the management of urinary incontinence. Bladder muscle stretch, a lack of estrogen, and aging are 3 notable DU risk factors. The aim of this research is to better characterize the changes in cellular composition of the bladder that result from these 3 risk factors to gain a better understanding of DU pathogenesis and pathobiology. This research focuses on the effects of a lack of estrogen while also providing an outline for determining the effects of bladder muscle stretch and aging on the cellular composition of the bladder.
Predictors Of Adl Disability In Culturally Diverse Older Adults, Fernanda Winchester†, Rebecca Ellis‡, Maria Kosma‡, Katie E. Cherry‡, Priscilla D. Allen‡, Pamela A. Monroe‡, Robert H. Wood‡
Predictors Of Adl Disability In Culturally Diverse Older Adults, Fernanda Winchester†, Rebecca Ellis‡, Maria Kosma‡, Katie E. Cherry‡, Priscilla D. Allen‡, Pamela A. Monroe‡, Robert H. Wood‡
International Journal of Exercise Science
The purpose of this study was to utilize the disablement pathway model to examine the contribution of physical function, dyspnea, and pain to disability in activities-of-daily-living (ADL) in culturally diverse older adults. Participants were 51 older adults (age = 69.0 years ± 9.7; 76.5% African-American, 51.0% < high school education, 52.9% < $20,000 annual income) from an urban community center and an independent living housing facility for seniors. Participants completed the Functional Status Index (FSI), which provides ratings of need for assistance (FSIA) and pain (FSIP) with ADL, the Continuous Scale Physical Functional Performance 10-item Test (CS-PFP10), and an analog dyspnea scale. Hierarchical multiple regression analyses revealed that facility, physical function, pain, and dyspnea accounted for 50.5% of the variance in disability and that pain (β = .43, p < .01) and physical function (β = -.39, p < .01) were the only significant predictors. In the second model, facility, dyspnea, and pain explained 27.6% of the variance in physical function, and facility (β = .39, p < .01) and dyspnea (β = -.26, p = .05) were the only significant predictors. Based on the disablement pathway model, physical functional improvement and pain prevention and management should be targeted when designing culturally appropriate strategies for delaying disability and maintaining independent life.
Aging Affects Stretch-Induced P70s6k And 4e-Bp1 Phosphorylation In Fast- And Slow-Twitch Muscle, Sreevani Uddemarri
Aging Affects Stretch-Induced P70s6k And 4e-Bp1 Phosphorylation In Fast- And Slow-Twitch Muscle, Sreevani Uddemarri
Theses, Dissertations and Capstones
In the present investigation we compare the expression, basal activation and the ability of muscle stretch to activate the p70S6k pathway in the fast-twitch extensor digitorum longus (EDL) and slow-twitch soleus of adult (6 mo. old), aged (30 mo. old) and very aged (36 mo. old) Fischer 344 x Brown Norway rats. Immunoblotting demonstrated that the tissue content of mTOR, p70S6k, 4E-BP1 and GSK-3β decreased in the EDL and soleus in aged rats, while SHP-2 increased in the EDL and decreased in the soleus when compared to adult rats. Basal phosphorylation of 4E-BP1 increased in both the …