Physiology Commons^™

Invited Review: Adrenocortical Function In Avian And Non-Avian Reptiles: Insights From Dispersed Adrenocortical Cells., Rocco V. Carsia, Patrick J. Mcilroy, Henry B John-Alder

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Herein we review our work involving dispersed adrenocortical cells from several lizard species: the Eastern Fence Lizard (Sceloporus undulatus), Yarrow's Spiny Lizard (Sceloporus jarrovii), Striped Plateau Lizard (Sceloporus virgatus) and the Yucatán Banded Gecko (Coleonyx elegans). Early work demonstrated changes in steroidogenic function of adrenocortical cells derived from adult S. undulatus associated with seasonal interactions with sex. However, new information suggests that both sexes operate within the same steroidogenic budget over season. The observed sex effect was further explored in orchiectomized and ovariectomized lizards, some supported with exogenous testosterone. Overall, a suppressive effect of testosterone was evident, especially in cells …

Characterization And Estimation Of Musculoskeletal Pain Using Machine Learning, Boluwatife Faremi

Master's Theses

Traditional scales utilized for recording pain are known to be highly subjective and biased due to inaccuracies in recollecting actual pain intensities. As a result, machine learning (ML) models that are trained using these scores as ground truth are reported to have low performance for objective pain classification because of the huge disparity between what was felt in moments of pain and the scores recorded afterward.

In the present study, two devices were designed for gathering real-time, continuous in-session subjective pain scores and the recording of the autonomic nervous system (ANS) altered endodermal (EDA) activity. 24 participants were recruited to …

Alcapa – A Rare Cause Of Effort Angina In An Adult: A Case Report, Henita Joshna Menezes, Raghav R. Nagpal, Sonia R B D'Souza, Ramachandran Padmakumar

Manipal Journal of Nursing and Health Sciences

Introduction: ALCAPA – ‘Anomalous Left Coronary Artery from the Pulmonary Artery’, it is an infrequent congenital cardiovascular abnormality distinguished by the ‘left coronary artery’ originating from the ‘pulmonary artery’ in place of its normal origin, the aorta. Failing to treat this critical condition, might result in myocardial ischemia, left ventricular dysfunction, and a risk of sudden heart-related death.

Clinical manifestations: Exertional chest pain and fatigue since 6 months.

Diagnosis, therapeutic intervention, and outcomes: The diagnosis was established with the help of transoesophageal echocardiography and coronary angiogram. Surgical repair by Left Coronary Artery reimplantation was done with a successful outcome.

Conclusion: …

Timekeeper's Dilemma: How Photo-Thermal Cues Alter Flowering Duration, Kyle W. Swentowsky, Janlo M. Robil

Biology Faculty Publications

No abstract provided.

Mid-Gestation Maternofetal Inflammation Impacts Growth, Skeletal Muscle Glucose Metabolism, And Inflammatory Tone In The Ovine Fetus During Late Gestation, Zena Mariah Hicks

Department of Animal Science: Dissertations, Theses, and Student Research

Our 1^st and 2^nd studies assessed the impact of mid-gestation maternofetal inflammation on growth, skeletal muscle glucose metabolism, and inflammatory tone in the late gestation ovine fetus. The objective was to determine if inducing maternofetal inflammation during peak placental growth would lead to more profound IUGR characteristics in the fetus. MI-IUGR fetuses exhibited reduced body and skeletal muscle weights and hallmark asymmetric growth at late gestations. Fetuses had higher baseline glucose:insulin ratios and reduced glucose-stimulated insulin secretion. Moreover, hindlimb glucose oxidation was impaired independent of glucose uptake. Skeletal muscle specific glucose uptake and oxidation was reduced in MI-IUGR …

Use Of Electronic Ecological Momentary Assessment Methodologies In Physical Activity, Sedentary Behavior, And Sleep Research In Young Adults: Systematic Review, Kimberly R. Hartson, Luz Huntington-Moskos, Clara G. Sears, Gina Genova, Cara Mathis, Wessly Ford, Ryan E. Rhodes

Faculty and Staff Scholarship

Background: Recent technological advances allow for the repeated sampling of real-time data in natural settings using electronic ecological momentary assessment (eEMA). These advances are particularly meaningful for investigating physical activity, sedentary behavior, and sleep in young adults who are in a critical life stage for the development of healthy lifestyle behaviors.

Objective: This study aims to describe the use of eEMA methodologies in physical activity, sedentary behavior, and sleep research in young adults.

Methods: The PubMed, CINAHL, PsycINFO, Embase, and Web of Science electronic databases were searched through August 2022. Inclusion criteria were use of eEMA; sample of young adults …

Energy Costs Of Chair Sitting And Standing Video Exercises In Chinese Older Adults, Ages 60 To 89 Years, Zhenghua Cai, Minghui Quan, Muyang Huan, Guangli Sun, Stephen D. Herrmann, Barbara E. Ainsworth, Peijie Chen

International Journal of Exercise Science

International Journal of Exercise Science 16(7): 814-827, 2023. Home-based video exercise interventions improve older adults’ physiological performance and functional capacity. Little is known about the energy costs of video exercises in older adults. The Compendium of Physical Activities (PAs) has few items with PA metabolic equivalents (METs) in older adults. This study measured the energy costs of four chair and two standing exercises (sitting Tai Chi, Yoga, mobility ball, aerobics: standing, slow aerobics, and fast aerobics). Fifteen females and 14 males, 62-87 years (M ± SD, 73 ± 7.7 years), were categorized into three age groups (60-69, 70-79, 80-89). Oxygen …

Two Different Approaches To Dry-Land Training Do Not Improve The Water Performance Of Swimmers, Matheus Silva Norberto, Carlos Augusto Kalva-Filho, Guilherme Navarro Schneider, Eduardo Zapaterra Campos, Marcelo Papoti

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 770-790, 2023. Literature diverges about the performance improvement after dry-land training. Thus, the objective of the present study was to compare the effect of two models of dry-land training. Twenty-nine swimmers were divided into three groups, combined strength and power training (PTG), only strength training (STG), and a control group (CG). Measurements were taken for six weeks, before dry-land exposure (M1), after four weeks of specific training with exposure to dry-land training by two groups (M2), and after two weeks of taper without exposure to dry-land training (M3). Strength in specific exercises, jumping tests, …

Influence Of Systematic Training On Morpho-Physiological And Motor Ability Profiles Of Indian Young Female Rowers, Kayakers And Canoers, Tamoghni Manna, Snehunsu Adhikari, Alak Kumar Syamal

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 744-755, 2023. Our study was carried on junior female athletes (22 rowers, 11 kayakers and 7 canoers) adopting systemic training to explore the possible training manipulation that can be implicated in these three kinds of water sports, might be in a different way. Several morpho-physiological parameters and motor ability profiles were measured by standard methods. Accordingly, body weight (kg), performing time of 2.4 km run (sec), 6×10 meters shuttle run/agility (sec) of female rowers were reduced progressively and significantly from Preparatory Period (PP1) to General Practice Period (GPP) i.e., from (59.41±4.84) to (52.23±5.34), (773.04±92.64) …

Psychological And Physiological Responses Across Six Weeks Of Hiit And Mict In Previously Inactive Young Adults, Emily R. Dunston, Katrina Taylor

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 756-769, 2023. High-intensity interval training (HIIT) is suggested as a public health strategy to increase engagement in, and adherence to, physical activity. However, debate exists regarding the efficacy in inactive individuals. PURPOSE: To determine the physiological and psychological responses to three weeks of supervised and three weeks of unsupervised HIIT or moderate-intensity continuous training (MICT) in previously inactive adults. METHODS: Young adults (n = 20; 21.4 ± 2.2 years; 13 females) were randomized to six weeks of HIIT or MICT. Pre- and post-testing included anthropometric measures, an incremental exercise test, and body composition. …

The Effects Of Hiit Versus Mict And Sedentary Controls On Blood Lipid Concentrations In Nondiabetic Overweight And Obese Young Adults: A Meta-Analysis., Christian P. Mccormick, Garrett Mamikunian, David B. Thorp

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 791-813, 2023. With rates of obesity and dyslipidemia rising among young adults, this meta-analysis aimed to compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) and sedentary controls (CON) on low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and total cholesterol (TC) in nondiabetic overweight and obese young adults to determine if HIIT or MICT is more efficacious in improving dyslipidemia. Studies included in the analysis had to be randomized controlled trials or quasi-experimental studies, comparing the effects of HIIT versus MICT or CON on at least three variables of …

Resistance Training And Running Performance And Economy: A Literature Review, James Bottrill

University Honors Theses

Running performance is largely determined by maximal oxygen uptake (VO₂ max), velocity at VO₂ max, fractional utilisation of VO₂ max and running economy. Running economy is relatively under-researched and could be improved by resistance training because of its neuromuscular underpinnings. However, existing research on this topic is quite unorganised and inconclusive and is yet to prove a direct linkage between resistance training, running economy and performance. This literature review aimed to provide an organised overview of the existing literature, identify and address confounding variables and provide recommendations for future research. A search for studies was conducted via …

The Role Of Footwear, Foot Orthosis And Training-Related Strategies In The Prevention Of Bone Stress Injuries: A Systematic Review And Meta-Analysis, Alexandre Lavigne, Dominic Chicoine, Jean-François Esculier, François Desmeules, Pierre Fremont, Blaise Dubois

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 721-743, 2023. Objective: To evaluate the effectiveness of footwear, foot orthoses and training-related strategies to prevent lower extremity bone stress injury (BSI). Design: Systematic review and meta-analysis. Data sources: Four bibliographic databases (from inception until November 2021): Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and CINAHL. Eligibility criteria: Randomised controlled trials (RCTs) that assessed the risk of developing a BSI when using particular footwear, foot orthoses or training-related strategies such as muscle strengthening, stretching, and mechanical loading exercises. Results: Eleven studies were included in this systematic review. When wearing foot orthoses, the risk …

Radiofrequency Ablation As A Treatment Modality For Primary Hyperparathyroidism: A Systematic Literature Review, Peter P. Issa, Emad Kandil, Grace S. Lee

School of Medicine Faculty Publications

Background: Primary hyperparathyroidism (pHPT) is an endocrine disorder typically characterized by elevated serum calcium and elevated parathyroid hormone (PTH). While parathyroidectomy is the standard treatment, non-operative intervention such as radiofrequency ablation (RFA) has been adopted as an alternative for the management of pHPT, as it has been utilized in other endocrine glands such as thyroid and adrenal. In this literature review, we aim to evaluate the current practice of RFA for pHPT. Methods: A systematic literature search using PubMed, Web of Science, and Embase through June 2022 was conducted. Studies included in the review consisted of patient cohorts who had …

A Novel Role For Enos In Regulating Lymphatic Valve Development During Embryogenesis, Drishya Iyer

USF Tampa Graduate Theses and Dissertations

Lymphedema is a disease that occurs when lymph flow is impaired, resulting in tissue swelling, fibrosis, chronic inflammation and recurrent secondary infections. Lymphatic valves play a critical role in maintaining unidirectional lymph flow and evidence for valve defects have been reported in lymphedema patients. The lack of drugs that can correct lymphatic valve defects warrants a better understanding of the molecular regulators of lymphatic valve development and maintenance. Lymphatic valves first develop during embryogenesis in response to mechanotransduction signaling pathways triggered by oscillatory lymph flow. Since eNOS (gene name: Nos3) is a well characterized mechanotransduction signaling molecule in blood vessels, …

External Workloads Vary By Position And Game Result In Us-Based Professional Soccer Players, Gary M. Long, Sam M. Joyce, Robert T. Herrington, Kyle B. Fox, Jack E. Mumaugh

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 688-699, 2023. Professional soccer is a physically demanding sport that requires players to be highly trained. Advances using GPS allow the tracking of external workloads for individual players in practice and competition, however, there is a lack of evidence on how these measures impact match results. Therefore, we analyzed external workloads by player position and determined if they vary depending on the result of competitive matches. External workloads were analyzed in professional soccer players (n = 25) across 28 competitive games. One-way ANOVA determined if workloads varied by position (striker – ST, wide …

Efficacy Of A 6-Week Novel Exergaming Intervention Guided By Heart Rate Zones On Aerobic Performance In Children With Fetal Alcohol Spectrum Disorder And Attention-Deficit/Hyperactivity Disorder: A Feasibility Study, Trent Yamamoto, Bilal Pandit, Michael Viggiano, Mitchell S. Mologne, Kristin Daniels, David Gomez, Brett A. Dolezal

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 710-720, 2023. The purpose of this study was to determine the feasibility of a novel exergaming intervention guided by heart rate zones for children and adolescents with fetal alcohol spectrum disorder (FASD) and attention-deficit/hyperactivity disorder (ADHD). Eight study participants (6 females, 2 males, mean age= 11.4±1.4 years old) participated twice weekly over six weeks to complete twelve multimodal exergaming sessions. Participants significantly improved 6MWT from baseline to week 6 (575.4±55.0 m to 732.8±58.9 m; P<0.01), which conferred a 31% improvement in estimated VO_2max (31.5±5.5 ml/kg/min to 40.9±5.9 ml/kg/min), respectively. There was an upward trend of the mean percentage of time spent …

Body Mass Index But Not Physical Activity Level Moderates Lowered Cardiac Baroreflex Sensitivity In People Living With Hiv, Marcus Rangel, Juliana Barros, Deysiane Peres, Pedro Mira, Daniel Martinez, Mateus Laterza, Paulo Farinatti, Juliana Borges

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 700-709, 2023. Reduced cardiac baroreflex sensitivity (cBRS) is an autonomic marker associated with a worse cardiovascular prognosis. Whether cBRS is lowered in people living with HIV (PLHIV) is yet unclear, as well as potential moderator effects of body mass index (BMI) or physical activity (PA) level. The present study aims to compare the spontaneous cBRS in PLHIV vs. HIV-uninfected controls, and to determine among PLHIV the relationship between cBRS vs. body mass index (BMI) and PA level. Total, upward (cBRS+), and downward (cBRS-) cBRS gains were assessed using the sequential method from beat-to-beat …

Effects Of Daylight On College Students’ Physical And Mental Well-Being, Sathya Thenappan

Quantitative Social Science Undergraduate Senior Theses

While existing literature predominantly deals with the impact of daylight on adults in general and more specifically at the workplace, less is known about its impact on the college student demographic and daylight exposure levels at college residences. Given its considerable impact on both the physical and mental well-being of individuals, daylight has been used in the treatment of an assortment of diseases from seasonal affective disorder to depression. With college students constituting the majority of today’s people who suffer from mental health issues in society, uncovering the link between daylight exposure and its impact on the physical and mental …

Unearthing Complexity: Tangible Histories Of Water And Earth, Alexis Violet

Masters Theses

Unearthing Complexity investigates conceptions of time and surface through geological stories of the water and earth. Building on theories of deep time, hydrofeminism, critical zones, and grounding, I hope to foster a deeper awareness of time scales other than our own and a more tangible understanding of the embodied experience of matter in the universe. Working toward a new literacy of the water and earth in which they are recognized as living, changing bodies to which we are inherently tied at a molecular level, the site of this multiscalar inquiry occurs in the coastal zones of the Narragansett Bay where …

Role Of Chronic Stress-Induced Neuroinflammation In Rodent Locus Coeruleus Physiology And Anxiety-Like Behaviors, Arthur Anthony Alfonso Reyes

Graduate School of Biomedical Sciences Theses and Dissertations

The locus coeruleus (LC), the primary site of brain norepinephrine (NE), is a key anatomical brain region implicated in the stress response. Stress is a neuroendocrine physiologic response to a stressor that promotes organism survival through adaptive change and restoration of homeostasis. The central stress response, which drives behavioral and physiological change, is primarily mediated by activating the hypothalamic-pituitary-adrenal (HPA) axis. While advantageous in the short term, chronic stress exposure can lead to HPA axis and LC dysregulation, which are thought to contribute to the etiology of anxiety disorders. Previous studies demonstrate the effects of acute stress in increasing LC …

Physico-Chemical Characteristics Of Ensiled Cassava (Manihot Esculenta Crantz) And Sweetpotato (Ipomoea Batatas L. (Lam.)) Foliage, And Fermentation Kinetics Of Cassava Silage, Arnel N. Del Barrio, Christian V. Lualhati, Kimberly I B. Turaja, Ralph Jovi B. Saldajeno, Mauricio P. Bayubay Jr, Chesa A. Elenterio, Babylyn T. Salazar, Gerard F. Guadayo, Kamla Zyra G. Lavadia, Menandro M. Loresco

The Philippine Agricultural Scientist

This study was conducted to determine the physico-chemical characteristics of ensiled cassava (Manihot esculenta Crantz) and sweetpotato (Ipomoea batatas L. (Lam.)) foliage with or without additives molasses and rice bran. Six treatment combinations were from two crop species (cassava and sweetpotato) and three additives (without additive, 10% molasses, and 10% rice bran). The physical (color, odor, texture) and chemical characteristics (pH, total soluble sugars, Flieg point, dry matter, organic matter, ash, crude protein, NDF, ADF, hemicellulose) of the samples were evaluated following standard procedures. Fermentation kinetics of cassava foliage silage and ruminal in situ DM degradability of cassava …

Compositional Properties Of Flours And Starches From The Philippine National Seed And Industry Council-Registered Root Crops, Edgardo E. Tulin, Chinelo M. Cardaño, Anabella B. Tulin, Ma. Theresa P. Loreto, Ea Kristine Clarisse B. Tulin, Ma. Villa N. Yu

The Philippine Agricultural Scientist

Based in the Visayas State University, Philippines, the germplasm collection of the Philippine Root Crops Research and Training Center (PhilRootcrops) is home to several varieties that have not been fully characterized for their potential use in the production of functional foods. This study evaluated the compositional properties, amylose/amylopectin ratio, and glycemic index of flour and starches of 10 varieties of cassava (Manihot esculenta Crantz), sweet potato (Ipomoea batatas L. (Lam)), and taro (Colocasia esculenta L. Schott); 8 varieties of yam (Dioscorea alata L.); and 5 varieties of arrowroot (Maranta arundinacea L.), which was the recommended …

Southern Sea Otter (Enhydra Lutris Nereis) Fur Morphology, Thermal Function, And Buoyancy Across Ontogeny, Kate Riordan

Master's Theses

Sea otters (Enhydra lutris) have the densest fur of any animal, and the hairs function to trap a layer of air that is used for insulation. When a sea otter is born, it has a natal pelage (baby fur), and sea otters eventually molt that fur and replace it with a pelt resembling the adult fur. Sea otter fur is composed of 3 types of hairs: underhairs, intermediate hairs, and guard hairs. Sea otters are more susceptible to the negative effects of oiling from oil spills compared to other marine mammal species because they solely rely on fur …

Differential Inhibition Of Anaplerotic Pyruvate Carboxylation And Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity Of Selenium Agents In Human Lung Cancer, Teresa W-M Fan, Jason Winnike, Ahmad Al-Attar, Alex C. Belshoff, Pawel Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N. Lane

Markey Cancer Center Faculty Publications

Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus investigated the toxic action of these Se agents in two non-small cell lung cancer (NSCLC) cell lines and ex vivo organotypic cultures (OTC) of NSCLC patient lung tissues. Stable isotope-resolved metabolomics (SIRM) using 13C6-glucose and 13C5,15N2-glutamine tracers with gene knockdowns were employed to examine metabolic dysregulations associated with cell type- and treatment-dependent phenotypic changes. Inhibition of key anaplerotic processes, pyruvate carboxylation (PyC) and glutaminolysis were elicited by …

Hydric Physiology Of Lizards, Savannah Weaver

Master's Theses

Chapter 1: Animals can respond to extreme climate by behaviorally avoiding it, or by physiologically coping with it. We understand behavioral thermoregulation and physiological thermal tolerances, but water balance has largely been neglected. Climate change includes both global warming and changes in precipitation regimes, so improving our understanding of organismal water balance is increasingly urgent. We assessed the hydric physiology of endangered Blunt-nosed Leopard Lizards (Gambelia sila) by measuring cutaneous evaporative water loss (CEWL), plasma osmolality, body mass, and body condition throughout their active season. On average, G. sila had low CEWL that is likely desert-adaptive, and high …

Effects Of Intertidal Position On The Response To Oxygen And Desiccation Stress In The Common Acorn Barnacle, Balanus Glandula, Megan M. Dotterweich

Master's Theses

Sessile invertebrates in the rocky intertidal experience intermittent periods of air exposure due to tidal flux, presenting risks of temperature extremes, hypoxia, nutrient limitation, and most dangerously, desiccation. Microscale variation in severity and frequency of these risks is widely dependent on vertical position within the intertidal zone. Common acorn barnacles (Balanus glandula) have a wide vertical distribution in the intertidal, creating large differences in microhabitat between the highest and lowest individuals in the population. This study set out to explore whether tidal position dependent differences exist in the response to oxygen and desiccation stress in B. glandula. …

Biomechanical And Psychophysical Underpinnings Of Balance Dysfunction In Individuals With Traumatic Brain Injury, Naphtaly Ehrenberg

Dissertations

Falls are a major burden on healthcare infrastructure, especially in older adults and even more so in older individuals that are living in institutions. According to data from the Centers for Disease Control and Prevention (CDC), from 2010 to 2020, unintentional falls were the leading cause of nonfatal emergency department visits for all age groups except among individuals from 15-24 years of age, where unintentional falls ranked a very close second to being unintentionally struck by or against. Among older individuals living in the community, approximately 30-35% fall at least once in a given year, and around three times as …

A Clinical Practice Review Of Percutaneous Ethanol Injection For Thyroid Nodules: State Of The Art For Benign, Cystic Lesions, Robert D.E. Clark, Xinyi Luo, Peter P. Issa, Ralph P. Tufano, Emad Kandil

School of Medicine Faculty Publications

Percutaneous ethanol injection (PEI) is a widely used treatment option for cystic and predominantly cystic thyroid nodules. It has several advantages over other treatment modalities. Compared to surgery, PEI is less painful, can be performed in the outpatient setting, and carries less risk of transient or permanent side effects. Compared to other minimally invasive techniques such as radiofrequency ablation (RFA), PEI is less expensive and does not require specialized equipment. PEI performs well in the context of cystic nodules. PEI does not perform as well as other techniques in solid nodules, so its use as a primary treatment is limited …

Gpr75 Deficiency Attenuates High Fat Diet-Driven Obesity And Glucose Intolerance, Sakib Hossain

NYMC Student Theses and Dissertations

Recently, a collaboration between Regeneron Pharmaceuticals and the Schwartzman-Garcia labs at New York Medical College published an exome sequencing study of individuals across the United Kingdom, United States, and Mexico which concluded that individuals possessing non-functioning, truncated mutations to the orphan g protein coupled receptor (GPCR), GPR75, had lower BMI and 54% reduced likelihood of obesity. The present study was undertaken to fully characterize the metabolic phenotype of Gpr75 deficient mice when fed a high fat diet (HFD) and explore potential mechanisms by which GPR75 activation links to increased adiposity and decreased glucose tolerance. After 14 weeks of HFD-feeding we …