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2016

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Articles 211 - 240 of 338

Full-Text Articles in Physiology

The Role Of Hypoxia On Pyruvate Kinase M2, Mammalian Target Of Rapamycin, Mitochondrial Function, And Cell Invasion In The Trophoblast, Rebecca Lutz Kimball Mar 2016

The Role Of Hypoxia On Pyruvate Kinase M2, Mammalian Target Of Rapamycin, Mitochondrial Function, And Cell Invasion In The Trophoblast, Rebecca Lutz Kimball

Theses and Dissertations

This thesis will be organized into two chapters discussing the role of hypoxia in the human placenta. The goal of this thesis is to characterize pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in hypoxic conditions in the trophoblast. Understanding the mechanisms of placental metabolism can lead to further treatments for placental diseases. Chapter one covers the background of intrauterine growth restriction, hypoxia, placental metabolism, and pyruvate kinase M2 (PKM2). Little is currently understood about the role of the mitochondria in placental diseases. Expression of PKM2, trophoblast cell invasion, and mitochondrial function is shown to be …

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A Neuroimaging Investigation Of The Effects Of Age And Sleep On Pattern Separation, Christopher Robert Doxey Mar 2016

A Neuroimaging Investigation Of The Effects Of Age And Sleep On Pattern Separation, Christopher Robert Doxey

Theses and Dissertations

Effective memory representations must be specific to prevent interference between episodes that may overlap in terms of place, time, or items present. Pattern separation, a computational process performed by the hippocampus overcomes this interference by establishing non-overlapping memory representations. This project explores pattern separation and how it is impacted by age and sleep. Experiment 1. Structures of the medial temporal lobe (MTL) are known to be involved in declarative memory processes. However, little is known about how age-related changes in MTL structures, white matter integrity, and functional connectivity affect pattern separation processes in the MTL. In the present study, we …

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Rab8 Mediates Trpv4 Vesicle Trafficking To The Plasma Membrane In Hgf-Stimulated Mdck Cells, Hillary Jean Haws Mar 2016

Rab8 Mediates Trpv4 Vesicle Trafficking To The Plasma Membrane In Hgf-Stimulated Mdck Cells, Hillary Jean Haws

Theses and Dissertations

Epithelial to mesenchymal transition (EMT) is a process whereby epithelial cells, which act collectively through robust cell–cell interactions, take on mesenchymal characteristics, breaking cell–cell junctions to become solitary, invasive and motile. Our previous results show that a transient increase in calcium influxes through TRP channels at the plasma membrane is required for hepatocyte growth factor (HGF)– stimulated EMT. Since this transient increase requires an intact microtubule cytoskeleton, we propose that HGF stimulation results in the mobilization of calcium channels to the plasma membrane from an intracellular compartment via microtubule–dependent vesicle trafficking. Through immunofluorescence, we show that prior to HGF treatment, …

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Forward Chemical Genetics Drug Screen Yields Novel Proteases And Proteolytic Inhibitors Of Hgf–Induced Epithelial–Mesenchymal Transition, Jeffrey Thomas Schuler Mar 2016

Forward Chemical Genetics Drug Screen Yields Novel Proteases And Proteolytic Inhibitors Of Hgf–Induced Epithelial–Mesenchymal Transition, Jeffrey Thomas Schuler

Theses and Dissertations

Hepatocyte Growth Factor (HGF)–induced Epithelial–Mesenchymal Transition (EMT) is a complex cellular pathway that causes epithelial cell scattering by breaking cell–cell contacts, eliminating apical–basal polarity, and replacing epithelial markers and characteristics with mesenchymal markers. Early EMT events include a brief period of cell spreading, followed by cell compaction and cell–cell contact breaks. A forward chemical genetics drug screen of 50,000 unique compounds measuring HGF–induced cell scattering identified 26 novel EMT inhibitors, including 2 proteolytic inhibitors. Here, we show that B5500–4, one of the EMT inhibitors from the screen, blocks HGF–induced EMT by a predicted blocking of the protease furin, in addition …

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Identification And Characterization Of Serum Biomarkers Associated With Breast Cancer Progression, Adhari Abdullah Alzaabi Mar 2016

Identification And Characterization Of Serum Biomarkers Associated With Breast Cancer Progression, Adhari Abdullah Alzaabi

Theses and Dissertations

Despite the recognized advances in the treatment of breast cancer, it still accounts for 15% of all cancer-related deaths. 90% of breast cancer deaths are due to unpredicted metastasis. There is neither successful treatment for metastatic patients nor a specific test to predict or detect secondary lesions. Patients with primary tumor will be either over-treated with cytotoxic side effects or under-treated and risk recurrence. This necessitates the need for personalized treatment, which is hard to offer for such heterogeneous disease. Obstacles in treating breast cancer metastasis are mainly due to the gaps exist in the understanding of the molecular mechanism …

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Mechanical Conflict System: A Novel Operant Method For The Assessment Of Nociceptive Behavior, Steven E. Harte, Jessica B. Meyers, Renee R. Donahue, Bradley K. Taylor, Thomas J. Morrow Feb 2016

Mechanical Conflict System: A Novel Operant Method For The Assessment Of Nociceptive Behavior, Steven E. Harte, Jessica B. Meyers, Renee R. Donahue, Bradley K. Taylor, Thomas J. Morrow

Physiology Faculty Publications

A new operant test for preclinical pain research, termed the Mechanical Conflict System (MCS), is presented. Rats were given a choice either to remain in a brightly lit compartment or to escape to a dark compartment by crossing an array of height-adjustable nociceptive probes. Latency to escape the light compartment was evaluated with varying probe heights (0, .5, 1, 2, 3, and 4 mm above compartment floor) in rats with neuropathic pain induced by constriction nerve injury (CCI) and in naive control rats. Escape responses in CCI rats were assessed following intraperitoneal administration of pregabalin (10 and 30 mg/kg), morphine …

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The Glucose Model Of Mediation: Physiological Bases Of Willpower As Important Explanations For Common Mediation Behavior, Roy F. Baumeister, W. Scott Simpson, Stephen J. Ware, Daniel S. Weber Feb 2016

The Glucose Model Of Mediation: Physiological Bases Of Willpower As Important Explanations For Common Mediation Behavior, Roy F. Baumeister, W. Scott Simpson, Stephen J. Ware, Daniel S. Weber

Pepperdine Dispute Resolution Law Journal

Success in life requires the ability to resist urges and control behavior. This ability is commonly called “willpower,” the capacity to overcome impulses and engage in conscious acts of self-control. Social psychologists believe willpower is a finite resource dependent on physiological bases including glucose (from food and drink), sleep and other forms of rest, and the absence of stress. In short, people who are hungry, exhausted, or highly stressed tend to have less willpower than those who are well-fed, well-rested, and relatively stress-free. In addition, a person who exerts self-control (uses willpower) tends to reduce temporarily the amount of willpower …

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Efn-4 Functions In Lad-2-Mediated Axon Guidance In Caenorhabditis Elegans, Alicia A. Schwieterman, Cory J. Donelson, Jonathan L. Mcmurry, Martin L. Hudson Feb 2016

Efn-4 Functions In Lad-2-Mediated Axon Guidance In Caenorhabditis Elegans, Alicia A. Schwieterman, Cory J. Donelson, Jonathan L. Mcmurry, Martin L. Hudson

Faculty Articles

During development of the nervous system, growing axons rely on guidance molecules to direct axon pathfinding. A well-characterized family of guidance molecules are the membrane-associated ephrins, which together with their cognate Eph receptors, direct axon navigation in a contact-mediated fashion. InC. elegans, the ephrin-Eph signaling system is conserved and is best characterized for their roles in neuroblast migration during early embryogenesis. This study demonstrates a role for theC. elegansephrin EFN-4 in axon guidance. We provide both genetic and biochemical evidence that is consistent with theC. elegansdivergent L1 cell adhesion molecule LAD-2 acting as a non-canonical ephrin receptor to EFN-4 to …

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Modulating Foveal Representation Can Influence Visual Discrimination In The Periphery, Qing Yu, Won Mok Shim Feb 2016

Modulating Foveal Representation Can Influence Visual Discrimination In The Periphery, Qing Yu, Won Mok Shim

Dartmouth Scholarship

A previous study by Williams et al. (2008) provided evidence for a novel form of feedback in the visual system, whereby peripheral information is contained in foveal retinotopic cortex. Beyond its possible implication for peripheral object recognition, few studies have examined the effect of a direct behavioral manipulation of the foveal feedback representation. To address this question, we measured participants' peripheral visual discrimination performance while modulating their foveal representation in a series of psychophysical experiments. On each trial, participants discriminated the identities of briefly presented novel, three-dimensional objects or the orientations of gratings in a peripheral location while fixating at …

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Use Of Lecture Capture And Student Performance In Physiology., Chaya Gopalan Phd, Rim M. Hadgu, Sophia Huynh Feb 2016

Use Of Lecture Capture And Student Performance In Physiology., Chaya Gopalan Phd, Rim M. Hadgu, Sophia Huynh

SIUE Faculty Research, Scholarship, and Creative Activity

Lecture capture technology is fairly new and has gained interest among higher institutions, faculty and students alike. Live-lecture (LL) is captured in real-time and this recording, LC, is made available for students to access for later use, whether it be for review purpose or to replace a missed class. Student performance was compared between those attending LL only and the other group utilizing LC in addition to LL in two randomly chosen lectures. We found that the overall exam performance was indistinguishable between the LL and the LC groups. Additionally, there was no significant difference in student performance between the …

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Mw151 Inhibited Il-1Β Levels After Traumatic Brain Injury With No Effect On Microglia Physiological Responses, Adam D. Bachstetter, Zhengqiu Zhou, Rachel K. Rowe, Bin Xing, Danielle S. Goulding, Alyssa N. Conley, Pradoldej Sompol, Shelby Meier, Jose F. Abisambra, Jonathan Lifshitz, D. Martin Watterson, Linda J. Van Eldik Feb 2016

Mw151 Inhibited Il-1Β Levels After Traumatic Brain Injury With No Effect On Microglia Physiological Responses, Adam D. Bachstetter, Zhengqiu Zhou, Rachel K. Rowe, Bin Xing, Danielle S. Goulding, Alyssa N. Conley, Pradoldej Sompol, Shelby Meier, Jose F. Abisambra, Jonathan Lifshitz, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

A prevailing neuroinflammation hypothesis is that increased production of proinflammatory cytokines contributes to progressive neuropathology, secondary to the primary damage caused by a traumatic brain injury (TBI). In support of the hypothesis, post-injury interventions that inhibit the proinflammatory cytokine surge can attenuate the progressive pathology. However, other post-injury neuroinflammatory responses are key to endogenous recovery responses. Therefore, it is critical that pharmacological attenuation of detrimental or dysregulated neuroinflammatory processes avoid pan-suppression of inflammation. MW151 is a CNS-penetrant, small molecule experimental therapeutic that restores injury- or disease-induced overproduction of proinflammatory cytokines towards homeostasis without immunosuppression. Post-injury administration of MW151 in a …

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Anatomical Variation Of The Ulnar Collateral Ligament And Implications For Joing Stability And Surgical Rehabilitation, Jakob Gamboa, Dr. Jonathan Wisco Feb 2016

Anatomical Variation Of The Ulnar Collateral Ligament And Implications For Joing Stability And Surgical Rehabilitation, Jakob Gamboa, Dr. Jonathan Wisco

Journal of Undergraduate Research

In 1974, the first ulnar collateral ligament reconstructive surgery was performed on Los Angeles Dodgers’ pitcher, Tommy John. The damaged ligament of the medial elbow was repaired with tendons from the pitcher’s body. Since then, the surgery has been colloquially termed “Tommy John’s Surgery”, and the alarming increase of the rates of the procedure has now become a concern, being recently called an “epidemic” by the American Sports Medicine Institute1. The procedure possesses risk of complications, and can lead to shortened careers, decreased performance over time2, and can carry a heavy financial toll on individuals and …

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Testing The Effect Of Antioxidants On The Pathogenesis Of Alzheimer’S Disease Through The Rage/Nf-Kb Inflammatory Pathway, Harrison Snyder, Jonathan Wisco Feb 2016

Testing The Effect Of Antioxidants On The Pathogenesis Of Alzheimer’S Disease Through The Rage/Nf-Kb Inflammatory Pathway, Harrison Snyder, Jonathan Wisco

Journal of Undergraduate Research

The Receptor for Advanced Glycation Endproducts (RAGE) is known to have a role in inflammatory processes. When produced in excess it induces oxidative stress by activating a number of ligand enzymes, resulting in the generation of excessive cytosolic reactive oxidant species. This oxidative stress then stimulates Nuclear Factor Kappa-B (NF-kB), which regulates immune response and inflammation. When RAGE is incorrectly regulated, inflammation occurs in otherwise healthy tissue, a process implicated in neurodegenerative disorders like Alzheimer’s disease. RAGE is found throughout the body and is seen in greater concentration in inflamed tissues; it has also been found in the brain tissue …

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Alzheimer’S Disease And The P.V236e Variant In The Apoe Gene, Alton Chad Sorensen, John Kauwe Feb 2016

Alzheimer’S Disease And The P.V236e Variant In The Apoe Gene, Alton Chad Sorensen, John Kauwe

Journal of Undergraduate Research

I was interested in trying to validate the findings of the publication by Medway et al. concerning the SNP rs199768005 using data from the Cache Country data set. Unfortunately, of the 4703 people from our data set, only 10 were carriers. Using R statistical analysis, I found that the p-value for this SNP with an association to protect for Alzheimer’s Disease (AD) was not significant. It was similarly not significant in its association with Any AD. I also ran other models to include for factors such as education or age in conjunction with this SNP and its association with AD …

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Ligament Microstructure Analysis, Michael Gillespie, Jonathan Wisco Feb 2016

Ligament Microstructure Analysis, Michael Gillespie, Jonathan Wisco

Journal of Undergraduate Research

Due to the relatively poor fiber contrast of tendons in comparison with muscles, the anatomical, and therefore, functional relationship of muscle attachments to bones via tendons has not been well mapped. We were interested in mapping the 3D gross anatomical structure of tendons using a MicroScribe 3D digitizer (GoMeasure3D, Amherst, VA), with the goal to compare fibrous architecture between tendons of various types of muscles and muscle classes. We developed a stain made of blue dye and powdered sugar to increase fiber visibility, thus allowing for 3D digitization. This technique was applied to human cadaveric calcaneal tendon and quadriceps tendon.

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Analyzing Structural Differences In Quadriceps Femoris Tendon Fibers Using Microscribe Technology, Nathaniel Hainsworth, Jon Wisco Feb 2016

Analyzing Structural Differences In Quadriceps Femoris Tendon Fibers Using Microscribe Technology, Nathaniel Hainsworth, Jon Wisco

Journal of Undergraduate Research

Not all tendons and ligaments are created equally. Many have different structural characteristics based on functionality or need for stability. This turns out to be true even between different portions of the same tendon. This project’s purpose was to analyze and compare structural differences between tendon fibers of the patellar portion and quadriceps portion of the quadriceps femoris tendon. We hypothesized that there are significant structural differences between these two portions because they act very different biomechanically, as well as different in the amount of tension/strain put on each portion. We mapped individual tendon fibers of both portions using MicroScribe …

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Three-Dimensional Model Of Undocumented Lingual Nerve Branches For The Education Of The International Anatomy, Medical, And Dental Population, Craig D. Clayton, Dr. Jonathan Wisco Feb 2016

Three-Dimensional Model Of Undocumented Lingual Nerve Branches For The Education Of The International Anatomy, Medical, And Dental Population, Craig D. Clayton, Dr. Jonathan Wisco

Journal of Undergraduate Research

The floor of the oral cavity is covered by a mucosal layer to protect underlying structures against the digestive events of the mouth. Ducts of the salivary glands open into this mucosa along the lingual frenulum. The lingual nerve from the mandibular division of the trigeminal nerve immediately begins to branch after passing through the foramen ovale, and continues its descent medial to the inferior alveolar nerve. Just superior to the angle of the mandible, the nerve turns anteriorly 90 degrees and continues a lateral to medial path to the anterior of the mouth. It crosses the submandibular salivary duct …

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The Role Of Wnt Secretion From Neural Crest Cells In Proper Craniofacial Development, Bradley Haynes, Stark Michael Feb 2016

The Role Of Wnt Secretion From Neural Crest Cells In Proper Craniofacial Development, Bradley Haynes, Stark Michael

Journal of Undergraduate Research

Both Wnt signaling and neural crest cells (NCCs) have a well-established role in the development of facial bones and cartilage. Wnt signaling is known to be required for neural crest cell formation; however, Wnt expression originating from the neural crest after their specification by Wnt1 has not been carefully explored. The purpose of our study is to investigate the role of Wnt secretion from NCCs in craniofacial development. Our hypothesis is that loss of Wnt secretion from NCCs will lead to improper craniofacial development and contribute to facial structure abnormalities.

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Application Of Sihler’S Stain To Expose Cardiac Conduction Nerve Fibers, Adam Jorgensen, Jonathan J. Wisco Feb 2016

Application Of Sihler’S Stain To Expose Cardiac Conduction Nerve Fibers, Adam Jorgensen, Jonathan J. Wisco

Journal of Undergraduate Research

Arrhythmia is a serious heart condition that affects 14 million people in the United Statesi, and is characterized by irregular frequency of atrial and ventricular beats.ii The most serious effects of arrhythmia include sudden cardiac arrest and stroke.iii About 383,000 cases of cardiac arrest are recorded annually in the United States alone.iv In a report complied in 2011 by the World Health Organization, stroke has the second highest death rate of any disease worldwide, ending the lives of 6.1 million people annually.v Recent developments in cardiac ablation have helped in the treatment of arrhythmia …

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Isothermal Titration Calorimetry Uncovers Substrate Promiscuity Of Bicupin Oxalate Oxidase From Ceriporiopsis Subvermispora, Hassan Rana, Patricia Moussatche, Lis Souza Rocha, Ellen W. Moomaw Feb 2016

Isothermal Titration Calorimetry Uncovers Substrate Promiscuity Of Bicupin Oxalate Oxidase From Ceriporiopsis Subvermispora, Hassan Rana, Patricia Moussatche, Lis Souza Rocha, Ellen W. Moomaw

Faculty Articles

Isothermal titration calorimetry (ITC) may be used to determine the kinetic parameters of enzymecatalyzed reactions when neither products nor reactants are spectrophotometrically visible and when the reaction products are unknown. We report here the use of the multiple injection method of ITC to characterize the catalytic properties of oxalate oxidase (OxOx) from Ceriporiopsis subvermispora (CsOxOx), a manganese dependent enzyme that catalyzes the oxygen-dependent oxidation of oxalate to carbon dioxide in a reaction coupled with the formation of hydrogen peroxide. CsOxOx is the first bicupin enzyme identified that catalyzes this reaction. The multiple injection ITC method of measuring OxOx activity involves …

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Novel G-Protein Coupled Receptor Expression And Modulation Of Synaptic Plasticity, Michael Thayer Christensen, Dr. Jeff Edwards Feb 2016

Novel G-Protein Coupled Receptor Expression And Modulation Of Synaptic Plasticity, Michael Thayer Christensen, Dr. Jeff Edwards

Journal of Undergraduate Research

According to the Centers for Disease Control and Prevention, Alzheimer’s disease – infamously known for its patients’ loss of memory and other intellectual abilities – is the sixth most common cause of death in the United States. Sadly this is just one of many ailments people experience that result in learning and memory loss. Why do so many suffer from these neurodegenerative states? One fundamental problem is that the complex learning and remembering process is not well understood. A specific brain region called the hippocampus is involved in short-term declarative memory; however, many of its intricate signaling pathways that mediate …

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Confirming The Spatial Relationship Between Iron, Tau Protein, And Amyloid Beta Within The Subiculum As A Means To Better Detect Alzheimer’S Disease With Magnetic Resonance Imaging, Brandon Herrington, Jonathan Wisco Feb 2016

Confirming The Spatial Relationship Between Iron, Tau Protein, And Amyloid Beta Within The Subiculum As A Means To Better Detect Alzheimer’S Disease With Magnetic Resonance Imaging, Brandon Herrington, Jonathan Wisco

Journal of Undergraduate Research

As the 6th leading cause of death in the United States1, and because of the significant deterioration it causes in the quality of life of its victims, Alzheimer’s disease is an area where research to improve its early diagnosis is paramount to establishing new treatments. Alzheimer’s disease appears to show its effects at a particularly early stage within the hippocampus2. More specifically, the subicular area of the hippocampus is noted as a region that is subjected to more severe pathological changes due to the disease3. Braak staging is a method used to classify, …

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Gene Expression Microarray Data From Human Microvascular Endothelial Cells Supplemented With A Low Concentration Of Niacin, Nica M. Borradaile, Jennifer M. Hughes-Large Feb 2016

Gene Expression Microarray Data From Human Microvascular Endothelial Cells Supplemented With A Low Concentration Of Niacin, Nica M. Borradaile, Jennifer M. Hughes-Large

Physiology and Pharmacology Publications

The systemic lipid modifying drug, niacin, can directly improve human microvascular endothelial cell angiogenic function under lipotoxic conditions, possibly through activation of niacin receptors [1]. Here we provide accompanying data collected using Affymetrix GeneChip microarrays to identify changes in gene expression in human microvascular endothelial cells treated with 10 μM niacin. Statistical analyses of robust multi-array average (RMA) values revealed that only 16 genes exhibited greater than 1.3-fold differential expression. Of these 16, only 5 were identified protein coding genes, while 3 of the remaining 11 genes appeared to be small nuclear/nucleolar RNAs. Altered expression of EFCAB4B, …

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Optogenetic Stimulation Of Drosophila Heart Rate At Different Temperatures And Ca2+ Concentrations, Yuechen Zhu, Henry Uradu, Zana R. Majeed, Robin L. Cooper Feb 2016

Optogenetic Stimulation Of Drosophila Heart Rate At Different Temperatures And Ca2+ Concentrations, Yuechen Zhu, Henry Uradu, Zana R. Majeed, Robin L. Cooper

Biology Faculty Publications

Optogenetics is a revolutionary technique that enables noninvasive activation of electrically excitable cells. In mammals, heart rate has traditionally been modulated with pharmacological agents or direct stimulation of cardiac tissue with electrodes. However, implanted wires have been known to cause physical damage and damage from electrical currents. Here, we describe a proof of concept to optically drive cardiac function in a model organism, Drosophila melanogaster. We expressed the light sensitive channelrhodopsin protein ChR2.XXL in larval Drosophila hearts and examined light‐induced activation of cardiac tissue. After demonstrating optical stimulation of larval heart rate, the approach was tested at low temperature …

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Sensory Integration In Zebrafish Larvae, Hannah Waddel, Dr. Arminda Suli Feb 2016

Sensory Integration In Zebrafish Larvae, Hannah Waddel, Dr. Arminda Suli

Journal of Undergraduate Research

A major task of the central nervous system is to make sense of the environment and mount an appropriate reaction. The ability to organize and integrate inputs from different sensory systems is critical for survival in animals. Sensory integration dysfunction is implicated in human disorders such as autism and dyslexia. Swimming behaviors such as rheotaxis, defined as swimming against a current, require the integration of different sensory systems such as mechanosensory hair cells, the visual system, and the vestibular system. In this project, we attempted to create an assay to measure the rheotaxis behavior of Danio rerio (zebrafish) larvae, in …

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The Role Of Subtelomeric Silencing In Aging, Mark Roth, Jonathan Alder, Phd Feb 2016

The Role Of Subtelomeric Silencing In Aging, Mark Roth, Jonathan Alder, Phd

Journal of Undergraduate Research

Telomeres, located at the ends of chromosomes, are repetitive DNA sequences composed of TTAGGG repeated thousands of times. Each time a cell copies its DNA a small amount of telomeric DNA is lost due to the end replication problem. Because of this, telomeres are eventually lost. New telomeres are synthesized by telomerase. Telomerase has both a protein reverse transcriptase component (TERT) and an RNA template (TERC) that it uses to synthesize new telomeres; however, expression is tightly controlled and is not expressed in most cells in our bodies. This limits the number of times that most of our cells can …

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Exercising To Stay Mentally Fit, Tyler Hammond, Dr. Jerffrey Edwards Feb 2016

Exercising To Stay Mentally Fit, Tyler Hammond, Dr. Jerffrey Edwards

Journal of Undergraduate Research

Both exercise and stress have an impact on learning and memory. Exercise appears to have positive effects on learning and memory while stress appears to have negative effects on learning and memory. Previous work in our lab has demonstrated that exercise enhances long-term potentiation mediated by electrical stimulus in the hippocampus and that stress decreases long-term potentiation mediated by electrical stimulus in the hippocampus. Long-term potentiation is a measure of the strengthening of the synapses following an electrical stimulus intended to model learning and memory. The hippocampus is the area of the brain commonly deemed responsible for long-term declarative memories.

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Sex Differences In Fatigability Of Dynamic Contractions, Sandra K. Hunter Feb 2016

Sex Differences In Fatigability Of Dynamic Contractions, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Women are usually less fatigable than men during single-limb isometric contractions, primarily because of sex-related differences in contractile mechanisms. It is less clear whether these sex differences in muscle fatigue occur for dynamic fatiguing tasks. This review highlights new findings that the sex difference in fatigability for dynamic shortening contractions with a single limb is dependent on the contraction velocity and the muscle group involved. Recent studies demonstrate that women are less fatigable than men for a dynamic task as follows: (i) the elbow-flexor muscles at slow- but not high-velocity contractions; and (ii) the knee-extensor muscles when muscle fatigue was …

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Dietary Supplementation With Organoselenium Accelerates Recovery Of Bladder Expression, But Does Not Improve Locomotor Function, Following Spinal Cord Injury, Carolyn A. Meyer, Ranjana Singh, Mackenzie T. Jones, Chen-Guang Yu, Ronan F. Power, James W. Geddes Jan 2016

Dietary Supplementation With Organoselenium Accelerates Recovery Of Bladder Expression, But Does Not Improve Locomotor Function, Following Spinal Cord Injury, Carolyn A. Meyer, Ranjana Singh, Mackenzie T. Jones, Chen-Guang Yu, Ronan F. Power, James W. Geddes

Spinal Cord and Brain Injury Research Center Faculty Publications

Selenium is an essential element required for activity of several antioxidant enzymes, including glutathione peroxidase. Because of the critical role of the antioxidant system in responding to traumatic events, we hypothesized that dietary selenium supplementation would enhance neuroprotection in a rodent model of spinal cord injury. Rats were maintained on either a control or selenium-enriched diet prior to, and following, injury. Dietary selenium supplementation, provided as selenized yeast added to normal rat chow, resulted in a doubling of selenium levels in the spinal cord. Dietary selenium reduced the time required for recovery of bladder function following thoracic spinal cord injury. …

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Gender Representation In The Vision Sciences: A Longitudinal Study, Emily A. Cooper, Ana Radonjic Jan 2016

Gender Representation In The Vision Sciences: A Longitudinal Study, Emily A. Cooper, Ana Radonjic

Dartmouth Scholarship

Understanding the current status and historical trends of gender representation within a research field is an important component of fostering a diverse and inclusive scientific community. Here, we report on the gender representation of a large sample of the vision science research community—the attendees of the Annual Meeting of the Vision Sciences Society (VSS). Our analysis shows that the majority of scientists at all career levels in our sample are male. This imbalance is most pronounced for the senior scientists, whereas predoctoral students are nearly balanced between the genders. Historically, the gender imbalance was larger than it is at present, …

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