Physiology Commons^™

Molecular Remodeling Of Tip Links Underlies Mechanosensory Regeneration In Auditory Hair Cells, Artur A. Indzhykulian, Ruben Stepanyan, Anastasiia Nelina, Kateri J. Spinelli, Zubair M. Ahmed, Inna A. Belyantseva, Thomas B. Friedman, Peter G. Barr-Gillespie, Gregory I. Frolenkov

Physiology Faculty Publications

Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory stereocilia and convey force to yet unidentified transduction channels. Current models postulate a static composition of the tip link, with protocadherin 15 (PCDH15) at the lower and cadherin 23 (CDH23) at the upper end of the link. In terminally differentiated mammalian auditory hair cells, tip links are subjected to sound-induced forces throughout an organism's life. Although hair cells can regenerate disrupted tip links and restore hearing, the molecular details of this process are unknown. We developed a novel implementation of backscatter electron scanning microscopy to visualize simultaneously …

Associations Between Alcohol Consumption And Fasting Blood Glucose In Young Adults, Julie Ann Lucca

Master's Theses

Current research shows moderate alcohol consumption is associated with decreased risk of diabetes and excessive consumption or binge drinking can cause insulin resistance and diabetes. In 2010, diabetes was the seventh leading cause of death in the United Statesand was responsible for significant health complications: blindness, kidney failure, and limb amputations, and is a large national economic burden. Fasting blood glucose (FBG) is a tool used to help diagnose diabetes. Abnormally high FBG, ≥100 mg/dl, is indicative of diabetes and pre-diabetes. Few studies have observed diabetic prevalence among young adults or college students. Studying young adults can help provide added …

Does Naloxone Reinstate Secondary Hyperalgesia In Humans After Resolution Of A Burn Injury? A Placebo-Controlled, Double-Blind, Randomized, Cross-Over Study, Manuel P. Pereira, Mads U. Werner, Thomas K. Ringsted, Michael C. Rowbotham, Bradley K. Taylor, Joergen B. Dahl

Physiology Faculty Publications

INTRODUCTION: Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear. Recent animal studies, carried out after the resolution of inflammatory pain, have demonstrated reinstatement of tactile hypersensitivity following administration of μ-opioid-receptor-antagonists. In the present study in humans, we analyzed the effect of naloxone when given after the resolution of secondary hyperalgesia following a first-degree burn injury.

METHODS: Twenty-two healthy volunteers were included in this placebo-controlled, randomized, double-blind, cross-over study. Following baseline assessment of thermal and mechanical thresholds, a first-degree burn injury …

Intra-Mitochondrial Injury During Ischemia-Reperfusion, Hema Aluri

Theses and Dissertations

Cardiac injury is increased following ischemia-reperfusion. Mitochondria are the “effector organelles” that are damaged during ischemia (ISC) when there is no blood flow. Resumption of metabolism by damaged mitochondria during reperfusion (REP) results in increased cell injury. Current therapeutic interventions to pre-condition and post-condition the heart during ISC are ineffective during certain conditions like aging and diabetes due to defects in the signaling cascades. In contrast, mitochondrial-based strategies are effective in protecting the heart during ISC-REP. Hence direct therapeutic targeting of dysfunctional mitochondria will provide the potential to bypass the upstream signaling defects and intervene directly upon the effector organelle. …

Validation Of Antibodies Used To Study Hypoxia Inducible Factors In Two Species Of Fundulus, Jenna D. Hill

LSU New Orleans Theses and Dissertations

Hypoxia inducible factors (HIFs) are transcription factors and the master regulators of oxygen-dependent gene expression in animals. The focus of this thesis is the distribution of HIF protein in tissues of the fish Fundulus heteroclitus and F. grandis, two widespread species that occur in naturally hypoxic waters. Polyclonal antibodies against HIF-1α, HIF-2α, and HIF-3α were tested on proteins made in vitro and on extracts made from several tissues of normoxic and hypoxic fish. Antibodies against HIF-1α and 3α bound specifically to full length protein made in vitro, and produced bands on western blots of nuclear extracts of near …

Unhealthy Behaviors And The Relationship To Body Mass Index (Bmi) In College Students, J. Popivchak, B. Larouere, Carena S. Winters

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Comparing Physiological Responses While Walking On A Standard Motorized Treadmill And Curve Treadmill, J. Phipps, S. Miller, S. Voran, M. Lister, Harold S. Kieffer

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Relationships Between Peak Oxygen Uptake And Arterial Function: A Preliminary Study, M. Pearman, E. Devallance, S. Fournier, D. Bonner, B. E. Warden, W. Gharib, D. Donley, P. Chantler

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Cardiovascular Responses To High Intensity Aerobic And Anaerobic Exercises, A. Parker, P. Messersmith, K. Beil, K. Mahoney, K. Jones, J. A. Mckenzie, S. D. Mccole

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

The Effects Of Caffeine On Maximal Anaerobic Exercise, K. Ogden, J. Haak, Harold S. Kieffer, N. Marlowe

International Journal of Exercise Science: Conference Proceedings

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Effects Of Creatine Monohydrate Vs. Creatine Hydrochloride On Muscle Endurance Performance, K. Naylor, C. Albright, C. Liggitt, A. Kolenc, R. Robinson, W. Braun, J. Sanders

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Gender-Specific Equations For Predicting Maximal Heart Rate In Exercise Stress Testing, T. Nagle, E. Godlasky, S. Weber-Peters, R. Bradford, N. Miller, M. Lott

International Journal of Exercise Science: Conference Proceedings

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The Relationship Between Body Composition And Baseball Performance In Division Ii Baseball Players, B. Muth, C. A. Witmer, S. E. Davis, J. Guers

International Journal of Exercise Science: Conference Proceedings

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Body Image And Associated Behaviors Among College-Aged Students, E. Miller, B. Larouere, Carena S. Winters

International Journal of Exercise Science: Conference Proceedings

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Validity Of Using Functional Threshold Power And Intermittent Power To Predict Mountain Bike Race Outcome, M. Miller, G. Moir

International Journal of Exercise Science: Conference Proceedings

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Can Standing Long Jump Distance Be Predicted From Standing Vertical Jump Distance?, L. Merk, C. Michael, Ben Meyer

International Journal of Exercise Science: Conference Proceedings

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Effects Of A Two Week College Weight Training Course On Body Weight, Power, And Strength, J. Mcnamara

International Journal of Exercise Science: Conference Proceedings

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Relationship Of Mechanomyographic Amplitude To Torque Using A New Accelerometer Based Device, M. J. Mcmahon, S. Mookerjee

International Journal of Exercise Science: Conference Proceedings

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High Dietary Sodium Reduces Flow Mediated Dilation In Humans With Salt Sensitive & Salt Resistant Bp, E. L. Matthews, J. J. Dupont, J. L. Greaney, S. L. Lennon-Edwards, D. G. Edwards, W. B. Farquhar

International Journal of Exercise Science: Conference Proceedings

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Does Eating A Meal Before Testing Alter The Percent Body Fat Measurement Determined By Bioelectrical Impedance Analysis?, B. Masteller, Curt B. Dixon, Joseph L. Andreacci

International Journal of Exercise Science: Conference Proceedings

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Voluntary Wheel Running Augments Vascular Function In Rats With Chronic Kidney Disease, C. R. Martens, J. M. Kuczmarski, S. L. Lennon-Edwards, D. G. Edwards

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Comparing The Effect Of Overspeed Training On Ncaa Division Iii Lacrosse Athletes, N. Marlowe, K. Flanick, D. Rohrer, L. Burtnett, Harold S. Kieffer

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Metabolic Responses To High Intensity Aerobic And Anaerobic Exercises, K. Mahoney, K. Beil, P. Messersmith, A. Parker, K. Jones, S. D. Mccole, J. A. Mckenzie

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Impact Of Pe Physical Activity Levels On Percent Body Fat: Examined Against Healthy Fitness Zone, W. Liu, R. Nichols, T. Zillifro

International Journal of Exercise Science: Conference Proceedings

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Vascular Changes Following Exercise-Induced Hyperthermia, W. Lefferts, E. Hultquist, K Heffernan, P. Fehling, D. Smith

International Journal of Exercise Science: Conference Proceedings

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Examination Of Sedentary Time, Physical Activity, And Body Mass Index (Bmi) In College-Aged Students, B. Larouere, Carena S. Winters

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Regression Models For Strength Assessment Method Selection And Performance Predictions, C. Lefever, J. H. Anning, B. T. Jensen

International Journal of Exercise Science: Conference Proceedings

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Fitness Assessment Of College Age Students Enrolled In A General Education Fitness Class, J. M. Kuznicki, T. R. Mcconnell

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Serum Sil-6rα Predicts Impairments In Cutaneous Nitric Oxide-Dependent Vasodilation In Humans, J. Kutz, J. Cannon, W. Larry Kenney, L. Alexander-Holowatz

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Juvenile Spondylarthropy In High School Athlete, Tim Koba, Andrew Getzin Md

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.