Physiology Commons^™

Myogenin Modulates Exercise Endurance By Altering Skeletal Muscle Metabolism, James Eric Meadows

Dissertations and Theses (Open Access)

The function of myogenic regulatory factors (MRFs) during adult life is not well understood. The requirement of one of these MRFs, myogenin (Myog), during embryonic muscle development suggests an equally important role in adult muscle. In this study, we have determined the function of myogenin during adult life using a conditional allele of Myog. In contrast to embryonic development, myogenin is not required for adult viability, and Myog-deleted mice exhibited no remarkable phenotypic changes during sedentary life. Remarkably, sedentary Myog-deleted mice demonstrated enhanced exercise endurance during involuntary treadmill running. Altered blood glucose and lactate levels in sedentary Myog-deleted mice after …

Determining Intensity Levels For Selected Wii Fit Activities In College Aged Individuals, Joshua D. Grieser

Boise State University Theses and Dissertations

Introduction: Physical activity is important to the proper growth, development, and overall health of an individual. Current physical activity trends show declines in activity level throughout aging. To counteract inactivity many physical activity interventions have been implemented in different age groups and yet very little change in activity level has been seen. The Nintendo Wii® offers a popular technological intervention tool with its movement oriented game play. The physiological costs and intensity of the Nintendo Wii Fit® game have not been thoroughly researched, yet the Wii is being used as a physical activity tool in many arenas. Purpose: The purpose …

The Complexity And Origins Of The Human Eye: A Brief Study On The Anatomy, Physiology, And Origin Of The Eye, Evan T. Sebastian

Senior Honors Theses

The human eye has been the cause of much controversy in regards to its complexity and how the human eye came to be. Through following and discussing the anatomical and physiological functions of the eye, a better understanding of the argument of origins can be seen. The anatomy of the human eye and its many functions are clearly seen, through its complexity. When observing the intricacy of vision and all of the different aspects and connections, it does seem that the human eye is a miracle, no matter its origins. Major biological functions and processes occurring in the retina show …

Effect Of The E3 Fitness Grips On Running Economy, Julie A. Szabo*, Brian B. Parr‡, Jarod A. Holt*, Christopher M. Dewitt‡

International Journal of Exercise Science

Int J Exerc Sci 3(2) : 64-67, 2010. The purpose of this study was to evaluate the effect of the E3 Fitness Grips (BioGrip, Inc., Rancho Cordova, CA) on running economy, as measured by oxygen uptake (VO2), and heart rate (HR) during submaximal treadmill running. Eleven subjects, seven female and four male, completed a submaximal running test on a treadmill while VO2 and HR were measured continuously. After achieving steady-state at a speed and grade that elicited a VO2 equivalent to 70% VO2max, the subjects ran for five minutes holding the E3 Fitness Grips (G) and five minutes without the …

Heat Stress And Injury Prevention Practices During Summer High School Football Training In South Texas, Christopher M. Hearon‡, Alberto Ruiz‡, Zachary J. Taylor†

International Journal of Exercise Science

Int J Exerc Sci 3(2) : 55-63, 2010. The purpose was to describe practice conditions influencing the risk of heat stress to athletes in summer football training in South Texas high schools, and to compare these conditions to ACSM recommendations for heat stress/injury risk reduction in this population. Thirty (N=30) high school summer football practices were observed. Wet bulb globe temperature (WBGT) was measured before/after practices and practices were observed for: duration/ structure; athlete clothing; and rest break frequency/duration/content. Practices averaged 125+31 min and WBGT (pre- to post-practice) was 29.7+2.1°C to 31.2+2.2°C for morning, and 31.2+1.6°C to 28.9+1.2°C for evening …

Leveraging Online Learning Resources To Teach Core Research Skills To Undergraduates At A Diverse Research University, Brian K. Mcfarlin, Whitney L. Breslin, Katie C. Carpenter, Kelley Strohacker, Randi J. Weintraub

International Journal of Exercise Science

Int J Exerc Sci 3(2) : 49-54, 2010. Today’s students have unique learning needs and lack knowledge of core research skills. In this program report, we describe an online approach that we developed to teach core research skills to freshman and sophomore undergraduates. Specifically, we used two undergraduate kinesiology (KIN) courses designed to target students throughout campus (KIN1304: Public Health Issues in Physical Activity and Obesity) and specifically kinesiology majors (KIN1252: Foundations of Kinesiology). Our program was developed and validated at the 2nd largest ethnically diverse research university in the United States, thus we believe that it would be effective …

The Effects Of 2 Different Arm Positions On Maximum Trunk Flexion In The Bodyweight Squat, A. Page Glave, Jacilyn Olson, Danika K. Applegate, Ro Di Brezzo

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Protein Evolution Via Amino Acid And Codon Elimination, Lise Goltermann, Marie Sofie Yoo Larsen, Ranat Banerjee, Andreas C. Joerger, Michael Ibba, Thomas Bentin

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Background
Global residue-specific amino acid mutagenesis can provide important biological insight and generate proteins with altered properties, but at the risk of protein misfolding. Further, targeted libraries are usually restricted to a handful of amino acids because there is an exponential correlation between the number of residues randomized and the size of the resulting ensemble. Using GFP as the model protein, we present a strategy, termed protein evolution via amino acid and codon elimination, through which simplified, native-like polypeptides encoded by a reduced genetic code were obtained via screening of reduced-size ensembles.

Methodology/Principal Findings
The strategy involves combining a sequential …

Small Molecule Inhibitors Of Mapk And Pi3k Pathways Enhance Mda-7 Lethality In Renal Cell Carcinoma, Patrick Eulitt

Theses and Dissertations

Renal cell carcinoma accounted for an estimated 57,760 new cases and estimated 12,980 deaths in the United States in 2009. Current treatment options for systemic renal cell carcinoma yield markedly low response percentages; however, recent cytokine therapy experiments have produced promising results. A novel adenovirus, Ad.5/3-mda-7, has been synthesized to efficiently infect renal cancer cells with the mda-7 gene. This gene encodes for the cytokine MDA-7/IL-24 that has the ability to specifically target transformed cells. Assays performed with this adenovirus resulted in an increased percentage of cell death in renal cancer cells when compared to infection with Ad.5/3-cmv empty vector. …

How The Sequence Of A Gene Can Tune Its Translation, Kurt Fredrick, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010, Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.

The Effects Of Gdf8 And Activin A On Muscle Atrophy, Amy Sato '10

Honor Scholar Theses

Muscle atrophy and weakening are major health care concerns. For instance sarcopenia, which is a condition of extreme muscle loss and weakening due to aging, was estimated to have cost over 18.5 billion for the year 2000 in the US (Dirks & Leeuwenburgh, 2005). Abilities that depend upon muscle quality like strength, functional mobility, and balance are all key components for how people evaluate their self-rated health (SRH) and quality of life (QoL) (Ozcan et al., 2005; Sirola et al., 2010). Interestingly, SRH and QoL also serve as strong predictors for institutionalization, disability, and mortality for elderly populations (Marzetti & …

Relationship Of Rate Of Loading In Overground And Treadmill Gait, Cameron E. Sheid, Jody L. Riskowski, Huiying Yu

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Human Physiology Community Education, Sasha Volgamore, Kristen Mitchell

Service-Learning Program

The purpose of our project was to educate community members of all age groups to provide them with a basic knowledge of the fundamental workings of the human body, with specific emphasis on skeletal muscle physiology and cardiovascular physiology. It is our hope that members of our target audiences will use this information for future self-directed inquiries into human physiology with regard to their own bodies. Regardless of their age, everyone can decide to eat healthier and live a more active lifestyle. With the knowledge we provided the community, we hope they will appreciate that a healthy lifestyle is paramount …

The Correlation Between Visual Observations And Inclinometric Measurements For Special Tests Related To Patellofemoral Pain Syndrome, Erin Quada

Human Movement Studies & Special Education Theses & Dissertations

Patellofemoral pain syndrome (PFPS) is generally described as an insidious onset with pain increasing during running, jumping, ascending and descending stairs as well as sitting with the knees flexed for an extended period of time. Clinicians often use special tests in injury evaluations and range of motion assessments, usually making a visual observation of that status of the patient. The purpose of this study was to examine how interval measurements utilized in flexibility and range of motion assessments correlate with visual observations of special tests (active knee extension test, Thomas test, Ober's test, rectus femoris flexibility, and Craig's test). The …

The Effects Of Two Different Fatigue Protocols On Lower Extremity Kinematics And Kinetics During An Unanticipated Running Stop-Jump, David L. Quammen

Human Movement Studies & Special Education Theses & Dissertations

Altered neuromuscular control strategies and biomechanical movement risk factors are most likely to contribute to the increased incidence of non-contact ACL injury for female athletes. Neuromuscular control strategies and movement patterns are further altered when the effects of fatigue are present. The purpose of this study was to determine neuromechanical differences between two fatigue protocols [Slow Linear Oxidative Fatigue Protocol (SLO-FP) and Functional Agility Short-Term Fatigue Protocol (FASTFP)] when performing a running stop-jump task (RS). A sample of convenience of fifteen Division I female soccer players (age= 19.2 ± 0.8 years; height= 1.67 ± 0.05 m; mass= 61.7 ± 8.1 …

The Effects Of Two Types Of Fatigue On An Unanticipated Side-Step Cutting Task As Measured By Kinematic And Kinetic Variables, Shawn E. Lucci

Human Movement Studies & Special Education Theses & Dissertations

Fatigue has been shown to alter the neuromechanics of lower extremity. To date, no study has examined the effects of two types of fatigue on kinetics and kinematics. To determine neuromechanical differences between two fatigue protocols [Slow Linear Oxidative Fatigue Protocol (SLO-FP) and Functional Agility Short-Term Fatigue Protocol (FAST-FP)] when performing an unanticipated sidestep cutting task. Fifteen female collegiate soccer players (age=19.2±0.8 years; height=l.67±0.05m; mass=61.7±8.lkg) participated in this study. Participants were free of lower extremity injury at time of participation, and performed five successful trials of a sidestep cutting (SS) task pre and post fatigue protocols. For the SLO-FP, a …

The Effects Of Cocaine And Ecstasy On Cardiac Myocytes And The Intact Myocardium, David A. Tiangco

Theses and Dissertations in Biomedical Sciences

Cocaine and ecstasy are widely used illicit drugs. Both drugs have undergone intense scrutiny as information regarding their side-effects has become available. One important yet incomplete area of investigation pertains to their effects on the heart. The purpose of the current studies was to test the hypothesis that exposure to cocaine or ecstasy will adversely affect cellular homeostasis and normal heart function. Cultured cardiac myocytes (H9c2) and New Zealand White rabbits (Oryctolagus cuniculus) were used to measure the responses to various concentrations of cocaine or ecstasy at both the cellular and intact organ system levels. We observed that cocaine and …

Effects Of Surface Depth And Compaction On Impact Deceleration Of Dirt And Synthetic Surface Materials For Equine Racetracks, Akihiro Yamaguchi, Jacob J. Setterbo, Mont Hubbard, Shrinivasa K. Upadhyaya, Susan M. Stover

International Journal of Exercise Science: Conference Proceedings

Abstract is attached.

Quantative Semg Description Of Upper Extremity Muscle Activation During Baseball Pitching: Pre Fatigue & Fatigue, Hillary Plummer, Gretchen D. Oliver, David W. Keeley

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Validity Of Two Dimensional Vicon Motus Software At Varying Camera Angles, Dayanand Kiran, Mary Carlson, Daniel Medrano Jr., Darla R. Smith

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Model Predicting Shoulder Distraction Force During Baseball Pitching, David W. Keeley, Gretchen D. Oliver

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Next Generation Design For An In-Home Video Game Enhanced Physical Therapy System For Pediatric Patients With Cerebral Palsy, Meghan Huber

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Daily Knee Joint Laxity In Females Across A Menstrual Cycle And Males Across A Calendar Month, Daniel Medrano Jr., Darla R. Smith, Dayanand Kiran, Mary E. Carlson

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

How Children Walk: Bout Length During Real-World Locomotor Behavior, Michael S. Orendurff

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

The Effect Of Exercise On Balance And Peripheral Neuropathy In Older Adults With Type 2 Diabetes, Elisabeth I. Cavegn, Jody Riskowski

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Effects Of Different Crutch Types And Arm Dominance On Shoulder Joint Kinetics During Three Point Swing Through Gait, Kunal Singhal, Jeffery B. Casebolt, Moon-Seok Kwon, Elina Jackson, Young-Hoo Kwon

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

The Effect Of Target Height On The Trunk, Pelvis, And Thigh Kinematics In The Taekwondo Roundhouse Kick, Jae-Woong Kim, Je-Min Kim, Sang-Woo Lee, Ki-Hoon Han, Young-Hoo Kwon

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

Characterization Of Gait Using Inertial Measurement Units And Neural Networks, Stephen Slaughter, Caroline Hilbert, Noah Jouett, Maureen Mcewen

International Journal of Exercise Science: Conference Proceedings

No abstract provided.

The Effects Of Niacin And Aerobic Exercise In Postmenopausal Women Glucose, Insulin And C-Peptide Profiles, Heidi Bidstrup, Yunsuk Koh, James Rowe, David Nichols, Vic Ben-Ezra, Kyle Biggerstaff

International Journal of Exercise Science: Conference Proceedings

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A Rapid, Flow Cytometry-Based Assay For The Determination Of Natural Killer Cell Activity In Isolated Periphery Blood Mononuclear Cells, Emily C.P. Lavoy, Brian K. Mcfarlin

International Journal of Exercise Science: Conference Proceedings

Natural killer cell activity (NKCA) is an important assessment of innate immunity in humans. Natural killer (NK) cells are known to be affected by exercise; therefore it is of interest to have an efficient method for measuring NKCA in pre- and post-exercise blood samples. Assays for NKCA include incubating human NK cells (effector cells) with stained target cells. The target cells are typically from the human leukemia cell line K562. The number of K562 target cells killed can be determined using a dead cell dye. Control target cells incubated alone provide a measure of spontaneous cell death. PURPOSE: The purpose …