Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (19)
- Medical Sciences (10)
- Cellular and Molecular Physiology (7)
- Medical Specialties (7)
- Systems and Integrative Physiology (7)
-
- Medical Physiology (6)
- Biology (3)
- Medical Immunology (3)
- Neuroscience and Neurobiology (3)
- Endocrinology (2)
- Genetics and Genomics (2)
- Medical Microbiology (2)
- Molecular Genetics (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Animal Sciences (1)
- Bacteriology (1)
- Cardiology (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Critical Care (1)
- Developmental Biology (1)
- Diseases (1)
- Endocrinology, Diabetes, and Metabolism (1)
- Exercise Physiology (1)
- Exercise Science (1)
- Gastroenterology (1)
- Immunology and Infectious Disease (1)
- Institution
- Publication Year
- Publication
-
- Physiology Faculty Publications (15)
- Journal Articles: Cellular & Integrative Physiology (6)
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (2)
- Biological Sciences Faculty Publications (1)
- Biology Faculty Publications (1)
-
- Biology, Chemistry, and Environmental Sciences Faculty Articles and Research (1)
- ETSU Faculty Works (1)
- Faculty Publications (1)
- Faculty Publications, Biological Sciences (1)
- Mahurin Honors College Capstone Experience/Thesis Projects (1)
- Masters Theses & Specialist Projects (1)
- NYMC Faculty Publications (1)
- School of Medicine Publications and Presentations (1)
- Senior Honors Theses (1)
Articles 31 - 34 of 34
Full-Text Articles in Physiology
Association Between Chronic Liver And Colon Inflammation During The Development Of Murine Syngeneic Graft-Versus-Host Disease, Jason Anthony Brandon, Jacqueline Perez-Rodriguez, C. Darrell Jennings, Donald A. Cohen, Vishal J. Sindhava, Subbarao Bondada, Alan M. Kaplan, J. Scott Bryson
Association Between Chronic Liver And Colon Inflammation During The Development Of Murine Syngeneic Graft-Versus-Host Disease, Jason Anthony Brandon, Jacqueline Perez-Rodriguez, C. Darrell Jennings, Donald A. Cohen, Vishal J. Sindhava, Subbarao Bondada, Alan M. Kaplan, J. Scott Bryson
Microbiology, Immunology, and Molecular Genetics Faculty Publications
The murine model of cyclosporine A (CsA)-induced syngeneic graft-versus-host disease (SGVHD) is a bone marrow (BM) transplantation model that develops chronic colon inflammation identical to other murine models of CD4+ T cell-mediated colitis. Interestingly, SGVHD animals develop chronic liver lesions that are similar to the early peribiliary inflammatory stages of clinical chronic liver disease, which is frequently associated with inflammatory bowel disease (IBD). Therefore, studies were initiated to investigate the chronic liver inflammation that develops in the SGVHD model. To induce SGVHD, mice were lethally irradiated, reconstituted with syngeneic BM, and treated with CsA. All of the SGVHD animals …
Acid-Sensing Ion Channels And Pain, Qihai Gu, Lu-Yuan Lee
Acid-Sensing Ion Channels And Pain, Qihai Gu, Lu-Yuan Lee
Physiology Faculty Publications
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.
Enkephalin-Encoding Herpes Simplex Virus-1 Decreases Inflammation And Hotplate Sensitivity In A Chronic Pancreatitis Model, Hong Yang, Terry A. Mcnearney, Rong Chu, Ying Lu, Yong Ren, David C. Yeomans, Steven P. Wilson, Karin N. Westlund
Enkephalin-Encoding Herpes Simplex Virus-1 Decreases Inflammation And Hotplate Sensitivity In A Chronic Pancreatitis Model, Hong Yang, Terry A. Mcnearney, Rong Chu, Ying Lu, Yong Ren, David C. Yeomans, Steven P. Wilson, Karin N. Westlund
Physiology Faculty Publications
Background: A chronic pancreatitis model was developed in young male Lewis rats fed a high-fat and alcohol liquid diet beginning at three weeks. The model was used to assess time course and efficacy of a replication defective herpes simplex virus type 1 vector construct delivering human cDNA encoding preproenkephalin (HSV-ENK).
Results: Most surprising was the relative lack of inflammation and tissue disruption after HSV-ENK treatment compared to the histopathology consistent with pancreatitis (inflammatory cell infiltration, edema, acinar cell hypertrophy, fibrosis) present as a result of the high-fat and alcohol diet in controls. The HSV-ENK vector delivered to the pancreatic surface …
Il-1Α And Tnf-Α Down-Regulate Crh Receptor-2 Mrna Expression In The Mouse Heart, Sarah C. Coste, Kurt A. Heldwein, Susan L. Stevens, Eric Tobar-Dupres, Mary P. Stenzel-Poore
Il-1Α And Tnf-Α Down-Regulate Crh Receptor-2 Mrna Expression In The Mouse Heart, Sarah C. Coste, Kurt A. Heldwein, Susan L. Stevens, Eric Tobar-Dupres, Mary P. Stenzel-Poore
Faculty Publications
Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysaccharide, a model of systemic immune activation, and inflammation. We postulated that inflammatory cytokines may regulate CRH receptor type 2. We show that systemic IL-1α administration significantly down-regulates CRH receptor type 2 mRNA in mouse heart. In addition, TNFα treatment also reduces CRH receptor type 2 mRNA expression, although the effect was not as marked as with …