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Full-Text Articles in Physiology
Atrial Fibrillation In Aging: Mechanisms And Potential Therapeutics, Mengmeng Chang
Atrial Fibrillation In Aging: Mechanisms And Potential Therapeutics, Mengmeng Chang
USF Tampa Graduate Theses and Dissertations
Atrial fibrillation (AF) is one of the most common cardiac arrhythmias seen in the clinics, and currently available antiarrhythmic pharmacotherapies in AF are not very effective. Although AF has been recognized as an aging-mediated disease, our understanding of the electrophysiological pathways that link aging and AF remain incomplete, which limits breakthroughs in the development of novel antiarrhythmic treatments for this disease. Studies have shown that aging increases the generation of reactive oxygen species (ROS) in the heart, and high levels of ROS have been associated with development of AF in animals and patients. Additionally, in some forms of AF, the …
Metabolic Therapy For Age-Dependent Impaired Wound Healing, Shannon Lynn Kesl
Metabolic Therapy For Age-Dependent Impaired Wound Healing, Shannon Lynn Kesl
USF Tampa Graduate Theses and Dissertations
Chronic wounds represent an under-acknowledged socioeconomic epidemic, affecting 1.8 million new patients per year and costing the US health care system upwards of $25 billion annually. This substantial cost is rapidly growing due to a disproportionate occurrence in the ever-aging population. Key features associated with age-related impairment of wound healing include limited energy and nutrient exchange, unremitting inflammations, increased reactive oxygen species (ROS), and diminished blood flow. Most chronic wound therapies target specific molecular mechanisms; however, there are often multiple mitigating factors that prevent normal wound closure. This is likely one reason most wound therapies are minimally effective. In the …