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Full-Text Articles in Physiology

Soluble Epoxide Hydrolase Is Down-Regulated In The Brains Of Female Hs Rats Compared To Ns Rats, Dr. James Porter Apr 2013

Soluble Epoxide Hydrolase Is Down-Regulated In The Brains Of Female Hs Rats Compared To Ns Rats, Dr. James Porter

Journal of Undergraduate Research

We were able to use RT-PCR to confirm that mRNA expression for brain soluble epoxide hydrolase was significantly down-regulated. The magnitude of relative down-regulation was on the same order as that found using microarray analysis. This was an important finding since microarray data cannot be published unless corroborating evidence is found using a separate technology (these data were presented at the Experimental Biology 2010 meeting in April, 2010).


Receptors For Advanced Glycation End-Products (Rage) Mediates Particulate Matter-Induced Pulmonary Inflammation, Dr. Paul Reynolds Apr 2013

Receptors For Advanced Glycation End-Products (Rage) Mediates Particulate Matter-Induced Pulmonary Inflammation, Dr. Paul Reynolds

Journal of Undergraduate Research

Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important in the early stages of my faculty appointment at BYU. First of all, I have been able to move my on site research program forward and involve many undergraduates in the process. Specific to the current MEG award, involved students and I have been able to accomplish the proposed research. We have been successful in conducting pilot studies that reveal possible roles for RAGE in mechanisms of lung inflammation induced by both diesel particulate matter (PM) and cigarette …


How Does The Effect Of Cholesterol Vary Between The Inner And Outer Membrane?, Dr. John Bell Mar 2013

How Does The Effect Of Cholesterol Vary Between The Inner And Outer Membrane?, Dr. John Bell

Journal of Undergraduate Research

This proposal was designed to use fluorescence spectroscopy to identify in as much detail as possible physical properties of model membranes in effort to understand roles of cholesterol in biological membranes. The following questions were addressed: how does the effect of cholesterol differ between the inner and outer faces of the cell membrane; can fluorescence spectroscopy distinguish between homogenous and heterogeneous mixtures of membrane components; and what is the biophysical mechanism associated with one of the fluorescent probes used (merocyanine 540)? These questions were addressed with three specific aims. All three aims have been accomplished. One paper was published during …


Role Of Amp Kinase In The Regulation Of Cortisol Release From The Adrenal Gland, Dr. Allan M. Judd Mar 2013

Role Of Amp Kinase In The Regulation Of Cortisol Release From The Adrenal Gland, Dr. Allan M. Judd

Journal of Undergraduate Research

Throughout the three years the funding of this proposal was utilized , I (Dr. Judd) have weekly laboratory meetings and journal clubs for undergraduate and graduate students in the laboratory. At the journal club, recently published articles related to their research projects are presented by the students and the hypothesis, techniques, data, and conclusions of each of the manuscripts discussed. I also interact with these students to help them plan their presentation and lead the discussion of the manuscript at the end of the presentation. The articles that are chosen for discussion are generally published in “Endocrinology” , the premiere …