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Articles 1 - 4 of 4
Full-Text Articles in Physiology
The Identification Of Novel Protein-Protein Interactions In Liver That Affect Glucagon Receptor Activity, Junfeng Han, Ming Zhang, Sean Froese, Feihan F. Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyu Huang, Weiping Jia, Stéphane Angers, Michael B. Wheeler, Li Wei
The Identification Of Novel Protein-Protein Interactions In Liver That Affect Glucagon Receptor Activity, Junfeng Han, Ming Zhang, Sean Froese, Feihan F. Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyu Huang, Weiping Jia, Stéphane Angers, Michael B. Wheeler, Li Wei
Faculty Publications
Glucagon regulates glucose homeostasis by controlling glycogenolysis and gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can exacerbate hyperglycemia contributing to type 2 diabetes (T2D). Thus, it is important to understand how glucagon receptor (GCGR) activity and signaling is controlled in hepatocytes. To better understand this, we sought to identify proteins that interact with the GCGR to affect ligand-dependent receptor activation. A Flag-tagged human GCGR was recombinantly expressed in Chinese hamster ovary (CHO) cells, and GCGR complexes were isolated by affinity purification (AP). Complexes were then analyzed by mass spectrometry (MS), and protein-GCGR interactions were validated by co-immunoprecipitation (Co-IP) …
Adiponectin And Selenium Rich Diet Can Act As A Complimentary Medicine In The Treatment Of Intestinal And Chronic Inflammation Induced Colon Cancer, Arpit Saxena
Theses and Dissertations
Colon cancer is the second largest cause of cancer death in United States. Chronic inflammation and obesity predispose patients to colon cancer. Adipose tissue is a source of bioactive substances called adipokines. Adiponectin (APN), an adipokine has anti-inflammatory property and found at lower levels in obese patients. Selenium (Se), a trace mineral and a dietary supplement, is inversely associated with cancer risk and possess anti-inflammatory and anti-carcinogenic properties. The overall purpose of this dissertation is to determine if chronic inflammation leading to colon and intestinal cancer are regulated by APN or Se rich diet or both. The working hypothesis is …
Novel Drug 2-Benzoyl-3-Phenyl 6,7-Dichloroquinoxaline 1,4-Dioxide Induces Colon Cancer Cell Apoptosis Through Hif-1Α Pathway, Alexander-Jacques Theodore Sougiannis
Novel Drug 2-Benzoyl-3-Phenyl 6,7-Dichloroquinoxaline 1,4-Dioxide Induces Colon Cancer Cell Apoptosis Through Hif-1Α Pathway, Alexander-Jacques Theodore Sougiannis
Theses and Dissertations
Recent developments in the field of cancer genomics have shown transcription factor HIF-1α as a major player in the survival and proliferation of colorectal tumors. Hypoxia targeted drug engineering has led to significant advancements in cancer treatments as a method of directly utilizing the hypoxic regions against the tumor. Novel drug DCQ (2-benzoyl-3-phenyl 6,7-dichloroquinoxaline 1,4-dioxide) has shown promising anti-tumor results in-vitro and in-vivo. The purpose of this study was to utilize a tumor xenograft and genetic mouse model of colorectal cancer to investigate the safety, clinical effectiveness, and mechanism of action of DCQ. Methods: 10 week old Balb/c mice were …
Cardiorespiratory Fitness, Body Fatness Effect On Submaximal Systolic Blood Pressure And Cardiovascular Prognosis Among Young Adults, Vivek Kumar Prasad
Cardiorespiratory Fitness, Body Fatness Effect On Submaximal Systolic Blood Pressure And Cardiovascular Prognosis Among Young Adults, Vivek Kumar Prasad
Theses and Dissertations
Cardiovascular (CV) diseases (CVDs) are known to be the leading cause of death globally, as CVDs account for the highest rate of mortality compared to any other causes. The mortality from CVDs, is projected to increase to nearly 23.3 million by 2030. Mortality number due to CVD in the United States is 600,000 per year, thus representing nearly 1 in every 4 deaths. Exercise blood pressure (BP) is an important marker of CV events that are associated with incident CV morbidity and mortality among individuals with or without any CVD at present. Elevated exercise BP among individuals with normal resting …