Physiology Commons^™

Analysis Of The Potentials And Topographical Relations Between The Olfactory Bulb And Prepyriform Cortex, William S. Seibly

Loma Linda University Electronic Theses, Dissertations & Projects

Olfactory bulb efferents sweep caudally over the prepyriform cortex in a broad fiber sheet called the lateral olfactory tract (LOT). The LOT begins as a compact sheet of fibers in the olfactory peduncle and narrows to a bundle caudally. It is the primary axonal pathway between the olfactory bulb and the cortex. The shape and cross-sectional area of the LOT was measured from histologic sections. The cross-sectional area diminishes to about half from rostral to caudal measurements. An array of 58 electrodes spaced at intervals of 1 mm was constructed to conform to the curvilinear surface and geometry of the …

The Rate Of The Healing Process In Venous Thrombi Produced By A Sclerosing Agent With Special Attention To Endothelial Lining, Kiyoshi Tanaka

Loma Linda University Electronic Theses, Dissertations & Projects

Despite extensive clinical and experimental investigations of venous thrombosis, relatively little is known about the early phases of healing of the venous thrombus. Soon after its discovery heparin has become the most popular agent for the prevention and treatment of venous thrombosis, but there are a number of unanswered questions regarding the most satisfactory treatment for venous thrombosis.

One area of controversy has been the duration of anticoagulation therapy for acute venous thrombosis. If the anticoagulant is discontinued too soon, the thrombus may continue to propagate. Prolonged anticoagulant therapy exposes the patient to the risk of serious hemorrhage. The objective …

Patterns Of Fetal Lamb Regional Cerebral Blood Flow During And After Prolonged Hypoxia, Stephen Ashwal, John S. Majcher, Nestor Vain, Lawrence D. Longo

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract not included]

Speculation: In the fetal lamb during prolonged intrauterine hypoxia, total and regional cerebral blood flows increase to the same extent without evidence of preferential shunting to critical brainstem or subcortical areas. Neuropathologic studies have indicated relative sparing of these areas during similar animal experimental or human neonatal conditions. This suggests that the pattern of hypoxic ischemic insult to the neonatal central nervous system associated with asphyxia may differ from that produced by hypoxia alone. In addition, during asphyxia these pathologic changes may result primarily from hypotension and decreased regional cerebral blood flow, or from regional metabolic derangements …

The Effects Of Orally Administered Charcoal On Intestinal Gas, Herbert J. Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

Our primary objectives were to determine if orally administered charcoal effectively decreased intestinal gas, and relieved subjective symptoms associated with a high gas producing meal.

The adsorptive properties of charcoal for those gases usually found in intestines (CO₂, H₂, CH₄, H₂S) were first tested by placing measured samples of each gas alone with weighted samples of activated charcoal in a respirometer.

The degree of adsorption of each gas by charcoal was determined. Charcoal effectively adsorbed H₂ and CO₂.

A group of normal human males were fed a gas producing …

Isolation And Chemico-Physiologic Characterization Of A Parotid Hormone Activity From Porcine Glands, Jean-Marc Tieche

Loma Linda University Electronic Theses, Dissertations & Projects

For the past decade, evidence has accumulated which suggests that the resistance of the teeth to dental decay is in part under systemic control. It was shown that the resistance is accomplished through the optimal operation of a dentinal fluid transport mechanism which is believed to be hormonally controlled by the hypothalamic-parotid gland endocrine axis. Although circumstantial evidence for such an endocrine function was strong, the isolation of a parotid hormone which stimulates the dentinal fluid transport mechanism remained to be accomplished.

Using modern biochemical techniques, a methodology was designed to isolate and purify the hormone from porcine parotid glands. …

Effect Of Time And Diet On The Immune Status Of Mice Challenged With Herpes-Transformed Cells, Daila S. Gridley

Loma Linda University Electronic Theses, Dissertations & Projects

Human Herpes simplex virus type 2 (HSV 2)-transformed Balb/c mouse cells (H238 cells) are malignant in Balb/c mice. The immune stratus of mice bearing H238 cell-induced tumors was studied and changes in immune response with time and with altered diet of the mice were measured.

In the experiments dealing with the status of immunity with time after tumor cell injection, mice were fed Purina Laboratory Chow (P.L.C.), injected with H238 cells, and sacrificed three to eight weeks post-injection. In the diet experiments, groups of mice were fed either P.L.C. or one of six equicaloric diets, consisting of low or high …

An Electrophysiological Analysis Of The Primary Input To The Cat Prepyriform Cortex, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

Properties of the lateral olfactory tract (LOT) action potential and cortical evoked potential (EPSP) were studied using discrete stimuli applied to the tract in acute and chronic preparations. Stimulus response curves for both presynaptic (action) and postsynaptic (EPSP) potentials were sigmoidal and linearly related over the entire range. Simulated action potentials were used to determine the diameter to amplitude relationship, an intermediate step for finding the threshold as a function of tract axon diameter. Our results indicate that threshold is proportional to (diameter) ^-3.4 instead of (diameter) ^-1 as found by others in frog peripheral nerve. Further work is required …

Effects Of Cariogenic And Noncariogenic Diets On The Concentration Of The Parotid Hormone Releasing Factor In Rat Hypothalami, Melva Joan Brown

Loma Linda University Electronic Theses, Dissertations & Projects

Hypothalamic and cortical extracts from various cariogenically grouped rats which had been maintained on either a Purina diet or a high sucrose diet (HSD) for three months were infused intravenously into 28 days old rats to determine if there was a titer of parotid hormone releasing factor (PRF) capable of facilitating fluid movement (FM) in the teeth. The hypothalamic and cortical extracts obtained from Purina-fed rats with 0-caries and the hypothalamic extracts from BSD-fed rats conclusively demonstrated FM stimulatory ability. Other Purina-fed groups were essentially biologically ineffective, however, extracts from HSD-fed caries groups including scores 11-40 demonstrated extremely potent FM …

The Effect Of Insulin, Fluoride And Methyl Xanthines On The Hypothalamic-Parotid Gland Endocrine Axis, Reagan Ondler

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine the effect of insulin and fluoride on dentinal fluid movement (FM) in high-sucrose fed rats as mediated through the hypothalamic-parotid gland endocrine axis. In conjunction with the fluoride study, the possible involvement of cAMP was examined through the use of several methyl xanthines which are recognized as phosphodiesterase inhibitors.

Twenty-one day old, male Sprague Dawley rats were maintained on a high-sugar diet (62% sucrose) for 8-9 days at which time intravenous or arterial infusions of insulin, fluoride or the methyl xanthines were performed. Additional procedures included collecting plasma from rats which had …

Bone Regeneration Over Submerged Dental Roots In Dogs, Roger Lee Plata

Loma Linda University Electronic Theses, Dissertations & Projects

Nonendodontically treated roots were submerged 1.5 to 2.0 mm. below the alveolar crest in three dogs. Twelve roots were treated in this manner. Regeneration of alveolar bone can be seen in three weeks with complete bone coverage in five weeks. A complete lamina dura can be seen around the amputated roots.

Bone failed to regenerate over two of the twelve roots. In one case there was delayed healing due to the early loss of some sutures. A sinus tract developed connecting the oral environment with the contents of the pulp. This led to bone resorption and a necrotic pulp. In …

A Method Of Analyzing Mandibular Movement, Richard B. Mccoy

Loma Linda University Electronic Theses, Dissertations & Projects

Mandibular movement is considered to be a fundamental factor in the study, analysis, and treatment of occlusion. For many years, dentists have realized that dental health depends upon the compatibility of mandibular movements and occlusion. This realization has led to the development of new methods and techniques for recording accurately and scientifically the movements of the mandible. In order for this data to be of scientific value, it must be stored in a usable form which is easily available for analysis.

The purpose of this research project was to develop a procedure for storing and recalling mandibular-movement information. Before such …

Studies On The Regulation Of Cell Growth And Contact Inhibition Using Concanavalin A And Dibutyryl Adenosine Cyclic Monophosphate, Robert W. Teel

Loma Linda University Electronic Theses, Dissertations & Projects

Both dibutyryl cyclic AMP and trypsinized concanavalin A have been shown to inhibit growth in certain cell lines but little testing of these substances has been done using human tumor cell lines. Further, there are at this time no published experimental attempts to correlate the effects on growth with a particular phase of the cell cycle in any cell line.

My experimental data show that the human tumor cell lines HeLa, HEp 2 and KB exhibit pronounced inhibition of growth when treated with trypsinized concanavalin A and reach a contact-inhibited state at a density far below that to which these …

Mathematical Model Of Placental Oxygen And Carbon Dioxide Exchange, Ester P. Hill

Loma Linda University Electronic Theses, Dissertations & Projects

This model of placental CO₂ and O₂ exchange calculates the time course of changes in P_^CO2, [HCO₃^-], and [H⁺] in each of four "compartments" of placental exchange vessels: maternal erythrocytes, maternal plasma, fetal plasma and fetal erythrocytes. The changes in hemoglobin-bound CO₂ (carbamate) and oxyhemoglobin contents within the erythrocytes are also calculated, permitting consideration of the Haldane and Bohr effects. Equations were written to represent one-dimensional steady state CO₂ and O₂ diffusion between concurrent maternal and fetal capillaries and the subsequent hydration, carbamino and oxyhemoglobin reactions. The equations …

Cardioregulatory Role Of The Abdominal Ganglion Of Aplysia Californica, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood pressure monitoring. The presence and cardioregulatory effects of axons in the nerves was investigated by electrical stimulation. Fine-tipped glass microelectrodes inserted into ganglionic neurons were used to determine the relationship between the neuronal and cardiac activities.

The principal results are listed below.

1. Primarily inhibitory responses are obtained from both right and left connective stimulation, with some evidence for …

The Effect Of Exercise On Metabolic Rate With Time In Overweight And Normal Weight Subjects, Roberta Jewell Keswick

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies in the Lome Linda University laboratory showed that obese subjects on an exercise program lost approximately one pound more per week as compared to a non-exercise group. Energy expenditure calculations of the exercise did not account for the total caloric deficit required to lose the additional pound. The present study was designed to investigate changes in BMR and metabolic rate with time for normal weight and overweight subjects involved in a practical exercise program. The relationship of changes in BMR and metabolic rate in coping with the problems of obesity were also studied.

Fifteen subjects, eight overweight and …

A Methodology For The Determination Of The Relationship Between Quantitative Occlusal Forces And The Masticatory Muscles, William Melvin Taskey

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Regeneration-Like Responses In Organ Culture Of Adult Hamster Cheek Pouch Tissue And The Effects Of Tissue Extracts, Metabolic Inhibitors And Oxygen, Raymond G. Hall Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Periosteal Circulation And Its Contribution To The Nutrition Of Compact Bone, Jean Elaine Tassell

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

The Piezoelectric Effect Of Bone In Vitro, Lloyd E. Gauntt

Loma Linda University Electronic Theses, Dissertations & Projects

The mechanism of bone deposition and resorption, under stress, is incompletely understood. The direct piezoelectric properties of bone have been suggested as playing an active role in the internal morphology of bone tissue.

This study was designed to fabricate an apparatus and develop a technique to measure, quantitatively, the direct piezoelectric effect of the crystallites of bone.

In vitro studies were done with bone samples taken from bovine femur. The samples were subjected to stress loading and were observed to exhibit a pressure-induced electrical phenomenon. The amplitude of the potentials generated was dependent upon the magnitude of the bony deformation. …

Electromyographic Analysis Of The Temporal And Masseter Muscles During The Para-Retentional Period In Orthodontic Patients, Thomas L. Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

This study was initiated to compare electromyographically the activity of the masseter and temporal muscles during the early retentional period in orthodontic patients. Electromyographic recordings were taken at the following times: (1) before typical edgewise appliance was removed, (2) at time of retainer insertion, (3) after eight to twelve weeks of retainer wearing, and (4) one day following occlusal equilibration. Electromyograms from the orthodontic group of subjects were compared with electromyograms from a group of subjects with normal occlusion, and a group of subjects with untreated Class II, Division 1 malocclusions. There was a total of thirteen subjects studied: five …

The Effect Of Infection With Polyoma Virus On The Protein, Rna, And Dna Of Mouse Embryo Cell Cultures, Lawrence E. Mcconnehey

Loma Linda University Electronic Theses, Dissertations & Projects

In four separate experiments mouse embryo cell monolayers infected with polyoma virus and uninfected control mouse embryo cells were maintained in Eagle’s Minimum Essential Medium for periods of time ranging from 0 to 168 hours. The cell layers were removed from the glass by trypsinization. Samples of the cells were counted in a Coulter Counter and the remainder of the cells frozen after centrifugation, in a button. Later, the buttons were thawed and protein, RNA, and DNA analyses were performed on each sample. The micrograms per million cells of protein. RNA, and DNA were determined for each sample and plotted …

Acute Effects Of Acetazoleamide (Diamox) Administration On Pulmonary Carbon Dioxide Exchange In Humans, George G. Burton

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies dealing with the effects of oral acetazoleamide (Diamox^R) administration in humans have yielded equivocal results. Effects of intravenous administration of this agent, a potent carbonic anhydrase inhibitor, have not been studied until recently. It is postulated that difficulty in interpreting these results has risen in part from failure to evaluate given parameters in terms of drug concentrations or degree of carbonic anhydrase inhibition achieved.

These concentrations were ascertained throughout the present work of this Thesis, which deals with the effects of both small and large doses of this agent upon ventilatory parameters in man.

In these …

The Pacemaker Function Of The Small Intestine, Robert W. Hasselbrack

Loma Linda University Electronic Theses, Dissertations & Projects

New evidence is presented to clarify to some extent the significance of the gradient of rhythmicity in the small intestine of the unanesthetized dog. The gradient of rhythmicity was studied on five dogs prepared with duodenal fistulas. Rhythmic contractions were recorded from the small intestine by a small rubber balloon. The gradient of rhythmicity was found to decrease in a stepwise manner as the distance from the pylorus is increased. Roughly, the rhythmic contractions were found to be 18 to 19 per minute in the duodenum and 14 to 15 per minute in the ileum. In the terminal ileum there …

Artificial Respiration During The Apnea Of Cerebral Trauma, Thorvald W. Christiansen

Loma Linda University Electronic Theses, Dissertations & Projects

Cerebral concussion often results in profound respiratory depression. The earlier workers in the field of experimental concussion concluded that artificial respiration could be a life preserving procedure in 4 many instances. More recently, however, it has been held that this form of resuscitation is of little or no value.

Because of this conflict in viewpoint and inasmuch as the latter interpretation was made as a result of studies that were not primarily directed towards assessing the worth of artificial respiration during the apnea of experimentally induced concussion, this study was planned with the hope of resolving the differences of opinion. …

The Visceral To Skin Temperature Gradient In Restraint Hypothermia, Glenn L. Foster

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Summary: The effects of restraint on skin, subcutaneous, and deep visceral temperatures of rats exposed to environmental temperatures of 0°C, 8°C, 16°C, and 28°C are determined. The temperature gradients of restrained and unrestrained rats at 0°G are compared.

From the data presented, it is felt that one factor in the thermolability of restrained animals is an increased heat loss. There is also evidence suggesting a decreased metabolic rate, the chemical nature of which is unknown Which of these two factors plays the greater role is yet to be determined.

Pathological Physiology As A Basis For Medical Practice, Walter E. Macpherson

Medical Arts and Sciences: A Scientific Journal of the College of Medical Evangelists

No abstract provided.