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Articles 121 - 150 of 241
Full-Text Articles in Physiology
An Exploratory Study Of Aquatic Walking On Symptoms And Functional Limitations In Persons With Knee Osteoarthritis: Part 1, John M. Coons, Brandon Grubbs, Vaughn W. Barry, Ryan T. Conners, Sandra Stevens
An Exploratory Study Of Aquatic Walking On Symptoms And Functional Limitations In Persons With Knee Osteoarthritis: Part 1, John M. Coons, Brandon Grubbs, Vaughn W. Barry, Ryan T. Conners, Sandra Stevens
International Journal of Aquatic Research and Education
This paper represents Part 1 of a study that explored the effects of an underwater treadmill (UT) walking program on pain and function in adults with knee osteoarthritis (KOA). The Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC), numerical rating scale (NRS), timed up-and-go (TUG), and 10-m walk were assessed in 6 adults (62.7 ±14.2 years) who participated in an 8-week (3x/wk) UT walking intervention based on the Arthritis Foundation’s Walk With Ease (WWE) program. Walking pace was self-selected, and walking duration of each session was increased from 10 to 45 minutes throughout the study. Knee pain and function were …
An Exploratory Study Of The Effects Of Aquatic Walking On Function And Muscle Activity In Knee Osteoarthritis: Part 2, John M. Coons, Brandon Grubbs, Conor Theiss, Vaughn W. Barry, Sandra Stevens
An Exploratory Study Of The Effects Of Aquatic Walking On Function And Muscle Activity In Knee Osteoarthritis: Part 2, John M. Coons, Brandon Grubbs, Conor Theiss, Vaughn W. Barry, Sandra Stevens
International Journal of Aquatic Research and Education
This paper presents Part 2 of a study that investigated the effects of an 8-week (3x/week) underwater treadmill (UT) walking intervention on knee osteoarthritis (KOA) outcomes in 6 adults with KOA (62.7 ± 14.2 years). The Knee Outcome Survey (KOS) for activities of daily living and muscle activity during a 10-m walk and a 20 cm step down were measured before and after the intervention. The following KOS measures improved after the UT walking program (p < 0.05; g > 0.8): stiffness, swelling, weakness, walking, going up stairs, going downstairs, kneeling on the front of the knee, squatting, and sitting with the …
The Real-Time Classification Of Competency Swimming Activity Through Machine Learning, Larry Powell, Seth Polsley, Drew Casey, Tracy Hammond
The Real-Time Classification Of Competency Swimming Activity Through Machine Learning, Larry Powell, Seth Polsley, Drew Casey, Tracy Hammond
International Journal of Aquatic Research and Education
Every year, an average of 3,536 people die from drowning in America. The significant factors that cause unintentional drowning are people’s lack of water safety awareness and swimming proficiency. Current industry and research trends regarding swimming activity recognition and commercial motion sensors focus more on lap swimming utilized by expert swimmers and do not account for freeform activities. Enhancing swimming education through wearable technology can aid people in learning efficient and effective swimming techniques and water safety. We developed a novel wearable system capable of storing and processing sensor data to categorize competitive and survival swimming activities on a mobile …
Enhancing The Quality Of Life For Senior Citizens: A Facilitator’S Guidebook For Mindful Music And Movement, Shannon Sexton
Enhancing The Quality Of Life For Senior Citizens: A Facilitator’S Guidebook For Mindful Music And Movement, Shannon Sexton
Mindfulness Studies Theses
Music appreciation and enjoyment enhance well-being throughout the lifespan. The challenges and constraints that people experience as they age can lead to lack of access to music, decreased physical activity, and fewer avenues for creative expression. Group music and movement interventions created for older populations offer opportunities for social connection and improved quality of life. Mindful practices add further benefit when combined with these interventions. Current available programs are scarce and most often do not encompass mixed modalities. In addition, the benefits of these programs do not show long-term sustainability. The purpose of this thesis is to explore the effects …
Changes In Running Biomechanics In Master Runners Over Age 50: A Systematic Review, Matthew Klein, Chris Patterson
Changes In Running Biomechanics In Master Runners Over Age 50: A Systematic Review, Matthew Klein, Chris Patterson
Faculty Publications - College of Physical Therapy
The number of individuals over 50 years of age participating in recreational and competitive running has increased over the past ten years. It has been established that older runners experience a reduction in strength and power. These changes may contribute to different running biomechanics from younger runners. The pur-pose of this study was to synthesise the current evidence on run-ning biomechanical differences in the lower extremity between masters runners over 50 years and younger runners under 40 years. The systematic data search included CINAHL, MEDLINE, and SPORTDiscus databases. Fourteen cross-sectional studies that com-pared lower extremity biomechanics of masters runners to …
The Effects Of Vitamin D Supplementation On Athletic Performance And Injury Prevention, Amani Adeeb Abushamma
The Effects Of Vitamin D Supplementation On Athletic Performance And Injury Prevention, Amani Adeeb Abushamma
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Vitamin D supplementation has numerous effects on athletic performance and plays a significant role in preventing an athlete’s risk of getting injuries. Vitamin D has an impact on numerous physiological functions such as: bone health, muscle function, inflammatory response, and immune function. An athlete’s bone and muscle health are essential for maximum performance and career success. A bone fracture due to vitamin D deficiency can delay an athlete’s training and ultimately inhibit obtaining a collegiate scholarship and/or contract. A cross sectional study found that more than half of athletic trainers did not view 25-hydroxyvitamin D(25[OH]) testing and vitamin D supplementation …
Effects Of Exercise On Parkinson's Symptom Relief, Brooke Burnett
Effects Of Exercise On Parkinson's Symptom Relief, Brooke Burnett
The Eleanor Mann School of Nursing Undergraduate Honors Theses
In this review of twenty research articles, the effects of moderate exercise therapy on the symptoms of Parkinson’s Disease will be explored. Appropriate literature was located using the research question, “In older adults with a Parkinson’s Disease Diagnosis, how does moderate exercise influence the symptoms of this disease?” Twenty peer-reviewed research articles were examined for the impact of different forms of exercise on various symptoms associated with Parkinson’s. Nineteen of the articles reviewed provide substantial evidence in support of exercise therapy as a treatment option for people with Parkinson’s, and one of the articles found inconclusive evidence neither in support …
Hyperbaric Oxygen Therapy And Wound Healing, Karen E. Lucero Ortega
Hyperbaric Oxygen Therapy And Wound Healing, Karen E. Lucero Ortega
Student Publications
Hyperbaric Oxygen Therapy (HBOT) has been around since the 1860s and is now a well-established form of treatment. HBOT has been proven to be a safe therapeutic option and has been successful in treating non-healing wounds, traumatic wounds, and radiation-induced wounds. There has also been success in treating other conditions such as inflammatory bowel disease, carbon monoxide poisoning, and decompression sickness with HBOT. The way HBOT works is by exposing the body to 100% pure oxygen in a closed chamber, which exceeds normal atmospheric pressure by two to three times. With HBOT, large amounts of oxygen enters the body, which …
Extreme Exposure To Cold: A Method To Enhance Physical Wellness And Recovery, Mallory E. Duggan
Extreme Exposure To Cold: A Method To Enhance Physical Wellness And Recovery, Mallory E. Duggan
Student Publications
This paper reviews the current literature on Cryotherapy and its ability to enhance physical wellness and recovery. The paper details the proposed mechanisms of Cryotherapy as well as its various clinical applications regarding the treatment of numerous diseases and physical exercise recovery. The paper also details the possible limitations/detrimental effects of Cryotherapy usage.
In This Issue (13:4), Stephen J. Langendorfer Ph.D.
In This Issue (13:4), Stephen J. Langendorfer Ph.D.
International Journal of Aquatic Research and Education
Greetings, IJARE readers and welcome to the fourth issue of Volume 13. I admit being quite excited about this issue. It is jam-packed with outstanding papers from six different countries that deserve your readership and attention.
Effect Of Water Depth On Heart Rate And Core Temperature During Underwater Treadmill Walking, Carrie E. Bajenski, Brianna R. Brandon, Cailey A. Curry, Leslie Fajardo, Ryan T. Conners
Effect Of Water Depth On Heart Rate And Core Temperature During Underwater Treadmill Walking, Carrie E. Bajenski, Brianna R. Brandon, Cailey A. Curry, Leslie Fajardo, Ryan T. Conners
International Journal of Aquatic Research and Education
Exercising using an underwater treadmill (UTM) has become a popular modality; however, few studies have focused on the physiological demands of UTM walking at varying water depths. Thus, the objective of this study was to investigate changes in heart rate (HR) and core temperature (CT) values in college-aged males and females while exercising at different water immersion depths using an UTM. Twenty participants (age = 21.50 ± 2.19 years; height = 169.04 ± 10.85cm; weight = 75.56 ± 22.28kg) walked at water depths of 10cm below the xiphoid process and at the level of the superior iliac crest (I.C.). Each …
A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann
A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann
Graduate Theses/Dissertations
Many people in the United States suffer from poor mental health which can lead to suicide, self-harm, or negative effects on job performance and relationships. Not everyone can afford traditional therapy nor feels comfortable with it. With a greater emphasis placed on taking care of one’s mental health during the COVID-19 pandemic, there should also be a greater emphasis placed on finding alternative types of therapy that can be matched to individuals based on their personalities and preferences. One such alternative is outdoor exercise. This review was conducted to examine whether exercising or performing physical activity outdoors results in greater …
Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr.
Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr.
Physiology Faculty Publications
Many of the molecular and cellular mechanisms discovered to regulate skeletal muscle hypertrophy were first identified using the rodent synergist ablation model. This model reveals the intrinsic capability and necessary pathways of skeletal muscle growth in response to mechanical overload (MOV). Reminiscent of the rapid cellular growth observed with cancer, we hypothesized that in response to MOV, skeletal muscle would undergo metabolic programming to sustain increased demands to support hypertrophy. To test this hypothesis, we analyzed the gene expression of specific metabolic pathways taken from transcriptomic microarray data of a MOV time course. We found an upregulation of genes involved …
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi
Purdue Journal of Service-Learning and International Engagement
Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …
Do Water Safety Lessons Improve Water Safety Knowledge?, Michael J. Tipton, Joseph Muller, Cristian Abelairas Gomez, Jo Corbett
Do Water Safety Lessons Improve Water Safety Knowledge?, Michael J. Tipton, Joseph Muller, Cristian Abelairas Gomez, Jo Corbett
International Journal of Aquatic Research and Education
A person, usually a child or young adult, dies by drowning every 90 seconds around the planet. Most drowning prevention initiatives do not assess the efficacy of the intervention. In this study, thirteen- to fourteen-year-olds had their level of water safety knowledge (covering cold shock, rips and tides) assessed before, just after, and 3-6 months after one, 25-minute water safety lesson on these topics. We evaluated the knowledge gained and retained on water safety “awareness” (i.e., knowledge of risks) and “confidence” in terms of knowing what to do in an emergency. The results demonstrated that the lesson significantly increased water …
Fusion And Beyond: Satellite Cell Contributions To Loading-Induced Skeletal Muscle Adaptation, Kevin A. Murach, Christopher S. Fry, Esther E. Dupont-Versteegden, John J. Mccarthy, Charlotte A. Peterson
Fusion And Beyond: Satellite Cell Contributions To Loading-Induced Skeletal Muscle Adaptation, Kevin A. Murach, Christopher S. Fry, Esther E. Dupont-Versteegden, John J. Mccarthy, Charlotte A. Peterson
Center for Muscle Biology Faculty Publications
Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways. The fusion of satellite cells, driven by cell-autonomous and/or extrinsic factors, contributes new myonuclei to muscle fibers, associates with load-induced hypertrophy, and may support focal membrane damage repair and long-term myonuclear transcriptional output. Recent studies have also revealed that satellite cells communicate within their niche to mediate muscle remodeling in response to resistance exercise, regulating the activity of numerous cell types through various mechanisms such as secretory signaling and cell–cell contact. Muscular adaptation to resistance and endurance activity can be initiated and sustained for a period of …
Developing An Adaptive Rock Climbing Curriculum For Suny Cortland Outdoor Pursuits 2021, Rebekah Mills
Developing An Adaptive Rock Climbing Curriculum For Suny Cortland Outdoor Pursuits 2021, Rebekah Mills
Master's Theses
SUNY Cortland Outdoor Pursuits opened in August of 2015 with the completion of the newly constructed Student Life Center. Outdoor Pursuits is a smaller department within the Recreational Sports Department. Outdoor Pursuits offers rock climbing services at its facility located in the Student Life Center. Currently, Outdoor Pursuits offers Bouldering and Top Roping services only when the Student Life Center is open, these hours are typically 3-10 pm. Monday-Friday and Saturday-Sunday 2-8 pm. These services are only provided to eligible SUNY Cortland faculty, staff, students, alumni, and other affiliated members. As the facility has grown in popularity during its operation, …
Perceptions Of Water Competencies, Drowning Risk And Aquatic Participation Among Older Adults, Teresa Stanley, Kevin Moran
Perceptions Of Water Competencies, Drowning Risk And Aquatic Participation Among Older Adults, Teresa Stanley, Kevin Moran
International Journal of Aquatic Research and Education
New Zealand has an aging population and, despite falling drowning tolls in all other age groups (WSNZ, 2019c), older adults have continued to drown in both increasing numbers and proportion. The reasons for this are not well understood since very little drowning research has focused on older people. A water safety survey (N = 389) seeking information on older adults’ aquatic recreational practices and perceptions of safety was conducted at the end of the summer season, 2019. Most adults (86%, n = 335) reported some aquatic activity in the previous year, but those aged 65+ years (66%) were significantly …
In This Issue (13:2), Stephen J. Langendorfer Ph.D.
In This Issue (13:2), Stephen J. Langendorfer Ph.D.
International Journal of Aquatic Research and Education
front matter to Volume 13, Issue 2
Surfboard Paddling Technique And Neuromechanical Control: A Narrative Review, Wynand Volschenk, Zachary J. Crowley-Mchattan, John W. Whitting, Rudi A. Meir, Alec K. Mckenzie
Surfboard Paddling Technique And Neuromechanical Control: A Narrative Review, Wynand Volschenk, Zachary J. Crowley-Mchattan, John W. Whitting, Rudi A. Meir, Alec K. Mckenzie
International Journal of Aquatic Research and Education
Surfboard paddling is an essential activity when surfing. Research investigating surfboard paddling, especially as it pertains to neuromechanical control and techniques used, is limited. Previous research made use of swim ergometers to examine surfboard paddling demands. The validity of using swim ergometers in surfboard paddling research and training deserves further analysis. To establish ecologically valid findings, researchers have begun to use swim flumes and still-water paddling environments to investigate paddling efficiency and technique. This emerging body of research has reported that muscle activation patterns, intensities, and timings differ as surfers move through different paddle stroke phases. A deeper understanding of …
The Effects Of Concussion On Quantity Of Sleep And Quality Of Sleep, Taren Asheton Bone
The Effects Of Concussion On Quantity Of Sleep And Quality Of Sleep, Taren Asheton Bone
Theses, Dissertations and Capstones
This study observed how a concussion's effects change the quantity and quality of sleep in collegiate athletes. There is a lack of research pertaining to this topic, explicitly involving collegiate athletes and the changes in sleep outcomes during concussion recovery from a concussion. The study design is a convenient cohort in the field involving athletes from two local universities. Participants wore a Readiband™ device for seven to ten days or throughout their concussion recovery. There were differences in total minutes in bed and calculated minutes in bed between concussed and non-concussed participants. This study indicates that concussion affects the quantity …
Biomechanical Properties Of Land Based And Shallow Water Wait: A Comparative Review Of Literature, Mostafa Yaghoubi, Philip Fink, Wyatt H. Page, Sarah P. Shultz
Biomechanical Properties Of Land Based And Shallow Water Wait: A Comparative Review Of Literature, Mostafa Yaghoubi, Philip Fink, Wyatt H. Page, Sarah P. Shultz
International Journal of Aquatic Research and Education
Aquatic locomotion exercises are frequently used in rehabilitation and cross-training for land-based athletes. Hydrostatic pressure, thermal conductivity and drag force affect a person's ability to move; therefore, it is important to understand differences of biomechanical gait in water vs land. This review investigated biomechanical differences between shallow water and land-based exercises. PubMed, Google Scholar, SPORTDiscus and Scopus were searched; 33 studies included walking forward (27), backward (6) and running (6). Electromyographic amplitude was similar or less in submaximal intensity during aquatic gait, in comparison to on land. At maximal intensities, however, the amplitude was similar (n=5) or higher (n=4) in …
Cardiovascular And Stride Frequency Differences During Land And Aquatic Treadmill Walking, Jessica Burton, Sarah Duffey, Amber Hammonds, Anna Leduc, Rachel Shumate, John Coons, Ryan T. Conners
Cardiovascular And Stride Frequency Differences During Land And Aquatic Treadmill Walking, Jessica Burton, Sarah Duffey, Amber Hammonds, Anna Leduc, Rachel Shumate, John Coons, Ryan T. Conners
International Journal of Aquatic Research and Education
This study examined heart rate (HR) and stride frequency (SF) values of 30 college-aged males and females during dry-land (DL) and aquatic walking (AW). Aquatic walking trials were completed in an underwater treadmill with the water depth at waist level; the water temperature (31℃ ± 0.1℃) and room temperature (26.6℃ ± 0.1℃) were maintained at thermoneutral levels throughout the study. During each walking condition, HR and SF were recorded at treadmill speeds of 1 mph, 2 mph, and 3 mph. Participants were instructed to walk with their hands at their sides swinging as they would when walking on dry-land unless …
Features Of Acceleration And Angular Velocity Using Thigh Imus During Walking In Water, Koichi Kaneda, Yuji Ohgi, Mark Mckean, Brendan Burkett
Features Of Acceleration And Angular Velocity Using Thigh Imus During Walking In Water, Koichi Kaneda, Yuji Ohgi, Mark Mckean, Brendan Burkett
International Journal of Aquatic Research and Education
Ten participants were assessed while walking in water and on land with wearable inertial measurement units (IMUs) attached to the right thigh. Longitudinal acceleration, anterior-posterior acceleration, and frontal axis angular velocity were measured at 100 Hz, matched with video analysis sampled at 25 Hz during the walking trials. The longitudinal acceleration showed almost 1 g from initial heel contact to 70% of one cycle, and the anterior-posterior acceleration showed a sinusoidal pattern, synchronizing the approximate posture of the thigh in water. The frontal axis angular velocity fluctuated less while walking in water compared with on land, because thigh motion speed …
Assessment Of Antebrachial And Carpal Muscle Activity During Smartphone Use: Is “Selfie Wrist” A Real Phenomenon?, Monica Stacy
Assessment Of Antebrachial And Carpal Muscle Activity During Smartphone Use: Is “Selfie Wrist” A Real Phenomenon?, Monica Stacy
Honors Theses
Reports in the media by celebrities have sparked an interest in a phenomenon being called “selfie-wrist,” in which smartphone users develop symptoms traditionally associated with carpal tunnel syndrome (CTS). There has been no research to date which investigates the claims of “selfie wrist.” The primary aim of this study was to address the validity of “selfie wrist” claims. The secondary aim of this study was to further investigate the effects of texting on musculoskeletal health, taking into account the differences between texting one-handed versus two-handed, and the effect of using a grip device while texting.
The experiment consisted of an …
Staff Training In Aquatics For Individuals With Disabilities: The Quest, Susan J. Grosse
Staff Training In Aquatics For Individuals With Disabilities: The Quest, Susan J. Grosse
International Journal of Aquatic Research and Education
Trained instructors in general programs have the ability and resources to initiate and follow through with developing water safe individuals who are capable swimmers. Specific staff training to prepare individuals to facilitate aquatic participation for individuals with disabilities is currently extremely limited. The purpose of this article is to examine the barriers to specialized staff training in aquatics for individuals with disabilities, to suggest necessary staff training content, and to propose topics for further research in the area of staff training. Seeking development of quality staff training programs for those working in aquatics for individuals with disabilities is the quest.
Training Evaluation For Introductory Ocean Lifeguard Instruction: A Practical Example From California, William A. Koon, Ryan M. Gates, Jack Futoran
Training Evaluation For Introductory Ocean Lifeguard Instruction: A Practical Example From California, William A. Koon, Ryan M. Gates, Jack Futoran
International Journal of Aquatic Research and Education
Ocean lifeguards have several responsibilities that require precise training. California State Parks is one of the largest providers of open water lifeguard services in the United States, and trains approximately 200 new lifeguards per year. As part of our lifeguard training section’s quality improvement efforts, we conducted a training needs assessment to help determine how well our introductory ocean lifeguard training curriculum prepared lifeguards to perform job related tasks upon successful completion of the training program. We surveyed both first year and seasoned lead lifeguards on operational needs, training gaps, and specific subject areas. We identified several areas where our …
The Impact Of Exercise In Spaceflight And Microgravity Environments, William Bybee
The Impact Of Exercise In Spaceflight And Microgravity Environments, William Bybee
Mahurin Honors College Capstone Experience/Thesis Projects
Since mankind’s first spaceflight, a significant barricade in reaching distant planets has been the damaging effects of microgravity upon the human body. Effects range from loss in bone mineral density and severe muscle atrophy to autoimmune disorders. The most effective countermeasure of these effects to date is exercise. Implementation of exercise in microgravity is not an easy task, so various specialized equipment must be utilized to effectively administer it. Even with this equipment, exercise as it is currently used does not entirely prevent body systems from undergoing detrimental changes. New modalities and implementations are currently being investigated that may significantly …
Effects Of A Strength Training Intervention And Quality Of Life: Case Study On A Sedentary Adult Female, Lucas Frazier
Effects Of A Strength Training Intervention And Quality Of Life: Case Study On A Sedentary Adult Female, Lucas Frazier
Williams Honors College, Honors Research Projects
The purpose of the project is to evaluate physiological and quality of life changes in a
sedentary, senior-aged (55 or older) female using a six-week strength training
intervention. This case study will instruct how to perform a push-pull-legs split
routine by going to the gym three times per week. Prior to the six week intervention,
both quantitative and qualitative variables will be collected to assess baseline data,
including the subject’s resting heart rate, resting blood pressure, grip strength, one-
repetition maximum on seven whole body exercises (dumbbell bicep curl, tricep
pushdown, barbell bench press, wide-grip lat pull-down, seated dumbbell press, …
Chronic Muscle Weakness And Mitochondrial Dysfunction In The Absence Of Sustained Atrophy In A Preclinical Sepsis Model, Allison M. Owen, Samir P. Patel, Jeffrey D. Smith, Beverly K. Balasuriya, Stephanie F. Mori, Gregory S. Hawk, Arnold J. Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G. Rabchevsky, Timothy A. Butterfield, Karyn A. Esser, Charlotte A. Peterson, Marlene E. Starr, Hiroshi Saito
Chronic Muscle Weakness And Mitochondrial Dysfunction In The Absence Of Sustained Atrophy In A Preclinical Sepsis Model, Allison M. Owen, Samir P. Patel, Jeffrey D. Smith, Beverly K. Balasuriya, Stephanie F. Mori, Gregory S. Hawk, Arnold J. Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G. Rabchevsky, Timothy A. Butterfield, Karyn A. Esser, Charlotte A. Peterson, Marlene E. Starr, Hiroshi Saito
Physiology Faculty Publications
Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness, we first surpassed a critical barrier by establishing a murine model of sepsis with ICU-like interventions that allows for the study of survivors. We show that sepsis survivors have profound weakness for at least 1 month, even after recovery of muscle mass. Abnormal mitochondrial ultrastructure, impaired respiration and electron transport chain activities, and persistent protein oxidative damage were evident in the muscle of …