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Articles 1 - 7 of 7
Full-Text Articles in Physiology
An Evaluation Of Induced Shear Stress On Endothelial Cellular Adhesion Molecules, Edward B. Crabb
An Evaluation Of Induced Shear Stress On Endothelial Cellular Adhesion Molecules, Edward B. Crabb
Theses and Dissertations
The pathophysiology of atherosclerotic cardiovascular disease (CVD) is highlighted by vascular dysfunction and low-grade vascular inflammation. Furthermore, the site-specific distribution of atherosclerosis throughout the arterial vasculature is primarily determined by local hemodynamic force. Therefore, this dissertation outlines three experiments designed to investigate the role of acute mental and physical (i.e., aerobic exercise), and vascular wall shear stress (SS) on the inflammatory aspects of atherosclerosis. Chapter 2 examines the effect of acute laboratory-induced mental stress on intracellular pro-inflammatory signaling pathways in peripheral blood mononuclear cells. Chapter 3 investigates the impact of acute laboratory-induced mental stress and maximal aerobic exercise on the …
Impact Of Aerobic Exercise On Monocyte Subset Receptor Expression And Macrophage Polarization, Anson M. Blanks
Impact Of Aerobic Exercise On Monocyte Subset Receptor Expression And Macrophage Polarization, Anson M. Blanks
Theses and Dissertations
Atherosclerotic cardiovascular disease (CVD) is hallmarked by inflammatory immune activation, particularly by the induction of a response by monocytes. Classical (CD14++CD16-) are anti-inflammatory mediators under homeostatic conditions, while intermediate (CD14++CD16+) and non-classical (CD14LowCD16++) monocytes promote inflammation following activation. Monocyte activation and functionality is dependent upon receptor expression and ligand production by a variety of cells, including monocytes. Alterations in the expression of surface receptors often have a direct impact upon monocyte function, such as the increased pro-inflammatory cytokine production in response to activation that accompanies elevated CD14 expression …
Metabolic Limits And Adaptation In Humans: Daily Energy Expenditure In Race Across The Usa Athletes, Caitlin Thurber
Metabolic Limits And Adaptation In Humans: Daily Energy Expenditure In Race Across The Usa Athletes, Caitlin Thurber
Theses and Dissertations
A longitudinal doubly labeled water study of total energy expenditure (TEE) in Race Across the USA athletes, examining the effects of extremely high levels of activity on metabolic adaptation.
Adiponectin And Selenium Rich Diet Can Act As A Complimentary Medicine In The Treatment Of Intestinal And Chronic Inflammation Induced Colon Cancer, Arpit Saxena
Theses and Dissertations
Colon cancer is the second largest cause of cancer death in United States. Chronic inflammation and obesity predispose patients to colon cancer. Adipose tissue is a source of bioactive substances called adipokines. Adiponectin (APN), an adipokine has anti-inflammatory property and found at lower levels in obese patients. Selenium (Se), a trace mineral and a dietary supplement, is inversely associated with cancer risk and possess anti-inflammatory and anti-carcinogenic properties. The overall purpose of this dissertation is to determine if chronic inflammation leading to colon and intestinal cancer are regulated by APN or Se rich diet or both. The working hypothesis is …
Novel Drug 2-Benzoyl-3-Phenyl 6,7-Dichloroquinoxaline 1,4-Dioxide Induces Colon Cancer Cell Apoptosis Through Hif-1Α Pathway, Alexander-Jacques Theodore Sougiannis
Novel Drug 2-Benzoyl-3-Phenyl 6,7-Dichloroquinoxaline 1,4-Dioxide Induces Colon Cancer Cell Apoptosis Through Hif-1Α Pathway, Alexander-Jacques Theodore Sougiannis
Theses and Dissertations
Recent developments in the field of cancer genomics have shown transcription factor HIF-1α as a major player in the survival and proliferation of colorectal tumors. Hypoxia targeted drug engineering has led to significant advancements in cancer treatments as a method of directly utilizing the hypoxic regions against the tumor. Novel drug DCQ (2-benzoyl-3-phenyl 6,7-dichloroquinoxaline 1,4-dioxide) has shown promising anti-tumor results in-vitro and in-vivo. The purpose of this study was to utilize a tumor xenograft and genetic mouse model of colorectal cancer to investigate the safety, clinical effectiveness, and mechanism of action of DCQ. Methods: 10 week old Balb/c mice were …
Cardiorespiratory Fitness, Body Fatness Effect On Submaximal Systolic Blood Pressure And Cardiovascular Prognosis Among Young Adults, Vivek Kumar Prasad
Cardiorespiratory Fitness, Body Fatness Effect On Submaximal Systolic Blood Pressure And Cardiovascular Prognosis Among Young Adults, Vivek Kumar Prasad
Theses and Dissertations
Cardiovascular (CV) diseases (CVDs) are known to be the leading cause of death globally, as CVDs account for the highest rate of mortality compared to any other causes. The mortality from CVDs, is projected to increase to nearly 23.3 million by 2030. Mortality number due to CVD in the United States is 600,000 per year, thus representing nearly 1 in every 4 deaths. Exercise blood pressure (BP) is an important marker of CV events that are associated with incident CV morbidity and mortality among individuals with or without any CVD at present. Elevated exercise BP among individuals with normal resting …
Comparison Of Two Different Sprint Interval Training Work-To-Rest Ratios On Acute Metabolic And Inflammatory Responses, Christopher R. Harnish
Comparison Of Two Different Sprint Interval Training Work-To-Rest Ratios On Acute Metabolic And Inflammatory Responses, Christopher R. Harnish
Theses and Dissertations
High intensity exercise is believed to yield greater results on health and human performance than moderate intensity exercise. Extensive research indicates that not only do high-intensity interval training (HIT) and sprint interval training (SIT) produce significant improvements in cardiovascular fitness and disease, they may be more effective at improving long-term metabolic function, including insulin sensitivity (Si), by producing more mitochondria. Moreover, compliance rates for HIT and SIT participation are reported to be the same or better than traditional moderate intensity exercise. Because lack of time is often cited as major hindrance to exercise participation, SIT is also seen as a …